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The map label for this gene is parC [H]

Identifier: 114797721

GI number: 114797721

Start: 900998

End: 903232

Strand: Direct

Name: parC [H]

Synonym: HNE_0881

Alternate gene names: 114797721

Gene position: 900998-903232 (Clockwise)

Preceding gene: 114799258

Following gene: 114799505

Centisome position: 24.32

GC content: 62.42

Gene sequence:

>2235_bases
ATGTCCAAATCTACCGCCGAGCCCCCTGCGGACCGGATCATAAACGAGCCGATGAGCGAAGCGCTGTCAAAGCGCTATCT
CGCCTATGCGCTCTCCACGATCACGTCCCGCGCGCTGCCCGATGTCCGCGATGGCCTCAAGCCCGTCCAGCGCCGCATCC
TCTATGGCATGCGCGTCCTGCGCCTTGATCCGGAAGGCGGCTACCGCAAATGCGCCAAGATCGTCGGCGATGTCATGGGT
AACTACCACCCCCATGGCGACAGCTCGATCTATGACACGCTCGTCCGCCTCGCCCAGGATTTCAACGTTCGCTATCCCCT
CGTCGATGGCCAGGGCAACTTCGGTAATATCGACGGGGACAGCGCCGCCGCCTACCGCTACACCGAAGCGCGCATGACGC
GCGGCGCCGAGCTGCTGATGGAAGGCCTCGACGAAAACGCCGTCGATTTCCGCCCCAACTATGCCGAGAATGACGAGGAA
CCCGTCGTCCTCCCCGCCGGCTTCCCGAACCTTCTGGCCAATGGCGCCACCGGCATCGCAGTCGGCATGGCCACCTCCAT
TCCGCCCCACAACGTTGCCGAGATCATCGACGCGGCCCGCCACCTGATCGAAAAGCCCAAAGCGACCACAGAAGAACTCA
TGGAGTTTGTTCAGGGCCCGGACTTTCCAACCGGCGGCGTGATCGTGGAAGACCGCGCCTCGATGCTGGAGGCTTACGAG
ACGGGGCGGGGCGCCTTCCGTATGCGCGCCCGCTGGCATGTCGAAGATACCGGCCGGGGTACCTACCAGATCATCGTTAC
CGAGATCCCCTATCAGGTTCAGAAATCACGCCTGCTGGAAAAGCTCTCAGAGCTGCTCGAAGCCAAGAAGGTCCCGCTGC
TGGAAGACGTGCGCGACGAGTCCGCCGAGGATGTCCGCCTCGTGCTCGTCCCGCGCGCCAAGACGGTTGAGCCCGACGTG
CTGATGGAAAGCCTCTTCCGGACCTGCGATCTGGAAACGCGCTTCAGCTTGAACATGAACGTGCTGCACAAGGGCGCGCC
CCAGGTCATGGGCCTGCGCGATGTGCTCCAGGCTTATCTCGACCACCGCCGCGAAGTCGTCGTGCGCCGGGCCGAATTCC
GCCTCGACAAGATCGAGAAGCGCCTGCACATCCTGGAAGGCTTCCTGAAAGCCTACCTCAATATTGATGAAGTGATCCGC
ATCATCCGGACAGAGGACGAGCCCAAGCCCGTCCTGATGAAGCGGTTCAAGATTTCCGACATCCAGGCCGAAGCGATCCT
GAACCTCCGCCTGCGCGCCCTGCGCAAGCTGGAAGAGATGGAAATCCAGGGCGAGCATACCAAACTGACTGAGGAGCGCG
ACGAACTCGTCTTGCTGATCGGCTCGGTCCGCCGCCAATGGACGCGCGTTTCGAAAGAGCTCAAAGCGGCCCGTGACGAA
TTTGATCCGTCCACCGCGCTCGGCCGCCGCCGCGCCACCTTTGAGCAGGCCCCTACGGTTGACCTTGCCGCCGCACTGGA
AGCCACCCGTCCGAAAGAGCCCGTAACGGTCGTCCTCTCGGCGCAGGGCTGGATTCGCGGCATGAAGGGCCACGGCCTTG
ATCCCGATACGATCAAGTTCAAGGAAGGCGACGGGCCGAGCTTCACCGAAGAAGTGATGAGCACCGACAAGCTCGTCTTC
ATGTCTTCCGATGGGCGCGCCTTCATGCTGCCCGCCGACAAGCTCCCCGGCGGGCGCGGCCATGGCGAGCCGATCCGCAT
TTCGATCGAGCTTGAAGACAATGTCGCCATCGTGGGCATGTTCAAGTTTGAGCCTGAGCGCAAACGCGTGATGGCTTCCT
CTACGGGGTATGGCTTCGTTGTTCCGGAGGCGGAGCTTGAGTCAAACCGCAAGGCGGGCAAACAGATCGTCAACACCGGC
GGGGGCCATCTCAATGTCTGCGTGCCGGTGCTCGGCGACATGATCGCGGTCGTCGGCACCAACCGCAAGATGCTGATCTT
CCCGCTGAAGGATCTGCCCGAAATGCCCCGCGGCAAGGGCAACAAGCTCCAGTCCTACAGCGGCGGGGCAGAACTCGCTG
ACCTCATTACCTTCGACAAACGTGACGGCCTGATCGTCGTCACAGGGGGCCGCTTCCGCGCCTTCGAAGAATGGAAAGAG
TGGAAGGGCCAGCGCGCCCAGGCTGGCAAGGTTGTGCCTAAAGGCTTTCCGCGCACAGGCACGTTCAGCGGGTAA

Upstream 100 bases:

>100_bases
AAACGCCGGTTTCTGTTAACCTGCGCGCAATTGCGAGTCGGGCTATACCCTGACCCGTAAACCCGCACCAGAATGTGGCG
AGACCTGCAACGAGGCCAGA

Downstream 100 bases:

>100_bases
TCCCGAACACGGGACGTCTGCTGTGAGCAACCCAGCCTCCATCCTCTCCATACCCATGGGGAGGATGGAGGCGGGGCACG
GTGAAAGGTGAATGCAACGC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MSKSTAEPPADRIINEPMSEALSKRYLAYALSTITSRALPDVRDGLKPVQRRILYGMRVLRLDPEGGYRKCAKIVGDVMG
NYHPHGDSSIYDTLVRLAQDFNVRYPLVDGQGNFGNIDGDSAAAYRYTEARMTRGAELLMEGLDENAVDFRPNYAENDEE
PVVLPAGFPNLLANGATGIAVGMATSIPPHNVAEIIDAARHLIEKPKATTEELMEFVQGPDFPTGGVIVEDRASMLEAYE
TGRGAFRMRARWHVEDTGRGTYQIIVTEIPYQVQKSRLLEKLSELLEAKKVPLLEDVRDESAEDVRLVLVPRAKTVEPDV
LMESLFRTCDLETRFSLNMNVLHKGAPQVMGLRDVLQAYLDHRREVVVRRAEFRLDKIEKRLHILEGFLKAYLNIDEVIR
IIRTEDEPKPVLMKRFKISDIQAEAILNLRLRALRKLEEMEIQGEHTKLTEERDELVLLIGSVRRQWTRVSKELKAARDE
FDPSTALGRRRATFEQAPTVDLAAALEATRPKEPVTVVLSAQGWIRGMKGHGLDPDTIKFKEGDGPSFTEEVMSTDKLVF
MSSDGRAFMLPADKLPGGRGHGEPIRISIELEDNVAIVGMFKFEPERKRVMASSTGYGFVVPEAELESNRKAGKQIVNTG
GGHLNVCVPVLGDMIAVVGTNRKMLIFPLKDLPEMPRGKGNKLQSYSGGAELADLITFDKRDGLIVVTGGRFRAFEEWKE
WKGQRAQAGKVVPKGFPRTGTFSG

Sequences:

>Translated_744_residues
MSKSTAEPPADRIINEPMSEALSKRYLAYALSTITSRALPDVRDGLKPVQRRILYGMRVLRLDPEGGYRKCAKIVGDVMG
NYHPHGDSSIYDTLVRLAQDFNVRYPLVDGQGNFGNIDGDSAAAYRYTEARMTRGAELLMEGLDENAVDFRPNYAENDEE
PVVLPAGFPNLLANGATGIAVGMATSIPPHNVAEIIDAARHLIEKPKATTEELMEFVQGPDFPTGGVIVEDRASMLEAYE
TGRGAFRMRARWHVEDTGRGTYQIIVTEIPYQVQKSRLLEKLSELLEAKKVPLLEDVRDESAEDVRLVLVPRAKTVEPDV
LMESLFRTCDLETRFSLNMNVLHKGAPQVMGLRDVLQAYLDHRREVVVRRAEFRLDKIEKRLHILEGFLKAYLNIDEVIR
IIRTEDEPKPVLMKRFKISDIQAEAILNLRLRALRKLEEMEIQGEHTKLTEERDELVLLIGSVRRQWTRVSKELKAARDE
FDPSTALGRRRATFEQAPTVDLAAALEATRPKEPVTVVLSAQGWIRGMKGHGLDPDTIKFKEGDGPSFTEEVMSTDKLVF
MSSDGRAFMLPADKLPGGRGHGEPIRISIELEDNVAIVGMFKFEPERKRVMASSTGYGFVVPEAELESNRKAGKQIVNTG
GGHLNVCVPVLGDMIAVVGTNRKMLIFPLKDLPEMPRGKGNKLQSYSGGAELADLITFDKRDGLIVVTGGRFRAFEEWKE
WKGQRAQAGKVVPKGFPRTGTFSG
>Mature_743_residues
SKSTAEPPADRIINEPMSEALSKRYLAYALSTITSRALPDVRDGLKPVQRRILYGMRVLRLDPEGGYRKCAKIVGDVMGN
YHPHGDSSIYDTLVRLAQDFNVRYPLVDGQGNFGNIDGDSAAAYRYTEARMTRGAELLMEGLDENAVDFRPNYAENDEEP
VVLPAGFPNLLANGATGIAVGMATSIPPHNVAEIIDAARHLIEKPKATTEELMEFVQGPDFPTGGVIVEDRASMLEAYET
GRGAFRMRARWHVEDTGRGTYQIIVTEIPYQVQKSRLLEKLSELLEAKKVPLLEDVRDESAEDVRLVLVPRAKTVEPDVL
MESLFRTCDLETRFSLNMNVLHKGAPQVMGLRDVLQAYLDHRREVVVRRAEFRLDKIEKRLHILEGFLKAYLNIDEVIRI
IRTEDEPKPVLMKRFKISDIQAEAILNLRLRALRKLEEMEIQGEHTKLTEERDELVLLIGSVRRQWTRVSKELKAARDEF
DPSTALGRRRATFEQAPTVDLAAALEATRPKEPVTVVLSAQGWIRGMKGHGLDPDTIKFKEGDGPSFTEEVMSTDKLVFM
SSDGRAFMLPADKLPGGRGHGEPIRISIELEDNVAIVGMFKFEPERKRVMASSTGYGFVVPEAELESNRKAGKQIVNTGG
GHLNVCVPVLGDMIAVVGTNRKMLIFPLKDLPEMPRGKGNKLQSYSGGAELADLITFDKRDGLIVVTGGRFRAFEEWKEW
KGQRAQAGKVVPKGFPRTGTFSG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=362, Percent_Identity=26.7955801104972, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI19913406, Length=357, Percent_Identity=26.3305322128852, Blast_Score=77, Evalue=8e-14,
Organism=Escherichia coli, GI1789396, Length=737, Percent_Identity=42.1981004070556, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1788562, Length=675, Percent_Identity=40.1481481481482, Blast_Score=435, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI212645845, Length=379, Percent_Identity=26.1213720316623, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=392, Percent_Identity=29.0816326530612, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=383, Percent_Identity=27.9373368146214, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115534553, Length=172, Percent_Identity=31.9767441860465, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=332, Percent_Identity=29.5180722891566, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17136538, Length=354, Percent_Identity=27.683615819209, Blast_Score=78, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83093; Mature: 82961

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSTAEPPADRIINEPMSEALSKRYLAYALSTITSRALPDVRDGLKPVQRRILYGMRVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEE
RLDPEGGYRKCAKIVGDVMGNYHPHGDSSIYDTLVRLAQDFNVRYPLVDGQGNFGNIDGD
EECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
SAAAYRYTEARMTRGAELLMEGLDENAVDFRPNYAENDEEPVVLPAGFPNLLANGATGIA
CCHHEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHCCCCEEE
VGMATSIPPHNVAEIIDAARHLIEKPKATTEELMEFVQGPDFPTGGVIVEDRASMLEAYE
EECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHH
TGRGAFRMRARWHVEDTGRGTYQIIVTEIPYQVQKSRLLEKLSELLEAKKVPLLEDVRDE
CCCCEEEEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
SAEDVRLVLVPRAKTVEPDVLMESLFRTCDLETRFSLNMNVLHKGAPQVMGLRDVLQAYL
CCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHCCCCCHHCCHHHHHHHHH
DHRREVVVRRAEFRLDKIEKRLHILEGFLKAYLNIDEVIRIIRTEDEPKPVLMKRFKISD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHCH
IQAEAILNLRLRALRKLEEMEIQGEHTKLTEERDELVLLIGSVRRQWTRVSKELKAARDE
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHC
FDPSTALGRRRATFEQAPTVDLAAALEATRPKEPVTVVLSAQGWIRGMKGHGLDPDTIKF
CCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCHHHCCCCCCCCCCCCEEE
KEGDGPSFTEEVMSTDKLVFMSSDGRAFMLPADKLPGGRGHGEPIRISIELEDNVAIVGM
ECCCCCCHHHHHHCCCCEEEEECCCCEEEEEHHCCCCCCCCCCEEEEEEEECCCEEEEEE
FKFEPERKRVMASSTGYGFVVPEAELESNRKAGKQIVNTGGGHLNVCVPVLGDMIAVVGT
EEECCHHHHHEECCCCCEEEECCHHHHCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCC
NRKMLIFPLKDLPEMPRGKGNKLQSYSGGAELADLITFDKRDGLIVVTGGRFRAFEEWKE
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCEEEEECCCCHHHHHHHH
WKGQRAQAGKVVPKGFPRTGTFSG
HCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKSTAEPPADRIINEPMSEALSKRYLAYALSTITSRALPDVRDGLKPVQRRILYGMRVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEE
RLDPEGGYRKCAKIVGDVMGNYHPHGDSSIYDTLVRLAQDFNVRYPLVDGQGNFGNIDGD
EECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
SAAAYRYTEARMTRGAELLMEGLDENAVDFRPNYAENDEEPVVLPAGFPNLLANGATGIA
CCHHEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHCCCCEEE
VGMATSIPPHNVAEIIDAARHLIEKPKATTEELMEFVQGPDFPTGGVIVEDRASMLEAYE
EECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHH
TGRGAFRMRARWHVEDTGRGTYQIIVTEIPYQVQKSRLLEKLSELLEAKKVPLLEDVRDE
CCCCEEEEEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
SAEDVRLVLVPRAKTVEPDVLMESLFRTCDLETRFSLNMNVLHKGAPQVMGLRDVLQAYL
CCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHCCCCCHHCCHHHHHHHHH
DHRREVVVRRAEFRLDKIEKRLHILEGFLKAYLNIDEVIRIIRTEDEPKPVLMKRFKISD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHCH
IQAEAILNLRLRALRKLEEMEIQGEHTKLTEERDELVLLIGSVRRQWTRVSKELKAARDE
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHC
FDPSTALGRRRATFEQAPTVDLAAALEATRPKEPVTVVLSAQGWIRGMKGHGLDPDTIKF
CCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCHHHCCCCCCCCCCCCEEE
KEGDGPSFTEEVMSTDKLVFMSSDGRAFMLPADKLPGGRGHGEPIRISIELEDNVAIVGM
ECCCCCCHHHHHHCCCCEEEEECCCCEEEEEHHCCCCCCCCCCEEEEEEEECCCEEEEEE
FKFEPERKRVMASSTGYGFVVPEAELESNRKAGKQIVNTGGGHLNVCVPVLGDMIAVVGT
EEECCHHHHHEECCCCCEEEECCHHHHCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCC
NRKMLIFPLKDLPEMPRGKGNKLQSYSGGAELADLITFDKRDGLIVVTGGRFRAFEEWKE
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCEEEEECCCCHHHHHHHH
WKGQRAQAGKVVPKGFPRTGTFSG
HCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9426128; 11259647 [H]