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The map label for this gene is purE [H]

Identifier: 114798773

GI number: 114798773

Start: 3640999

End: 3641493

Strand: Direct

Name: purE [H]

Synonym: HNE_3506

Alternate gene names: 114798773

Gene position: 3640999-3641493 (Clockwise)

Preceding gene: 114798024

Following gene: 114800267

Centisome position: 98.27

GC content: 65.05

Gene sequence:

>495_bases
ATGAACAAGGCGCGCTCTCCGGTCGTGGGCATCATCATGGGCAGCCAGTCGGACTGGCCGGTGATGCGCGAGGCCGCGAA
GATACTCGAAGATATGGGCGTCGCTTTCGAAGCGAAGATCGTTTCGGCGCACCGCACGCCCCAGCGGCTGGTCGAATATG
CGACCACTGCCAAGGATCGCGGGTTGAAGGTGATCATCGCCGGCGCGGGCGGGGCAGCCCACCTGCCGGGCATGGCCGCT
TCGATGACGCCCCTGCCCGTTCTGGGCGTGCCGGTTCAGTCCAAGGCGCTTAAAGGCCTCGATAGTCTTCTCTCTATTGT
GCAGATGCCCAAGGGCGTTCCGGTGGGCACGCTGGCCATTGGCGAAGCGGGCGCGGCCAATGCGGGCATTCTGGCGGCCT
CGATCATTGCGCTGCAGGACGACGCGGTGGCCGCAAAGCTGGACGCGTTCCGCACGGCGCAGACCGAGAGCGTGAAAGAG
GTTCCCGAGGAATGA

Upstream 100 bases:

>100_bases
GAGAGCCCGTTCACGGGGCGCGCCAACTTTCCCCTCACAGGAGCGGTTGACGGTCAGCAGCGCGCTCTTATGGTGCGCGC
TTTCCAGCGGCGAGGCAGGC

Downstream 100 bases:

>100_bases
GCCCGCTTCGCCCCGGCGCGACGATCGGGATATTGGGCGGCGGGCAGCTTGGCCGGATGCTGGCGAGCGCGGCCGCGCAG
CTTGGCTTTGATGTGCTGAT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MNKARSPVVGIIMGSQSDWPVMREAAKILEDMGVAFEAKIVSAHRTPQRLVEYATTAKDRGLKVIIAGAGGAAHLPGMAA
SMTPLPVLGVPVQSKALKGLDSLLSIVQMPKGVPVGTLAIGEAGAANAGILAASIIALQDDAVAAKLDAFRTAQTESVKE
VPEE

Sequences:

>Translated_164_residues
MNKARSPVVGIIMGSQSDWPVMREAAKILEDMGVAFEAKIVSAHRTPQRLVEYATTAKDRGLKVIIAGAGGAAHLPGMAA
SMTPLPVLGVPVQSKALKGLDSLLSIVQMPKGVPVGTLAIGEAGAANAGILAASIIALQDDAVAAKLDAFRTAQTESVKE
VPEE
>Mature_164_residues
MNKARSPVVGIIMGSQSDWPVMREAAKILEDMGVAFEAKIVSAHRTPQRLVEYATTAKDRGLKVIIAGAGGAAHLPGMAA
SMTPLPVLGVPVQSKALKGLDSLLSIVQMPKGVPVGTLAIGEAGAANAGILAASIIALQDDAVAAKLDAFRTAQTESVKE
VPEE

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=162, Percent_Identity=58.641975308642, Blast_Score=156, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324702, Length=152, Percent_Identity=57.8947368421053, Blast_Score=178, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16849; Mature: 16849

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKARSPVVGIIMGSQSDWPVMREAAKILEDMGVAFEAKIVSAHRTPQRLVEYATTAKDR
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHEEEHHHCCCCHHHHHHHHHHHCCC
GLKVIIAGAGGAAHLPGMAASMTPLPVLGVPVQSKALKGLDSLLSIVQMPKGVPVGTLAI
CCEEEEECCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
GEAGAANAGILAASIIALQDDAVAAKLDAFRTAQTESVKEVPEE
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKARSPVVGIIMGSQSDWPVMREAAKILEDMGVAFEAKIVSAHRTPQRLVEYATTAKDR
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHEEEHHHCCCCHHHHHHHHHHHCCC
GLKVIIAGAGGAAHLPGMAASMTPLPVLGVPVQSKALKGLDSLLSIVQMPKGVPVGTLAI
CCEEEEECCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
GEAGAANAGILAASIIALQDDAVAAKLDAFRTAQTESVKEVPEE
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]