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The map label for this gene is fadA [H]

Identifier: 114798967

GI number: 114798967

Start: 765360

End: 766610

Strand: Reverse

Name: fadA [H]

Synonym: HNE_0758

Alternate gene names: 114798967

Gene position: 766610-765360 (Counterclockwise)

Preceding gene: 114798754

Following gene: 114798177

Centisome position: 20.69

GC content: 63.23

Gene sequence:

>1251_bases
ATGGCTGAAGCCTATATCATCGACGCTGTCCGCACCCCGCGCGGCATCGGCAAAGTTGGCAAGGGCGCCCTCGCCCACAT
GCACCCGCAGCACCTCGCCGCAACCGTTCTCAGCGCCATCGCCGAGCGCAACAAGCTCGACACGGCAACGGTCGACGACA
TCATCTGGGGCACCTCCAGCCAGCGCGGCGCGCAGGGCGCCGACATGGGCCGCATGGCCGCGCTTGATGCCGGTTTCGAC
ATCAAGGCTTCGGGCGTGACGCTCGACCGTTTCTGCGGCTCGGGCATCACCACCGTTTCGCTCGCCGCTGCACAGATCAT
GTCCGGCATGGAAGACTGCGTGATCGCAGGCGGCTGCGAAATGATGAGCTACACGGCTGCCAGCGCAGACCCGAAAAACC
CGCCCACGATGGACGCCGGCAACACCCGCCTGCGCGAGAAGCACCCGCAATCACAGCAGGGCGTTTGCGCCGACGCGATC
GCCACGCTGGAAGGCATCGACCGCGAAGCCGTTGACCGCCTCGCCGTCACCAGCCAGCAGCGCGCTGCCCGCGCCATTTC
CGAGGGCCGCTTCAACAAGTCGGTTGTTCCTGTTTACAACGTGGACGGAACACTTGCGCTTGACCATGAAGAGTTCCCGC
GTCCGCAGACGACGATGGAAAGCCTGGCTGGCCTGAAAACCGTGTTCGGCATGTACATGGACATTCCGGTCGACGACCAG
GGCAACACCTATGGCAACATGGTGACGCGCAAGTATCCCCAGCTCGAAGGCAAGGTGAACCATGTTCACCATGCGGGTAA
CTCCTCGGGCGTGGTTGACGGCGCAGCTGCTATCCTCGTCACCTCGGAAGCTTACATGAAGAAGCACGGCCTGAAGCCGC
GCGCCCGTATCGTTGCGACGGCGAACATGGGCGACTGCCCGACGCTGATGCTCAACGCACCGGTCGCGGCTGCGAAGAAA
GTGCTCGAAAAAGCTGGCCTGAAAACCACCGACATCGACGTCTACGAAATCAACGAGGCTTTCTCGGTTGTTGCCGAGAA
GTTCATCCGTGATCTCGACCTCGACCGCGAGAAGGTGAACATCAATGGCGGCGCAATGGCGCTGGGCCACCCGATCGGCG
CAACCGGCTCGATCCTGATCGGCACCGCGCTGGACGAGCTTGAGCGTTCGGGCGGCCGTTATGGTCTCGTGACGATGTGT
GCCGCTGGCGGCATGGCCCCTGCGATCATCATCGAGCGCGTCGAAGCCTGA

Upstream 100 bases:

>100_bases
CTGACCCGGCGTCACGGCTTCCCATGGTCCTTACGCGCGCGTAAGCCTGAAGCCAGACGCCATTTGAGCGCGCCTATCCA
TAAAGACAGGGAGTACCATC

Downstream 100 bases:

>100_bases
TCTTCCCGCAAGGGATAAAAAGAGAAGACCCCGCCGGTTTGCGCCGGCGGGGTTTTTCTTTGCCGCTGGCGGGCGCGCCC
CGCCGCTGATACCCTCCGTG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAEAYIIDAVRTPRGIGKVGKGALAHMHPQHLAATVLSAIAERNKLDTATVDDIIWGTSSQRGAQGADMGRMAALDAGFD
IKASGVTLDRFCGSGITTVSLAAAQIMSGMEDCVIAGGCEMMSYTAASADPKNPPTMDAGNTRLREKHPQSQQGVCADAI
ATLEGIDREAVDRLAVTSQQRAARAISEGRFNKSVVPVYNVDGTLALDHEEFPRPQTTMESLAGLKTVFGMYMDIPVDDQ
GNTYGNMVTRKYPQLEGKVNHVHHAGNSSGVVDGAAAILVTSEAYMKKHGLKPRARIVATANMGDCPTLMLNAPVAAAKK
VLEKAGLKTTDIDVYEINEAFSVVAEKFIRDLDLDREKVNINGGAMALGHPIGATGSILIGTALDELERSGGRYGLVTMC
AAGGMAPAIIIERVEA

Sequences:

>Translated_416_residues
MAEAYIIDAVRTPRGIGKVGKGALAHMHPQHLAATVLSAIAERNKLDTATVDDIIWGTSSQRGAQGADMGRMAALDAGFD
IKASGVTLDRFCGSGITTVSLAAAQIMSGMEDCVIAGGCEMMSYTAASADPKNPPTMDAGNTRLREKHPQSQQGVCADAI
ATLEGIDREAVDRLAVTSQQRAARAISEGRFNKSVVPVYNVDGTLALDHEEFPRPQTTMESLAGLKTVFGMYMDIPVDDQ
GNTYGNMVTRKYPQLEGKVNHVHHAGNSSGVVDGAAAILVTSEAYMKKHGLKPRARIVATANMGDCPTLMLNAPVAAAKK
VLEKAGLKTTDIDVYEINEAFSVVAEKFIRDLDLDREKVNINGGAMALGHPIGATGSILIGTALDELERSGGRYGLVTMC
AAGGMAPAIIIERVEA
>Mature_415_residues
AEAYIIDAVRTPRGIGKVGKGALAHMHPQHLAATVLSAIAERNKLDTATVDDIIWGTSSQRGAQGADMGRMAALDAGFDI
KASGVTLDRFCGSGITTVSLAAAQIMSGMEDCVIAGGCEMMSYTAASADPKNPPTMDAGNTRLREKHPQSQQGVCADAIA
TLEGIDREAVDRLAVTSQQRAARAISEGRFNKSVVPVYNVDGTLALDHEEFPRPQTTMESLAGLKTVFGMYMDIPVDDQG
NTYGNMVTRKYPQLEGKVNHVHHAGNSSGVVDGAAAILVTSEAYMKKHGLKPRARIVATANMGDCPTLMLNAPVAAAKKV
LEKAGLKTTDIDVYEINEAFSVVAEKFIRDLDLDREKVNINGGAMALGHPIGATGSILIGTALDELERSGGRYGLVTMCA
AGGMAPAIIIERVEA

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=417, Percent_Identity=33.0935251798561, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI167614485, Length=421, Percent_Identity=33.2541567695962, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI4501853, Length=423, Percent_Identity=35.2245862884161, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4557237, Length=432, Percent_Identity=31.4814814814815, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4504327, Length=449, Percent_Identity=30.0668151447661, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=50.561797752809, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1787663, Length=432, Percent_Identity=40.5092592592593, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI48994986, Length=421, Percent_Identity=36.104513064133, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1788554, Length=425, Percent_Identity=36.7058823529412, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI87082165, Length=425, Percent_Identity=34.8235294117647, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=26.7605633802817, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI133906874, Length=427, Percent_Identity=33.0210772833724, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25147385, Length=422, Percent_Identity=31.042654028436, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17535921, Length=425, Percent_Identity=28.9411764705882, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=420, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17551802, Length=465, Percent_Identity=27.0967741935484, Blast_Score=124, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=31.5, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=429, Percent_Identity=32.6340326340326, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24655093, Length=423, Percent_Identity=34.9881796690307, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI17648125, Length=424, Percent_Identity=32.7830188679245, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24640423, Length=424, Percent_Identity=31.1320754716981, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI17137578, Length=450, Percent_Identity=27.7777777777778, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 43869; Mature: 43737

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAYIIDAVRTPRGIGKVGKGALAHMHPQHLAATVLSAIAERNKLDTATVDDIIWGTSS
CCCEEEEECHHCCCCCCHHCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCC
QRGAQGADMGRMAALDAGFDIKASGVTLDRFCGSGITTVSLAAAQIMSGMEDCVIAGGCE
CCCCCCCCCCHHHEECCCCCEEECCEEHHHHHCCCCHHHHHHHHHHHCCHHHHEEECCCH
MMSYTAASADPKNPPTMDAGNTRLREKHPQSQQGVCADAIATLEGIDREAVDRLAVTSQQ
HHEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
RAARAISEGRFNKSVVPVYNVDGTLALDHEEFPRPQTTMESLAGLKTVFGMYMDIPVDDQ
HHHHHHHHCCCCCCEEEEEECCCEEEECHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCC
GNTYGNMVTRKYPQLEGKVNHVHHAGNSSGVVDGAAAILVTSEAYMKKHGLKPRARIVAT
CCCHHHHHHHCCCCCCCCHHHEEECCCCCCCCCCCEEEEEECHHHHHHCCCCCCCEEEEE
ANMGDCPTLMLNAPVAAAKKVLEKAGLKTTDIDVYEINEAFSVVAEKFIRDLDLDREKVN
CCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEE
INGGAMALGHPIGATGSILIGTALDELERSGGRYGLVTMCAAGGMAPAIIIERVEA
CCCCEEEECCCCCCCCCEEEHHHHHHHHHCCCCEEHHHHHHCCCCCHHHHHEECCC
>Mature Secondary Structure 
AEAYIIDAVRTPRGIGKVGKGALAHMHPQHLAATVLSAIAERNKLDTATVDDIIWGTSS
CCEEEEECHHCCCCCCHHCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCC
QRGAQGADMGRMAALDAGFDIKASGVTLDRFCGSGITTVSLAAAQIMSGMEDCVIAGGCE
CCCCCCCCCCHHHEECCCCCEEECCEEHHHHHCCCCHHHHHHHHHHHCCHHHHEEECCCH
MMSYTAASADPKNPPTMDAGNTRLREKHPQSQQGVCADAIATLEGIDREAVDRLAVTSQQ
HHEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
RAARAISEGRFNKSVVPVYNVDGTLALDHEEFPRPQTTMESLAGLKTVFGMYMDIPVDDQ
HHHHHHHHCCCCCCEEEEEECCCEEEECHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCC
GNTYGNMVTRKYPQLEGKVNHVHHAGNSSGVVDGAAAILVTSEAYMKKHGLKPRARIVAT
CCCHHHHHHHCCCCCCCCHHHEEECCCCCCCCCCCEEEEEECHHHHHHCCCCCCCEEEEE
ANMGDCPTLMLNAPVAAAKKVLEKAGLKTTDIDVYEINEAFSVVAEKFIRDLDLDREKVN
CCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEE
INGGAMALGHPIGATGSILIGTALDELERSGGRYGLVTMCAAGGMAPAIIIERVEA
CCCCEEEECCCCCCCCCEEEHHHHHHHHHCCCCEEHHHHHHCCCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]