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The map label for this gene is bioF [C]

Identifier: 114798527

GI number: 114798527

Start: 1272238

End: 1273377

Strand: Direct

Name: bioF [C]

Synonym: HNE_1248

Alternate gene names: 114798527

Gene position: 1272238-1273377 (Clockwise)

Preceding gene: 114797276

Following gene: 114797529

Centisome position: 34.34

GC content: 67.02

Gene sequence:

>1140_bases
ATGACATCTTTTGAACGGCTGAAAGCCTTTGCGGAGCAGAAACTGAGCCAGCTGGAAGCGACCGGACAGCGCCGCAGCCT
TGTGGAAACGGCGCGGGAGACGGGCGGACGGGCCGCGCGGGCCGGGCGGGACGTGATTTCCTTCTGCGACAATGATTATC
TTTCCCTCTCGCATGACGCCCGCGTCACGCAAGCGGCGGCGGATGCGGCCCGGCTTTATGGCGCCGGAAGCGGGGGATCG
CGGCTGATCACCGGGAATCACCCCCTCAACGCCGCCCTCGAAGACCGGCTGGCGCGCCTCAAGGGCACCGAGGGCGCGCG
GGTGTTCGGATCGGGCTTTCTGGCCAATCTGGGGACGATCCCCGCGCTGGTGGGCAAGGGGGACACCATCGTCATGGATG
AGCTGGCCCATGCGTGCATGCATGGCGGGGCGCGGCTTTCCGGGGCGCAGGTGCGCCTGTTCCGGCATAATGACGTGGCC
GAGGCCGCCCGCCTGGTGAAGGACGCGGCCGGACAGGTGCTGCTGCTGACCGAGACCGTGTTTTCGATGGACGGGGATGT
GGCGCCATTATCTGAGCTGGGCGCGCTGGCCGAAGCCACCGGGGCGTGGCTGATGACCGATGACGCGCATGGGCTTGGCG
TCGTGAAGCAGGATAACCCGGCGCAGATCCAGATGGGGACGCTGTCGAAGGCGGTCGGCGGGTATGGCGGCTATGTGTGC
GGGCCTGCGCCGCTGATGGATTTGCTGACGAGCCGGGCGCGGAGTTTTGTCTATACGACCGGCCTGCCACCGCCTGTGCT
GGCAGCGGCGATTGCGGCGCTGGACGTGATGGAGGCCGAGCCGGAGCGCGGGGCAAAAGCGAGTAGACATGCGGCGCTGT
TCTGCGAGCTTTTGGGTCTGCCGGCGCCTTCCAGCGTGATCGTGCCAATCATCATCGGGCCGGAGGCAGAAGCGATGCGG
GTTTCCGCGGCTCTGCTGGAGCGCGGGTATCTGGTGACGGCGATCAGGCCGCCGACTGTGCCGGCGGGCACCGCGCGGCT
GCGAGTGACGTTTGCCGCCGGACATGAGGAGGCGGACGTGCGCGCCTTTGCCGGGGCGCTGAAAGAGATCATGGAGCTGG
CATGCGCAGTTACTTTGTAA

Upstream 100 bases:

>100_bases
CTCCTAAAGGGTCCGTTGCTGCGGGCATTCGACGCTTGGCATGCCCCGCGTGCATCCCCTAGGACAGGCGCGGCGCAACG
GCCAGAGGATTGTAAGCCCG

Downstream 100 bases:

>100_bases
CGGCAACCGGCACCGACATTGGCAAGACATATGTCAGTGCCCGGCTGATTTCAGCCTGGCGGGCGCAGGGTTATGTCGCG
CAGGCGACAAAGCCGGTGAT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTSFERLKAFAEQKLSQLEATGQRRSLVETARETGGRAARAGRDVISFCDNDYLSLSHDARVTQAAADAARLYGAGSGGS
RLITGNHPLNAALEDRLARLKGTEGARVFGSGFLANLGTIPALVGKGDTIVMDELAHACMHGGARLSGAQVRLFRHNDVA
EAARLVKDAAGQVLLLTETVFSMDGDVAPLSELGALAEATGAWLMTDDAHGLGVVKQDNPAQIQMGTLSKAVGGYGGYVC
GPAPLMDLLTSRARSFVYTTGLPPPVLAAAIAALDVMEAEPERGAKASRHAALFCELLGLPAPSSVIVPIIIGPEAEAMR
VSAALLERGYLVTAIRPPTVPAGTARLRVTFAAGHEEADVRAFAGALKEIMELACAVTL

Sequences:

>Translated_379_residues
MTSFERLKAFAEQKLSQLEATGQRRSLVETARETGGRAARAGRDVISFCDNDYLSLSHDARVTQAAADAARLYGAGSGGS
RLITGNHPLNAALEDRLARLKGTEGARVFGSGFLANLGTIPALVGKGDTIVMDELAHACMHGGARLSGAQVRLFRHNDVA
EAARLVKDAAGQVLLLTETVFSMDGDVAPLSELGALAEATGAWLMTDDAHGLGVVKQDNPAQIQMGTLSKAVGGYGGYVC
GPAPLMDLLTSRARSFVYTTGLPPPVLAAAIAALDVMEAEPERGAKASRHAALFCELLGLPAPSSVIVPIIIGPEAEAMR
VSAALLERGYLVTAIRPPTVPAGTARLRVTFAAGHEEADVRAFAGALKEIMELACAVTL
>Mature_378_residues
TSFERLKAFAEQKLSQLEATGQRRSLVETARETGGRAARAGRDVISFCDNDYLSLSHDARVTQAAADAARLYGAGSGGSR
LITGNHPLNAALEDRLARLKGTEGARVFGSGFLANLGTIPALVGKGDTIVMDELAHACMHGGARLSGAQVRLFRHNDVAE
AARLVKDAAGQVLLLTETVFSMDGDVAPLSELGALAEATGAWLMTDDAHGLGVVKQDNPAQIQMGTLSKAVGGYGGYVCG
PAPLMDLLTSRARSFVYTTGLPPPVLAAAIAALDVMEAEPERGAKASRHAALFCELLGLPAPSSVIVPIIIGPEAEAMRV
SAALLERGYLVTAIRPPTVPAGTARLRVTFAAGHEEADVRAFAGALKEIMELACAVTL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=356, Percent_Identity=35.1123595505618, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI284448556, Length=356, Percent_Identity=35.1123595505618, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI83977442, Length=354, Percent_Identity=34.180790960452, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI83977440, Length=354, Percent_Identity=34.180790960452, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI83977444, Length=354, Percent_Identity=34.180790960452, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4502025, Length=349, Percent_Identity=34.3839541547278, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI40316939, Length=349, Percent_Identity=34.3839541547278, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=31.8801089918256, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI119220554, Length=381, Percent_Identity=29.6587926509186, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI5454084, Length=264, Percent_Identity=28.7878787878788, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786993, Length=336, Percent_Identity=39.2857142857143, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1790046, Length=335, Percent_Identity=32.8358208955224, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=353, Percent_Identity=32.8611898016997, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI32566772, Length=363, Percent_Identity=28.099173553719, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17560914, Length=301, Percent_Identity=26.578073089701, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17560912, Length=301, Percent_Identity=26.578073089701, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71982617, Length=274, Percent_Identity=23.3576642335766, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=274, Percent_Identity=23.3576642335766, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=360, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=355, Percent_Identity=26.4788732394366, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323954, Length=261, Percent_Identity=24.904214559387, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24662918, Length=362, Percent_Identity=29.0055248618785, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI17137420, Length=359, Percent_Identity=34.8189415041783, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI17136286, Length=343, Percent_Identity=26.8221574344023, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653280, Length=273, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653276, Length=273, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653278, Length=273, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 39479; Mature: 39347

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFERLKAFAEQKLSQLEATGQRRSLVETARETGGRAARAGRDVISFCDNDYLSLSHDA
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEECCCCC
RVTQAAADAARLYGAGSGGSRLITGNHPLNAALEDRLARLKGTEGARVFGSGFLANLGTI
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHCCH
PALVGKGDTIVMDELAHACMHGGARLSGAQVRLFRHNDVAEAARLVKDAAGQVLLLTETV
HHHHCCCCEEHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEHHH
FSMDGDVAPLSELGALAEATGAWLMTDDAHGLGVVKQDNPAQIQMGTLSKAVGGYGGYVC
HHCCCCCCCHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCEEEEHHHHHHHCCCCCCCC
GPAPLMDLLTSRARSFVYTTGLPPPVLAAAIAALDVMEAEPERGAKASRHAALFCELLGL
CHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PAPSSVIVPIIIGPEAEAMRVSAALLERGYLVTAIRPPTVPAGTARLRVTFAAGHEEADV
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCHHH
RAFAGALKEIMELACAVTL
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSFERLKAFAEQKLSQLEATGQRRSLVETARETGGRAARAGRDVISFCDNDYLSLSHDA
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEECCCCC
RVTQAAADAARLYGAGSGGSRLITGNHPLNAALEDRLARLKGTEGARVFGSGFLANLGTI
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHCCH
PALVGKGDTIVMDELAHACMHGGARLSGAQVRLFRHNDVAEAARLVKDAAGQVLLLTETV
HHHHCCCCEEHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEHHH
FSMDGDVAPLSELGALAEATGAWLMTDDAHGLGVVKQDNPAQIQMGTLSKAVGGYGGYVC
HHCCCCCCCHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCEEEEHHHHHHHCCCCCCCC
GPAPLMDLLTSRARSFVYTTGLPPPVLAAAIAALDVMEAEPERGAKASRHAALFCELLGL
CHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PAPSSVIVPIIIGPEAEAMRVSAALLERGYLVTAIRPPTVPAGTARLRVTFAAGHEEADV
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCHHH
RAFAGALKEIMELACAVTL
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA