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The map label for this gene is putP2 [H]

Identifier: 114797475

GI number: 114797475

Start: 1682263

End: 1683714

Strand: Direct

Name: putP2 [H]

Synonym: HNE_1645

Alternate gene names: 114797475

Gene position: 1682263-1683714 (Clockwise)

Preceding gene: 114798292

Following gene: 114799816

Centisome position: 45.4

GC content: 62.53

Gene sequence:

>1452_bases
ATGATCACTGCTATCAGCTTCGTCCTTATACTGCTTTCCTTTGTGGTCATCGGCCTCGCTTCTGGCCGTAAGGCAACAGG
CAAGCGAAAGGATTATTATCTGGCCAGCAGCAGCGTCAGCCCCTGGCTCGCGGGGCTTTCGGCGGTCGCCACAAACAATT
CCGGCTACATGTTCATCGGCGTCATAGGTTTCACCTACCAGACAGGCCTGGCGGCCATGTGGCTGATGATCGGCTGGATC
GTGGGCGACTTCATCGGCTCCAGCTTCATTCACAAACGCCTGCGCCAGGCCACGGCAAAAACCGGTGAGGCCTCCTTCGC
CGGGGTCATCGCCCGTTGGTATGGCGAGAAGTTCGGCATCTGGCAGAAGATTGCCGGCGTCATCATGATCGTTTTCCTGA
TCGCCTATGCCGCCGCCCAGATTTCCGCAGGCGGCAAGGCGCTGGAAGGCGTCCTCGGTATCAACCCATGGACCGGCGCC
GTCATGGTCGCCGCCATGGTGCTGCTATACTCGATCGTCGGCGGCATCCGCGCTTCCATCTGGACCGATGGCGCCCAGTC
CATCACCATGATGTTCGCCATGACCATCCTGCTCATCGCCGCCTTCGCGGGTGTAGGCGGCGTCAGCGGCGCACTGGAAC
TCTGGAGCGCCATCCCCGGTTTCCTTGATCCTTTCCCGGATGATCTTCTCTTTCCCGGCGCGCTCGGCATGGGGCTCTTT
ATTGTCGGTTGGCTGTTCGCCGGTTTCTCCGTGGTCGGCCAGCCCCATGTGATGGTCCGCTTCATGGCGCTCGATCACGA
CCGCAATATGGGCCGCGCCCGCGCCTGGTATTATGGCTACTTCACCATCTTCTATCTCCTCGCCACCGGGGTAGGCATGC
TCTCGCGCCTCTATCTGCCAGACCTTGCCGACATCGACCCCGAACTCGCCCTGCCCATGATGGCAACAGAGCTTCTCCCG
CCCGTCCTGGTCGGCGTGATCCTTGCGGGCATTTTCGCGGCCACCATGTCGACGGCGGACTCTCTGGTCCTCTCCTGTTC
GGCGTCCTTCACCCACGATCTGGCGCCCGAACGGCTTGAGACCCCGCTCATCCTCAAGACGGCAACTGCCGTCTCCATCC
TGATCGCCCTCGGCCTAGCCCTTTCGGGCAATCAGAGCGTGTTCAGTCTCGTCATCCTCGCCTGGTCCACCCTGGCGGCC
GCCTTTGCGCCCCTGTTGACGCTCTATGCCCTCCGCCGGCGCGTGTCGGAGCCTGTGGCCATCATGATGCTGGTCCTCGG
TGTCAGTATCGCCCTGTTCTGGCGCTTTGGCCTCGGCTGGCATGAGAGCATCTATGAGGGCCTGCCGGGCATCCTCGTGC
CGCTCATCATCGGTTGGTTCCTGTCGGAGCGCCGGGAAATTGCGGCCAGCCCGGAGCCCGCCGCCGAGACCAGCCCCAGC
GCCGCAGAGTAA

Upstream 100 bases:

>100_bases
TTGCCATCGCGGAGTTTGACCCGCGCGGCGAGCCTGAACAATCCGACCAGCCAGACCTTTTCGCAGGGCCCATGCCTGCC
AGCCCGCAGGAGACTGCCTC

Downstream 100 bases:

>100_bases
GTCTGCCCCTCCGCTGAAGAGGCGGTTGCGGCCTGTTCATCGCCATTCTCGTTTACTGGTCATCCTGCGCCTTCGGGCGC
GGGAATGGCCGAAACTGTGT

Product: solute/sodium symporter (SSS) family protein

Products: NA

Alternate protein names: Proline permease 2 [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MITAISFVLILLSFVVIGLASGRKATGKRKDYYLASSSVSPWLAGLSAVATNNSGYMFIGVIGFTYQTGLAAMWLMIGWI
VGDFIGSSFIHKRLRQATAKTGEASFAGVIARWYGEKFGIWQKIAGVIMIVFLIAYAAAQISAGGKALEGVLGINPWTGA
VMVAAMVLLYSIVGGIRASIWTDGAQSITMMFAMTILLIAAFAGVGGVSGALELWSAIPGFLDPFPDDLLFPGALGMGLF
IVGWLFAGFSVVGQPHVMVRFMALDHDRNMGRARAWYYGYFTIFYLLATGVGMLSRLYLPDLADIDPELALPMMATELLP
PVLVGVILAGIFAATMSTADSLVLSCSASFTHDLAPERLETPLILKTATAVSILIALGLALSGNQSVFSLVILAWSTLAA
AFAPLLTLYALRRRVSEPVAIMMLVLGVSIALFWRFGLGWHESIYEGLPGILVPLIIGWFLSERREIAASPEPAAETSPS
AAE

Sequences:

>Translated_483_residues
MITAISFVLILLSFVVIGLASGRKATGKRKDYYLASSSVSPWLAGLSAVATNNSGYMFIGVIGFTYQTGLAAMWLMIGWI
VGDFIGSSFIHKRLRQATAKTGEASFAGVIARWYGEKFGIWQKIAGVIMIVFLIAYAAAQISAGGKALEGVLGINPWTGA
VMVAAMVLLYSIVGGIRASIWTDGAQSITMMFAMTILLIAAFAGVGGVSGALELWSAIPGFLDPFPDDLLFPGALGMGLF
IVGWLFAGFSVVGQPHVMVRFMALDHDRNMGRARAWYYGYFTIFYLLATGVGMLSRLYLPDLADIDPELALPMMATELLP
PVLVGVILAGIFAATMSTADSLVLSCSASFTHDLAPERLETPLILKTATAVSILIALGLALSGNQSVFSLVILAWSTLAA
AFAPLLTLYALRRRVSEPVAIMMLVLGVSIALFWRFGLGWHESIYEGLPGILVPLIIGWFLSERREIAASPEPAAETSPS
AAE
>Mature_483_residues
MITAISFVLILLSFVVIGLASGRKATGKRKDYYLASSSVSPWLAGLSAVATNNSGYMFIGVIGFTYQTGLAAMWLMIGWI
VGDFIGSSFIHKRLRQATAKTGEASFAGVIARWYGEKFGIWQKIAGVIMIVFLIAYAAAQISAGGKALEGVLGINPWTGA
VMVAAMVLLYSIVGGIRASIWTDGAQSITMMFAMTILLIAAFAGVGGVSGALELWSAIPGFLDPFPDDLLFPGALGMGLF
IVGWLFAGFSVVGQPHVMVRFMALDHDRNMGRARAWYYGYFTIFYLLATGVGMLSRLYLPDLADIDPELALPMMATELLP
PVLVGVILAGIFAATMSTADSLVLSCSASFTHDLAPERLETPLILKTATAVSILIALGLALSGNQSVFSLVILAWSTLAA
AFAPLLTLYALRRRVSEPVAIMMLVLGVSIALFWRFGLGWHESIYEGLPGILVPLIIGWFLSERREIAASPEPAAETSPS
AAE

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=479, Percent_Identity=29.0187891440501, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI17941285, Length=397, Percent_Identity=26.9521410579345, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI206597487, Length=479, Percent_Identity=24.6346555323591, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4507031, Length=337, Percent_Identity=25.2225519287834, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI4507033, Length=388, Percent_Identity=25.2577319587629, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787251, Length=462, Percent_Identity=26.8398268398268, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87082237, Length=364, Percent_Identity=27.4725274725275, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790503, Length=522, Percent_Identity=23.9463601532567, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51532; Mature: 51532

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITAISFVLILLSFVVIGLASGRKATGKRKDYYLASSSVSPWLAGLSAVATNNSGYMFIG
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHEECCCCEEEEE
VIGFTYQTGLAAMWLMIGWIVGDFIGSSFIHKRLRQATAKTGEASFAGVIARWYGEKFGI
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
WQKIAGVIMIVFLIAYAAAQISAGGKALEGVLGINPWTGAVMVAAMVLLYSIVGGIRASI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
WTDGAQSITMMFAMTILLIAAFAGVGGVSGALELWSAIPGFLDPFPDDLLFPGALGMGLF
HCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHCCCCCCHHCCCCHHHHHHH
IVGWLFAGFSVVGQPHVMVRFMALDHDRNMGRARAWYYGYFTIFYLLATGVGMLSRLYLP
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLADIDPELALPMMATELLPPVLVGVILAGIFAATMSTADSLVLSCSASFTHDLAPERLE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHC
TPLILKTATAVSILIALGLALSGNQSVFSLVILAWSTLAAAFAPLLTLYALRRRVSEPVA
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IMMLVLGVSIALFWRFGLGWHESIYEGLPGILVPLIIGWFLSERREIAASPEPAAETSPS
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
AAE
CCC
>Mature Secondary Structure
MITAISFVLILLSFVVIGLASGRKATGKRKDYYLASSSVSPWLAGLSAVATNNSGYMFIG
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHEECCCCEEEEE
VIGFTYQTGLAAMWLMIGWIVGDFIGSSFIHKRLRQATAKTGEASFAGVIARWYGEKFGI
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
WQKIAGVIMIVFLIAYAAAQISAGGKALEGVLGINPWTGAVMVAAMVLLYSIVGGIRASI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
WTDGAQSITMMFAMTILLIAAFAGVGGVSGALELWSAIPGFLDPFPDDLLFPGALGMGLF
HCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHCCCCCCHHCCCCHHHHHHH
IVGWLFAGFSVVGQPHVMVRFMALDHDRNMGRARAWYYGYFTIFYLLATGVGMLSRLYLP
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLADIDPELALPMMATELLPPVLVGVILAGIFAATMSTADSLVLSCSASFTHDLAPERLE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHC
TPLILKTATAVSILIALGLALSGNQSVFSLVILAWSTLAAAFAPLLTLYALRRRVSEPVA
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IMMLVLGVSIALFWRFGLGWHESIYEGLPGILVPLIIGWFLSERREIAASPEPAAETSPS
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
AAE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA