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The map label for this gene is obgE

Identifier: 114798904

GI number: 114798904

Start: 2715194

End: 2716264

Strand: Direct

Name: obgE

Synonym: HNE_2562

Alternate gene names: 114798904

Gene position: 2715194-2716264 (Clockwise)

Preceding gene: 114799714

Following gene: 114799947

Centisome position: 73.28

GC content: 64.24

Gene sequence:

>1071_bases
ATGAAGTTCCTCGATCAGGCCAAGGTATATATCCGCTCCGGCGGCGGCGGCGCAGGCTGCGTCTCGTTCCGGCGCGAGAA
GTTCGTCGAATATGGCGGCCCTGATGGCGGCGATGGCGGGCGCGGCGGCGACGTATGGATCGAGGCCGTAGAAGGTCTCA
ACACGCTGATCGACTTCCGCTACCAGCAGCACTTCAAAGCTGCGCGCGGCGGCCACGGCATGGGCAAACAGCGCACAGGC
GCGCGCGGCGAAGATGCTGTTCTGAAAGTGCCCGTCGGCACACAGATCTATGAAGAAGATCAGGAAACGATGATCGCAGA
CCTCACCGAGGTCGGCCAGCGTGTCCTGCTGGCGCCCGGCGGCAATGGCGGCTGGGGCAATCTGCGCTTCAAATCCTCGA
TCAACCAGGCCCCGCGCCGCTCCAATCCCGGTGAAGAAGGCGAGGAGCGCTGGATCTGGCTGCGCCTCAAACTCATCGCG
GATGCGGGCCTCGTCGGCCTGCCGAACGCGGGCAAGTCCACCTTCCTCTCGGTCGCCACAGCGGCCAACCCGAAGATTGC
GGACTATCCGTTCACGACCCTTCATCCCGGCCTCGGCGTCGTCGATCTGGGTACCTCCACGCGCTTCGTGCTGGCAGACA
TCCCCGGCCTCATCGAGGGCGCCGCCGAAGGCGCGGGCCTCGGCCACCGCTTCCTCGGCCATGTCGAGCGCTGCAAGGTG
CTCCTCCACCTGATCGACTGTACGCAGGACGACCCCGCCGGCGCCTACCGCACCATCCGGTCAGAGCTTGAAGCTTACGA
TGCTGACTTCGCCGACCGCCCCGAGATTGTCGCCCTCAACAAGATCGACGCCCTGACGCCCGAACTCGTCAAGGAACAGC
TCAAGCAACTGAAAAAAGTCTACAAGGGCAAACCCCTCCTCATCTCCGGCGTCACCGGCGCCGGCGTCAAGGATGCCCTC
TACGCCATCGCGCAGCACCTCGGCTTCAACAACGACGACATCCCCCTGCCCAAACCTTCAAACGCCGACGAAGAAGATCC
CGACACGGACCAACCCTGGAGCCCGGTGTAA

Upstream 100 bases:

>100_bases
CTGCCCTGCGGGCGTAACACCATGTTCTCAAAGGGCCGCGGCCATGCCGCAGACCACATCATGATGGCGCGTATCGCCTG
AAACGGATAAAGACCACCCC

Downstream 100 bases:

>100_bases
CCGCTCCCCTGCCCCAAACGCCCGCTTCAGGAAAATCTGCTCAATACAGAAACGCCCACGGATGAAACCGTGGGCGCCTG
AATAATACTGGCCTGAGAGA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKFLDQAKVYIRSGGGGAGCVSFRREKFVEYGGPDGGDGGRGGDVWIEAVEGLNTLIDFRYQQHFKAARGGHGMGKQRTG
ARGEDAVLKVPVGTQIYEEDQETMIADLTEVGQRVLLAPGGNGGWGNLRFKSSINQAPRRSNPGEEGEERWIWLRLKLIA
DAGLVGLPNAGKSTFLSVATAANPKIADYPFTTLHPGLGVVDLGTSTRFVLADIPGLIEGAAEGAGLGHRFLGHVERCKV
LLHLIDCTQDDPAGAYRTIRSELEAYDADFADRPEIVALNKIDALTPELVKEQLKQLKKVYKGKPLLISGVTGAGVKDAL
YAIAQHLGFNNDDIPLPKPSNADEEDPDTDQPWSPV

Sequences:

>Translated_356_residues
MKFLDQAKVYIRSGGGGAGCVSFRREKFVEYGGPDGGDGGRGGDVWIEAVEGLNTLIDFRYQQHFKAARGGHGMGKQRTG
ARGEDAVLKVPVGTQIYEEDQETMIADLTEVGQRVLLAPGGNGGWGNLRFKSSINQAPRRSNPGEEGEERWIWLRLKLIA
DAGLVGLPNAGKSTFLSVATAANPKIADYPFTTLHPGLGVVDLGTSTRFVLADIPGLIEGAAEGAGLGHRFLGHVERCKV
LLHLIDCTQDDPAGAYRTIRSELEAYDADFADRPEIVALNKIDALTPELVKEQLKQLKKVYKGKPLLISGVTGAGVKDAL
YAIAQHLGFNNDDIPLPKPSNADEEDPDTDQPWSPV
>Mature_356_residues
MKFLDQAKVYIRSGGGGAGCVSFRREKFVEYGGPDGGDGGRGGDVWIEAVEGLNTLIDFRYQQHFKAARGGHGMGKQRTG
ARGEDAVLKVPVGTQIYEEDQETMIADLTEVGQRVLLAPGGNGGWGNLRFKSSINQAPRRSNPGEEGEERWIWLRLKLIA
DAGLVGLPNAGKSTFLSVATAANPKIADYPFTTLHPGLGVVDLGTSTRFVLADIPGLIEGAAEGAGLGHRFLGHVERCKV
LLHLIDCTQDDPAGAYRTIRSELEAYDADFADRPEIVALNKIDALTPELVKEQLKQLKKVYKGKPLLISGVTGAGVKDAL
YAIAQHLGFNNDDIPLPKPSNADEEDPDTDQPWSPV

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=321, Percent_Identity=39.8753894080997, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI111955139, Length=292, Percent_Identity=37.3287671232877, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI111955063, Length=126, Percent_Identity=42.8571428571429, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4758796, Length=124, Percent_Identity=33.8709677419355, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI58761500, Length=106, Percent_Identity=35.8490566037736, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4557537, Length=90, Percent_Identity=38.8888888888889, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789574, Length=332, Percent_Identity=52.1084337349398, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1787454, Length=140, Percent_Identity=33.5714285714286, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790615, Length=204, Percent_Identity=27.9411764705882, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=305, Percent_Identity=37.7049180327869, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17552324, Length=304, Percent_Identity=29.9342105263158, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17509631, Length=158, Percent_Identity=34.1772151898734, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321962, Length=158, Percent_Identity=38.6075949367089, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=106, Percent_Identity=34.9056603773585, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24585318, Length=292, Percent_Identity=35.958904109589, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI20129375, Length=325, Percent_Identity=37.2307692307692, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24640873, Length=196, Percent_Identity=29.5918367346939, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24640877, Length=196, Percent_Identity=29.5918367346939, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24640875, Length=196, Percent_Identity=29.5918367346939, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17981711, Length=115, Percent_Identity=33.0434782608696, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_HYPNA (Q0BZ39)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761254.1
- ProteinModelPortal:   Q0BZ39
- SMR:   Q0BZ39
- STRING:   Q0BZ39
- GeneID:   4288490
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2562
- NMPDR:   fig|228405.5.peg.2463
- TIGR:   HNE_2562
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- PhylomeDB:   Q0BZ39
- ProtClustDB:   PRK12299
- BioCyc:   HNEP81032:HNE_2562-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 38327; Mature: 38327

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLDQAKVYIRSGGGGAGCVSFRREKFVEYGGPDGGDGGRGGDVWIEAVEGLNTLIDFR
CCCHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YQQHFKAARGGHGMGKQRTGARGEDAVLKVPVGTQIYEEDQETMIADLTEVGQRVLLAPG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEECC
GNGGWGNLRFKSSINQAPRRSNPGEEGEERWIWLRLKLIADAGLVGLPNAGKSTFLSVAT
CCCCCCCEEEHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCHHEEEEEE
AANPKIADYPFTTLHPGLGVVDLGTSTRFVLADIPGLIEGAAEGAGLGHRFLGHVERCKV
CCCCCCCCCCCHHCCCCCCEEECCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH
LLHLIDCTQDDPAGAYRTIRSELEAYDADFADRPEIVALNKIDALTPELVKEQLKQLKKV
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHCCCHHHHHHHHHHHHHH
YKGKPLLISGVTGAGVKDALYAIAQHLGFNNDDIPLPKPSNADEEDPDTDQPWSPV
HCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKFLDQAKVYIRSGGGGAGCVSFRREKFVEYGGPDGGDGGRGGDVWIEAVEGLNTLIDFR
CCCHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YQQHFKAARGGHGMGKQRTGARGEDAVLKVPVGTQIYEEDQETMIADLTEVGQRVLLAPG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEECC
GNGGWGNLRFKSSINQAPRRSNPGEEGEERWIWLRLKLIADAGLVGLPNAGKSTFLSVAT
CCCCCCCEEEHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCHHEEEEEE
AANPKIADYPFTTLHPGLGVVDLGTSTRFVLADIPGLIEGAAEGAGLGHRFLGHVERCKV
CCCCCCCCCCCHHCCCCCCEEECCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH
LLHLIDCTQDDPAGAYRTIRSELEAYDADFADRPEIVALNKIDALTPELVKEQLKQLKKV
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHCCCHHHHHHHHHHHHHH
YKGKPLLISGVTGAGVKDALYAIAQHLGFNNDDIPLPKPSNADEEDPDTDQPWSPV
HCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA