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The map label for this gene is clpA [C]

Identifier: 114797928

GI number: 114797928

Start: 1039139

End: 1041454

Strand: Direct

Name: clpA [C]

Synonym: HNE_1030

Alternate gene names: 114797928

Gene position: 1039139-1041454 (Clockwise)

Preceding gene: 114799620

Following gene: 114800004

Centisome position: 28.05

GC content: 61.79

Gene sequence:

>2316_bases
TTGCCACGTCTCTCACCGTCTCTCGAAACCGCCCTCGAAAAGGCCCTCATGCTCGCGTCCGAACGCGATCATGAATACGC
CACGCTCGAGCATCTCCTTCTGGCGCTCACCGAAGATGAGCACGCCCGTGAAGTCATGGGGGCCTGCAAGGTAGATATCG
AGGCCCTCCGCGGAGACCTGACCCGCTACATTGACGAGGAGCTTTCCAGCCTCATCGTTGATGACAGCGAAGGCCGGGTC
CAGCCGACGGCTGCCTTCCAACGCGTCGTTCAGCGCGCCATCCTGCACGTCGAAAGCTCGGGCCGCGAAGAAGTGACGGG
CGCCAACGTCCTCGTCTCGATCTTCTCCGAGCGCGAAAGCCATGCCGCCTACTTCCTGCAAGAGCAGGACATGACCCGGT
ATGACGCGGTGAATTTCATCTCTCACGGCGTCGCCAAGCAGCCGGGCATGTCACGCCCGTCTACCCCGCGCGGCGCAGAA
GCCTCAGAGGAAGAACCGGTGAAGCAGGGCCATGAGGCACTCGACACCTATTGCGTGAACCTCAACGCCAAGGCGCGGGC
CGGCAAGATCGACCCGCTGATCGGCCGCGACATGGAAGTGAACCGCTGCATTGAGGTTCTCTGCCGCCGCAACAAGAACA
ACCCCATCCTCGTCGGCGATCCCGGGGTGGGCAAAACGGCCATTGCCGAAGGCCTTGCCAAGCGCATCGTCGATGGCGAA
GCGCCCGAAATCCTGGACGACGCGATCATCTGGTCGCTCGACATGGGCGCCCTGCTGGCCGGCACCCGCTATCGCGGTGA
CTTTGAAGAGCGCCTCAAATCGGTGATGAAGGAACTCGAGCAGCAGGAAAAAGCCATCCTGTTCATCGACGAGATCCACA
CCATCATCGGCGCCGGCGCTACGTCCGGCGGCGCGATGGATGCCTCCAACCTGCTGAAGCCTGCGCTCCAGTCCGGCGGC
CTGCGCTGCATGGGCTCGACCACCTTCAAGGAATACAAACAGCACTTCGAGAAGGACCGCGCGCTTTCCCGCCGCTTCCG
CAAGATTGATGTGGTGGAGCCAACCGTTCCGGACACGATCAAGATCCTCACGGGTCTGAAATCGAAGTTCGAGGATTTCC
ACGGCCTGAAATACACCAACGACGCCATCAAGGCGGCCGTCGAGCTGTCAGACCGCTACATCACCGACCGCAAGCTGCCC
GACAAGGCGATTGATGTCGTTGACGAGGCCGGCGCCGCCCAATGGCTGCTCCCCGCTTCGAAGCGCAAGAAAACCGTCGG
CATCCGCGACATCGAAGCCGTCGTCGCCAAGATCGCGCGCATTCCGCCCAAGCAGGTTACGTCTGACGACGCCGCGGCGC
TGAAATCGCTCGACGCCGACCTCAAGCGCGTCGTGTTCGGCCAGGACGAAGCCATCGAAGCCCTCGCGGCCTCGATCAAG
CTCGCCCGCGCCGGCCTGCGCGAGCCCAACAAGCCCATCGGCTCCTACCTGTTCACCGGCCCCACGGGCGTTGGTAAAAC
AGAAGTTGCCAAACAGCTTGCCTCCATCATGGGCGTCGAGATGCTGCGCTTCGACATGTCCGAATACATGGAGCGTCATA
CCGTCAGCCGTCTGATCGGCGCGCCTCCGGGCTATGTCGGTTATGATGAAGGCGGTCTGCTTACGGACGGTGTGGACCAA
CACCCCCACTGCGTCCTCCTGCTCGACGAGATCGAGAAGGCCCACCCGGACCTCTTCAACATCCTGTTGCAGGTGATGGA
CAATGGCGCGCTGACCGATGCCAACGGCCGCAAGGTCGACTTCCGCAATGTCATCGTCATCATGACGACGAATGCGGGCG
CGTCGGACGCGGCGAAAAACTCCATCGGCTTTGGCCGTGGCAAGAAGGACGAAGAGCAGGAAGAGGCGCTCAAGCGCATG
TTCACGCCCGAGTTCCGCAACCGCCTCGACGCCATCGTCACCTTCGGTGGCCTCACCCCGCAGATCATCGACCGCGTCGT
CGAGAAGTTCATCCTTCAGCTGGAAGTTCAGCTGGAAGACCGCAACGTCTCCATCGAAGTGTCGAAACCAGCGCGCGAAT
GGCTGGCTAAGCGCGGCTTTGACGCTGAAATGGGCGCGCGGCCTCTGTCCCGCACGATCCAGGAATTCGTCAAGAAGCCG
ATGGCGGAAGAACTCCTCTTCGGCCAGCTCCAGAAGGGCGGCGTCGTCAAGATCGACCTCAACAAGGCCGGCGAAGAACT
CACCTTCAAATACATCGCCGAACCGCCCAAGAAGAAGAAACCCACCAAGGACGCCACCGAAGAACCGGCGAACTGA

