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The map label for this gene is htpX

Identifier: 114798607

GI number: 114798607

Start: 3511506

End: 3512399

Strand: Direct

Name: htpX

Synonym: HNE_3367

Alternate gene names: 114798607

Gene position: 3511506-3512399 (Clockwise)

Preceding gene: 114800244

Following gene: 114799841

Centisome position: 94.78

GC content: 66.11

Gene sequence:

>894_bases
ATGGGCACGGCCAAGACCTTCACCCTTCTCGCCGCGATGACGGCAATCTTCATGGCAATCGGCTTTCTGGTCGGCGGCAT
GGCGGGCATGATCCTCGCTTTCGTGGTCGCGGCCGGCATGAACGTGTTTGCCTGGTGGAACTCCGACAAGATGGTGCTGC
GCATGCAGGGGGCGCAGGAAGTGCTGCCCGATACGAAAAACCCGATGCTGCGCGCCTTTGGCGAAGATGTCGCGCGCCTG
GCGGAGAATGCCGGCCTGCCCGCCCCGCGAATCTACATCATCGACACGCCCCAGCCCAACGCCTTCGCCACGGGCCGCAA
CCCTCAGAACGCCGCCGTGGCCGCGACGACTGGCCTGCTGAACATGCTCAACCGCGAGGAAGTCGCCGGCGTGATGGCGC
ATGAACTGGCCCACGTTCAGAACCGCGACACGTTGACGATGACGGTGACCGCAACGCTCGCCGGTGCCATCGGCATGCTG
GCAAACTTTGCGCTGTTCTTCGGCCGGGATCGCGCGGGGCTGATCGGGTCCATCGCGATCATGATCTTTGCGCCGATGGC
GGCTGCGCTGGTGCAGATGGCGATCAGCCGCTCGCGCGAATATGTGGCCGACAAGCGCGGGGCGGAGATTTGCGGCAACC
CGCTCTGGCTCGCCTCGGCGCTGGAAAAGATCGAACGCGGCGCGCGCTCCCAGATCAACCCCTATGCCGAGCGCAGCCCG
GCGATGGCGCATATGTATATCTCCAACCCCCTCAACGGGCGCGGGCAGGACAAGCTGTTCTCCACCCACCCTTCCACCGC
CAACCGCGTGGAAGCCCTGCGCCGCATGGCGGGCGAGATGGGCATCTCGGGCGTGGCAGCCCCAACCGCGCGCTCCAGCG
GGCCTTGGGGTTGA

Upstream 100 bases:

>100_bases
AAATCTTTCCCAGTCATTCACCCCTTCCCATATAGGTAGGCGTCTGCGAAGTGCTGCAAAGCGCGCGGCAGCGTTCTTGT
TGATGAGGAGCACCCCACCG

Downstream 100 bases:

>100_bases
CCCTTACAATTCTAATCCGGAGGTCCTCGGTTTGAGCGGCGCCCCTATCCGGTTGGCCGCGGGCCGCCTTCTGAACCTCG
TGCTCGACAAGAAGCGCACG

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MGTAKTFTLLAAMTAIFMAIGFLVGGMAGMILAFVVAAGMNVFAWWNSDKMVLRMQGAQEVLPDTKNPMLRAFGEDVARL
AENAGLPAPRIYIIDTPQPNAFATGRNPQNAAVAATTGLLNMLNREEVAGVMAHELAHVQNRDTLTMTVTATLAGAIGML
ANFALFFGRDRAGLIGSIAIMIFAPMAAALVQMAISRSREYVADKRGAEICGNPLWLASALEKIERGARSQINPYAERSP
AMAHMYISNPLNGRGQDKLFSTHPSTANRVEALRRMAGEMGISGVAAPTARSSGPWG

Sequences:

>Translated_297_residues
MGTAKTFTLLAAMTAIFMAIGFLVGGMAGMILAFVVAAGMNVFAWWNSDKMVLRMQGAQEVLPDTKNPMLRAFGEDVARL
AENAGLPAPRIYIIDTPQPNAFATGRNPQNAAVAATTGLLNMLNREEVAGVMAHELAHVQNRDTLTMTVTATLAGAIGML
ANFALFFGRDRAGLIGSIAIMIFAPMAAALVQMAISRSREYVADKRGAEICGNPLWLASALEKIERGARSQINPYAERSP
AMAHMYISNPLNGRGQDKLFSTHPSTANRVEALRRMAGEMGISGVAAPTARSSGPWG
>Mature_296_residues
GTAKTFTLLAAMTAIFMAIGFLVGGMAGMILAFVVAAGMNVFAWWNSDKMVLRMQGAQEVLPDTKNPMLRAFGEDVARLA
ENAGLPAPRIYIIDTPQPNAFATGRNPQNAAVAATTGLLNMLNREEVAGVMAHELAHVQNRDTLTMTVTATLAGAIGMLA
NFALFFGRDRAGLIGSIAIMIFAPMAAALVQMAISRSREYVADKRGAEICGNPLWLASALEKIERGARSQINPYAERSPA
MAHMYISNPLNGRGQDKLFSTHPSTANRVEALRRMAGEMGISGVAAPTARSSGPWG

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=271, Percent_Identity=29.520295202952, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_HYPNA (Q0BWV3)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_762040.1
- ProteinModelPortal:   Q0BWV3
- STRING:   Q0BWV3
- MEROPS:   M48.004
- GeneID:   4289866
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3367
- NMPDR:   fig|228405.5.peg.3223
- TIGR:   HNE_3367
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- PhylomeDB:   Q0BWV3
- ProtClustDB:   PRK01345
- BioCyc:   HNEP81032:HNE_3367-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31612; Mature: 31481

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 135-135

Signals:

None

Transmembrane regions:

HASH(0x161106cc)-; HASH(0x166c8934)-; HASH(0x15e3811c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.7 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTAKTFTLLAAMTAIFMAIGFLVGGMAGMILAFVVAAGMNVFAWWNSDKMVLRMQGAQE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCHH
VLPDTKNPMLRAFGEDVARLAENAGLPAPRIYIIDTPQPNAFATGRNPQNAAVAATTGLL
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCCCHHHHHHHHH
NMLNREEVAGVMAHELAHVQNRDTLTMTVTATLAGAIGMLANFALFFGRDRAGLIGSIAI
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
MIFAPMAAALVQMAISRSREYVADKRGAEICGNPLWLASALEKIERGARSQINPYAERSP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHCCC
AMAHMYISNPLNGRGQDKLFSTHPSTANRVEALRRMAGEMGISGVAAPTARSSGPWG
CEEEEEECCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
GTAKTFTLLAAMTAIFMAIGFLVGGMAGMILAFVVAAGMNVFAWWNSDKMVLRMQGAQE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCHH
VLPDTKNPMLRAFGEDVARLAENAGLPAPRIYIIDTPQPNAFATGRNPQNAAVAATTGLL
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCCCHHHHHHHHH
NMLNREEVAGVMAHELAHVQNRDTLTMTVTATLAGAIGMLANFALFFGRDRAGLIGSIAI
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
MIFAPMAAALVQMAISRSREYVADKRGAEICGNPLWLASALEKIERGARSQINPYAERSP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHCCC
AMAHMYISNPLNGRGQDKLFSTHPSTANRVEALRRMAGEMGISGVAAPTARSSGPWG
CEEEEEECCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA