Click here to switch to the map view.

The map label for this gene is dxs

Identifier: 114798103

GI number: 114798103

Start: 1896131

End: 1898053

Strand: Reverse

Name: dxs

Synonym: HNE_1838

Alternate gene names: 114798103

Gene position: 1898053-1896131 (Counterclockwise)

Preceding gene: 114797210

Following gene: 114799586

Centisome position: 51.23

GC content: 62.04

Gene sequence:

>1923_bases
ATGACAGAGACACGCCCCAACCGCCTCCTGGACGCTATTGATACGCCGTCCGACCTCAAAGGCCGCAGCCGCGCCGATCT
GAAACAGATCGCGGCGGAAGTGCGCGAGGAGGTCGTGGATGTCGTGTCCGTGACCGGCGGGCATCTCGGGTCAGGCCTCG
GCGTGGTTGAGCTGACGGTGGCGATCCATTCGGTGTTTGACACGCCCGATGACAAGCTGGTCTGGGATGTTGGCCACCAA
TGCTACCCGCACAAGATCCTGACTGGCCGCAAGGACCGGATGCGGACATTGCGCCAGGGCGGGGGGCTTTCCGGGTTCAC
CAAGCGCTCGGAGAGCGAGTATGACCCGTTTGGCGCGGCGCATGCGTCGACCTCGATTTCGGCCGGGCTCGGCTTTGCCA
AGTCGCGGGATCTGCAGAACAAGGACAATCATGTCATCTGCGTGATCGGCGACGGGTCAATGTCCGCCGGGATGGCTTAT
GAAGCGATGAACAATGCGGGCGCAGACCGTTCGCGGATGATCGTGATCCTCAACGATAACGACATGTCGATTGCCCCGCC
TGTGGGCGCGATGAGCCATTATTTCTCGCGGCTGGTTTCGTCGCGGCCCTACAGGGGCCTGCGCCGGATTGCCAAGAAGG
TTGTCCAGCCGATGGGGCTGGAATCTCCCGCGCGGCGGGCAGAGGAGTATCTGCGCGGCTTTGCGATGGGCGGCACGCTC
TTCGAGGAGATGGGCTTTTACTATATCGGCCCCGTTGACGGGCATGACCTCGATACGCTGCTCGACCTGCTGGAGAACAT
CAAGGCGATGCAGGATGGGCCGATCCTGCTGCATGTGGTGACGCAGAAGGGTAAGGGCTATGCGCCGGCGGAGAACTCCG
CCGACAAGTATCACGGCGTTTCGAAGTTTTCGGTGGTTACCGGCGAGCAGGCCAAGGGCGCCGGTGGTCCCCCGAGCTAT
CAGAAGGTGTTCGGACAGACACTGGCAAAGCTGGGCGAGACCGACGACAAGATCTGCGCGATTACGGCGGCGATGCCATC
TGGTACGAGTACGGACATTTTTGGCAAGAAGTTTCCAGACCGGCATTTTGATGTTGGCATTGCCGAGCAGCATGCGGTGA
CGTTTGCCGCCGGGCTTGCCGCCGATGGCATGAAGCCGTTCTGCGCGATCTACTCGACCTTCCTTCAGCGTGGCTATGAT
CAGGTTGTGCATGATGTGGCGATCCAGCAATTGCCGGTGCGCTTTGCGATCGACCGGGCAGGGCTAGTGGGCGCTGACGG
GGCGACCCATGCGGGCAGCTTTGACATCGGCTATCTGGGCGCGTTGCCGGGATTCGTCTGCATGGCGCCGTCGGATGAAG
CGGAGCTGGCGCGGATGGTGTTGACCTCGCTGGAAATCGACGACCGGCCGAGCGCGGTTCGCTATCCGCGCGGCGAAGGC
GTTGGGGTGGTGATCCCTGATCTTCTGAAGCCGCTGGAAATCGGCAAGGGCAGGGTTGTGCGCGAGGGCACATCGATTGC
GATTCTATCCTATGGCACACGTCTGCAGGAAGCGCTCAAGGCGGCTGAGATGCTGGCCGCTCAAGGGCTGAGCGCGACGG
TGGCGGACGCCCGTTTTGCCAAGCCGCTGGACAACGAACTGATCGAGCGCCTTGCCAGAGAGCATGAAGTGCTCGTCACG
ATTGAAGAAGGTTCGCGCGGCGGCTTTGGCAGCTTTGTGCTGGAGCACCTTGCCAATTGCGGTGGGCTGGATGCGGGGCT
CAAGGTTCGTGTCATGACGCTGCCGGATGTGTTCCAGGATCATGATACGCCTGCGGCTATGTATGATCAGGCCGGGCTGA
CGGCGCGCCATATTGCAGCGCGCGCGATTGAGGCACTTGGCCGGGGCGACCTGTCAGCAATTGAGCGCCTAGCCTCCGCC
TGA

Upstream 100 bases:

>100_bases
TTTTCCGTGACAAGGCCCACATCCTGCTGCATTCCGTTGATTATGTGCTGAACAGACCCCGTTAAAAGCGGGTACGCGAC
GACCAGAAAAGCACGCTGAT

Downstream 100 bases:

>100_bases
GGCATCGCCACACTAACATCACACTTCGGCCCTGTGCGCGATCAATCAGGCAGGGTATGCAGAGGCGTTAGAAATCCGTT
TCCGCCTGCAAGAAGGAAGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MTETRPNRLLDAIDTPSDLKGRSRADLKQIAAEVREEVVDVVSVTGGHLGSGLGVVELTVAIHSVFDTPDDKLVWDVGHQ
CYPHKILTGRKDRMRTLRQGGGLSGFTKRSESEYDPFGAAHASTSISAGLGFAKSRDLQNKDNHVICVIGDGSMSAGMAY
EAMNNAGADRSRMIVILNDNDMSIAPPVGAMSHYFSRLVSSRPYRGLRRIAKKVVQPMGLESPARRAEEYLRGFAMGGTL
FEEMGFYYIGPVDGHDLDTLLDLLENIKAMQDGPILLHVVTQKGKGYAPAENSADKYHGVSKFSVVTGEQAKGAGGPPSY
QKVFGQTLAKLGETDDKICAITAAMPSGTSTDIFGKKFPDRHFDVGIAEQHAVTFAAGLAADGMKPFCAIYSTFLQRGYD
QVVHDVAIQQLPVRFAIDRAGLVGADGATHAGSFDIGYLGALPGFVCMAPSDEAELARMVLTSLEIDDRPSAVRYPRGEG
VGVVIPDLLKPLEIGKGRVVREGTSIAILSYGTRLQEALKAAEMLAAQGLSATVADARFAKPLDNELIERLAREHEVLVT
IEEGSRGGFGSFVLEHLANCGGLDAGLKVRVMTLPDVFQDHDTPAAMYDQAGLTARHIAARAIEALGRGDLSAIERLASA

Sequences:

>Translated_640_residues
MTETRPNRLLDAIDTPSDLKGRSRADLKQIAAEVREEVVDVVSVTGGHLGSGLGVVELTVAIHSVFDTPDDKLVWDVGHQ
CYPHKILTGRKDRMRTLRQGGGLSGFTKRSESEYDPFGAAHASTSISAGLGFAKSRDLQNKDNHVICVIGDGSMSAGMAY
EAMNNAGADRSRMIVILNDNDMSIAPPVGAMSHYFSRLVSSRPYRGLRRIAKKVVQPMGLESPARRAEEYLRGFAMGGTL
FEEMGFYYIGPVDGHDLDTLLDLLENIKAMQDGPILLHVVTQKGKGYAPAENSADKYHGVSKFSVVTGEQAKGAGGPPSY
QKVFGQTLAKLGETDDKICAITAAMPSGTSTDIFGKKFPDRHFDVGIAEQHAVTFAAGLAADGMKPFCAIYSTFLQRGYD
QVVHDVAIQQLPVRFAIDRAGLVGADGATHAGSFDIGYLGALPGFVCMAPSDEAELARMVLTSLEIDDRPSAVRYPRGEG
VGVVIPDLLKPLEIGKGRVVREGTSIAILSYGTRLQEALKAAEMLAAQGLSATVADARFAKPLDNELIERLAREHEVLVT
IEEGSRGGFGSFVLEHLANCGGLDAGLKVRVMTLPDVFQDHDTPAAMYDQAGLTARHIAARAIEALGRGDLSAIERLASA
>Mature_639_residues
TETRPNRLLDAIDTPSDLKGRSRADLKQIAAEVREEVVDVVSVTGGHLGSGLGVVELTVAIHSVFDTPDDKLVWDVGHQC
YPHKILTGRKDRMRTLRQGGGLSGFTKRSESEYDPFGAAHASTSISAGLGFAKSRDLQNKDNHVICVIGDGSMSAGMAYE
AMNNAGADRSRMIVILNDNDMSIAPPVGAMSHYFSRLVSSRPYRGLRRIAKKVVQPMGLESPARRAEEYLRGFAMGGTLF
EEMGFYYIGPVDGHDLDTLLDLLENIKAMQDGPILLHVVTQKGKGYAPAENSADKYHGVSKFSVVTGEQAKGAGGPPSYQ
KVFGQTLAKLGETDDKICAITAAMPSGTSTDIFGKKFPDRHFDVGIAEQHAVTFAAGLAADGMKPFCAIYSTFLQRGYDQ
VVHDVAIQQLPVRFAIDRAGLVGADGATHAGSFDIGYLGALPGFVCMAPSDEAELARMVLTSLEIDDRPSAVRYPRGEGV
GVVIPDLLKPLEIGKGRVVREGTSIAILSYGTRLQEALKAAEMLAAQGLSATVADARFAKPLDNELIERLAREHEVLVTI
EEGSRGGFGSFVLEHLANCGGLDAGLKVRVMTLPDVFQDHDTPAAMYDQAGLTARHIAARAIEALGRGDLSAIERLASA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=501, Percent_Identity=24.1516966067864, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4507521, Length=501, Percent_Identity=24.1516966067864, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI133778974, Length=547, Percent_Identity=24.1316270566728, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI225637459, Length=410, Percent_Identity=23.9024390243902, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI225637463, Length=410, Percent_Identity=23.9024390243902, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI225637461, Length=410, Percent_Identity=23.9024390243902, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI156564403, Length=269, Percent_Identity=28.996282527881, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI291084858, Length=261, Percent_Identity=28.3524904214559, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=50.974025974026, Blast_Score=586, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17539652, Length=546, Percent_Identity=24.9084249084249, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17538422, Length=231, Percent_Identity=28.1385281385281, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=228, Percent_Identity=30.7017543859649, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45551847, Length=432, Percent_Identity=27.0833333333333, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45550715, Length=432, Percent_Identity=27.0833333333333, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24645119, Length=432, Percent_Identity=27.0833333333333, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24666278, Length=540, Percent_Identity=23.1481481481481, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21358145, Length=230, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650940, Length=230, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_HYPNA (Q0C154)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760539.1
- ProteinModelPortal:   Q0C154
- SMR:   Q0C154
- STRING:   Q0C154
- GeneID:   4289598
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1838
- NMPDR:   fig|228405.5.peg.1767
- TIGR:   HNE_1838
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- PhylomeDB:   Q0C154
- ProtClustDB:   PRK05444
- BioCyc:   HNEP81032:HNE_1838-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68528; Mature: 68397

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETRPNRLLDAIDTPSDLKGRSRADLKQIAAEVREEVVDVVSVTGGHLGSGLGVVELTV
CCCCCCHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AIHSVFDTPDDKLVWDVGHQCYPHKILTGRKDRMRTLRQGGGLSGFTKRSESEYDPFGAA
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCH
HASTSISAGLGFAKSRDLQNKDNHVICVIGDGSMSAGMAYEAMNNAGADRSRMIVILNDN
HCCCCHHHCCCCHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEEECCC
DMSIAPPVGAMSHYFSRLVSSRPYRGLRRIAKKVVQPMGLESPARRAEEYLRGFAMGGTL
CCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHH
FEEMGFYYIGPVDGHDLDTLLDLLENIKAMQDGPILLHVVTQKGKGYAPAENSADKYHGV
HHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHCCC
SKFSVVTGEQAKGAGGPPSYQKVFGQTLAKLGETDDKICAITAAMPSGTSTDIFGKKFPD
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCC
RHFDVGIAEQHAVTFAAGLAADGMKPFCAIYSTFLQRGYDQVVHDVAIQQLPVRFAIDRA
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCC
GLVGADGATHAGSFDIGYLGALPGFVCMAPSDEAELARMVLTSLEIDDRPSAVRYPRGEG
CEECCCCCCCCCCCCCHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VGVVIPDLLKPLEIGKGRVVREGTSIAILSYGTRLQEALKAAEMLAAQGLSATVADARFA
CEEECHHHHHHHHCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHC
KPLDNELIERLAREHEVLVTIEEGSRGGFGSFVLEHLANCGGLDAGLKVRVMTLPDVFQD
CCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHC
HDTPAAMYDQAGLTARHIAARAIEALGRGDLSAIERLASA
CCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
TETRPNRLLDAIDTPSDLKGRSRADLKQIAAEVREEVVDVVSVTGGHLGSGLGVVELTV
CCCCCHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AIHSVFDTPDDKLVWDVGHQCYPHKILTGRKDRMRTLRQGGGLSGFTKRSESEYDPFGAA
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCH
HASTSISAGLGFAKSRDLQNKDNHVICVIGDGSMSAGMAYEAMNNAGADRSRMIVILNDN
HCCCCHHHCCCCHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEEECCC
DMSIAPPVGAMSHYFSRLVSSRPYRGLRRIAKKVVQPMGLESPARRAEEYLRGFAMGGTL
CCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHH
FEEMGFYYIGPVDGHDLDTLLDLLENIKAMQDGPILLHVVTQKGKGYAPAENSADKYHGV
HHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHCCC
SKFSVVTGEQAKGAGGPPSYQKVFGQTLAKLGETDDKICAITAAMPSGTSTDIFGKKFPD
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCC
RHFDVGIAEQHAVTFAAGLAADGMKPFCAIYSTFLQRGYDQVVHDVAIQQLPVRFAIDRA
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCC
GLVGADGATHAGSFDIGYLGALPGFVCMAPSDEAELARMVLTSLEIDDRPSAVRYPRGEG
CEECCCCCCCCCCCCCHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VGVVIPDLLKPLEIGKGRVVREGTSIAILSYGTRLQEALKAAEMLAAQGLSATVADARFA
CEEECHHHHHHHHCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHC
KPLDNELIERLAREHEVLVTIEEGSRGGFGSFVLEHLANCGGLDAGLKVRVMTLPDVFQD
CCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHC
HDTPAAMYDQAGLTARHIAARAIEALGRGDLSAIERLASA
CCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA