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The map label for this gene is mutL [H]

Identifier: 114799039

GI number: 114799039

Start: 928151

End: 930055

Strand: Direct

Name: mutL [H]

Synonym: HNE_0913

Alternate gene names: 114799039

Gene position: 928151-930055 (Clockwise)

Preceding gene: 114800226

Following gene: 114800070

Centisome position: 25.05

GC content: 67.87

Gene sequence:

>1905_bases
ATGGCTGATTCTGCTCCCCCCCGTCCGACGATCCGCAAACTGCCCGCTGATGTGGTCAACCGCATCGCGGCGGGCGAGGT
CGTCGAGCGGCCCGCAGCCGCGGTGAAGGAGCTTGTGGAAAACGCCCTCGATGCCGGCGCGCGCAGCATTGCCATCGCCA
TCGAGGAAGGCGGCCTCAAGCGCATCACCATCGAAGATGATGGCTGCGGCCTCTCCGCCGATGACCTGCTGATCGCGCTG
GAGCGTCACGCCACCTCCAAACTCGTGCCGGACACCGAAGGCCGCGTAGACCTCCTCAACATCTACACGATGGGGTTCCG
CGGCGAGGCCTTGCCCTCCATTGCCTCGGTCAGCCGCATGCGCATCGTTTCCCGCGCCAGCGGGGAAGACGCCGCCGAAA
TCTTCTCCGATGCCGGCCGCCTCGACGGTCCCCGTCCCGCCGCCTTTACCGGCCGCAGCGAAACCGGCACCCGCATCGAC
GTGAACGACCTTTTCCACGCCACGCCCGCCCGCCTCAAATTCATGCGCGGCGAACGCGCCGAAGCGATGGCCGTCACCGA
CGCGGTCAAGCGCCTCGCCATGGCCAATCCGGAAGTCGCCTTCAGCCTCGAAAGCAATGGCCGCAGCCTCTTCCGCTATC
CCGCTGAAGGTCCGGGCGATGCCGGGCGCCTCAAACGCCTCGGCGCGATCATGGGCCGGGACTTTTCAGACAATGCCGTC
GCCGTCGACGCCACGCGCGAAGGCGTGCGCCTGTCAGGCTTTGCGGGCCTGCCAACACTCAATCGCGGCAACGCGCAGAT
GCAGTTCCTGTTCGTCAATGGCCGCCCGGTGAAAGACCGTATGCTGACAGGCGTGGTACGCGCCGCCTATCAGGATTTCC
TGGCGCGGGACCGCCACCCGATGGCCGCGCTGTTTGTGGACCTTGATCCCGAAGGCGTGGACGTCAACGTCCACCCCGCC
AAAACCGAAGTGCGTTTCCGCGATGCAGGCGGCGTGCGCGGCCTGATGATCTCGGCGCTGCGCCACGCGCTCGCCGCCGC
CGGCCACCGCGCCTCCACCACCGTCGCCGGCTTCGCCCTCGGCAAGGCCCGCGCCGAGCCCGCCCCGCAGGCCGGCTTCC
TCTGGCAGGCGCCCCAGCCGGGTGGCTATGTCCAGCGCCCCGCCATGCCCCCGCAAGGCTACGCCGCCCGCCAGGTGGAA
GAAGACGGCGCCAGCGCCCCCTTCGCCCCACGCGGCTATGTGCCAGACTATGTCCCCGATCAGGGCGCTCCGGGCGCAAA
GGTCGAAACCGGCCCCATGCCCGCGCCGGGCATGCTCGGGGAATACCCCCTCGGCGCCGCCCGTGCCCAGGTCCACGAAA
CCTATATCATCGCTCAGACGGCGGACGGCATCGTCATCGTCGACCAGCATGCCGCCCATGAGCGCCTCGTCTACGAAGCC
ATGAAACGCCAGATGGCCGAAGGCGGCGTCCGGCGTCAGGCGCTGCTCATCCCGGATATTGTCGAACTCTCCGAAGACGA
AGCCCACCGCGTCTGCGCCCGCGCTGAGGAACTCGCCGCCCTTGGCCTCGAAATCGAGCCTTTCGGCCCCGGCGCCATCG
CCGTACGCGCCACGCCCGCCCTCTTCGGAGAGATGGACGCCGCCGGCCTCATCCGCGATCTCGCCGATGATTTTGCCGAA
TATGAAGCGGGCCTCACCCTGTCGGAACGCTTCGAAGAAGTGATGGGCAACATGGCCTGCCGCTCCTCCATCCGCGCCGG
GCGCCGTCTGAATGCGGATGAAATGAACGCGCTCCTGCGCCAGATGGAAGCCACACCCCATTCGGGCCAGTGCAATCACG
GCCGCCCCACCTATGTCGAGCTGAAACTCGCCGACATCGAACGCCTCTTCGGCCGCCGGGGATGA

Upstream 100 bases:

>100_bases
TTTATCAAAACCCGCAGAAACAAGGCGCTGGCGCCAGTATCCGCCGGGCCGCAGCGCGCCAGACGACATCCCGCCCCGGA
TCGGCTAATCTTTGCCCCTC

Downstream 100 bases:

>100_bases
CCGGGATGCGGCTCAGCCGGCGCAGCCTGATGGCAGGGGTCGCAGGCGCGGCCCTCACTGCCTGCGCTCACCGGGCAGAC
CCCATGCGTATCCCCGCCGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MADSAPPRPTIRKLPADVVNRIAAGEVVERPAAAVKELVENALDAGARSIAIAIEEGGLKRITIEDDGCGLSADDLLIAL
ERHATSKLVPDTEGRVDLLNIYTMGFRGEALPSIASVSRMRIVSRASGEDAAEIFSDAGRLDGPRPAAFTGRSETGTRID
VNDLFHATPARLKFMRGERAEAMAVTDAVKRLAMANPEVAFSLESNGRSLFRYPAEGPGDAGRLKRLGAIMGRDFSDNAV
AVDATREGVRLSGFAGLPTLNRGNAQMQFLFVNGRPVKDRMLTGVVRAAYQDFLARDRHPMAALFVDLDPEGVDVNVHPA
KTEVRFRDAGGVRGLMISALRHALAAAGHRASTTVAGFALGKARAEPAPQAGFLWQAPQPGGYVQRPAMPPQGYAARQVE
EDGASAPFAPRGYVPDYVPDQGAPGAKVETGPMPAPGMLGEYPLGAARAQVHETYIIAQTADGIVIVDQHAAHERLVYEA
MKRQMAEGGVRRQALLIPDIVELSEDEAHRVCARAEELAALGLEIEPFGPGAIAVRATPALFGEMDAAGLIRDLADDFAE
YEAGLTLSERFEEVMGNMACRSSIRAGRRLNADEMNALLRQMEATPHSGQCNHGRPTYVELKLADIERLFGRRG

Sequences:

>Translated_634_residues
MADSAPPRPTIRKLPADVVNRIAAGEVVERPAAAVKELVENALDAGARSIAIAIEEGGLKRITIEDDGCGLSADDLLIAL
ERHATSKLVPDTEGRVDLLNIYTMGFRGEALPSIASVSRMRIVSRASGEDAAEIFSDAGRLDGPRPAAFTGRSETGTRID
VNDLFHATPARLKFMRGERAEAMAVTDAVKRLAMANPEVAFSLESNGRSLFRYPAEGPGDAGRLKRLGAIMGRDFSDNAV
AVDATREGVRLSGFAGLPTLNRGNAQMQFLFVNGRPVKDRMLTGVVRAAYQDFLARDRHPMAALFVDLDPEGVDVNVHPA
KTEVRFRDAGGVRGLMISALRHALAAAGHRASTTVAGFALGKARAEPAPQAGFLWQAPQPGGYVQRPAMPPQGYAARQVE
EDGASAPFAPRGYVPDYVPDQGAPGAKVETGPMPAPGMLGEYPLGAARAQVHETYIIAQTADGIVIVDQHAAHERLVYEA
MKRQMAEGGVRRQALLIPDIVELSEDEAHRVCARAEELAALGLEIEPFGPGAIAVRATPALFGEMDAAGLIRDLADDFAE
YEAGLTLSERFEEVMGNMACRSSIRAGRRLNADEMNALLRQMEATPHSGQCNHGRPTYVELKLADIERLFGRRG
>Mature_633_residues
ADSAPPRPTIRKLPADVVNRIAAGEVVERPAAAVKELVENALDAGARSIAIAIEEGGLKRITIEDDGCGLSADDLLIALE
RHATSKLVPDTEGRVDLLNIYTMGFRGEALPSIASVSRMRIVSRASGEDAAEIFSDAGRLDGPRPAAFTGRSETGTRIDV
NDLFHATPARLKFMRGERAEAMAVTDAVKRLAMANPEVAFSLESNGRSLFRYPAEGPGDAGRLKRLGAIMGRDFSDNAVA
VDATREGVRLSGFAGLPTLNRGNAQMQFLFVNGRPVKDRMLTGVVRAAYQDFLARDRHPMAALFVDLDPEGVDVNVHPAK
TEVRFRDAGGVRGLMISALRHALAAAGHRASTTVAGFALGKARAEPAPQAGFLWQAPQPGGYVQRPAMPPQGYAARQVEE
DGASAPFAPRGYVPDYVPDQGAPGAKVETGPMPAPGMLGEYPLGAARAQVHETYIIAQTADGIVIVDQHAAHERLVYEAM
KRQMAEGGVRRQALLIPDIVELSEDEAHRVCARAEELAALGLEIEPFGPGAIAVRATPALFGEMDAAGLIRDLADDFAEY
EAGLTLSERFEEVMGNMACRSSIRAGRRLNADEMNALLRQMEATPHSGQCNHGRPTYVELKLADIERLFGRRG

