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The map label for this gene is strE [H]

Identifier: 114797818

GI number: 114797818

Start: 2858592

End: 2859554

Strand: Reverse

Name: strE [H]

Synonym: HNE_2698

Alternate gene names: 114797818

Gene position: 2859554-2858592 (Counterclockwise)

Preceding gene: 114797179

Following gene: 114798805

Centisome position: 77.18

GC content: 58.57

Gene sequence:

>963_bases
ATGCATCTTGAGAAGCGCGTTCTGATTACGGGCGGGGCCGGGTTTATCGGCTCATTCCTCTGCGAGCGGCTGCTGGAGGC
GGGCGCCACGGTGCTTTGCCTCGACAATTTCTTCACCGGCACACGGATGAATGTGGCGCATCTGATGGGCCATCCCCGGT
TTGAGCTGATGCGCCATGATGTGTGCTTTCCGCTCTATGTCGAGGTGGACGAAATCTACAACATGGCCTGCCCGGCAAGC
CCGGTGCATTATCAGTTCGATCCGGTGCAGACGACCAAGACCAGCGTTCACGGCGCCATCAACATGCTGGGCCTGGCCAA
GCGCCTGAAAGCCAAAATTCTTCAGGCCTCCACATCGGAAGTCTATGGCGATCCCGTAATCCATCCGCAGACGGAAGAGT
ATTGGGGCAACGTGAACCCCATCGGGCCGCGTTCCTGCTATGATGAAGGCAAGCGTTGCGCCGAAACGCTGTTCTTCGAT
TATCACCGCCAGCATGCGCTGCGGATCAAGGTCGCCCGTATCTTCAATACCTATGGGCCGCGGATGCATCCCAATGACGG
GCGGGTCGTTTCCAACTTCATTGTTCAGGCCCTGAAGGGCGAAGACATCACGCTTTATGGCGATGGTTCCCAGACGCGCA
GCTTCTGTTATGTCGATGATCTTGTGCGCGGCCTGATAAGTCTGATGGAAACCCCCGACAGCGTGACCGGCCCCATCAAT
ATCGGCAATCCGGGGGAGTTCACCATCCGTCAGCTGGCCGAAACCGTCATCGACCTGACGGGCGCCCGGTCAAAGCTCGT
ATTCCGGCCGCTGCCTCAGGACGACCCGAAGCAGCGCCAGCCTGACATCACCAAGGCCCGCGAAATCCTGAAATGGGAGC
CGTCGGTCGAGTTGCGCGACGGCCTTTCCAAGACCATCGCCTATTTCGATACGCTGCTGGCAGACCGGAATATGAAGGTC
TGA

Upstream 100 bases:

>100_bases
GCGCAGGGAATTGCGGCGATCTGTGTTCCTGTGCTCTGCTTTATCGACTAAACGCAATTTTTCGCAGAGTTGATTTGTTT
GAATTCGGGATTGGACGACC

Downstream 100 bases:

>100_bases
TCAGCCGGCGATTTCGGCGCGGATAACTTCGTCGATCTTGGGAAGATTGGCGCCTTCGATGGCCTGATCGCCGACGAAAT
AGCCAGGTGTGCCGCCAACA

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MHLEKRVLITGGAGFIGSFLCERLLEAGATVLCLDNFFTGTRMNVAHLMGHPRFELMRHDVCFPLYVEVDEIYNMACPAS
PVHYQFDPVQTTKTSVHGAINMLGLAKRLKAKILQASTSEVYGDPVIHPQTEEYWGNVNPIGPRSCYDEGKRCAETLFFD
YHRQHALRIKVARIFNTYGPRMHPNDGRVVSNFIVQALKGEDITLYGDGSQTRSFCYVDDLVRGLISLMETPDSVTGPIN
IGNPGEFTIRQLAETVIDLTGARSKLVFRPLPQDDPKQRQPDITKAREILKWEPSVELRDGLSKTIAYFDTLLADRNMKV

Sequences:

>Translated_320_residues
MHLEKRVLITGGAGFIGSFLCERLLEAGATVLCLDNFFTGTRMNVAHLMGHPRFELMRHDVCFPLYVEVDEIYNMACPAS
PVHYQFDPVQTTKTSVHGAINMLGLAKRLKAKILQASTSEVYGDPVIHPQTEEYWGNVNPIGPRSCYDEGKRCAETLFFD
YHRQHALRIKVARIFNTYGPRMHPNDGRVVSNFIVQALKGEDITLYGDGSQTRSFCYVDDLVRGLISLMETPDSVTGPIN
IGNPGEFTIRQLAETVIDLTGARSKLVFRPLPQDDPKQRQPDITKAREILKWEPSVELRDGLSKTIAYFDTLLADRNMKV
>Mature_320_residues
MHLEKRVLITGGAGFIGSFLCERLLEAGATVLCLDNFFTGTRMNVAHLMGHPRFELMRHDVCFPLYVEVDEIYNMACPAS
PVHYQFDPVQTTKTSVHGAINMLGLAKRLKAKILQASTSEVYGDPVIHPQTEEYWGNVNPIGPRSCYDEGKRCAETLFFD
YHRQHALRIKVARIFNTYGPRMHPNDGRVVSNFIVQALKGEDITLYGDGSQTRSFCYVDDLVRGLISLMETPDSVTGPIN
IGNPGEFTIRQLAETVIDLTGARSKLVFRPLPQDDPKQRQPDITKAREILKWEPSVELRDGLSKTIAYFDTLLADRNMKV

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=305, Percent_Identity=58.6885245901639, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI7657641, Length=326, Percent_Identity=26.3803680981595, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788589, Length=342, Percent_Identity=25.4385964912281, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI48994969, Length=338, Percent_Identity=25.4437869822485, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788353, Length=337, Percent_Identity=24.6290801186944, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788365, Length=324, Percent_Identity=25, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17539532, Length=316, Percent_Identity=58.8607594936709, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI115532424, Length=326, Percent_Identity=28.2208588957055, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=342, Percent_Identity=28.3625730994152, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356223, Length=310, Percent_Identity=59.0322580645161, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 36035; Mature: 36035

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLEKRVLITGGAGFIGSFLCERLLEAGATVLCLDNFFTGTRMNVAHLMGHPRFELMRHD
CCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHCCCHHHHHHHC
VCFPLYVEVDEIYNMACPASPVHYQFDPVQTTKTSVHGAINMLGLAKRLKAKILQASTSE
CCEEEEEEHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYGDPVIHPQTEEYWGNVNPIGPRSCYDEGKRCAETLFFDYHRQHALRIKVARIFNTYGP
HCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RMHPNDGRVVSNFIVQALKGEDITLYGDGSQTRSFCYVDDLVRGLISLMETPDSVTGPIN
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCEE
IGNPGEFTIRQLAETVIDLTGARSKLVFRPLPQDDPKQRQPDITKAREILKWEPSVELRD
CCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHH
GLSKTIAYFDTLLADRNMKV
HHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHLEKRVLITGGAGFIGSFLCERLLEAGATVLCLDNFFTGTRMNVAHLMGHPRFELMRHD
CCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHCCCHHHHHHHC
VCFPLYVEVDEIYNMACPASPVHYQFDPVQTTKTSVHGAINMLGLAKRLKAKILQASTSE
CCEEEEEEHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYGDPVIHPQTEEYWGNVNPIGPRSCYDEGKRCAETLFFDYHRQHALRIKVARIFNTYGP
HCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RMHPNDGRVVSNFIVQALKGEDITLYGDGSQTRSFCYVDDLVRGLISLMETPDSVTGPIN
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCEE
IGNPGEFTIRQLAETVIDLTGARSKLVFRPLPQDDPKQRQPDITKAREILKWEPSVELRD
CCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHH
GLSKTIAYFDTLLADRNMKV
HHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1661369 [H]