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The map label for this gene is pyrH

Identifier: 114798646

GI number: 114798646

Start: 1813991

End: 1814746

Strand: Direct

Name: pyrH

Synonym: HNE_1770

Alternate gene names: 114798646

Gene position: 1813991-1814746 (Clockwise)

Preceding gene: 114799266

Following gene: 114797846

Centisome position: 48.96

GC content: 54.5

Gene sequence:

>756_bases
ATGCAGTCCGGCGCGTCTGAAACCAACAAGTTGAAATATCGCCGTGTGCTTCTCAAGCTGTCTGGTGAAGCCTTGATGGG
GGGAGGGCAGTTCGGAATCGATATTCCGACCTGTGAGCAATTCGCTCGGGCAATTGCAGAGGCCAGGGAAGCGGGCGCCG
AAATATGCCTGGTTATCGGTGGCGGCAATATCTTCCGGGGAGTGGCGGGAGCCGCAAAAGGTATGGAGCGCGCCCAGGCT
GACTCCATGGGCATGCTTGCTACAGTTATGAATGCCCTCGCCATGCAAAGCGTTCTGGAGAACCTAGGAGTTCCTACCCG
AGTCCAATCAGCCCTGAATATGGATGCAATCTGCGAACCTTATATCCGGCGCCGTGCCCATCGGCACATGGAAAAGGGCC
GCGTGGTAATCTTTGCGGCCGGCATCGGAAATCCATTCTTTACCACCGATACCGGCGCGGCTTTGCGGGCGATTGAAATG
AACTGCGACGCGCTCCTGAAGGGCACACAGGTAGACGGTGTATACACGGCCGATCCGAAGCTGGACGCTACAGCGACGCG
CTACCATCAGGTTGCTTACCAGGAAATTCTCGCCAAGGATTTGAAAGTGATGGACTCGTCAGCAGTCAGTTTGATGAGAG
ACAATAACATTCCAATCGTCGTATTTTCGCTCAAAGAAGAAGGCTCCCTGTTAAATGTCCTTTATGGACGAGGGACTTCG
ACGACGATCACCAAAGAGGGAGCAGAGAAGCCATGA

Upstream 100 bases:

>100_bases
CTTTCAGCCCATGAGGGGCTTTGAACAATCCCGGCTGCCCCTAGGAGCGGCCGGGATTATTTTATCCAGCGCTCAGAATA
CAAGGGATTGAGGTCTAATT

Downstream 100 bases:

>100_bases
GCTACAGCAAGCAGGATATTGAACGAAGAATGGAGGGCGCCCTGGCTTCATTGGCGTCGGAATTTGCTGGCCTGCGCACT
GGGCGCGCTTCGGTGAACCT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MQSGASETNKLKYRRVLLKLSGEALMGGGQFGIDIPTCEQFARAIAEAREAGAEICLVIGGGNIFRGVAGAAKGMERAQA
DSMGMLATVMNALAMQSVLENLGVPTRVQSALNMDAICEPYIRRRAHRHMEKGRVVIFAAGIGNPFFTTDTGAALRAIEM
NCDALLKGTQVDGVYTADPKLDATATRYHQVAYQEILAKDLKVMDSSAVSLMRDNNIPIVVFSLKEEGSLLNVLYGRGTS
TTITKEGAEKP

Sequences:

>Translated_251_residues
MQSGASETNKLKYRRVLLKLSGEALMGGGQFGIDIPTCEQFARAIAEAREAGAEICLVIGGGNIFRGVAGAAKGMERAQA
DSMGMLATVMNALAMQSVLENLGVPTRVQSALNMDAICEPYIRRRAHRHMEKGRVVIFAAGIGNPFFTTDTGAALRAIEM
NCDALLKGTQVDGVYTADPKLDATATRYHQVAYQEILAKDLKVMDSSAVSLMRDNNIPIVVFSLKEEGSLLNVLYGRGTS
TTITKEGAEKP
>Mature_251_residues
MQSGASETNKLKYRRVLLKLSGEALMGGGQFGIDIPTCEQFARAIAEAREAGAEICLVIGGGNIFRGVAGAAKGMERAQA
DSMGMLATVMNALAMQSVLENLGVPTRVQSALNMDAICEPYIRRRAHRHMEKGRVVIFAAGIGNPFFTTDTGAALRAIEM
NCDALLKGTQVDGVYTADPKLDATATRYHQVAYQEILAKDLKVMDSSAVSLMRDNNIPIVVFSLKEEGSLLNVLYGRGTS
TTITKEGAEKP

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=49.7854077253219, Blast_Score=228, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_HYPNA (Q0C1B9)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760474.1
- ProteinModelPortal:   Q0C1B9
- SMR:   Q0C1B9
- STRING:   Q0C1B9
- GeneID:   4290392
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1770
- NMPDR:   fig|228405.5.peg.1704
- TIGR:   HNE_1770
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q0C1B9
- BioCyc:   HNEP81032:HNE_1770-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26903; Mature: 26903

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: BINDING 61-61 BINDING 62-62 BINDING 66-66 BINDING 81-81 BINDING 169-169 BINDING 170-170 BINDING 175-175 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSGASETNKLKYRRVLLKLSGEALMGGGQFGIDIPTCEQFARAIAEAREAGAEICLVIG
CCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEE
GGNIFRGVAGAAKGMERAQADSMGMLATVMNALAMQSVLENLGVPTRVQSALNMDAICEP
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
YIRRRAHRHMEKGRVVIFAAGIGNPFFTTDTGAALRAIEMNCDALLKGTQVDGVYTADPK
HHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCEEEEEECCHHHHCCCCEECCEEECCCC
LDATATRYHQVAYQEILAKDLKVMDSSAVSLMRDNNIPIVVFSLKEEGSLLNVLYGRGTS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEEECCCCC
TTITKEGAEKP
CEEECCCCCCC
>Mature Secondary Structure
MQSGASETNKLKYRRVLLKLSGEALMGGGQFGIDIPTCEQFARAIAEAREAGAEICLVIG
CCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEE
GGNIFRGVAGAAKGMERAQADSMGMLATVMNALAMQSVLENLGVPTRVQSALNMDAICEP
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
YIRRRAHRHMEKGRVVIFAAGIGNPFFTTDTGAALRAIEMNCDALLKGTQVDGVYTADPK
HHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCEEEEEECCHHHHCCCCEECCEEECCCC
LDATATRYHQVAYQEILAKDLKVMDSSAVSLMRDNNIPIVVFSLKEEGSLLNVLYGRGTS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEEECCCCC
TTITKEGAEKP
CEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA