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The map label for this gene is hbdA [H]

Identifier: 114797883

GI number: 114797883

Start: 3604911

End: 3605789

Strand: Reverse

Name: hbdA [H]

Synonym: HNE_3469

Alternate gene names: 114797883

Gene position: 3605789-3604911 (Counterclockwise)

Preceding gene: 114797076

Following gene: 114799034

Centisome position: 97.32

GC content: 58.82

Gene sequence:

>879_bases
ATGACAGCGATCAAGACCGTCGGCGTCATTGGTGCCGGCCAGATGGGCAACGGCATTGCGCATGTGAGCGCGCTGGCAGG
CTATGATGTAATCCTCAGCGATGTGTCTGAAGCGGCGCTCAAGGCGGGCATGGACTCGATCGAGCGCAATATGAGCCGCC
AGGTGGCGCGCGAGATGATCAATCTGGACGAGATGCAGGTCGCGCTGAAGCGCATCAAGCCGTCGACGTCGGTGAAGGCG
CATGAAGCCTCTGACATGATCATCGAGGCAGCCACCGAGAAGCGCGACGTGAAGGAGCAGATCTTCCGCAGCGTATGTGA
TGTGATCCAGCCCCACGCCCTGCTGGCGACCAATACCTCCTCGATCTCGATCACGAAGCTCGCATCGGTCACTGACCGCC
CGGAGCGGTTCATCGGCCTGCACTTCATGAACCCTGTGCCGCTGATGAAGCTGGTTGAAGTCATCCGGGGCCTGAATACC
GATCAGCAGACCTATGAAACAGTGATCGAGTATACCAAGGCTATCGGCAAGACGACGACGAATGCCGAGGACTATCCGGC
GTTCATTGTGAACCGCATCCTGATGCCGATGATTAATGAGGCGGTCTATACGCTGTATGAAGGCGTGGGCTCGGTCCATT
CGATCGACACGGCGATGAAGCTGGGCGCAAACCATCCGATGGGGCCGCTGCAGCTGGCAGACTTTATCGGCCTCGATACC
TGTCTCTCGATCATGCAGGTGCTGCATGACGGGTTGGCCGATACCAAATATCGCCCGTGCCCGCTGCTGGTGAAGTTCGT
GGAGGCTGGCTGGCTCGGCAAGAAGACCGGCAAGGGCTTCTATGACTATTCCGGCGATGTGCCGATCCCCAGCCGGTAA

Upstream 100 bases:

>100_bases
TTTTCTTTGGGGCTGCCCCGCACCTGCCAGCCGGACTTTGACGCAGTGCACAATGAGGTATATCCAACCCCCAGCATTGG
AAATCAGGGAAGTGATGGGC

Downstream 100 bases:

>100_bases
TCCTGGTTACCGGTTTTACCATAAAAATTAGGAATCCTTGCATTCGCGACAGGGTTCTAAACGCCTGATTAACACAGTTT
CGGCAGGCTGCTTTCGGATA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTAIKTVGVIGAGQMGNGIAHVSALAGYDVILSDVSEAALKAGMDSIERNMSRQVAREMINLDEMQVALKRIKPSTSVKA
HEASDMIIEAATEKRDVKEQIFRSVCDVIQPHALLATNTSSISITKLASVTDRPERFIGLHFMNPVPLMKLVEVIRGLNT
DQQTYETVIEYTKAIGKTTTNAEDYPAFIVNRILMPMINEAVYTLYEGVGSVHSIDTAMKLGANHPMGPLQLADFIGLDT
CLSIMQVLHDGLADTKYRPCPLLVKFVEAGWLGKKTGKGFYDYSGDVPIPSR

Sequences:

>Translated_292_residues
MTAIKTVGVIGAGQMGNGIAHVSALAGYDVILSDVSEAALKAGMDSIERNMSRQVAREMINLDEMQVALKRIKPSTSVKA
HEASDMIIEAATEKRDVKEQIFRSVCDVIQPHALLATNTSSISITKLASVTDRPERFIGLHFMNPVPLMKLVEVIRGLNT
DQQTYETVIEYTKAIGKTTTNAEDYPAFIVNRILMPMINEAVYTLYEGVGSVHSIDTAMKLGANHPMGPLQLADFIGLDT
CLSIMQVLHDGLADTKYRPCPLLVKFVEAGWLGKKTGKGFYDYSGDVPIPSR
>Mature_291_residues
TAIKTVGVIGAGQMGNGIAHVSALAGYDVILSDVSEAALKAGMDSIERNMSRQVAREMINLDEMQVALKRIKPSTSVKAH
EASDMIIEAATEKRDVKEQIFRSVCDVIQPHALLATNTSSISITKLASVTDRPERFIGLHFMNPVPLMKLVEVIRGLNTD
QQTYETVIEYTKAIGKTTTNAEDYPAFIVNRILMPMINEAVYTLYEGVGSVHSIDTAMKLGANHPMGPLQLADFIGLDTC
LSIMQVLHDGLADTKYRPCPLLVKFVEAGWLGKKTGKGFYDYSGDVPIPSR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=42.3611111111111, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=40.8496732026144, Blast_Score=214, Evalue=6e-56,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=31.8021201413428, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI261878539, Length=296, Percent_Identity=32.0945945945946, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI68989263, Length=296, Percent_Identity=32.0945945945946, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI115430219, Length=237, Percent_Identity=25.7383966244726, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787661, Length=287, Percent_Identity=41.1149825783972, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1790281, Length=269, Percent_Identity=31.2267657992565, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=34.9624060150376, Blast_Score=144, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=294, Percent_Identity=43.5374149659864, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=40.6896551724138, Blast_Score=219, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=38.3275261324042, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=33.0985915492958, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=33.0985915492958, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=33.0985915492958, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=32.0422535211268, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=31.3380281690141, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=26.0714285714286, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI115533614, Length=202, Percent_Identity=24.2574257425743, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203623, Length=202, Percent_Identity=24.2574257425743, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=35.2112676056338, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=35.2112676056338, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=35.2112676056338, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31888; Mature: 31757

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIKTVGVIGAGQMGNGIAHVSALAGYDVILSDVSEAALKAGMDSIERNMSRQVAREMI
CCCHHHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLDEMQVALKRIKPSTSVKAHEASDMIIEAATEKRDVKEQIFRSVCDVIQPHALLATNTS
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SISITKLASVTDRPERFIGLHFMNPVPLMKLVEVIRGLNTDQQTYETVIEYTKAIGKTTT
CEEHHHHHHHCCCHHHHEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
NAEDYPAFIVNRILMPMINEAVYTLYEGVGSVHSIDTAMKLGANHPMGPLQLADFIGLDT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
CLSIMQVLHDGLADTKYRPCPLLVKFVEAGWLGKKTGKGFYDYSGDVPIPSR
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAIKTVGVIGAGQMGNGIAHVSALAGYDVILSDVSEAALKAGMDSIERNMSRQVAREMI
CCHHHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLDEMQVALKRIKPSTSVKAHEASDMIIEAATEKRDVKEQIFRSVCDVIQPHALLATNTS
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SISITKLASVTDRPERFIGLHFMNPVPLMKLVEVIRGLNTDQQTYETVIEYTKAIGKTTT
CEEHHHHHHHCCCHHHHEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
NAEDYPAFIVNRILMPMINEAVYTLYEGVGSVHSIDTAMKLGANHPMGPLQLADFIGLDT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
CLSIMQVLHDGLADTKYRPCPLLVKFVEAGWLGKKTGKGFYDYSGDVPIPSR
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]