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The map label for this gene is mltA [H]

Identifier: 114797762

GI number: 114797762

Start: 5111

End: 6349

Strand: Direct

Name: mltA [H]

Synonym: HNE_0008

Alternate gene names: 114797762

Gene position: 5111-6349 (Clockwise)

Preceding gene: 114799709

Following gene: 114798383

Centisome position: 0.14

GC content: 66.75

Gene sequence:

>1239_bases
ATGATCCGTTTTGCTGCTCTCCTGTTTTCCGCCCTTGTCCTGGCCGCGTGCCAATCCACCCCGCGTCCTGCGGCGCCGGT
AGTGGTCCAGCCTGGCCCGACACCAGGCCAGACACCGGGCACTGTCCGCCCGCCGCCAGCATCCCTGCCGACGAGCTATC
GGGATCTGCCCGGCTGGCAGGGCGCGACGCTTGCCCCGTCGCTGGAAGCGTTTCGCCGCACATGCGACCGCTTTACCCGC
CGCGCCTGGGACGCGCCGCTCTCGCGCAGTGTCGCGTGGGCCGGCACGGCAGCAGACTGGGCGCCTGCCTGCGAAGCCCT
CGCCGCACCGCTCGATGAAGGCGCCACGCGCCGGGCCTTCGAAACACTTTTCATCCCGGTAGAGATCATCGACCCGGAAG
GAAAACCGCGCTTCACGGGCTATTTCGAACCGACCTATGAAGCCCGCCGCGCGCCGGAGCCTGGCTTTACAGAGCCTGTC
TTCGCAGTGCCGTCTGACTTCGTTGCCAATGGCGACAGTCCGTTGCAACGGCTTCCCAACGGCACCACGCGGCCCTATCC
GCCCCGCGCCGAGATCACCGCCAAAGGCGGCCAGGCGATCGCCTGGGCACACCCGACAGATGTGTTCTTCCTCCAGATCC
AGGGTTCGGGCCGGCTCACCTTTCCTGACGGCACAACGCTGCGTGCCGCGTATGCCGCGCATAATGGCCAGCCGTTCAGA
TCCACCGCCAACTGGCTGATTGAAACCGGCCGCATCACGCGCGGCGAAGGCTCGATGCAGGGCATCCGGGCCTGGATGGA
CCGTGCGTCCCCGGAAGAAGTGCGCCAGTCAATGAACATCAACCCGCGCTTCGTCTTCTTTCAGTCTTTGCCCGAGGGCG
ATCCGGAGCTTGGCCCCACCGGCGCGCACAATGTTCCGCTCACGCCGTTCGGATCAATGGCGATTGACCCCTCCTTCCAT
GCTCTCGGTGTGCCGATGTTCGTACAGACCTCCGCGCCCGGTCTTGGCGGAGACTGGTCAGGCCTCCTGATCGCCCAGGA
TACCGGCGGCGCGATCAAAGGCCCGGTGCGCGGTGACATTTATTTCGGCACGGGCTTTGACGCAGGCCAGCGCGCCGGCA
CAATGAACGCGCAAGGCCGTCTCTGGGTGCTTTTGCCGCTCACCGTAGCCGAACGCCTCCGTCAGTCGCTCGAATCCGGC
CCGGTCGCCGCGCGCACGCCTGCGCCAGGCGCGGGCTGA

Upstream 100 bases:

>100_bases
CTCCAGCGATCCCAATTGGCTGCTCGACGATGTTGAGGTTGCCGCCTGACACATCTCTCAGGTGACATGCTGAGGAGTTT
CGCGGCATAACGGACCGGCC

Downstream 100 bases:

>100_bases
CCGGCATGAAATCGCGCCGGCTCAGCGAGGAAGAGACGCGGGCCTGGGCAAAGGTCGCCGCCACGGTGAAGCGTATCGGC
CCGCAGGAAGCCTCCCTGCC

Product: putative transglycosylase MltA

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MIRFAALLFSALVLAACQSTPRPAAPVVVQPGPTPGQTPGTVRPPPASLPTSYRDLPGWQGATLAPSLEAFRRTCDRFTR
RAWDAPLSRSVAWAGTAADWAPACEALAAPLDEGATRRAFETLFIPVEIIDPEGKPRFTGYFEPTYEARRAPEPGFTEPV
FAVPSDFVANGDSPLQRLPNGTTRPYPPRAEITAKGGQAIAWAHPTDVFFLQIQGSGRLTFPDGTTLRAAYAAHNGQPFR
STANWLIETGRITRGEGSMQGIRAWMDRASPEEVRQSMNINPRFVFFQSLPEGDPELGPTGAHNVPLTPFGSMAIDPSFH
ALGVPMFVQTSAPGLGGDWSGLLIAQDTGGAIKGPVRGDIYFGTGFDAGQRAGTMNAQGRLWVLLPLTVAERLRQSLESG
PVAARTPAPGAG

Sequences:

>Translated_412_residues
MIRFAALLFSALVLAACQSTPRPAAPVVVQPGPTPGQTPGTVRPPPASLPTSYRDLPGWQGATLAPSLEAFRRTCDRFTR
RAWDAPLSRSVAWAGTAADWAPACEALAAPLDEGATRRAFETLFIPVEIIDPEGKPRFTGYFEPTYEARRAPEPGFTEPV
FAVPSDFVANGDSPLQRLPNGTTRPYPPRAEITAKGGQAIAWAHPTDVFFLQIQGSGRLTFPDGTTLRAAYAAHNGQPFR
STANWLIETGRITRGEGSMQGIRAWMDRASPEEVRQSMNINPRFVFFQSLPEGDPELGPTGAHNVPLTPFGSMAIDPSFH
ALGVPMFVQTSAPGLGGDWSGLLIAQDTGGAIKGPVRGDIYFGTGFDAGQRAGTMNAQGRLWVLLPLTVAERLRQSLESG
PVAARTPAPGAG
>Mature_412_residues
MIRFAALLFSALVLAACQSTPRPAAPVVVQPGPTPGQTPGTVRPPPASLPTSYRDLPGWQGATLAPSLEAFRRTCDRFTR
RAWDAPLSRSVAWAGTAADWAPACEALAAPLDEGATRRAFETLFIPVEIIDPEGKPRFTGYFEPTYEARRAPEPGFTEPV
FAVPSDFVANGDSPLQRLPNGTTRPYPPRAEITAKGGQAIAWAHPTDVFFLQIQGSGRLTFPDGTTLRAAYAAHNGQPFR
STANWLIETGRITRGEGSMQGIRAWMDRASPEEVRQSMNINPRFVFFQSLPEGDPELGPTGAHNVPLTPFGSMAIDPSFH
ALGVPMFVQTSAPGLGGDWSGLLIAQDTGGAIKGPVRGDIYFGTGFDAGQRAGTMNAQGRLWVLLPLTVAERLRQSLESG
PVAARTPAPGAG

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=269, Percent_Identity=35.6877323420074, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43982; Mature: 43982

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRFAALLFSALVLAACQSTPRPAAPVVVQPGPTPGQTPGTVRPPPASLPTSYRDLPGWQ
CHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GATLAPSLEAFRRTCDRFTRRAWDAPLSRSVAWAGTAADWAPACEALAAPLDEGATRRAF
CCCCCHHHHHHHHHHHHHHHHHHCCCHHCCEEECCCCCHHHHHHHHHHCCCCCCHHHHEE
ETLFIPVEIIDPEGKPRFTGYFEPTYEARRAPEPGFTEPVFAVPSDFVANGDSPLQRLPN
EEEEEEEEEECCCCCCCEEEEECCCHHHHCCCCCCCCCCEEECCCHHHCCCCCHHHHCCC
GTTRPYPPRAEITAKGGQAIAWAHPTDVFFLQIQGSGRLTFPDGTTLRAAYAAHNGQPFR
CCCCCCCCCCEEEECCCCEEEEECCCEEEEEEEECCCEEECCCCCEEEEEEHHCCCCCCH
STANWLIETGRITRGEGSMQGIRAWMDRASPEEVRQSMNINPRFVFFQSLPEGDPELGPT
HHHHHEEECCCEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
GAHNVPLTPFGSMAIDPSFHALGVPMFVQTSAPGLGGDWSGLLIAQDTGGAIKGPVRGDI
CCCCCCCCCCCCEEECCCHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCEECCCCCEE
YFGTGFDAGQRAGTMNAQGRLWVLLPLTVAERLRQSLESGPVAARTPAPGAG
EEECCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEECCCCCCCC
>Mature Secondary Structure
MIRFAALLFSALVLAACQSTPRPAAPVVVQPGPTPGQTPGTVRPPPASLPTSYRDLPGWQ
CHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GATLAPSLEAFRRTCDRFTRRAWDAPLSRSVAWAGTAADWAPACEALAAPLDEGATRRAF
CCCCCHHHHHHHHHHHHHHHHHHCCCHHCCEEECCCCCHHHHHHHHHHCCCCCCHHHHEE
ETLFIPVEIIDPEGKPRFTGYFEPTYEARRAPEPGFTEPVFAVPSDFVANGDSPLQRLPN
EEEEEEEEEECCCCCCCEEEEECCCHHHHCCCCCCCCCCEEECCCHHHCCCCCHHHHCCC
GTTRPYPPRAEITAKGGQAIAWAHPTDVFFLQIQGSGRLTFPDGTTLRAAYAAHNGQPFR
CCCCCCCCCCEEEECCCCEEEEECCCEEEEEEEECCCEEECCCCCEEEEEEHHCCCCCCH
STANWLIETGRITRGEGSMQGIRAWMDRASPEEVRQSMNINPRFVFFQSLPEGDPELGPT
HHHHHEEECCCEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
GAHNVPLTPFGSMAIDPSFHALGVPMFVQTSAPGLGGDWSGLLIAQDTGGAIKGPVRGDI
CCCCCCCCCCCCEEECCCHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCEECCCCCEE
YFGTGFDAGQRAGTMNAQGRLWVLLPLTVAERLRQSLESGPVAARTPAPGAG
EEECCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]