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The map label for this gene is macA [H]

Identifier: 114799816

GI number: 114799816

Start: 1684011

End: 1685354

Strand: Direct

Name: macA [H]

Synonym: HNE_1646

Alternate gene names: 114799816

Gene position: 1684011-1685354 (Clockwise)

Preceding gene: 114797475

Following gene: 114800370

Centisome position: 45.45

GC content: 64.21

Gene sequence:

>1344_bases
ATGAACGCGCGCTGGACCTGGCTCATCATTGCGGCTGTCGCTGTAATCGCTGCCTGGTTTGCCTGGCAGACGGTGTGGGG
CGGCGAAAAAGCTCCTGAATACCAGACCGCCGAGGTCACACGCGGAGACATCGAAGTGTCGATCTCTTCGGCTGGCAAGG
TGGCCCCAAAGGATACGGTCGCCGTCGGCGCCCAGGTCTCAGGCCAGTTGACTGAGCTTCTGGTCGAGGCCGGTGACCTT
GTCGAAGAAGGCCAGCTTCTCGCCCGGATCGATGCCACCATCGCCGAAACCAATGTCGAAGGCAGCCGCGCCCAGCTTCT
GGAGCTTCAGGCAAGCCGCACCCAGCAGCAGGCCACGCTTGAACTGGCCAAGGCAAATGCTGACCGCGCCAAGATGCTGT
TCGAGAACGACGCTGTTGCCCGCGCCGACTTTGAAGCCTCGCAAGCTGAATACGCGATCGCTGTTGGCCGCCTGGAAGCC
ATCAACGCCCAGATCACCCGCCAGAGTTCGTCGCTCCGCGCCCTTCAGGCCACCCTCGAATTCACCAATATATATGCGCC
GATTTCCGGCACGGTCGTGTCCCTGGAGGCGGTCGAGGGCCAGACCCTTAACGCGAACCAGACCGCGCCAACCATCCTCA
CGCTGGCTGACCTCACCATCATGACCGTCGAGACCGATGTGTCCGAAGCTGATGTCCTGCGCGTCAAGCCGGGGCAGGCG
GCCTGGTTCTCTACGCTGGGCGACTCCAGCCGCCGCTGGGAAACCTCTGTCCGCCAGATCCTTCCGACCCCTGAAGTTCT
CAACGATGTGGTCCTCTACAAGGCGCTGCTCGACATTGAAAATCCGGAAAACCTCCTTAAGCCGGAAATGACCGCGCAGG
TCTTCTTCGTCACCGGCTCGGCTAAGGACGCCATCCTTGTCCCGGTCACAGCCTTGCAGGCCAATCCGCCGCGCCGTGAA
TGGTCAGGCGGCGCCGGCGCACGCACAGCCTCCGCTGGTGGTGAGCGGGAAGGGCGCCAGGGCGGTTTCATGCAGGCAGA
GGCCAGTGAACCGGCCGCCGCGCCCGCCCAGGATGACAGCCGCCGCAAAGCCTTCTCCGAAGCACGCAAAGCTTATCCCG
ATGCCGAAGTTGCCACCGTCCTCGTCATGGGGCCGGATGGCACGCCGCGCCCGCGTCCTGTTCTCGTCGGTCTCAAGACC
CGCACGCAGGCTGAAATCCTCTTCGGTCTCGACCCCGGCCAGACTGTGGTGACCGGCGAAGTGACAATTGAGCGCCCGGC
CTCGCAGGAGCGGGATGGCCCGCCTCGCGGCATGGGCCCTCCAGGCGGCATGCGCCGCGGTTGA

Upstream 100 bases:

>100_bases
GTTCCTCGCGACGGATAATCACCGGGCCTTCGTTGAAGTTCCCAGAGACTGTTTGAAGAGACTGTTTGAAGCTGAGTGCC
CCATGATCAAGACCAAACGG

Downstream 100 bases:

>100_bases
CCGGATAACCGTCATGACCCCACCCCTGATCGAACTGAAGGACGTGACCCGCTATTACGGGTCCGGCGATACCGAAGTCC
GCGCTCTGGACGGCGTATCT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MNARWTWLIIAAVAVIAAWFAWQTVWGGEKAPEYQTAEVTRGDIEVSISSAGKVAPKDTVAVGAQVSGQLTELLVEAGDL
VEEGQLLARIDATIAETNVEGSRAQLLELQASRTQQQATLELAKANADRAKMLFENDAVARADFEASQAEYAIAVGRLEA
INAQITRQSSSLRALQATLEFTNIYAPISGTVVSLEAVEGQTLNANQTAPTILTLADLTIMTVETDVSEADVLRVKPGQA
AWFSTLGDSSRRWETSVRQILPTPEVLNDVVLYKALLDIENPENLLKPEMTAQVFFVTGSAKDAILVPVTALQANPPRRE
WSGGAGARTASAGGEREGRQGGFMQAEASEPAAAPAQDDSRRKAFSEARKAYPDAEVATVLVMGPDGTPRPRPVLVGLKT
RTQAEILFGLDPGQTVVTGEVTIERPASQERDGPPRGMGPPGGMRRG

Sequences:

>Translated_447_residues
MNARWTWLIIAAVAVIAAWFAWQTVWGGEKAPEYQTAEVTRGDIEVSISSAGKVAPKDTVAVGAQVSGQLTELLVEAGDL
VEEGQLLARIDATIAETNVEGSRAQLLELQASRTQQQATLELAKANADRAKMLFENDAVARADFEASQAEYAIAVGRLEA
INAQITRQSSSLRALQATLEFTNIYAPISGTVVSLEAVEGQTLNANQTAPTILTLADLTIMTVETDVSEADVLRVKPGQA
AWFSTLGDSSRRWETSVRQILPTPEVLNDVVLYKALLDIENPENLLKPEMTAQVFFVTGSAKDAILVPVTALQANPPRRE
WSGGAGARTASAGGEREGRQGGFMQAEASEPAAAPAQDDSRRKAFSEARKAYPDAEVATVLVMGPDGTPRPRPVLVGLKT
RTQAEILFGLDPGQTVVTGEVTIERPASQERDGPPRGMGPPGGMRRG
>Mature_447_residues
MNARWTWLIIAAVAVIAAWFAWQTVWGGEKAPEYQTAEVTRGDIEVSISSAGKVAPKDTVAVGAQVSGQLTELLVEAGDL
VEEGQLLARIDATIAETNVEGSRAQLLELQASRTQQQATLELAKANADRAKMLFENDAVARADFEASQAEYAIAVGRLEA
INAQITRQSSSLRALQATLEFTNIYAPISGTVVSLEAVEGQTLNANQTAPTILTLADLTIMTVETDVSEADVLRVKPGQA
AWFSTLGDSSRRWETSVRQILPTPEVLNDVVLYKALLDIENPENLLKPEMTAQVFFVTGSAKDAILVPVTALQANPPRRE
WSGGAGARTASAGGEREGRQGGFMQAEASEPAAAPAQDDSRRKAFSEARKAYPDAEVATVLVMGPDGTPRPRPVLVGLKT
RTQAEILFGLDPGQTVVTGEVTIERPASQERDGPPRGMGPPGGMRRG

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=306, Percent_Identity=41.8300653594771, Blast_Score=227, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 47711; Mature: 47711

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARWTWLIIAAVAVIAAWFAWQTVWGGEKAPEYQTAEVTRGDIEVSISSAGKVAPKDTV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCE
AVGAQVSGQLTELLVEAGDLVEEGQLLARIDATIAETNVEGSRAQLLELQASRTQQQATL
EECCCCCHHHHHHHHHHCCHHHCCCEEEEHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
ELAKANADRAKMLFENDAVARADFEASQAEYAIAVGRLEAINAQITRQSSSLRALQATLE
HHHHCCCCHHHEEECCCCCEECCCCCCCCCEEEEEHHHHHHCHHEECCCHHHHHHHHHHH
FTNIYAPISGTVVSLEAVEGQTLNANQTAPTILTLADLTIMTVETDVSEADVLRVKPGQA
HHEEEECCCCCEEEEEECCCCEECCCCCCCEEEEEECEEEEEEECCCCCCCEEEECCCCC
AWFSTLGDSSRRWETSVRQILPTPEVLNDVVLYKALLDIENPENLLKPEMTAQVFFVTGS
HHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEEEECC
AKDAILVPVTALQANPPRREWSGGAGARTASAGGEREGRQGGFMQAEASEPAAAPAQDDS
CCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCH
RRKAFSEARKAYPDAEVATVLVMGPDGTPRPRPVLVGLKTRTQAEILFGLDPGQTVVTGE
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEE
VTIERPASQERDGPPRGMGPPGGMRRG
EEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNARWTWLIIAAVAVIAAWFAWQTVWGGEKAPEYQTAEVTRGDIEVSISSAGKVAPKDTV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCE
AVGAQVSGQLTELLVEAGDLVEEGQLLARIDATIAETNVEGSRAQLLELQASRTQQQATL
EECCCCCHHHHHHHHHHCCHHHCCCEEEEHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
ELAKANADRAKMLFENDAVARADFEASQAEYAIAVGRLEAINAQITRQSSSLRALQATLE
HHHHCCCCHHHEEECCCCCEECCCCCCCCCEEEEEHHHHHHCHHEECCCHHHHHHHHHHH
FTNIYAPISGTVVSLEAVEGQTLNANQTAPTILTLADLTIMTVETDVSEADVLRVKPGQA
HHEEEECCCCCEEEEEECCCCEECCCCCCCEEEEEECEEEEEEECCCCCCCEEEECCCCC
AWFSTLGDSSRRWETSVRQILPTPEVLNDVVLYKALLDIENPENLLKPEMTAQVFFVTGS
HHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEEEECC
AKDAILVPVTALQANPPRREWSGGAGARTASAGGEREGRQGGFMQAEASEPAAAPAQDDS
CCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCH
RRKAFSEARKAYPDAEVATVLVMGPDGTPRPRPVLVGLKTRTQAEILFGLDPGQTVVTGE
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEE
VTIERPASQERDGPPRGMGPPGGMRRG
EEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]