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The map label for this gene is ptrB [H]

Identifier: 114798261

GI number: 114798261

Start: 2231971

End: 2234148

Strand: Reverse

Name: ptrB [H]

Synonym: HNE_2146

Alternate gene names: 114798261

Gene position: 2234148-2231971 (Counterclockwise)

Preceding gene: 114798626

Following gene: 114798457

Centisome position: 60.3

GC content: 64.28

Gene sequence:

>2178_bases
ATGGCTCATGCGTCAGGATTTTCGCGCCGCACGCTGCTGCAGACGATTGCGCTGGGCGCGCTGGCCGGGTGTGCCGCTGG
CGCGGGCGGCGGCGCCGCTTTTGCGCCGGGGGCGATTGCCCCACCTGTGGCGCCGCGCATTCCGTTCCGGATCGAGCAGC
TGGGCCGCGTGCGCGATGACCCCTACCGGTGGATGAAGTTCATTCCCGAGACGGGCACGCGGGAGATGCGCACGCTGCCG
GAGATGATCCGTACACATCTTGAGGCAGAGGCGGCCTATGCCGACGCCGTGCTGGCGCCGGCGCGCAAGCTTCAGCCGGA
GATCATTGCGCAGATGGTTGCGCAGCTGCCCGGCAATGACGCCCCGCCGCCGATCTGGGCGGGAGACTGGGCCTATTCGA
GCCATTATCCGGAAGGCAGCGAACACGCCGTTTATACCCGGATTTCTGCCCGCGAAGGCGCCGCGCCGGAAGTGTTGCTG
GACGAGGCGGCGCGCGCGCAGGGGACGGCTTACTATCGCACCACGGGTCATCAGGCGAGCCCGGATCATCGCTATTATGC
GTGGGCAGAGGATGTGATCGGCAATGACCGCCACCGGATCTGCATGAAAGACATGACGACGGCCGCGGTGTCTGTGCTCG
TACCGGAAGATGCCTATGGCTATGGCGGGCTGGTGTTCAGCCCGTCCTCACGTTTCCTGTTCTGGATCTGGCGGGACGAC
AAGAACCGCCCGACGCGGATTTACAGAACGCCCGTCGGCGGGGGCGAGGCTGTTCTGGTGCATGAGGAAACCAATCCGGC
GCTCTTTATGCAGATCAAACGGACGGCAGCGGGCGGCTATATCGCGATTACGCTGTCGGGGCCGGATATGTCCGAGGTGT
GGCTGGTTCCGGCAGAGGATGAGACGGGGGCGCCGCGTGTCGTTTTCCCGCGCCGGGATAAAGTACGCTATGAGATAGAG
GAGTGGAAAGAGGCACTCCTTGTGCTGACTGATGAAGGCGGCGCGATTGATAACAAGCTGCTGTCAATGCCGGCAGGCGC
CGCTACGCCGCAGGAGACGCTGGTGGCGCACCGGCCGGGCAGCCAGATACTGGAAGTGTTTCCCTTCGAGAAGGCGCTTG
TGCGCTTAGAGCGGCAGGACGGCCTGCATCAGCTGATCCTTCTGTTTGCGGATGGATCAGAAAAGGTGATCGGTTTTGAC
GAGGCCGCCTATACGCTGACCGTGCCACAGGGGCAGGCCTACGGCGCAGGCGCGTGCCGCATCACGTTCCAGTCGCCGCG
GCTGCCCGTACAATGGATGGATGTCGACCTGGAAACCGGCGCGCTGAGCCTTGTGCAGAAATCTGATCGCGCGGGGTATG
ATCCGGACCAATATGTTGTGGAGCGGGTGTTTGCGCCGGCGCCGGATGGGGCGAGTGTTCCGGTGACGCTGCTAAGCAGG
CGCGGGGCGGCGCGGGATGGGTCGATGCCTTGTGTGCTCTATGGATATGGTGCTTACGGCGTCTCCAGCGATCCGGAATT
TTCCGTGCCGGCGCTGGCGCTGGTGGATCGGGGCTGGACCTATGCGATCGCCCATGTGCGCGGCGGATCGGAGCGCGGGC
GGCAATGGTTCCTCGATGGGCGCCGCTTCAGCAAGCGCAACAGCTTTACAGACTTTGTGGCCTGCGCGGAGCATCTGATT
GATCTGGGCGTGACGCGCAAGGGCGCGGTTGTGGCGTATGGATTGTCAGCTGGCGGATTGCTGGTAGCCGGTGCGATGAA
TGAGGCGCCGCACCTTTGGGCGGGTGTCATCGCGCAGGTGCCGTTCGTGGACATGCTGAACACGATGAGCGACGCGGACC
ATCCGCTGGTGCCGCTGTTCCGGCCGGACTGGGGCGATCCGCTGGCAGATCCGGAGGCCTATGACTATATGTTCTCGATT
TCGCCCTATGAGAATGTTCAGGCCACGGCCTATCCGCCGCTGCTGTGCACGTCCGGCCTGAAAGATGACCGGGTCGGCTA
TTGGGAGGCGGCAAAGCTCGTCGCCGAAGTGCGCCACACGTCAACCGGCGCCGCGCCCGCGATCCTGGTGCTGGATGCTG
ATGCGGGCCACCAGTCCAGCGGCGGGCGCGGCGCCCAGTTTCAGGAAATGTCTCTCTACTGGGCGTTCGCGGAACTGGCC
GTTTCAGGCGCGCTTTAA

Upstream 100 bases:

>100_bases
GGGAGATTGGGCCGCTTTCAGGTTTCCAGCCCGGAGGGGCCTGATAGGGTGTTGGAAGAGGCTGGCGGTGTGCGCGGCAG
GATCGGGGAGATTTCGGGTG

Downstream 100 bases:

>100_bases
GACCGTTACTTTACCCTCATGGAACGAACATTTTCGGAGATGGTGAAGCTGACCGGTGCCGGGCAGGGGCCGATCTCGCC
TTCGATGCCAACGCCTTCGC

Product: protease II

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 725; Mature: 724

Protein sequence:

>725_residues
MAHASGFSRRTLLQTIALGALAGCAAGAGGGAAFAPGAIAPPVAPRIPFRIEQLGRVRDDPYRWMKFIPETGTREMRTLP
EMIRTHLEAEAAYADAVLAPARKLQPEIIAQMVAQLPGNDAPPPIWAGDWAYSSHYPEGSEHAVYTRISAREGAAPEVLL
DEAARAQGTAYYRTTGHQASPDHRYYAWAEDVIGNDRHRICMKDMTTAAVSVLVPEDAYGYGGLVFSPSSRFLFWIWRDD
KNRPTRIYRTPVGGGEAVLVHEETNPALFMQIKRTAAGGYIAITLSGPDMSEVWLVPAEDETGAPRVVFPRRDKVRYEIE
EWKEALLVLTDEGGAIDNKLLSMPAGAATPQETLVAHRPGSQILEVFPFEKALVRLERQDGLHQLILLFADGSEKVIGFD
EAAYTLTVPQGQAYGAGACRITFQSPRLPVQWMDVDLETGALSLVQKSDRAGYDPDQYVVERVFAPAPDGASVPVTLLSR
RGAARDGSMPCVLYGYGAYGVSSDPEFSVPALALVDRGWTYAIAHVRGGSERGRQWFLDGRRFSKRNSFTDFVACAEHLI
DLGVTRKGAVVAYGLSAGGLLVAGAMNEAPHLWAGVIAQVPFVDMLNTMSDADHPLVPLFRPDWGDPLADPEAYDYMFSI
SPYENVQATAYPPLLCTSGLKDDRVGYWEAAKLVAEVRHTSTGAAPAILVLDADAGHQSSGGRGAQFQEMSLYWAFAELA
VSGAL

Sequences:

>Translated_725_residues
MAHASGFSRRTLLQTIALGALAGCAAGAGGGAAFAPGAIAPPVAPRIPFRIEQLGRVRDDPYRWMKFIPETGTREMRTLP
EMIRTHLEAEAAYADAVLAPARKLQPEIIAQMVAQLPGNDAPPPIWAGDWAYSSHYPEGSEHAVYTRISAREGAAPEVLL
DEAARAQGTAYYRTTGHQASPDHRYYAWAEDVIGNDRHRICMKDMTTAAVSVLVPEDAYGYGGLVFSPSSRFLFWIWRDD
KNRPTRIYRTPVGGGEAVLVHEETNPALFMQIKRTAAGGYIAITLSGPDMSEVWLVPAEDETGAPRVVFPRRDKVRYEIE
EWKEALLVLTDEGGAIDNKLLSMPAGAATPQETLVAHRPGSQILEVFPFEKALVRLERQDGLHQLILLFADGSEKVIGFD
EAAYTLTVPQGQAYGAGACRITFQSPRLPVQWMDVDLETGALSLVQKSDRAGYDPDQYVVERVFAPAPDGASVPVTLLSR
RGAARDGSMPCVLYGYGAYGVSSDPEFSVPALALVDRGWTYAIAHVRGGSERGRQWFLDGRRFSKRNSFTDFVACAEHLI
DLGVTRKGAVVAYGLSAGGLLVAGAMNEAPHLWAGVIAQVPFVDMLNTMSDADHPLVPLFRPDWGDPLADPEAYDYMFSI
SPYENVQATAYPPLLCTSGLKDDRVGYWEAAKLVAEVRHTSTGAAPAILVLDADAGHQSSGGRGAQFQEMSLYWAFAELA
VSGAL
>Mature_724_residues
AHASGFSRRTLLQTIALGALAGCAAGAGGGAAFAPGAIAPPVAPRIPFRIEQLGRVRDDPYRWMKFIPETGTREMRTLPE
MIRTHLEAEAAYADAVLAPARKLQPEIIAQMVAQLPGNDAPPPIWAGDWAYSSHYPEGSEHAVYTRISAREGAAPEVLLD
EAARAQGTAYYRTTGHQASPDHRYYAWAEDVIGNDRHRICMKDMTTAAVSVLVPEDAYGYGGLVFSPSSRFLFWIWRDDK
NRPTRIYRTPVGGGEAVLVHEETNPALFMQIKRTAAGGYIAITLSGPDMSEVWLVPAEDETGAPRVVFPRRDKVRYEIEE
WKEALLVLTDEGGAIDNKLLSMPAGAATPQETLVAHRPGSQILEVFPFEKALVRLERQDGLHQLILLFADGSEKVIGFDE
AAYTLTVPQGQAYGAGACRITFQSPRLPVQWMDVDLETGALSLVQKSDRAGYDPDQYVVERVFAPAPDGASVPVTLLSRR
GAARDGSMPCVLYGYGAYGVSSDPEFSVPALALVDRGWTYAIAHVRGGSERGRQWFLDGRRFSKRNSFTDFVACAEHLID
LGVTRKGAVVAYGLSAGGLLVAGAMNEAPHLWAGVIAQVPFVDMLNTMSDADHPLVPLFRPDWGDPLADPEAYDYMFSIS
PYENVQATAYPPLLCTSGLKDDRVGYWEAAKLVAEVRHTSTGAAPAILVLDADAGHQSSGGRGAQFQEMSLYWAFAELAV
SGAL

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI284172420, Length=492, Percent_Identity=26.6260162601626, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI284172413, Length=492, Percent_Identity=26.6260162601626, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI70778815, Length=492, Percent_Identity=26.6260162601626, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI284172438, Length=492, Percent_Identity=26.6260162601626, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI284172431, Length=492, Percent_Identity=26.6260162601626, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI41349456, Length=275, Percent_Identity=32, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI108860686, Length=267, Percent_Identity=32.2097378277154, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI108860692, Length=236, Percent_Identity=33.0508474576271, Blast_Score=130, Evalue=6e-30,
Organism=Escherichia coli, GI1788150, Length=690, Percent_Identity=31.8840579710145, Blast_Score=348, Evalue=5e-97,
Organism=Drosophila melanogaster, GI24583414, Length=263, Percent_Identity=33.0798479087452, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221510989, Length=260, Percent_Identity=32.6923076923077, Blast_Score=124, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 78728; Mature: 78597

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHASGFSRRTLLQTIALGALAGCAAGAGGGAAFAPGAIAPPVAPRIPFRIEQLGRVRDD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
PYRWMKFIPETGTREMRTLPEMIRTHLEAEAAYADAVLAPARKLQPEIIAQMVAQLPGND
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCCC
APPPIWAGDWAYSSHYPEGSEHAVYTRISAREGAAPEVLLDEAARAQGTAYYRTTGHQAS
CCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCC
PDHRYYAWAEDVIGNDRHRICMKDMTTAAVSVLVPEDAYGYGGLVFSPSSRFLFWIWRDD
CCCCEEEEHHHHHCCCCCEEEHHHHCCEEEEEEECCCCCCCCCEEECCCCCEEEEEEECC
KNRPTRIYRTPVGGGEAVLVHEETNPALFMQIKRTAAGGYIAITLSGPDMSEVWLVPAED
CCCCCEEEECCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEECCCCCCCEEEEECCC
ETGAPRVVFPRRDKVRYEIEEWKEALLVLTDEGGAIDNKLLSMPAGAATPQETLVAHRPG
CCCCCEEEECCCCCCEEEHHHHCCEEEEEECCCCCCCHHHHCCCCCCCCCHHHEEEECCC
SQILEVFPFEKALVRLERQDGLHQLILLFADGSEKVIGFDEAAYTLTVPQGQAYGAGACR
HHHHHHCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCCCCCEEE
ITFQSPRLPVQWMDVDLETGALSLVQKSDRAGYDPDQYVVERVFAPAPDGASVPVTLLSR
EEECCCCCCEEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHC
RGAARDGSMPCVLYGYGAYGVSSDPEFSVPALALVDRGWTYAIAHVRGGSERGRQWFLDG
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEEECC
RRFSKRNSFTDFVACAEHLIDLGVTRKGAVVAYGLSAGGLLVAGAMNEAPHLWAGVIAQV
CHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHC
PFVDMLNTMSDADHPLVPLFRPDWGDPLADPEAYDYMFSISPYENVQATAYPPLLCTSGL
CHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCCC
KDDRVGYWEAAKLVAEVRHTSTGAAPAILVLDADAGHQSSGGRGAQFQEMSLYWAFAELA
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
VSGAL
HHCCC
>Mature Secondary Structure 
AHASGFSRRTLLQTIALGALAGCAAGAGGGAAFAPGAIAPPVAPRIPFRIEQLGRVRDD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
PYRWMKFIPETGTREMRTLPEMIRTHLEAEAAYADAVLAPARKLQPEIIAQMVAQLPGND
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCCC
APPPIWAGDWAYSSHYPEGSEHAVYTRISAREGAAPEVLLDEAARAQGTAYYRTTGHQAS
CCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCC
PDHRYYAWAEDVIGNDRHRICMKDMTTAAVSVLVPEDAYGYGGLVFSPSSRFLFWIWRDD
CCCCEEEEHHHHHCCCCCEEEHHHHCCEEEEEEECCCCCCCCCEEECCCCCEEEEEEECC
KNRPTRIYRTPVGGGEAVLVHEETNPALFMQIKRTAAGGYIAITLSGPDMSEVWLVPAED
CCCCCEEEECCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEECCCCCCCEEEEECCC
ETGAPRVVFPRRDKVRYEIEEWKEALLVLTDEGGAIDNKLLSMPAGAATPQETLVAHRPG
CCCCCEEEECCCCCCEEEHHHHCCEEEEEECCCCCCCHHHHCCCCCCCCCHHHEEEECCC
SQILEVFPFEKALVRLERQDGLHQLILLFADGSEKVIGFDEAAYTLTVPQGQAYGAGACR
HHHHHHCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCCCCCEEE
ITFQSPRLPVQWMDVDLETGALSLVQKSDRAGYDPDQYVVERVFAPAPDGASVPVTLLSR
EEECCCCCCEEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHC
RGAARDGSMPCVLYGYGAYGVSSDPEFSVPALALVDRGWTYAIAHVRGGSERGRQWFLDG
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEEECC
RRFSKRNSFTDFVACAEHLIDLGVTRKGAVVAYGLSAGGLLVAGAMNEAPHLWAGVIAQV
CHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHC
PFVDMLNTMSDADHPLVPLFRPDWGDPLADPEAYDYMFSISPYENVQATAYPPLLCTSGL
CHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCCC
KDDRVGYWEAAKLVAEVRHTSTGAAPAILVLDADAGHQSSGGRGAQFQEMSLYWAFAELA
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
VSGAL
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7629037 [H]