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The map label for this gene is zitB [H]

Identifier: 114798820

GI number: 114798820

Start: 545163

End: 546086

Strand: Reverse

Name: zitB [H]

Synonym: HNE_0549

Alternate gene names: 114798820

Gene position: 546086-545163 (Counterclockwise)

Preceding gene: 114799840

Following gene: 114797052

Centisome position: 14.74

GC content: 65.8

Gene sequence:

>924_bases
ATGCATGCTCACGGGCACAGTCATGGCCATGACCACAGCCATGCCGGTCATTCGCATGAACACCATGCCGACATGACCAG
CGCCGACTCGCGCCGCCGCGTGGCCATCGCCGCCGCGCTGACAGCCGGTTTCATGCTGGCCGAGATCGCCGGCGGCCTGA
TCTCCGGCTCCCTCGCCCTCCTGGCAGACGCCGCGCACATGTTCACCGATGCCGGCTCGCTCATCCTCGCCTGGATCGGC
TACAAGCTCGCCGAGCGTCCGGCAGATCCTCATCGCTCCTACGGCTTCGCGCGGATGAAGATCCTCGCCGCCTTCACCAA
TGGCGTCCTCCTGATCCTTCTGGGCCTCTGGATCATCTGGGAAGCGGTCCACCGTCTCCTCGCCCCGGTCGAGGTGATGG
GGGGACTGATGCTGCTGGTTGCGGCCGGCGGATTGCTGGTCAACATCGCCGCCTTTGCCGTCCTGCATGGCGGAGACCGG
GAAGACCTCAACATGCGCGGCGCCCTCTGGCATGTTGCCGGAGACCTCCTCGGCTCGGTCGCCGCCATCCTCGCGGCGGG
TGTCATCCTCTGGACGGGCTGGACCCCGGCCGATCCCATCCTCTCCGCTCTGGTCGCCGGGCTGGTGATCTTTGCCGGTG
TCCGCATCATGCGCCAGTCTGGCCACATCCTGCTCGAGGGGGCCCCCAACGAGCTGTCGGTGTCCGAAATTGTCCAGGAT
TTGTCCGCGAATGTCGCGGGTGTGGCGCGCGTGAGCCATGTGCATGCCTGGTCGTTGACCGAATCGCGCCCCCTGGTGAC
CCTCGAAGTCACGGCAAAACCCGGCACCAATCCCGAAATCCTGCGCCGCGATGTCAAAGCCCGCCTCGCCAGCGCCTTCA
AAGTGTCCCATGCCACCGTCGAAGTGATGTCGCAGCCTGAATAG

Upstream 100 bases:

>100_bases
CGATCATGATCATGCCCATGGGCCGGATGAAACCGCGGGCCTCGATTGCCCCGCCGATCCCGCCACGCATGACCATGGGC
CCGATCACGGCCACGACCAC

Downstream 100 bases:

>100_bases
CTGCCTTGCAGCAGGCCCGCCGGCGCTTTAACCCTCAGGCCAGACGCCCCATATGGGGCCAGACGACCGGCTGAGACTGC
CGGGCCAGACGCTTCAAGGA

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MHAHGHSHGHDHSHAGHSHEHHADMTSADSRRRVAIAAALTAGFMLAEIAGGLISGSLALLADAAHMFTDAGSLILAWIG
YKLAERPADPHRSYGFARMKILAAFTNGVLLILLGLWIIWEAVHRLLAPVEVMGGLMLLVAAGGLLVNIAAFAVLHGGDR
EDLNMRGALWHVAGDLLGSVAAILAAGVILWTGWTPADPILSALVAGLVIFAGVRIMRQSGHILLEGAPNELSVSEIVQD
LSANVAGVARVSHVHAWSLTESRPLVTLEVTAKPGTNPEILRRDVKARLASAFKVSHATVEVMSQPE

Sequences:

>Translated_307_residues
MHAHGHSHGHDHSHAGHSHEHHADMTSADSRRRVAIAAALTAGFMLAEIAGGLISGSLALLADAAHMFTDAGSLILAWIG
YKLAERPADPHRSYGFARMKILAAFTNGVLLILLGLWIIWEAVHRLLAPVEVMGGLMLLVAAGGLLVNIAAFAVLHGGDR
EDLNMRGALWHVAGDLLGSVAAILAAGVILWTGWTPADPILSALVAGLVIFAGVRIMRQSGHILLEGAPNELSVSEIVQD
LSANVAGVARVSHVHAWSLTESRPLVTLEVTAKPGTNPEILRRDVKARLASAFKVSHATVEVMSQPE
>Mature_307_residues
MHAHGHSHGHDHSHAGHSHEHHADMTSADSRRRVAIAAALTAGFMLAEIAGGLISGSLALLADAAHMFTDAGSLILAWIG
YKLAERPADPHRSYGFARMKILAAFTNGVLLILLGLWIIWEAVHRLLAPVEVMGGLMLLVAAGGLLVNIAAFAVLHGGDR
EDLNMRGALWHVAGDLLGSVAAILAAGVILWTGWTPADPILSALVAGLVIFAGVRIMRQSGHILLEGAPNELSVSEIVQD
LSANVAGVARVSHVHAWSLTESRPLVTLEVTAKPGTNPEILRRDVKARLASAFKVSHATVEVMSQPE

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=314, Percent_Identity=27.3885350318471, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI64762489, Length=314, Percent_Identity=28.6624203821656, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI289803013, Length=308, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI289803009, Length=308, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI289803007, Length=308, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI289803003, Length=308, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI21359890, Length=303, Percent_Identity=29.7029702970297, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI21361112, Length=306, Percent_Identity=29.7385620915033, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI20070323, Length=246, Percent_Identity=26.8292682926829, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI14210520, Length=309, Percent_Identity=23.3009708737864, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=31.0077519379845, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=31.0077519379845, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI52352803, Length=129, Percent_Identity=32.5581395348837, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI52351208, Length=126, Percent_Identity=34.1269841269841, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1786966, Length=283, Percent_Identity=42.756183745583, Blast_Score=203, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193210990, Length=327, Percent_Identity=27.82874617737, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17555794, Length=328, Percent_Identity=32.3170731707317, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17555796, Length=288, Percent_Identity=33.6805555555556, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32564488, Length=301, Percent_Identity=26.9102990033223, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320411, Length=167, Percent_Identity=35.3293413173653, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=126, Percent_Identity=38.0952380952381, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=124, Percent_Identity=37.0967741935484, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583858, Length=339, Percent_Identity=24.4837758112094, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656728, Length=283, Percent_Identity=27.5618374558304, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656724, Length=283, Percent_Identity=27.5618374558304, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656720, Length=283, Percent_Identity=27.5618374558304, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656715, Length=283, Percent_Identity=27.5618374558304, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357035, Length=283, Percent_Identity=27.5618374558304, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585900, Length=138, Percent_Identity=29.7101449275362, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585898, Length=138, Percent_Identity=29.7101449275362, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585896, Length=138, Percent_Identity=29.7101449275362, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921672, Length=138, Percent_Identity=29.7101449275362, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584409, Length=145, Percent_Identity=31.7241379310345, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574430, Length=145, Percent_Identity=30.3448275862069, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24645863, Length=124, Percent_Identity=31.4516129032258, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32434; Mature: 32434

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAHGHSHGHDHSHAGHSHEHHADMTSADSRRRVAIAAALTAGFMLAEIAGGLISGSLAL
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
LADAAHMFTDAGSLILAWIGYKLAERPADPHRSYGFARMKILAAFTNGVLLILLGLWIIW
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAVHRLLAPVEVMGGLMLLVAAGGLLVNIAAFAVLHGGDREDLNMRGALWHVAGDLLGSV
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AAILAAGVILWTGWTPADPILSALVAGLVIFAGVRIMRQSGHILLEGAPNELSVSEIVQD
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHH
LSANVAGVARVSHVHAWSLTESRPLVTLEVTAKPGTNPEILRRDVKARLASAFKVSHATV
HHCCHHHHHHHHHHEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVMSQPE
EECCCCC
>Mature Secondary Structure
MHAHGHSHGHDHSHAGHSHEHHADMTSADSRRRVAIAAALTAGFMLAEIAGGLISGSLAL
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
LADAAHMFTDAGSLILAWIGYKLAERPADPHRSYGFARMKILAAFTNGVLLILLGLWIIW
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAVHRLLAPVEVMGGLMLLVAAGGLLVNIAAFAVLHGGDREDLNMRGALWHVAGDLLGSV
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AAILAAGVILWTGWTPADPILSALVAGLVIFAGVRIMRQSGHILLEGAPNELSVSEIVQD
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHH
LSANVAGVARVSHVHAWSLTESRPLVTLEVTAKPGTNPEILRRDVKARLASAFKVSHATV
HHCCHHHHHHHHHHEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVMSQPE
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]