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The map label for this gene is ispA [C]

Identifier: 114797210

GI number: 114797210

Start: 1898089

End: 1898976

Strand: Reverse

Name: ispA [C]

Synonym: HNE_1839

Alternate gene names: 114797210

Gene position: 1898976-1898089 (Counterclockwise)

Preceding gene: 114800150

Following gene: 114798103

Centisome position: 51.25

GC content: 61.49

Gene sequence:

>888_bases
GTGACGAACTTCGAGCAGCGCCTCACGGAAGTTGCCGACAAGGTGACCGTGGCGCTCGATCAGTTGATCCCGCCTGCCAG
TGGGCCTGAAGCCAATCTCATGCGCGCCATGCGCCATGCCGCGTTGGCCAATGGCAAACGGATGCGGCCTTTCTTTGTGC
TGGAAACGGGCGCCATGTTTGGCGCGTCAGAGAAGAGCCTGTTGCGGACGGCAGCGGCGCTGGAATGCATTCACTGCTAT
TCCCTGGTACACGATGATCTGCCCTGCATGGACGATGATGATTTCCGGCGGGGGCAACCCACGGTTCACAAGGCGTTTGA
TGAGGCGACGGCTGTTCTGGCCGGGGACGCGCTGCTGACGCTGGCGTTCAAGATACTGGCGTCGAGCGAGACGCATGATG
ACCCGGCGGTGCGAGTGTTGCTGATTGAACGGCTGGCGGACGCGGCGGGCGCGCGGGGTATGGTGGGCGGCCAGATGATC
GACATGCTGGAAGAGGAAAGCCCCCGCGATCTCAACACGATCACCCGTATGCAGCGGCTGAAGACCGGGGCTCTGATTTC
GTATGCGCTGGAAGCTGGGGGCATCATCGGGCATGCCCGAGAAGCCGAGCGCAATGCGCTGGCGGGCTTTGCCAATGATC
TGGGGCTGGCCTACCAGATTGCCGATGACATCCTGGATGCCGAGGGCGACGAAAGCATCGTCGGGAAGGCTGTTTCCAAG
GACAAAGACGCCGGGAAGGCGAATTTTGTGACCCTTCTCGGGGTGGACGGGGCGCGGCAGAGGGTGCGGCTGCTCGCCGC
GCAAGCCAAGGAACATTTGGCAATTTTCCGTGACAAGGCCCACATCCTGCTGCATTCCGTTGATTATGTGCTGAACAGAC
CCCGTTAA

Upstream 100 bases:

>100_bases
GAGCTCAAGGTTGAGCAGATCGTTCAGGGGGCAGGCGGTCCAACGACCGAGCCGGCCTCCTTCGATTAGGTCTGTTGATA
TGGGGCCGGACCGGGGCGAA

Downstream 100 bases:

>100_bases
AAGCGGGTACGCGACGACCAGAAAAGCACGCTGATATGACAGAGACACGCCCCAACCGCCTCCTGGACGCTATTGATACG
CCGTCCGACCTCAAAGGCCG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTNFEQRLTEVADKVTVALDQLIPPASGPEANLMRAMRHAALANGKRMRPFFVLETGAMFGASEKSLLRTAAALECIHCY
SLVHDDLPCMDDDDFRRGQPTVHKAFDEATAVLAGDALLTLAFKILASSETHDDPAVRVLLIERLADAAGARGMVGGQMI
DMLEEESPRDLNTITRMQRLKTGALISYALEAGGIIGHAREAERNALAGFANDLGLAYQIADDILDAEGDESIVGKAVSK
DKDAGKANFVTLLGVDGARQRVRLLAAQAKEHLAIFRDKAHILLHSVDYVLNRPR

Sequences:

>Translated_295_residues
MTNFEQRLTEVADKVTVALDQLIPPASGPEANLMRAMRHAALANGKRMRPFFVLETGAMFGASEKSLLRTAAALECIHCY
SLVHDDLPCMDDDDFRRGQPTVHKAFDEATAVLAGDALLTLAFKILASSETHDDPAVRVLLIERLADAAGARGMVGGQMI
DMLEEESPRDLNTITRMQRLKTGALISYALEAGGIIGHAREAERNALAGFANDLGLAYQIADDILDAEGDESIVGKAVSK
DKDAGKANFVTLLGVDGARQRVRLLAAQAKEHLAIFRDKAHILLHSVDYVLNRPR
>Mature_294_residues
TNFEQRLTEVADKVTVALDQLIPPASGPEANLMRAMRHAALANGKRMRPFFVLETGAMFGASEKSLLRTAAALECIHCYS
LVHDDLPCMDDDDFRRGQPTVHKAFDEATAVLAGDALLTLAFKILASSETHDDPAVRVLLIERLADAAGARGMVGGQMID
MLEEESPRDLNTITRMQRLKTGALISYALEAGGIIGHAREAERNALAGFANDLGLAYQIADDILDAEGDESIVGKAVSKD
KDAGKANFVTLLGVDGARQRVRLLAAQAKEHLAIFRDKAHILLHSVDYVLNRPR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=176, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786623, Length=303, Percent_Identity=41.9141914191419, Blast_Score=187, Evalue=6e-49,
Organism=Escherichia coli, GI1789578, Length=204, Percent_Identity=30.8823529411765, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17505681, Length=182, Percent_Identity=31.3186813186813, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651612, Length=184, Percent_Identity=30.9782608695652, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31998; Mature: 31867

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFEQRLTEVADKVTVALDQLIPPASGPEANLMRAMRHAALANGKRMRPFFVLETGAMF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
GASEKSLLRTAAALECIHCYSLVHDDLPCMDDDDFRRGQPTVHKAFDEATAVLAGDALLT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAFKILASSETHDDPAVRVLLIERLADAAGARGMVGGQMIDMLEEESPRDLNTITRMQRL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
KTGALISYALEAGGIIGHAREAERNALAGFANDLGLAYQIADDILDAEGDESIVGKAVSK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
DKDAGKANFVTLLGVDGARQRVRLLAAQAKEHLAIFRDKAHILLHSVDYVLNRPR
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TNFEQRLTEVADKVTVALDQLIPPASGPEANLMRAMRHAALANGKRMRPFFVLETGAMF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
GASEKSLLRTAAALECIHCYSLVHDDLPCMDDDDFRRGQPTVHKAFDEATAVLAGDALLT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAFKILASSETHDDPAVRVLLIERLADAAGARGMVGGQMIDMLEEESPRDLNTITRMQRL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
KTGALISYALEAGGIIGHAREAERNALAGFANDLGLAYQIADDILDAEGDESIVGKAVSK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
DKDAGKANFVTLLGVDGARQRVRLLAAQAKEHLAIFRDKAHILLHSVDYVLNRPR
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]