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The map label for this gene is mscS [H]

Identifier: 114797606

GI number: 114797606

Start: 592674

End: 593507

Strand: Reverse

Name: mscS [H]

Synonym: HNE_0597

Alternate gene names: 114797606

Gene position: 593507-592674 (Counterclockwise)

Preceding gene: 114799133

Following gene: 114800372

Centisome position: 16.02

GC content: 59.11

Gene sequence:

>834_bases
ATGGACGAGACAATGAACCCCCAGGCCATCTGGGAGACTTTAGGCCCCTATCTTTTGCCCTTCGGATTGAGGGCGATCGG
CGCCCTGGTTCTGGTGATTGTCGGGCTGCGAATTGCCGGCTGGCTGAGCGGGTTGGTGCGCAAGCAGGCAAGCCGTAACC
CGCAGATTGATGTGACGCTGTCGAACTTCTTTGCGTCTCTGGTTCAGTGGGCGATTATTGCGGCGGTTGCGATCGCGACA
CTTCAGGTGTTTGGCGTGCAGGCGACGAGCTTTGTGGCGGTGCTGGGCGCGCTGACGCTGGCGATTGGTCTTTCGATGCA
GGGCGCGCTGGGCAACATTGCCTCGGGCGTGATGATCATGGTGTTCAGGCCCTACAAGCTGGGTGACTATATCGAGGCAG
CCGATGTCGCCGGCACGGTGAAGGATATTTCCCTCTTCCAGACCATTCTGGCGACCCCGGACAATATCAAGGTGATCATA
CCCAACAGCCAGGCCATCGATGATGTGATCAAGAACTATTCCGGCTTTGACCAGCGGCGCGTGGATGTGACCTTCGGCAT
CGATTACAATGACGACATGGACAAGGCGATCGCCATCATCCGCGCCGTGATCGACGAAGACCCCCGCATCCTGAGAGACC
CGGAGCCATTCGTCCGGGTGGTCAATCTGGGCGACAGTTCGGTGGATATCGCCTCGCGCAGCTGGGTGGCGTCGGATGAA
TACTGGCCGGTACGCCTCGACATTACCCACAAGGTGAAGGCCGCCTTCGACCGGGAAGGCATTTCCATTCCGTATCCGCA
CCGCACATTCGTGCAGAAGGTGGCGGCCGAGTAA

Upstream 100 bases:

>100_bases
GAATACATTCAATGCTGCAACAACAAGGAAAGGATCGCAGCCACACATAAATGCCGTATGCTGACCAACGACAGCAGGCT
CACCTCAAAAGGAGACTGAC

Downstream 100 bases:

>100_bases
GGCCGTCTCTGACGGCCCGGCCCTATCGGGAAACGGGCGGGGGGATTAGGATGTCTGCATGACCGACACGCCTGACGCCC
CTCGCCCCGATCCGCAGCCT

Product: mechanosensitive ion channel family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MDETMNPQAIWETLGPYLLPFGLRAIGALVLVIVGLRIAGWLSGLVRKQASRNPQIDVTLSNFFASLVQWAIIAAVAIAT
LQVFGVQATSFVAVLGALTLAIGLSMQGALGNIASGVMIMVFRPYKLGDYIEAADVAGTVKDISLFQTILATPDNIKVII
PNSQAIDDVIKNYSGFDQRRVDVTFGIDYNDDMDKAIAIIRAVIDEDPRILRDPEPFVRVVNLGDSSVDIASRSWVASDE
YWPVRLDITHKVKAAFDREGISIPYPHRTFVQKVAAE

Sequences:

>Translated_277_residues
MDETMNPQAIWETLGPYLLPFGLRAIGALVLVIVGLRIAGWLSGLVRKQASRNPQIDVTLSNFFASLVQWAIIAAVAIAT
LQVFGVQATSFVAVLGALTLAIGLSMQGALGNIASGVMIMVFRPYKLGDYIEAADVAGTVKDISLFQTILATPDNIKVII
PNSQAIDDVIKNYSGFDQRRVDVTFGIDYNDDMDKAIAIIRAVIDEDPRILRDPEPFVRVVNLGDSSVDIASRSWVASDE
YWPVRLDITHKVKAAFDREGISIPYPHRTFVQKVAAE
>Mature_277_residues
MDETMNPQAIWETLGPYLLPFGLRAIGALVLVIVGLRIAGWLSGLVRKQASRNPQIDVTLSNFFASLVQWAIIAAVAIAT
LQVFGVQATSFVAVLGALTLAIGLSMQGALGNIASGVMIMVFRPYKLGDYIEAADVAGTVKDISLFQTILATPDNIKVII
PNSQAIDDVIKNYSGFDQRRVDVTFGIDYNDDMDKAIAIIRAVIDEDPRILRDPEPFVRVVNLGDSSVDIASRSWVASDE
YWPVRLDITHKVKAAFDREGISIPYPHRTFVQKVAAE

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=251, Percent_Identity=40.2390438247012, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1786670, Length=173, Percent_Identity=28.3236994219653, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787591, Length=249, Percent_Identity=22.8915662650602, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367355, Length=186, Percent_Identity=24.1935483870968, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 30275; Mature: 30275

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDETMNPQAIWETLGPYLLPFGLRAIGALVLVIVGLRIAGWLSGLVRKQASRNPQIDVTL
CCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEH
SNFFASLVQWAIIAAVAIATLQVFGVQATSFVAVLGALTLAIGLSMQGALGNIASGVMIM
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEE
VFRPYKLGDYIEAADVAGTVKDISLFQTILATPDNIKVIIPNSQAIDDVIKNYSGFDQRR
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCEE
VDVTFGIDYNDDMDKAIAIIRAVIDEDPRILRDPEPFVRVVNLGDSSVDIASRSWVASDE
EEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEEEEECCCCCCCHHHCCEECCCC
YWPVRLDITHKVKAAFDREGISIPYPHRTFVQKVAAE
CEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MDETMNPQAIWETLGPYLLPFGLRAIGALVLVIVGLRIAGWLSGLVRKQASRNPQIDVTL
CCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEH
SNFFASLVQWAIIAAVAIATLQVFGVQATSFVAVLGALTLAIGLSMQGALGNIASGVMIM
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEE
VFRPYKLGDYIEAADVAGTVKDISLFQTILATPDNIKVIIPNSQAIDDVIKNYSGFDQRR
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCEE
VDVTFGIDYNDDMDKAIAIIRAVIDEDPRILRDPEPFVRVVNLGDSSVDIASRSWVASDE
EEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEEEEECCCCCCCHHHCCEECCCC
YWPVRLDITHKVKAAFDREGISIPYPHRTFVQKVAAE
CEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]