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The map label for this gene is purK [H]

Identifier: 114800267

GI number: 114800267

Start: 3641490

End: 3642569

Strand: Direct

Name: purK [H]

Synonym: HNE_3507

Alternate gene names: 114800267

Gene position: 3641490-3642569 (Clockwise)

Preceding gene: 114798773

Following gene: 114797561

Centisome position: 98.29

GC content: 64.17

Gene sequence:

>1080_bases
ATGAGCCCGCTTCGCCCCGGCGCGACGATCGGGATATTGGGCGGCGGGCAGCTTGGCCGGATGCTGGCGAGCGCGGCCGC
GCAGCTTGGCTTTGATGTGCTGATCTATTCGCCCGAAGATGATCCGCCGGCAGGTCGTGTCGCGGCGGGGGCCTTTCAGG
CCGACTGGGACGACGCCGAGGCGCTGACCGAGTTTGCCCAGGCCTGCGATGTGATCACGCTGGAATTTGAAAATGTGGCG
GTCGCGAGCGTTGAGGTGATCGAGAAGACCGGAAAGCGCGTGCTGCCGGGGGCGAAGTCTCTCTCCGTGTCTCAGGACCG
GATGACCGAGAAGACCTTTCTCAACGCGCACGGCATCCCCACAGCGCCGTTCCGCGAGATTAATTCGGCGGCTGATATTT
CCGCCGCTTTGGCGAGCCTCGGCGGCAAAGGCGTGTTGAAGACGCGCCGCGAAGGCTATGACGGCAAGGGGCAGGCCTGG
GTTTACGATGCGGCCGAAGCCGAAAAGGCCTGGGCGAAGATTGGCGCGATGCCGGCGATCCTGGAAGGCGCCATCGCATT
TGAGTGCGAAATCTCGGTGCTGGTGGCGCGCAGCGTTACAGGCGAAACGACCAGCTGGGCGCCGCCGCGCAACAGCCATG
AGAACGGGATTCTCGCGCGCTCGGTTGTGCCGTCTGGCCTCAGCAAAGCGGTGGAAGACGAAGCGCGCGCCAAGGCGATG
CATCTGGCCGATGAGCTGGGCCATGTGGGCGTTCTGGCGCTGGAGTTTTTTGTTTTGCCGGATGGCACGCTGCTGGCCAA
CGAATTTGCGCCCCGCGTGCACAATTCCGGCCATTGGACGCCTGAAGCCTGCCAGACCGGGCAGTTCGAGCAGCATATCC
GCTGCGTGGCCGGTTGGCCGCTGGGGGATACGCACCGGCTGTTTGATGCCGAGATGGCGAACCTGATCGGTGACGAGGGG
CTGGTTGACCCGGCAACGCTCAAGGCGAATGATGTTTTGACCCTTTACGGCAAGCGCGAAGCCCGGCCCGGACGCAAGAT
GGGCCATATCACGCGCCGCCTTGGCCCACGAAAGGACTAG

Upstream 100 bases:

>100_bases
TGGCGGCCTCGATCATTGCGCTGCAGGACGACGCGGTGGCCGCAAAGCTGGACGCGTTCCGCACGGCGCAGACCGAGAGC
GTGAAAGAGGTTCCCGAGGA

Downstream 100 bases:

>100_bases
ACCCATGCGCCTTCCCGTTTCCACCTGGCCCGACATTGAAGCCTGGCTGACCAAATCAAAGACCATCGTGATCCCCATCG
GCTCTTTCGAGCAGCATGGA

Product: phosphoribosylaminoimidazole carboxylase, ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSPLRPGATIGILGGGQLGRMLASAAAQLGFDVLIYSPEDDPPAGRVAAGAFQADWDDAEALTEFAQACDVITLEFENVA
VASVEVIEKTGKRVLPGAKSLSVSQDRMTEKTFLNAHGIPTAPFREINSAADISAALASLGGKGVLKTRREGYDGKGQAW
VYDAAEAEKAWAKIGAMPAILEGAIAFECEISVLVARSVTGETTSWAPPRNSHENGILARSVVPSGLSKAVEDEARAKAM
HLADELGHVGVLALEFFVLPDGTLLANEFAPRVHNSGHWTPEACQTGQFEQHIRCVAGWPLGDTHRLFDAEMANLIGDEG
LVDPATLKANDVLTLYGKREARPGRKMGHITRRLGPRKD

Sequences:

>Translated_359_residues
MSPLRPGATIGILGGGQLGRMLASAAAQLGFDVLIYSPEDDPPAGRVAAGAFQADWDDAEALTEFAQACDVITLEFENVA
VASVEVIEKTGKRVLPGAKSLSVSQDRMTEKTFLNAHGIPTAPFREINSAADISAALASLGGKGVLKTRREGYDGKGQAW
VYDAAEAEKAWAKIGAMPAILEGAIAFECEISVLVARSVTGETTSWAPPRNSHENGILARSVVPSGLSKAVEDEARAKAM
HLADELGHVGVLALEFFVLPDGTLLANEFAPRVHNSGHWTPEACQTGQFEQHIRCVAGWPLGDTHRLFDAEMANLIGDEG
LVDPATLKANDVLTLYGKREARPGRKMGHITRRLGPRKD
>Mature_358_residues
SPLRPGATIGILGGGQLGRMLASAAAQLGFDVLIYSPEDDPPAGRVAAGAFQADWDDAEALTEFAQACDVITLEFENVAV
ASVEVIEKTGKRVLPGAKSLSVSQDRMTEKTFLNAHGIPTAPFREINSAADISAALASLGGKGVLKTRREGYDGKGQAWV
YDAAEAEKAWAKIGAMPAILEGAIAFECEISVLVARSVTGETTSWAPPRNSHENGILARSVVPSGLSKAVEDEARAKAMH
LADELGHVGVLALEFFVLPDGTLLANEFAPRVHNSGHWTPEACQTGQFEQHIRCVAGWPLGDTHRLFDAEMANLIGDEGL
VDPATLKANDVLTLYGKREARPGRKMGHITRRLGPRKD

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=342, Percent_Identity=34.2105263157895, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788155, Length=363, Percent_Identity=26.7217630853994, Blast_Score=104, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=365, Percent_Identity=32.0547945205479, Blast_Score=172, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 38197; Mature: 38065

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50975 ATP_GRASP ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLRPGATIGILGGGQLGRMLASAAAQLGFDVLIYSPEDDPPAGRVAAGAFQADWDDAE
CCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCCCCHHH
ALTEFAQACDVITLEFENVAVASVEVIEKTGKRVLPGAKSLSVSQDRMTEKTFLNAHGIP
HHHHHHHHCCEEEEEECCEEHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHCCCCCC
TAPFREINSAADISAALASLGGKGVLKTRREGYDGKGQAWVYDAAEAEKAWAKIGAMPAI
CCCHHHHCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEECHHHHHHHHHHCCCHHH
LEGAIAFECEISVLVARSVTGETTSWAPPRNSHENGILARSVVPSGLSKAVEDEARAKAM
HCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHH
HLADELGHVGVLALEFFVLPDGTLLANEFAPRVHNSGHWTPEACQTGQFEQHIRCVAGWP
HHHHHHCCCEEEEEEEEECCCCCEEHHHHCCCCCCCCCCCHHHHCCCCHHHHEEEEECCC
LGDTHRLFDAEMANLIGDEGLVDPATLKANDVLTLYGKREARPGRKMGHITRRLGPRKD
CCCCHHHHHHHHHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SPLRPGATIGILGGGQLGRMLASAAAQLGFDVLIYSPEDDPPAGRVAAGAFQADWDDAE
CCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCCCCHHH
ALTEFAQACDVITLEFENVAVASVEVIEKTGKRVLPGAKSLSVSQDRMTEKTFLNAHGIP
HHHHHHHHCCEEEEEECCEEHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHCCCCCC
TAPFREINSAADISAALASLGGKGVLKTRREGYDGKGQAWVYDAAEAEKAWAKIGAMPAI
CCCHHHHCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEECHHHHHHHHHHCCCHHH
LEGAIAFECEISVLVARSVTGETTSWAPPRNSHENGILARSVVPSGLSKAVEDEARAKAM
HCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHH
HLADELGHVGVLALEFFVLPDGTLLANEFAPRVHNSGHWTPEACQTGQFEQHIRCVAGWP
HHHHHHCCCEEEEEEEEECCCCCEEHHHHCCCCCCCCCCCHHHHCCCCHHHHEEEEECCC
LGDTHRLFDAEMANLIGDEGLVDPATLKANDVLTLYGKREARPGRKMGHITRRLGPRKD
CCCCHHHHHHHHHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]