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The map label for this gene is dnaX [H]

Identifier: 114798398

GI number: 114798398

Start: 361448

End: 363184

Strand: Reverse

Name: dnaX [H]

Synonym: HNE_0372

Alternate gene names: 114798398

Gene position: 363184-361448 (Counterclockwise)

Preceding gene: 114799612

Following gene: 114797665

Centisome position: 9.8

GC content: 66.67

Gene sequence:

>1737_bases
ATGAGCGCTGACGATTCCTCCACAGGCGATGACGCCACTGGCGCCCTTTTCGGGGGCGGGGACGCGCCTGCGCCCGGCAA
GACCTATGAGGTGCTGGCCCGGAAATACCGCCCGCGCCGCTTTGAGGACCTGATCGGCCAGGAAGCGATGGTGCGCACGC
TGTCCAACGCCTTCGAAACCGGCCGGATCGCCCATGGCTTCATGCTGACGGGCGTGCGCGGGGTGGGCAAGACGACCACG
GCGCGCCTGCTGGCCCGCGGCCTGAACTATGAGCCCAAGGCGGATGCGAAGGGCAAGAAGGGCAAGGCGGCTGGCCCCTC
CATCCATCTCGACCCGCCGGGCGAGCATTGCGACGCGATCATGGCGAGTCGGCATCCTGATGTGCTGGAGCTCGACGCCG
CCTCCCGCACCGGCGTCGCCGATATGCGCGACTTGCTGGATTCGGCGCGCTACGGGCCGGTGTCCGCTCGCTACAAGGTC
TATATCATCGACGAAGTTCACATGCTGTCGAATGCGAGCTTCAACGCGCTGCTCAAGACGCTGGAAGAACCCCCGCCGCA
TCTGAAGTTCATCTTTGCGACGACCGAGATCCGCAAGGTGCCGGTGACGGTTCTCTCGCGCTGCCAGCGGTTTGATCTCA
AACGCCTCGATAGCGGCGAGCTTTCCCGCCACCTTGGCAATGTGGCGCAGAGCGAGGGGGCGAATGTTTCCGAGGAAGCC
CTCGCCCTGATTGCGCGGGCAGCCGAAGGCTCTGTGCGCGACGGGCTGTCGCTGCTCGATCAGGGCATTGTTCAGACTAC
GGACGGCGAGGAAGTCAGCGGCGCGGCAGTGCGCGCGATGCTGGGACTGGGCGACCGGGCGCGGCTGCTGGACGCGGTGG
AGAAAGCCGTTGGCGGCGACGCCAAAGGGGCGCTCGCCGAAGTGCGCGAGCAGGTGGCGGGCGGGGCTGATCCGGCAGTG
ATCCTGAAGGACATCCTTGATATTGCAGCCGATATTTCCGTGGCGCAGGCAACCGGCGACGACTGGACGCAGGCCGGCCC
GGCCGACTGGGCAAACCGCACCAGAGCGCTGGCCCAGCGCCTGACGCCCGCGCAGGCCGCGCGCAACTGGCAGCTGTTGC
TCTCTGGCTACGGCGACCTTCAGGTGGCGCCCGACCCGGCAACCGCGCTGAACATGGTGATCCTGCGGCTGGCGGCGGCC
TCTACCCTTCCGTCGCCGGAAGAAGCGGCCCGGATGATAGCCGAGGGGTCCCGTCCGCCGGGAAAGGATAATCCGCCCCT
TAAGGCACCGCCGCAGGCGCCCGGCGGCATAGAGAGCTTTGCCGACATGATCGCCATCATGGTGGCCGCGCGCGAGGTGG
GGCTGCAGGTGGATACCGAGCGGTTTGTGCGGCCTTCGCATTTTGAACCCGGAAAGCTTGCCTGCGCGCTGGCGCCGGGG
GCGCCGCAGGGGCTGTTGGGGCGGCTGAAAATCTTCCTGGAAACCTATAGCGATCTCGACTGGAGCGTGGAGGAAGCCGA
CACCGATACCGAGTCGGTGCGCGAGCGGGAGCGGCGAGAAAAGGCCGAGCGGATCGAGAGCGCCAAACAGGACCCACGGG
TGGCAGCCGCGCTGGCCCTGATACCCGGCGCCATCATCCTGGATGTAGAAGATCCGCCTGAACTGCTTGAAATGGAGGGC
GGCGAGGGCGATGTGACCAGCAACGTTATACCCTTGAAAACCCGCCGGCCGGCCTGA

Upstream 100 bases:

>100_bases
CCTTCTCCCTTGGGAGAAGGAGTTTGTGACACTTAAGACGAGCTGCCGTTTAAAGCCCTTTGCCCTTCGGGCCCTGCCCC
GCTAATGATTGGGCGGACCC

Downstream 100 bases:

>100_bases
CGGAGACCCGATCACCATGAAAGACCTCGCCCAGATCATGCAGCAAGCCCAGGCCATGCAGGCCAAGATGGCGGAAGTGC
AGCAGAAAATCGAGAATACC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSADDSSTGDDATGALFGGGDAPAPGKTYEVLARKYRPRRFEDLIGQEAMVRTLSNAFETGRIAHGFMLTGVRGVGKTTT
ARLLARGLNYEPKADAKGKKGKAAGPSIHLDPPGEHCDAIMASRHPDVLELDAASRTGVADMRDLLDSARYGPVSARYKV
YIIDEVHMLSNASFNALLKTLEEPPPHLKFIFATTEIRKVPVTVLSRCQRFDLKRLDSGELSRHLGNVAQSEGANVSEEA
LALIARAAEGSVRDGLSLLDQGIVQTTDGEEVSGAAVRAMLGLGDRARLLDAVEKAVGGDAKGALAEVREQVAGGADPAV
ILKDILDIAADISVAQATGDDWTQAGPADWANRTRALAQRLTPAQAARNWQLLLSGYGDLQVAPDPATALNMVILRLAAA
STLPSPEEAARMIAEGSRPPGKDNPPLKAPPQAPGGIESFADMIAIMVAAREVGLQVDTERFVRPSHFEPGKLACALAPG
APQGLLGRLKIFLETYSDLDWSVEEADTDTESVRERERREKAERIESAKQDPRVAAALALIPGAIILDVEDPPELLEMEG
GEGDVTSNVIPLKTRRPA

Sequences:

>Translated_578_residues
MSADDSSTGDDATGALFGGGDAPAPGKTYEVLARKYRPRRFEDLIGQEAMVRTLSNAFETGRIAHGFMLTGVRGVGKTTT
ARLLARGLNYEPKADAKGKKGKAAGPSIHLDPPGEHCDAIMASRHPDVLELDAASRTGVADMRDLLDSARYGPVSARYKV
YIIDEVHMLSNASFNALLKTLEEPPPHLKFIFATTEIRKVPVTVLSRCQRFDLKRLDSGELSRHLGNVAQSEGANVSEEA
LALIARAAEGSVRDGLSLLDQGIVQTTDGEEVSGAAVRAMLGLGDRARLLDAVEKAVGGDAKGALAEVREQVAGGADPAV
ILKDILDIAADISVAQATGDDWTQAGPADWANRTRALAQRLTPAQAARNWQLLLSGYGDLQVAPDPATALNMVILRLAAA
STLPSPEEAARMIAEGSRPPGKDNPPLKAPPQAPGGIESFADMIAIMVAAREVGLQVDTERFVRPSHFEPGKLACALAPG
APQGLLGRLKIFLETYSDLDWSVEEADTDTESVRERERREKAERIESAKQDPRVAAALALIPGAIILDVEDPPELLEMEG
GEGDVTSNVIPLKTRRPA
>Mature_577_residues
SADDSSTGDDATGALFGGGDAPAPGKTYEVLARKYRPRRFEDLIGQEAMVRTLSNAFETGRIAHGFMLTGVRGVGKTTTA
RLLARGLNYEPKADAKGKKGKAAGPSIHLDPPGEHCDAIMASRHPDVLELDAASRTGVADMRDLLDSARYGPVSARYKVY
IIDEVHMLSNASFNALLKTLEEPPPHLKFIFATTEIRKVPVTVLSRCQRFDLKRLDSGELSRHLGNVAQSEGANVSEEAL
ALIARAAEGSVRDGLSLLDQGIVQTTDGEEVSGAAVRAMLGLGDRARLLDAVEKAVGGDAKGALAEVREQVAGGADPAVI
LKDILDIAADISVAQATGDDWTQAGPADWANRTRALAQRLTPAQAARNWQLLLSGYGDLQVAPDPATALNMVILRLAAAS
TLPSPEEAARMIAEGSRPPGKDNPPLKAPPQAPGGIESFADMIAIMVAAREVGLQVDTERFVRPSHFEPGKLACALAPGA
PQGLLGRLKIFLETYSDLDWSVEEADTDTESVRERERREKAERIESAKQDPRVAAALALIPGAIILDVEDPPELLEMEGG
EGDVTSNVIPLKTRRPA

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=258, Percent_Identity=23.2558139534884, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI31881687, Length=258, Percent_Identity=23.2558139534884, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786676, Length=385, Percent_Identity=44.4155844155844, Blast_Score=285, Evalue=8e-78,
Organism=Saccharomyces cerevisiae, GI6322528, Length=306, Percent_Identity=22.5490196078431, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 61504; Mature: 61373

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADDSSTGDDATGALFGGGDAPAPGKTYEVLARKYRPRRFEDLIGQEAMVRTLSNAFET
CCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GRIAHGFMLTGVRGVGKTTTARLLARGLNYEPKADAKGKKGKAAGPSIHLDPPGEHCDAI
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHH
MASRHPDVLELDAASRTGVADMRDLLDSARYGPVSARYKVYIIDEVHMLSNASFNALLKT
HHCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHCCHHHHHHHH
LEEPPPHLKFIFATTEIRKVPVTVLSRCQRFDLKRLDSGELSRHLGNVAQSEGANVSEEA
HCCCCCCEEEEEEECHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHH
LALIARAAEGSVRDGLSLLDQGIVQTTDGEEVSGAAVRAMLGLGDRARLLDAVEKAVGGD
HHHHHHHHCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
AKGALAEVREQVAGGADPAVILKDILDIAADISVAQATGDDWTQAGPADWANRTRALAQR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LTPAQAARNWQLLLSGYGDLQVAPDPATALNMVILRLAAASTLPSPEEAARMIAEGSRPP
CCHHHHHCCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
GKDNPPLKAPPQAPGGIESFADMIAIMVAAREVGLQVDTERFVRPSHFEPGKLACALAPG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEECHHHCCCCCCCCCCCEEEEECCC
APQGLLGRLKIFLETYSDLDWSVEEADTDTESVRERERREKAERIESAKQDPRVAAALAL
CCHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IPGAIILDVEDPPELLEMEGGEGDVTSNVIPLKTRRPA
CCCEEEEECCCCHHHHHCCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SADDSSTGDDATGALFGGGDAPAPGKTYEVLARKYRPRRFEDLIGQEAMVRTLSNAFET
CCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GRIAHGFMLTGVRGVGKTTTARLLARGLNYEPKADAKGKKGKAAGPSIHLDPPGEHCDAI
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHH
MASRHPDVLELDAASRTGVADMRDLLDSARYGPVSARYKVYIIDEVHMLSNASFNALLKT
HHCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHCCHHHHHHHH
LEEPPPHLKFIFATTEIRKVPVTVLSRCQRFDLKRLDSGELSRHLGNVAQSEGANVSEEA
HCCCCCCEEEEEEECHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHH
LALIARAAEGSVRDGLSLLDQGIVQTTDGEEVSGAAVRAMLGLGDRARLLDAVEKAVGGD
HHHHHHHHCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
AKGALAEVREQVAGGADPAVILKDILDIAADISVAQATGDDWTQAGPADWANRTRALAQR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LTPAQAARNWQLLLSGYGDLQVAPDPATALNMVILRLAAASTLPSPEEAARMIAEGSRPP
CCHHHHHCCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
GKDNPPLKAPPQAPGGIESFADMIAIMVAAREVGLQVDTERFVRPSHFEPGKLACALAPG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEECHHHCCCCCCCCCCCEEEEECCC
APQGLLGRLKIFLETYSDLDWSVEEADTDTESVRERERREKAERIESAKQDPRVAAALAL
CCHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IPGAIILDVEDPPELLEMEGGEGDVTSNVIPLKTRRPA
CCCEEEEECCCCHHHHHCCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]