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=319, Percent_Identity=35.423197492163, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI4505913, Length=371, Percent_Identity=26.9541778975741, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI310128478, Length=371, Percent_Identity=26.9541778975741, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4505911, Length=341, Percent_Identity=26.099706744868, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI189458898, Length=341, Percent_Identity=26.099706744868, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI189458896, Length=334, Percent_Identity=27.2455089820359, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI310128480, Length=326, Percent_Identity=24.5398773006135, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI263191589, Length=226, Percent_Identity=27.4336283185841, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI91992162, Length=291, Percent_Identity=27.8350515463918, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI91992160, Length=291, Percent_Identity=27.8350515463918, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1790612, Length=341, Percent_Identity=42.2287390029325, Blast_Score=248, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71991825, Length=334, Percent_Identity=36.5269461077844, Blast_Score=178, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=374, Percent_Identity=25.668449197861, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=358, Percent_Identity=31.8435754189944, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325093, Length=729, Percent_Identity=22.4965706447188, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324247, Length=351, Percent_Identity=25.3561253561254, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323063, Length=358, Percent_Identity=24.0223463687151, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17136968, Length=321, Percent_Identity=36.7601246105919, Blast_Score=186, Evalue=6e-47,
Organism=Drosophila melanogaster, GI17136970, Length=363, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67945; Mature: 67814

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSAPPRPTIRKLPADVVNRIAAGEVVERPAAAVKELVENALDAGARSIAIAIEEGGLK
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEE
RITIEDDGCGLSADDLLIALERHATSKLVPDTEGRVDLLNIYTMGFRGEALPSIASVSRM
EEEEECCCCCCCHHHHEEEEHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHH
RIVSRASGEDAAEIFSDAGRLDGPRPAAFTGRSETGTRIDVNDLFHATPARLKFMRGERA
HHHHHCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEHHHHHCCCHHHHHHHCCCCH
EAMAVTDAVKRLAMANPEVAFSLESNGRSLFRYPAEGPGDAGRLKRLGAIMGRDFSDNAV
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEE
AVDATREGVRLSGFAGLPTLNRGNAQMQFLFVNGRPVKDRMLTGVVRAAYQDFLARDRHP
EEECCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
MAALFVDLDPEGVDVNVHPAKTEVRFRDAGGVRGLMISALRHALAAAGHRASTTVAGFAL
EEEEEEEECCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
GKARAEPAPQAGFLWQAPQPGGYVQRPAMPPQGYAARQVEEDGASAPFAPRGYVPDYVPD
HHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
QGAPGAKVETGPMPAPGMLGEYPLGAARAQVHETYIIAQTADGIVIVDQHAAHERLVYEA
CCCCCCEEECCCCCCCCCCCCCCCCHHHHHHEEEEEEEECCCCEEEECCCHHHHHHHHHH
MKRQMAEGGVRRQALLIPDIVELSEDEAHRVCARAEELAALGLEIEPFGPGAIAVRATPA
HHHHHHHCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECHH
LFGEMDAAGLIRDLADDFAEYEAGLTLSERFEEVMGNMACRSSIRAGRRLNADEMNALLR
HHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QMEATPHSGQCNHGRPTYVELKLADIERLFGRRG
HHHCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCC
>Mature Secondary Structure 
ADSAPPRPTIRKLPADVVNRIAAGEVVERPAAAVKELVENALDAGARSIAIAIEEGGLK
CCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEE
RITIEDDGCGLSADDLLIALERHATSKLVPDTEGRVDLLNIYTMGFRGEALPSIASVSRM
EEEEECCCCCCCHHHHEEEEHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHH
RIVSRASGEDAAEIFSDAGRLDGPRPAAFTGRSETGTRIDVNDLFHATPARLKFMRGERA
HHHHHCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEHHHHHCCCHHHHHHHCCCCH
EAMAVTDAVKRLAMANPEVAFSLESNGRSLFRYPAEGPGDAGRLKRLGAIMGRDFSDNAV
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEE
AVDATREGVRLSGFAGLPTLNRGNAQMQFLFVNGRPVKDRMLTGVVRAAYQDFLARDRHP
EEECCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
MAALFVDLDPEGVDVNVHPAKTEVRFRDAGGVRGLMISALRHALAAAGHRASTTVAGFAL
EEEEEEEECCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
GKARAEPAPQAGFLWQAPQPGGYVQRPAMPPQGYAARQVEEDGASAPFAPRGYVPDYVPD
HHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
QGAPGAKVETGPMPAPGMLGEYPLGAARAQVHETYIIAQTADGIVIVDQHAAHERLVYEA
CCCCCCEEECCCCCCCCCCCCCCCCHHHHHHEEEEEEEECCCCEEEECCCHHHHHHHHHH
MKRQMAEGGVRRQALLIPDIVELSEDEAHRVCARAEELAALGLEIEPFGPGAIAVRATPA
HHHHHHHCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECHH
LFGEMDAAGLIRDLADDFAEYEAGLTLSERFEEVMGNMACRSSIRAGRRLNADEMNALLR
HHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QMEATPHSGQCNHGRPTYVELKLADIERLFGRRG
HHHCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA