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The map label for this gene is fabF [H]

Identifier: 114798980

GI number: 114798980

Start: 2244883

End: 2246169

Strand: Reverse

Name: fabF [H]

Synonym: HNE_2156

Alternate gene names: 114798980

Gene position: 2246169-2244883 (Counterclockwise)

Preceding gene: 114798204

Following gene: 114800253

Centisome position: 60.63

GC content: 60.06

Gene sequence:

>1287_bases
ATGTCGAAGCGTCGTGTTGTCATCACCGGTATCGGTATTGTTTCTCCTCTGGCCAATGGCCGGGAGGCGACTTGGGAGCG
TCTGATTGCCGGTAAATCCGGCGCAGGCAAGATCGACAATTTCGACGCTTCGGACCTGCCGTGCAAAATCGCTTTTCAGG
TTCCGTGGGCCTCTGGCCGCGGCGGCGGAGAAGGCGATGAGCACGCTTTCGATCCTGATAAAGTGCTGTCCTCCAAGGAA
CAGCGCCGGATCGACGAGTTCATTCTGTACGGCATTGCCGCTGCAGACGAGGCGTTGGCCGATTCCGGCCTGAAGCTCGA
AACCGATGATCAAAAAGAACGCGCAGGCGTGATGATCGGATCTGGTATCGGTGGTCTTGAGACCATTTATGAAACCTCGA
TCACACTGCATGAGCACGGACCCCGGAAGGTCAGCCCGTTCTTCATTCCGGCGTCGCTGATCAACCTTGCCTCTGGACAG
ATTTCGATCCGGCATGGCCTCAAGGGCCCCAACCACTCTGTTGTTACGGCCTGTGCGACTGGCGCGCATGCGATCGGCGA
TTCTGCGCGTCTCATCTCTTACGGCGATGCTGATGTGATGGTGGCCGGTGGGGCTGAAGCGGTGATCGGCAGACTTGGCA
TTGCGGGTTTCTGCGCCGCCAAGGCCATGTCGACCAGCTTCAACGATACGCCCGAGAAGGCATCCCGCCCTTATGACAAG
GATCGGGATGGTTTCGTCATGGGTGAGGGCGCTGCTGTGCTCGTGCTTGAAGAGTATGAACACGCCAAGGCACGCGGCGC
GAAGATCTACGCTGAAGTGGCGGGCTATGGCCTGACCGGCGACGCGCATCACATCACCGCGCCGGCTGAAGGCGCCGAGG
GCGGCTATCGGGCCATGAAGATGGCGCTGAAAAATTCCGGTATCGACCCGGCCGAGATCGACTACGTCAATGCTCACGGC
ACCTCCACGCCGAAAGGCGATGAGGGTGAGGCTGGCGCCGTCGAACGCGCGTTCGGCGATCACGCGAAGAACATCTCCAT
GTCGTCAACCAAATCGGCTGTCGGACACCTGCTCGGCGCCGCTGGCGCGATCGAGGCCGCATTCTGCGCGCTCGCGATCC
GTGACCAGGTCATGCCGCCGACGTTGAACCTCGACAATCCGAGCTTCGAAACCGTGCTTGATCTCATTCCGCACAAGGCC
AAGAAAGGCCGCGTTCGCGCAGCCATGTCGAACAGCTTTGGCTTTGGCGGCACCAACGCATCCCTGGTTCTGCGCAAGGT
CGATTGA

Upstream 100 bases:

>100_bases
AGTTTAACATCGAGATCCCTGATGACGTGCAAGAGTCGATCCGTTCGGTCGGTGACGCCGTCTCGCACATCAAGGCCCAC
GTCTAAGGCGCTGGGTTGTC

Downstream 100 bases:

>100_bases
TCCTGCCACTTGGCCATCTGTTACACGAACGAACCGCTGGCCCACAGGCTGGCGGTTCTTTCATATCGGCCGGATGCGAA
GTCCAAGTAACGCCTGACAG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSKRRVVITGIGIVSPLANGREATWERLIAGKSGAGKIDNFDASDLPCKIAFQVPWASGRGGGEGDEHAFDPDKVLSSKE
QRRIDEFILYGIAAADEALADSGLKLETDDQKERAGVMIGSGIGGLETIYETSITLHEHGPRKVSPFFIPASLINLASGQ
ISIRHGLKGPNHSVVTACATGAHAIGDSARLISYGDADVMVAGGAEAVIGRLGIAGFCAAKAMSTSFNDTPEKASRPYDK
DRDGFVMGEGAAVLVLEEYEHAKARGAKIYAEVAGYGLTGDAHHITAPAEGAEGGYRAMKMALKNSGIDPAEIDYVNAHG
TSTPKGDEGEAGAVERAFGDHAKNISMSSTKSAVGHLLGAAGAIEAAFCALAIRDQVMPPTLNLDNPSFETVLDLIPHKA
KKGRVRAAMSNSFGFGGTNASLVLRKVD

Sequences:

>Translated_428_residues
MSKRRVVITGIGIVSPLANGREATWERLIAGKSGAGKIDNFDASDLPCKIAFQVPWASGRGGGEGDEHAFDPDKVLSSKE
QRRIDEFILYGIAAADEALADSGLKLETDDQKERAGVMIGSGIGGLETIYETSITLHEHGPRKVSPFFIPASLINLASGQ
ISIRHGLKGPNHSVVTACATGAHAIGDSARLISYGDADVMVAGGAEAVIGRLGIAGFCAAKAMSTSFNDTPEKASRPYDK
DRDGFVMGEGAAVLVLEEYEHAKARGAKIYAEVAGYGLTGDAHHITAPAEGAEGGYRAMKMALKNSGIDPAEIDYVNAHG
TSTPKGDEGEAGAVERAFGDHAKNISMSSTKSAVGHLLGAAGAIEAAFCALAIRDQVMPPTLNLDNPSFETVLDLIPHKA
KKGRVRAAMSNSFGFGGTNASLVLRKVD
>Mature_427_residues
SKRRVVITGIGIVSPLANGREATWERLIAGKSGAGKIDNFDASDLPCKIAFQVPWASGRGGGEGDEHAFDPDKVLSSKEQ
RRIDEFILYGIAAADEALADSGLKLETDDQKERAGVMIGSGIGGLETIYETSITLHEHGPRKVSPFFIPASLINLASGQI
SIRHGLKGPNHSVVTACATGAHAIGDSARLISYGDADVMVAGGAEAVIGRLGIAGFCAAKAMSTSFNDTPEKASRPYDKD
RDGFVMGEGAAVLVLEEYEHAKARGAKIYAEVAGYGLTGDAHHITAPAEGAEGGYRAMKMALKNSGIDPAEIDYVNAHGT
STPKGDEGEAGAVERAFGDHAKNISMSSTKSAVGHLLGAAGAIEAAFCALAIRDQVMPPTLNLDNPSFETVLDLIPHKAK
KGRVRAAMSNSFGFGGTNASLVLRKVD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=424, Percent_Identity=51.4150943396226, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI223972627, Length=194, Percent_Identity=44.3298969072165, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI41872631, Length=434, Percent_Identity=23.2718894009217, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1787337, Length=428, Percent_Identity=52.5700934579439, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1788663, Length=426, Percent_Identity=36.6197183098592, Blast_Score=252, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=427, Percent_Identity=39.344262295082, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=44.1509433962264, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=368, Percent_Identity=26.9021739130435, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=268, Percent_Identity=27.2388059701493, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=39.1982182628062, Blast_Score=303, Evalue=4e-83,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=48.1220657276995, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221330659, Length=370, Percent_Identity=25.4054054054054, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI19920632, Length=370, Percent_Identity=25.4054054054054, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24581345, Length=375, Percent_Identity=23.7333333333333, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44659; Mature: 44528

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVITGIGIVSPLANGREATWERLIAGKSGAGKIDNFDASDLPCKIAFQVPWASGR
CCCCEEEEEECHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
GGGEGDEHAFDPDKVLSSKEQRRIDEFILYGIAAADEALADSGLKLETDDQKERAGVMIG
CCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHCCEEEE
SGIGGLETIYETSITLHEHGPRKVSPFFIPASLINLASGQISIRHGLKGPNHSVVTACAT
CCCCCHHHHHHCEEEEECCCCCCCCCEEEHHHHHHHCCCCEEEECCCCCCCCCEEEEECC
GAHAIGDSARLISYGDADVMVAGGAEAVIGRLGIAGFCAAKAMSTSFNDTPEKASRPYDK
CCHHCCCCCEEEEECCCCEEEECCHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHCCCCCC
DRDGFVMGEGAAVLVLEEYEHAKARGAKIYAEVAGYGLTGDAHHITAPAEGAEGGYRAMK
CCCCEEEECCCEEEEEECCHHHHHCCCEEEEEHHCCCCCCCCCEEECCCCCCCCHHHHHH
MALKNSGIDPAEIDYVNAHGTSTPKGDEGEAGAVERAFGDHAKNISMSSTKSAVGHLLGA
HHHHHCCCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGAIEAAFCALAIRDQVMPPTLNLDNPSFETVLDLIPHKAKKGRVRAAMSNSFGFGGTNA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCC
SLVLRKVD
EEEEEECC
>Mature Secondary Structure 
SKRRVVITGIGIVSPLANGREATWERLIAGKSGAGKIDNFDASDLPCKIAFQVPWASGR
CCCEEEEEECHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
GGGEGDEHAFDPDKVLSSKEQRRIDEFILYGIAAADEALADSGLKLETDDQKERAGVMIG
CCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHCCEEEE
SGIGGLETIYETSITLHEHGPRKVSPFFIPASLINLASGQISIRHGLKGPNHSVVTACAT
CCCCCHHHHHHCEEEEECCCCCCCCCEEEHHHHHHHCCCCEEEECCCCCCCCCEEEEECC
GAHAIGDSARLISYGDADVMVAGGAEAVIGRLGIAGFCAAKAMSTSFNDTPEKASRPYDK
CCHHCCCCCEEEEECCCCEEEECCHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHCCCCCC
DRDGFVMGEGAAVLVLEEYEHAKARGAKIYAEVAGYGLTGDAHHITAPAEGAEGGYRAMK
CCCCEEEECCCEEEEEECCHHHHHCCCEEEEEHHCCCCCCCCCEEECCCCCCCCHHHHHH
MALKNSGIDPAEIDYVNAHGTSTPKGDEGEAGAVERAFGDHAKNISMSSTKSAVGHLLGA
HHHHHCCCCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGAIEAAFCALAIRDQVMPPTLNLDNPSFETVLDLIPHKAKKGRVRAAMSNSFGFGGTNA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCC
SLVLRKVD
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]