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The map label for this gene is acsA [H]

Identifier: 114798116

GI number: 114798116

Start: 1428780

End: 1430726

Strand: Direct

Name: acsA [H]

Synonym: HNE_1402

Alternate gene names: 114798116

Gene position: 1428780-1430726 (Clockwise)

Preceding gene: 114797134

Following gene: 114797096

Centisome position: 38.56

GC content: 61.68

Gene sequence:

>1947_bases
ATGAGCGACGATTCAAAAACGTATCCAGTTCCTGAAGCCTTTGCGAGCCAGGCAAACCTGACCCCGGAGAAATACCGGGA
AATGTATGCCGCCTCCATCGCCGACCCCGCCGCTTTCTGGGGTGAGCAGGGCAAGCGTCTGGACTGGATGACGCCCTACA
CCGTCGTCAAGGACGTCTCCTGGGAAACCGGAGACCTGCATGTCCGCTGGTATTCTGACGGCGTCCTCAACGTCACCGCC
AACTGCATCGACCGCCATCTGGACACGCGCGGCGACAAGGCCGCTTTCATCTGGGAAGGCGACAAGCCGGGCGAGAGCCA
CACCGTCACCTACCGCCAGCTTCACGCCTCTGTCAGCAAATTCGCCAACGTCCTGAAGGAACTCGGCGTCAAGAAGGGCG
ACCGCGTCACCATCTACATGCCGATGATCCTTGAGGCCGCCTACGCCATGCTCGCCTGCGCGCGCATCGGCGCGGTCCAT
TCGGTCGTCTTCGGCGGCTTCTCGCCTGAAGCGCTCGCGGGGCGCATTGTTGATTGCGGCTCCGAAGTTCTCATCACTGC
CGATGAAGGCCTGCGCGGGGGCAAGAGCGTTCCGCTGAAAGTGAACGCAGACAAAGCCGCAGGCATTGCCGGCGGTACCG
TTAAAAAGATGCTTGTCGTCAAGCGCACCGGCGGCAACGTCTCCATGACCGAAGGCCGCGACCACTGGCTGCACGAAATC
GGCGCGACCGTTTCGGCAGATTGCCCGCCCGAGCCGATGAACGCGGAAGACCCGCTGTTCATTCTGTATACGTCGGGTTC
CACGGGCAAGCCCAAAGGCGTGCTGCACACGACCGGCGGCTATCTCCTCTGGGCCTCGATGACGCATGAATACGTCTTTG
ATCTCAAGGAAAACGACATCTTCTGGTGCTCAGCCGATGTCGGCTGGGTCACCGGCCACACCTACATCATCTATGGCCCG
CTCGCGAATGGCGCCACCAGCGTGATGTTCGAAGGCGTGCCGACCTATCCGGACGCCAGCCGCTTCTGGCAGGTGTGCGA
CAAGCATCAGGTCACGATCTTCTACACCGCGCCCACCGCCATCCGCGCCCTGATGCGTGAAGGCGAAGGGCCGGTGAACA
AGACCTCCCGCAAATCCATCCGCCTCCTCGGCACGGTGGGCGAGCCGATCAACCCGGAAGCCTGGGAATGGTATTTCCAT
GTCGTCGGCGAAGCCCGCTGCCCCATCGTGGATACCTGGTGGCAGACCGAGACCGGCGGCACACTGATCGTGCCTCTGCC
AAACACCACGGATATGAAACCCGGCGCAGGCTCTCACCCCTTCTTCGGGATCAAGCCGATCCTCGTCGATGCCGATGGCA
GGGAGCTTGAAGGCGCTGCCGATGGAAATCTTCTGATCACCGATAGCTGGCCCGGCCAGATGCGCACCGTATACGGAGAT
CATCAGCGCTTCGTGGAAACCTATTTCACGGCCTATCCCGGCAAATACTTCACCGGCGATGGCTGCCGCCGCGACGCCGA
TGGCTTCTACTGGATCACAGGCCGCGTAGATGACGTGATCAACGTCTCGGGCCACCGGATGGGCACGGCGGAAGTGGAAA
GCGCCCTCGTCAGCCATGATGCCGTGGCCGAAGCCGCCGTCGTCGGCTATCCGCACGACATCAAGGGGCAGGGGATCTAT
GCCTATGTCACCCTGCGGGCAGGCTGCGAGGCCGATGATGCCTTGCGCAAAAACCTCGTCGCTCATGTGCGCAATGAAAT
CGGCCCGATTGCCTCGCCGGATCTCATCCAGTTCGCGCCGGGCCTGCCGAAAACCCGTTCGGGCAAGATCATGCGCCGCA
TTCTGCGCAAGATCGCCGAGAACGAGTTCTCCAATCTGGGCGATACCTCCACCCTGGCTGAACCGGAAGTCGTGAAAGAC
CTGATCGACAACCGCCAGAACCGTTGA

Upstream 100 bases:

>100_bases
GTCCGCCGGGCAAGGGCGGTGCGATGGGGCGTTTCACCGTCTCGACAAAACATGCATTCTGGGGGAAAGCCCCGGAGAAA
TTACGAAGGGAATGCCGGTC

Downstream 100 bases:

>100_bases
TCAGGAACCGCTAAATCTTCGCGCGGCCATCAAGGCTTTATTATCCCTGTCATGGGCATAAGCTCTGCTTCTATGCCTGC
TGAGGGGAGCCTGCATGGCC

Product: acetate--CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MSDDSKTYPVPEAFASQANLTPEKYREMYAASIADPAAFWGEQGKRLDWMTPYTVVKDVSWETGDLHVRWYSDGVLNVTA
NCIDRHLDTRGDKAAFIWEGDKPGESHTVTYRQLHASVSKFANVLKELGVKKGDRVTIYMPMILEAAYAMLACARIGAVH
SVVFGGFSPEALAGRIVDCGSEVLITADEGLRGGKSVPLKVNADKAAGIAGGTVKKMLVVKRTGGNVSMTEGRDHWLHEI
GATVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLLWASMTHEYVFDLKENDIFWCSADVGWVTGHTYIIYGP
LANGATSVMFEGVPTYPDASRFWQVCDKHQVTIFYTAPTAIRALMREGEGPVNKTSRKSIRLLGTVGEPINPEAWEWYFH
VVGEARCPIVDTWWQTETGGTLIVPLPNTTDMKPGAGSHPFFGIKPILVDADGRELEGAADGNLLITDSWPGQMRTVYGD
HQRFVETYFTAYPGKYFTGDGCRRDADGFYWITGRVDDVINVSGHRMGTAEVESALVSHDAVAEAAVVGYPHDIKGQGIY
AYVTLRAGCEADDALRKNLVAHVRNEIGPIASPDLIQFAPGLPKTRSGKIMRRILRKIAENEFSNLGDTSTLAEPEVVKD
LIDNRQNR

Sequences:

>Translated_648_residues
MSDDSKTYPVPEAFASQANLTPEKYREMYAASIADPAAFWGEQGKRLDWMTPYTVVKDVSWETGDLHVRWYSDGVLNVTA
NCIDRHLDTRGDKAAFIWEGDKPGESHTVTYRQLHASVSKFANVLKELGVKKGDRVTIYMPMILEAAYAMLACARIGAVH
SVVFGGFSPEALAGRIVDCGSEVLITADEGLRGGKSVPLKVNADKAAGIAGGTVKKMLVVKRTGGNVSMTEGRDHWLHEI
GATVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLLWASMTHEYVFDLKENDIFWCSADVGWVTGHTYIIYGP
LANGATSVMFEGVPTYPDASRFWQVCDKHQVTIFYTAPTAIRALMREGEGPVNKTSRKSIRLLGTVGEPINPEAWEWYFH
VVGEARCPIVDTWWQTETGGTLIVPLPNTTDMKPGAGSHPFFGIKPILVDADGRELEGAADGNLLITDSWPGQMRTVYGD
HQRFVETYFTAYPGKYFTGDGCRRDADGFYWITGRVDDVINVSGHRMGTAEVESALVSHDAVAEAAVVGYPHDIKGQGIY
AYVTLRAGCEADDALRKNLVAHVRNEIGPIASPDLIQFAPGLPKTRSGKIMRRILRKIAENEFSNLGDTSTLAEPEVVKD
LIDNRQNR
>Mature_647_residues
SDDSKTYPVPEAFASQANLTPEKYREMYAASIADPAAFWGEQGKRLDWMTPYTVVKDVSWETGDLHVRWYSDGVLNVTAN
CIDRHLDTRGDKAAFIWEGDKPGESHTVTYRQLHASVSKFANVLKELGVKKGDRVTIYMPMILEAAYAMLACARIGAVHS
VVFGGFSPEALAGRIVDCGSEVLITADEGLRGGKSVPLKVNADKAAGIAGGTVKKMLVVKRTGGNVSMTEGRDHWLHEIG
ATVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLLWASMTHEYVFDLKENDIFWCSADVGWVTGHTYIIYGPL
ANGATSVMFEGVPTYPDASRFWQVCDKHQVTIFYTAPTAIRALMREGEGPVNKTSRKSIRLLGTVGEPINPEAWEWYFHV
VGEARCPIVDTWWQTETGGTLIVPLPNTTDMKPGAGSHPFFGIKPILVDADGRELEGAADGNLLITDSWPGQMRTVYGDH
QRFVETYFTAYPGKYFTGDGCRRDADGFYWITGRVDDVINVSGHRMGTAEVESALVSHDAVAEAAVVGYPHDIKGQGIYA
YVTLRAGCEADDALRKNLVAHVRNEIGPIASPDLIQFAPGLPKTRSGKIMRRILRKIAENEFSNLGDTSTLAEPEVVKDL
IDNRQNR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=667, Percent_Identity=53.3733133433283, Blast_Score=708, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=680, Percent_Identity=52.2058823529412, Blast_Score=703, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=630, Percent_Identity=50.3174603174603, Blast_Score=639, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=625, Percent_Identity=37.28, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI42544132, Length=528, Percent_Identity=28.9772727272727, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI38505220, Length=607, Percent_Identity=29.8187808896211, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI122937307, Length=552, Percent_Identity=27.8985507246377, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI31982927, Length=624, Percent_Identity=24.6794871794872, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI115511026, Length=540, Percent_Identity=27.5925925925926, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI58082049, Length=526, Percent_Identity=26.615969581749, Blast_Score=153, Evalue=6e-37,
Organism=Homo sapiens, GI157311624, Length=529, Percent_Identity=26.6540642722117, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI157311622, Length=529, Percent_Identity=26.6540642722117, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI195947378, Length=462, Percent_Identity=24.6753246753247, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI42544134, Length=347, Percent_Identity=25.3602305475504, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI40807357, Length=566, Percent_Identity=23.8515901060071, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI187761345, Length=383, Percent_Identity=25.5874673629243, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI187761343, Length=383, Percent_Identity=25.5874673629243, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI38524616, Length=544, Percent_Identity=22.6102941176471, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI227499619, Length=562, Percent_Identity=22.0640569395018, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1790505, Length=640, Percent_Identity=60.9375, Blast_Score=837, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=623, Percent_Identity=38.0417335473515, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1788107, Length=572, Percent_Identity=23.9510489510489, Blast_Score=106, Evalue=6e-24,
Organism=Escherichia coli, GI221142682, Length=536, Percent_Identity=22.5746268656716, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI145693145, Length=541, Percent_Identity=23.8447319778189, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786810, Length=525, Percent_Identity=21.5238095238095, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=650, Percent_Identity=50.6153846153846, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71982997, Length=644, Percent_Identity=50.6211180124224, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17569507, Length=655, Percent_Identity=23.0534351145038, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=553, Percent_Identity=22.6039783001808, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=559, Percent_Identity=24.865831842576, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=615, Percent_Identity=22.9268292682927, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560140, Length=390, Percent_Identity=22.0512820512821, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=50.0777604976672, Blast_Score=633, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=639, Percent_Identity=47.4178403755869, Blast_Score=583, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319699, Length=367, Percent_Identity=23.7057220708447, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24667955, Length=643, Percent_Identity=54.1213063763608, Blast_Score=696, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=57.8291814946619, Blast_Score=651, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=58.0769230769231, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI21355225, Length=614, Percent_Identity=36.4820846905537, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI18859661, Length=527, Percent_Identity=22.7703984819734, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355181, Length=523, Percent_Identity=23.9005736137667, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24656500, Length=375, Percent_Identity=23.2, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648257, Length=364, Percent_Identity=24.1758241758242, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581924, Length=369, Percent_Identity=23.3062330623306, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71037; Mature: 70906