Upstream 100 bases:

>100_bases
CCATGAACATCCTCTCCAATGCGTCATGGAGAAAGAAGACTAAGCCACTATATACTCATCATAAGCCCCGTTCACACACA
CCCCCGGAAGGCTACCTCCT

Downstream 100 bases:

>100_bases
TCTTCTTCCAGCACGATAATCATCAAGGGCCGTCCCATCCGGGGCGGCCCTTTTGCTTTCCCCACCGTAACCACTCCCCA
ATCCTTCCAAACCCGCTAAC

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MPRLSPSLETALEKALMLASERDHEYATLEHLLLALTEDEHAREVMGACKVDIEALRGDLTRYIDEELSSLIVDDSEGRV
QPTAAFQRVVQRAILHVESSGREEVTGANVLVSIFSERESHAAYFLQEQDMTRYDAVNFISHGVAKQPGMSRPSTPRGAE
ASEEEPVKQGHEALDTYCVNLNAKARAGKIDPLIGRDMEVNRCIEVLCRRNKNNPILVGDPGVGKTAIAEGLAKRIVDGE
APEILDDAIIWSLDMGALLAGTRYRGDFEERLKSVMKELEQQEKAILFIDEIHTIIGAGATSGGAMDASNLLKPALQSGG
LRCMGSTTFKEYKQHFEKDRALSRRFRKIDVVEPTVPDTIKILTGLKSKFEDFHGLKYTNDAIKAAVELSDRYITDRKLP
DKAIDVVDEAGAAQWLLPASKRKKTVGIRDIEAVVAKIARIPPKQVTSDDAAALKSLDADLKRVVFGQDEAIEALAASIK
LARAGLREPNKPIGSYLFTGPTGVGKTEVAKQLASIMGVEMLRFDMSEYMERHTVSRLIGAPPGYVGYDEGGLLTDGVDQ
HPHCVLLLDEIEKAHPDLFNILLQVMDNGALTDANGRKVDFRNVIVIMTTNAGASDAAKNSIGFGRGKKDEEQEEALKRM
FTPEFRNRLDAIVTFGGLTPQIIDRVVEKFILQLEVQLEDRNVSIEVSKPAREWLAKRGFDAEMGARPLSRTIQEFVKKP
MAEELLFGQLQKGGVVKIDLNKAGEELTFKYIAEPPKKKKPTKDATEEPAN

Sequences:

>Translated_771_residues
MPRLSPSLETALEKALMLASERDHEYATLEHLLLALTEDEHAREVMGACKVDIEALRGDLTRYIDEELSSLIVDDSEGRV
QPTAAFQRVVQRAILHVESSGREEVTGANVLVSIFSERESHAAYFLQEQDMTRYDAVNFISHGVAKQPGMSRPSTPRGAE
ASEEEPVKQGHEALDTYCVNLNAKARAGKIDPLIGRDMEVNRCIEVLCRRNKNNPILVGDPGVGKTAIAEGLAKRIVDGE
APEILDDAIIWSLDMGALLAGTRYRGDFEERLKSVMKELEQQEKAILFIDEIHTIIGAGATSGGAMDASNLLKPALQSGG
LRCMGSTTFKEYKQHFEKDRALSRRFRKIDVVEPTVPDTIKILTGLKSKFEDFHGLKYTNDAIKAAVELSDRYITDRKLP
DKAIDVVDEAGAAQWLLPASKRKKTVGIRDIEAVVAKIARIPPKQVTSDDAAALKSLDADLKRVVFGQDEAIEALAASIK
LARAGLREPNKPIGSYLFTGPTGVGKTEVAKQLASIMGVEMLRFDMSEYMERHTVSRLIGAPPGYVGYDEGGLLTDGVDQ
HPHCVLLLDEIEKAHPDLFNILLQVMDNGALTDANGRKVDFRNVIVIMTTNAGASDAAKNSIGFGRGKKDEEQEEALKRM
FTPEFRNRLDAIVTFGGLTPQIIDRVVEKFILQLEVQLEDRNVSIEVSKPAREWLAKRGFDAEMGARPLSRTIQEFVKKP
MAEELLFGQLQKGGVVKIDLNKAGEELTFKYIAEPPKKKKPTKDATEEPAN
>Mature_770_residues
PRLSPSLETALEKALMLASERDHEYATLEHLLLALTEDEHAREVMGACKVDIEALRGDLTRYIDEELSSLIVDDSEGRVQ
PTAAFQRVVQRAILHVESSGREEVTGANVLVSIFSERESHAAYFLQEQDMTRYDAVNFISHGVAKQPGMSRPSTPRGAEA
SEEEPVKQGHEALDTYCVNLNAKARAGKIDPLIGRDMEVNRCIEVLCRRNKNNPILVGDPGVGKTAIAEGLAKRIVDGEA
PEILDDAIIWSLDMGALLAGTRYRGDFEERLKSVMKELEQQEKAILFIDEIHTIIGAGATSGGAMDASNLLKPALQSGGL
RCMGSTTFKEYKQHFEKDRALSRRFRKIDVVEPTVPDTIKILTGLKSKFEDFHGLKYTNDAIKAAVELSDRYITDRKLPD
KAIDVVDEAGAAQWLLPASKRKKTVGIRDIEAVVAKIARIPPKQVTSDDAAALKSLDADLKRVVFGQDEAIEALAASIKL
ARAGLREPNKPIGSYLFTGPTGVGKTEVAKQLASIMGVEMLRFDMSEYMERHTVSRLIGAPPGYVGYDEGGLLTDGVDQH
PHCVLLLDEIEKAHPDLFNILLQVMDNGALTDANGRKVDFRNVIVIMTTNAGASDAAKNSIGFGRGKKDEEQEEALKRMF
TPEFRNRLDAIVTFGGLTPQIIDRVVEKFILQLEVQLEDRNVSIEVSKPAREWLAKRGFDAEMGARPLSRTIQEFVKKPM
AEELLFGQLQKGGVVKIDLNKAGEELTFKYIAEPPKKKKPTKDATEEPAN

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=170, Percent_Identity=42.9411764705882, Blast_Score=154, Evalue=4e-37,
Organism=Escherichia coli, GI1787109, Length=749, Percent_Identity=59.4125500667557, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=417, Percent_Identity=42.4460431654676, Blast_Score=304, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6320464, Length=317, Percent_Identity=44.4794952681388, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323002, Length=238, Percent_Identity=50, Blast_Score=244, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 85062; Mature: 84931

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLSPSLETALEKALMLASERDHEYATLEHLLLALTEDEHAREVMGACKVDIEALRGDL
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TRYIDEELSSLIVDDSEGRVQPTAAFQRVVQRAILHVESSGREEVTGANVLVSIFSERES
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCHHHHHHHHHHHHHH
HAAYFLQEQDMTRYDAVNFISHGVAKQPGMSRPSTPRGAEASEEEPVKQGHEALDTYCVN
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEC
LNAKARAGKIDPLIGRDMEVNRCIEVLCRRNKNNPILVGDPGVGKTAIAEGLAKRIVDGE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCC
APEILDDAIIWSLDMGALLAGTRYRGDFEERLKSVMKELEQQEKAILFIDEIHTIIGAGA
CHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCC
TSGGAMDASNLLKPALQSGGLRCMGSTTFKEYKQHFEKDRALSRRFRKIDVVEPTVPDTI
CCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
KILTGLKSKFEDFHGLKYTNDAIKAAVELSDRYITDRKLPDKAIDVVDEAGAAQWLLPAS
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEECCCH
KRKKTVGIRDIEAVVAKIARIPPKQVTSDDAAALKSLDADLKRVVFGQDEAIEALAASIK
HCCCCCCHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LARAGLREPNKPIGSYLFTGPTGVGKTEVAKQLASIMGVEMLRFDMSEYMERHTVSRLIG
HHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGYDEGGLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDNGALTDANGRKVD
CCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCEECCCCCEEE
FRNVIVIMTTNAGASDAAKNSIGFGRGKKDEEQEEALKRMFTPEFRNRLDAIVTFGGLTP
ECCEEEEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
QIIDRVVEKFILQLEVQLEDRNVSIEVSKPAREWLAKRGFDAEMGARPLSRTIQEFVKKP
HHHHHHHHHHHHHHEEEEECCCEEEEECCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCC
MAEELLFGQLQKGGVVKIDLNKAGEELTFKYIAEPPKKKKPTKDATEEPAN
HHHHHHHHHHCCCCEEEEECCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PRLSPSLETALEKALMLASERDHEYATLEHLLLALTEDEHAREVMGACKVDIEALRGDL
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TRYIDEELSSLIVDDSEGRVQPTAAFQRVVQRAILHVESSGREEVTGANVLVSIFSERES
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCHHHHHHHHHHHHHH
HAAYFLQEQDMTRYDAVNFISHGVAKQPGMSRPSTPRGAEASEEEPVKQGHEALDTYCVN
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEC
LNAKARAGKIDPLIGRDMEVNRCIEVLCRRNKNNPILVGDPGVGKTAIAEGLAKRIVDGE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCC
APEILDDAIIWSLDMGALLAGTRYRGDFEERLKSVMKELEQQEKAILFIDEIHTIIGAGA
CHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCC
TSGGAMDASNLLKPALQSGGLRCMGSTTFKEYKQHFEKDRALSRRFRKIDVVEPTVPDTI
CCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
KILTGLKSKFEDFHGLKYTNDAIKAAVELSDRYITDRKLPDKAIDVVDEAGAAQWLLPAS
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEECCCH
KRKKTVGIRDIEAVVAKIARIPPKQVTSDDAAALKSLDADLKRVVFGQDEAIEALAASIK
HCCCCCCHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LARAGLREPNKPIGSYLFTGPTGVGKTEVAKQLASIMGVEMLRFDMSEYMERHTVSRLIG
HHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGYDEGGLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDNGALTDANGRKVD
CCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCEECCCCCEEE
FRNVIVIMTTNAGASDAAKNSIGFGRGKKDEEQEEALKRMFTPEFRNRLDAIVTFGGLTP
ECCEEEEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
QIIDRVVEKFILQLEVQLEDRNVSIEVSKPAREWLAKRGFDAEMGARPLSRTIQEFVKKP
HHHHHHHHHHHHHHEEEEECCCEEEEECCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCC
MAEELLFGQLQKGGVVKIDLNKAGEELTFKYIAEPPKKKKPTKDATEEPAN
HHHHHHHHHHCCCCEEEEECCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]