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The map label for this gene is envZ [H]

Identifier: 114798347

GI number: 114798347

Start: 3270446

End: 3271741

Strand: Direct

Name: envZ [H]

Synonym: HNE_3094

Alternate gene names: 114798347

Gene position: 3270446-3271741 (Clockwise)

Preceding gene: 114798914

Following gene: 114798533

Centisome position: 88.27

GC content: 61.65

Gene sequence:

>1296_bases
ATGCTCCGCCTGCGCGACATTACCCCCCGCGGTCTCTACGCCCGCAGCCTGCTGCTGATCCTCGCGCCCGTCCTGCTGAT
CCTGGGTCTGATGACCTGGTACTATTATTCCAGCCATATCGCCGAGATGAACCGCAAGCTTGGTCAGGGTATTGCCCGCG
ACGCGGCGCTGATCCGGGATGCCTGCATCAATCCGGAGTACGGCCCGGCAGACTATGCGCGGATACAATACCTTCTGGAA
ACGGAGTTTACCTGCGCCCTGCCCGAAAATGCCGTGCCCATCAGCGCCTTGCGCCAAGGCTTCTCATACAATGATACGCT
CAACAGTGAACTGGCCGCACGGCTTGGTGATAGGGTCTTCGTCGGCCAGGTCCCAAAAGAACCCAAGCTGCACATCCGGT
TCGCCGCCAGCGCTTCCACCGCAGAGATCATCATCGACCGCAAACGCGCGCTCGTCATCAATGCGCACTTCTTCATTGTC
TGGGTGATCTTCTTCTCACTGCTGATGGTTGCCCTCGCGATCGGTTTCCTCAACCAGCAGGTCCGCTCGATCCTTCGGCT
TTCAAGGGCGGCCCGCGCCTTTGGCCGGGGGCGAGATCTGGAGGGTTTCCGCCCTTCCGGGGCGACGGAAGTGCGCGATG
CCGCGCGCGCCATCATCGACATGAAGAACCGCCTCACATCCTTCGCTGAACAGCGCACCGCGATGCTGGCCGGCGTCAGC
CATGACCTGCGCACGCCGCTGACGCGCCTGAAACTGACCCTCGCACTCATGCCGGAGTCCGACGATCTCAAAGCGGCGCG
ATCAGATCTCAATGACATGGCGATGATGCTGGACGAATACCTCGCCTTTGCGCGCGGCGAGGAGGGCGACGAAGCGGCCG
AGTTTGACCTGGGCGCCCTGGTTCACGATGTAGTGGCAGGCTTTGGCCCACATGTTCCGGTCAGCGGCCCTCAGACACTG
ACCGCGCGGGGCCGCCCGCTTGCCCTGAAACGGGCGATTACAAATCTTGTCTCAAATGCGCTGAAATATGCCAGCCACGC
CCGCGTTACGCTCGTCAATGGACCGCATTGGGCTGAAGTGATCGTGGATGATGATGGCCCCGGCATACCCGCCGACCGTT
ATGAAGAAGCCTTCCGGCCCTTCTCTCGGCTGGATGACGCACGTAGCCAGAATGCCTCCGGCTCGGGTCTTGGGCTTACC
CTGGCACGCGATACAGCCCGGATGCATGGCGGCGATGTGCGTCTTGCGCCAAGCCCACTGGGTGGATTACGCGCAATCTT
AAGACTGCCGCACTAG

Upstream 100 bases:

>100_bases
CACGCCTGCGCCGCAAGATCGAGCCCAACCCCAAAGAACCGATCCATATCCAGACCGTGCGGGGCGTCGGCTACCGCCTG
ATGCCGGATTGAAACCCCGA

Downstream 100 bases:

>100_bases
ATAAGGTCGCCAGGACGTTCATCGGAGAAACCATGACTGCCACACGCACCAAACTCGTCATCCGCAATGCCAAGCCAAAG
GATATTGCGGCCATCCGCCC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLRLRDITPRGLYARSLLLILAPVLLILGLMTWYYYSSHIAEMNRKLGQGIARDAALIRDACINPEYGPADYARIQYLLE
TEFTCALPENAVPISALRQGFSYNDTLNSELAARLGDRVFVGQVPKEPKLHIRFAASASTAEIIIDRKRALVINAHFFIV
WVIFFSLLMVALAIGFLNQQVRSILRLSRAARAFGRGRDLEGFRPSGATEVRDAARAIIDMKNRLTSFAEQRTAMLAGVS
HDLRTPLTRLKLTLALMPESDDLKAARSDLNDMAMMLDEYLAFARGEEGDEAAEFDLGALVHDVVAGFGPHVPVSGPQTL
TARGRPLALKRAITNLVSNALKYASHARVTLVNGPHWAEVIVDDDGPGIPADRYEEAFRPFSRLDDARSQNASGSGLGLT
LARDTARMHGGDVRLAPSPLGGLRAILRLPH

Sequences:

>Translated_431_residues
MLRLRDITPRGLYARSLLLILAPVLLILGLMTWYYYSSHIAEMNRKLGQGIARDAALIRDACINPEYGPADYARIQYLLE
TEFTCALPENAVPISALRQGFSYNDTLNSELAARLGDRVFVGQVPKEPKLHIRFAASASTAEIIIDRKRALVINAHFFIV
WVIFFSLLMVALAIGFLNQQVRSILRLSRAARAFGRGRDLEGFRPSGATEVRDAARAIIDMKNRLTSFAEQRTAMLAGVS
HDLRTPLTRLKLTLALMPESDDLKAARSDLNDMAMMLDEYLAFARGEEGDEAAEFDLGALVHDVVAGFGPHVPVSGPQTL
TARGRPLALKRAITNLVSNALKYASHARVTLVNGPHWAEVIVDDDGPGIPADRYEEAFRPFSRLDDARSQNASGSGLGLT
LARDTARMHGGDVRLAPSPLGGLRAILRLPH
>Mature_431_residues
MLRLRDITPRGLYARSLLLILAPVLLILGLMTWYYYSSHIAEMNRKLGQGIARDAALIRDACINPEYGPADYARIQYLLE
TEFTCALPENAVPISALRQGFSYNDTLNSELAARLGDRVFVGQVPKEPKLHIRFAASASTAEIIIDRKRALVINAHFFIV
WVIFFSLLMVALAIGFLNQQVRSILRLSRAARAFGRGRDLEGFRPSGATEVRDAARAIIDMKNRLTSFAEQRTAMLAGVS
HDLRTPLTRLKLTLALMPESDDLKAARSDLNDMAMMLDEYLAFARGEEGDEAAEFDLGALVHDVVAGFGPHVPVSGPQTL
TARGRPLALKRAITNLVSNALKYASHARVTLVNGPHWAEVIVDDDGPGIPADRYEEAFRPFSRLDDARSQNASGSGLGLT
LARDTARMHGGDVRLAPSPLGGLRAILRLPH

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=454, Percent_Identity=29.0748898678414, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1790346, Length=248, Percent_Identity=31.4516129032258, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1787894, Length=287, Percent_Identity=28.9198606271777, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=29.9559471365639, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082128, Length=279, Percent_Identity=29.0322580645161, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=25, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=24.4979919678715, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=226, Percent_Identity=27.4336283185841, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=23.265306122449, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=26.056338028169, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=26.5217391304348, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=361, Percent_Identity=26.0387811634349, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.5964125560538, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=30.2127659574468, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47360; Mature: 47360

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLRDITPRGLYARSLLLILAPVLLILGLMTWYYYSSHIAEMNRKLGQGIARDAALIRD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
ACINPEYGPADYARIQYLLETEFTCALPENAVPISALRQGFSYNDTLNSELAARLGDRVF
HCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCEEE
VGQVPKEPKLHIRFAASASTAEIIIDRKRALVINAHFFIVWVIFFSLLMVALAIGFLNQQ
ECCCCCCCCEEEEEECCCCCHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VRSILRLSRAARAFGRGRDLEGFRPSGATEVRDAARAIIDMKNRLTSFAEQRTAMLAGVS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HDLRTPLTRLKLTLALMPESDDLKAARSDLNDMAMMLDEYLAFARGEEGDEAAEFDLGAL
HHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VHDVVAGFGPHVPVSGPQTLTARGRPLALKRAITNLVSNALKYASHARVTLVNGPHWAEV
HHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
IVDDDGPGIPADRYEEAFRPFSRLDDARSQNASGSGLGLTLARDTARMHGGDVRLAPSPL
EECCCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHCCCCEEECCCCC
GGLRAILRLPH
HHHHHHHHCCC
>Mature Secondary Structure
MLRLRDITPRGLYARSLLLILAPVLLILGLMTWYYYSSHIAEMNRKLGQGIARDAALIRD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
ACINPEYGPADYARIQYLLETEFTCALPENAVPISALRQGFSYNDTLNSELAARLGDRVF
HCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCEEE
VGQVPKEPKLHIRFAASASTAEIIIDRKRALVINAHFFIVWVIFFSLLMVALAIGFLNQQ
ECCCCCCCCEEEEEECCCCCHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VRSILRLSRAARAFGRGRDLEGFRPSGATEVRDAARAIIDMKNRLTSFAEQRTAMLAGVS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HDLRTPLTRLKLTLALMPESDDLKAARSDLNDMAMMLDEYLAFARGEEGDEAAEFDLGAL
HHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VHDVVAGFGPHVPVSGPQTLTARGRPLALKRAITNLVSNALKYASHARVTLVNGPHWAEV
HHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEE
IVDDDGPGIPADRYEEAFRPFSRLDDARSQNASGSGLGLTLARDTARMHGGDVRLAPSPL
EECCCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHCCCCEEECCCCC
GGLRAILRLPH
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]