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDSKTYPVPEAFASQANLTPEKYREMYAASIADPAAFWGEQGKRLDWMTPYTVVKDVS
CCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCCCCEEECCCCHHHHCCCC
WETGDLHVRWYSDGVLNVTANCIDRHLDTRGDKAAFIWEGDKPGESHTVTYRQLHASVSK
CCCCCEEEEEECCCEEEEEHHHHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHH
FANVLKELGVKKGDRVTIYMPMILEAAYAMLACARIGAVHSVVFGGFSPEALAGRIVDCG
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEECC
SEVLITADEGLRGGKSVPLKVNADKAAGIAGGTVKKMLVVKRTGGNVSMTEGRDHWLHEI
CCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEEECCCCEEECCCCHHHHHHH
GATVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLLWASMTHEYVFDLKENDI
CCEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCEEEEEECCCCE
FWCSADVGWVTGHTYIIYGPLANGATSVMFEGVPTYPDASRFWQVCDKHQVTIFYTAPTA
EEEECCCCEEECCEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHCCCCEEEEEECHHH
IRALMREGEGPVNKTSRKSIRLLGTVGEPINPEAWEWYFHVVGEARCPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCHHEEEEEEECCCCCCEEECCEECCCCC
TLIVPLPNTTDMKPGAGSHPFFGIKPILVDADGRELEGAADGNLLITDSWPGQMRTVYGD
EEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEECCH
HQRFVETYFTAYPGKYFTGDGCRRDADGFYWITGRVDDVINVSGHRMGTAEVESALVSHD
HHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
AVAEAAVVGYPHDIKGQGIYAYVTLRAGCEADDALRKNLVAHVRNEIGPIASPDLIQFAP
HHHHHHEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
GLPKTRSGKIMRRILRKIAENEFSNLGDTSTLAEPEVVKDLIDNRQNR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDDSKTYPVPEAFASQANLTPEKYREMYAASIADPAAFWGEQGKRLDWMTPYTVVKDVS
CCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCCCCEEECCCCHHHHCCCC
WETGDLHVRWYSDGVLNVTANCIDRHLDTRGDKAAFIWEGDKPGESHTVTYRQLHASVSK
CCCCCEEEEEECCCEEEEEHHHHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHH
FANVLKELGVKKGDRVTIYMPMILEAAYAMLACARIGAVHSVVFGGFSPEALAGRIVDCG
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEECC
SEVLITADEGLRGGKSVPLKVNADKAAGIAGGTVKKMLVVKRTGGNVSMTEGRDHWLHEI
CCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEEECCCCEEECCCCHHHHHHH
GATVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLLWASMTHEYVFDLKENDI
CCEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCEEEEEECCCCE
FWCSADVGWVTGHTYIIYGPLANGATSVMFEGVPTYPDASRFWQVCDKHQVTIFYTAPTA
EEEECCCCEEECCEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHCCCCEEEEEECHHH
IRALMREGEGPVNKTSRKSIRLLGTVGEPINPEAWEWYFHVVGEARCPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCHHEEEEEEECCCCCCEEECCEECCCCC
TLIVPLPNTTDMKPGAGSHPFFGIKPILVDADGRELEGAADGNLLITDSWPGQMRTVYGD
EEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEECCH
HQRFVETYFTAYPGKYFTGDGCRRDADGFYWITGRVDDVINVSGHRMGTAEVESALVSHD
HHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
AVAEAAVVGYPHDIKGQGIYAYVTLRAGCEADDALRKNLVAHVRNEIGPIASPDLIQFAP
HHHHHHEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
GLPKTRSGKIMRRILRKIAENEFSNLGDTSTLAEPEVVKDLIDNRQNR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA