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The map label for this gene is purL [H]

Identifier: 114797329

GI number: 114797329

Start: 2010803

End: 2013064

Strand: Direct

Name: purL [H]

Synonym: HNE_1942

Alternate gene names: 114797329

Gene position: 2010803-2013064 (Clockwise)

Preceding gene: 114798369

Following gene: 114799421

Centisome position: 54.27

GC content: 62.47

Gene sequence:

>2262_bases
ATGACCGATACTGCCGCCATTCTCTCCCATCTCACAGCCGAGCAGGACGCCGCCTCCGGTGTCGGGCACGGCATCAAGGC
CGATGAATGGGAACGCCTGGTCAGCCGCCTGGGCCGTAATCCCAATCTGGTGGAACTCGGCATCTATTCGGTGATGTGGT
CAGAGCACTGCTCCTACAAATCCTCCCGCCGCCACTTGTCGAAATTCCCGACCAAAGGCCCCCGCGTCATCCAGGGGCCG
GGCGAAAACGCCGGCGTCATCGACATCGGCGATGGCCAGGCCGCCATCTTCAAGATGGAGAGCCACAACCACCCCTCTTA
CATCGAGCCGTATCAAGGCGCGGCGACCGGCGTCGGCGGCATCCTGCGCGACGTCTTCACGATGGGCGCCCGGCCCGTTG
CCCTCGTCAACGCCCTGCGCTTCGGTGACCCCAGCCATCCGAAAACCCGCCAGCTTGTGGCAGGTGTCGTCGCTGGCATC
GGTGGCTATGGCAACTGTGTCGGCGTGCCCACCGTTGCCGGTGAAACCCAGTTCGACGAAGGCTATAACGGCAACATCCT
CGTCAATGCGATGGCTGTTGGCCTCGCCGATCAGGACAAGATCTTCTACGCCCGCGGCGCCCTGCCCGGCCTGCAGATCC
TTTATGTCGGTTCCAAGACGGGCCGCGACGGCATCCACGGCGCCACCATGGCCTCGGCAGAATTCACCGAAGGCGAGGAA
GACAACCGCCCCACGGTCCAGGTCGGCGACCCCTTCACGGAAAAACTGCTGATCGAAGCCTGCCTCGAATTGATGGCCAC
CGACGCCATCCAGTCCATCCAGGACATGGGCGCTGCTGGCCTCACCTCCTCCTCGGTCGAAATGGCTGATAAAGGCGGCG
TCGGCATCGAGATGGATCTCGACAAGGTGCCCCAGCGCGAAACCGGCATGACGGCCTATGAAATCATGCTGTCGGAAAGC
CAGGAGCGTATGCTGATGATCCTCAAGCCCGGCAAGGAAGCCGTGGCCAAGAAGATCTTCGACAAATGGGACCTCGACGC
CGAAGTGATCGGCGTGACCACAGACTCCGGACGCCTTGTACTCAAACAGTTCGGCGAAGTGGTGTGCGATATTCCGGTCG
CGCCGCTCGGCGAAGACGCGCCCAACTATGACCGTCCGTGGACGGAGCCGCCGAAACGCCCGGATTTCGACATTTCAAAA
CATCCTGCCCCGGCGAACTATGCCGAAGTGCTGACGAAGCTGATGTCGACCCCCGACATGGCCTCCAAACGCTGGGTCTG
GGAACAGTATGACCGGCACGTGATGAACGATACGATCGACTCGTCACAGTCGGGCGGCGACGCCGCTATCGTGCGCGTTC
ACGGCACCAACAAGGCCCTCGCCATCTGTTCGGACTGCAACCCCCATTACGTTGCTGCCGACCCGTATGAAGGCGGCAAG
CAGGCCGTGGCCGAAGCCTACCGCAACCTCTCCGCCGTCGGCGCCACGCCGATTGCGATCACGGACAACCTCAACTTCGG
CAACCCCGAAAAGCCCGCCACAATGGGCTATATCGTCAAGGCCATCGAAGGCATGGCCGAAGCGTGCCGGGTGCTGAACT
TCCCGGTCGTCTCGGGCAACGTCTCGCTCTACAACGAGACCGATGGCAAGGCCATTCCGCCCACCCCCGTCGTCGGCGGC
GTCGGCCTGATCGACGACCTCTCCAAAATTGCCACCCTGAAAGGCGCCCAGCCGGGCGACGCGCTGATTATCATTGGCGA
AAACGCAGCTGACTTTGGCGCCTCGCTCTATGCCCGCAAATGGCTTGGCCTGAAGGGCGACGACCTCGGCCCGCCCCCGC
CGGTTGATCTCGAAGACGAAATCCAGACCTCGGCCATCGTCCGCGAGCTGATTGCCAAGGGACTGGTCCACGCAGTCCAC
GACATCAGCGATGGCGGCCTGGCAGTCGCCGCTGCTGAAATGGCGCTGGCCGGCAATGTCGGCATCATGCTCGACGCGCA
GGCCGACCGCCTAGGCAGCCTCAGCCCACTGGCATACCTCTTCAGCGAAACGCAGGGCCGCTACCTCGTTGCCGCAAAGA
ATGAAGACGAAGTGTTCGACCTGCTCGGCGACATCCCGGCCCTCTTTGCAGGCACAGTGGAAAATACCGGCGCCATCACC
TTGATCCATGATCTGCGCAAGAGCGAAAAAACTGTCCTGCCGCTGCAGGATCTCCGCGCAGCCCATGAAGGCTGGCTGCC
CGGCTACATGAACGCTGTTTGA

Upstream 100 bases:

>100_bases
TTCCCTGCCCTCGCATGCTGCGCTGGATGCGTTGCTGGCAGTTGAACAGCCGGGCAAACCGGCCTAGCGCTGCGCCAAAT
CTCAAACACGGGCTGATGTG

Downstream 100 bases:

>100_bases
AGCATCACACAAATGACGCCCCCTCCCGGATAAGCGGAAGGGGGCGCCCTTTTGTCAGCTAAGCCTGATCAGGATCTGAT
TAGAACTTGTAGCCAACACC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MTDTAAILSHLTAEQDAASGVGHGIKADEWERLVSRLGRNPNLVELGIYSVMWSEHCSYKSSRRHLSKFPTKGPRVIQGP
GENAGVIDIGDGQAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVALVNALRFGDPSHPKTRQLVAGVVAGI
GGYGNCVGVPTVAGETQFDEGYNGNILVNAMAVGLADQDKIFYARGALPGLQILYVGSKTGRDGIHGATMASAEFTEGEE
DNRPTVQVGDPFTEKLLIEACLELMATDAIQSIQDMGAAGLTSSSVEMADKGGVGIEMDLDKVPQRETGMTAYEIMLSES
QERMLMILKPGKEAVAKKIFDKWDLDAEVIGVTTDSGRLVLKQFGEVVCDIPVAPLGEDAPNYDRPWTEPPKRPDFDISK
HPAPANYAEVLTKLMSTPDMASKRWVWEQYDRHVMNDTIDSSQSGGDAAIVRVHGTNKALAICSDCNPHYVAADPYEGGK
QAVAEAYRNLSAVGATPIAITDNLNFGNPEKPATMGYIVKAIEGMAEACRVLNFPVVSGNVSLYNETDGKAIPPTPVVGG
VGLIDDLSKIATLKGAQPGDALIIIGENAADFGASLYARKWLGLKGDDLGPPPPVDLEDEIQTSAIVRELIAKGLVHAVH
DISDGGLAVAAAEMALAGNVGIMLDAQADRLGSLSPLAYLFSETQGRYLVAAKNEDEVFDLLGDIPALFAGTVENTGAIT
LIHDLRKSEKTVLPLQDLRAAHEGWLPGYMNAV

Sequences:

>Translated_753_residues
MTDTAAILSHLTAEQDAASGVGHGIKADEWERLVSRLGRNPNLVELGIYSVMWSEHCSYKSSRRHLSKFPTKGPRVIQGP
GENAGVIDIGDGQAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVALVNALRFGDPSHPKTRQLVAGVVAGI
GGYGNCVGVPTVAGETQFDEGYNGNILVNAMAVGLADQDKIFYARGALPGLQILYVGSKTGRDGIHGATMASAEFTEGEE
DNRPTVQVGDPFTEKLLIEACLELMATDAIQSIQDMGAAGLTSSSVEMADKGGVGIEMDLDKVPQRETGMTAYEIMLSES
QERMLMILKPGKEAVAKKIFDKWDLDAEVIGVTTDSGRLVLKQFGEVVCDIPVAPLGEDAPNYDRPWTEPPKRPDFDISK
HPAPANYAEVLTKLMSTPDMASKRWVWEQYDRHVMNDTIDSSQSGGDAAIVRVHGTNKALAICSDCNPHYVAADPYEGGK
QAVAEAYRNLSAVGATPIAITDNLNFGNPEKPATMGYIVKAIEGMAEACRVLNFPVVSGNVSLYNETDGKAIPPTPVVGG
VGLIDDLSKIATLKGAQPGDALIIIGENAADFGASLYARKWLGLKGDDLGPPPPVDLEDEIQTSAIVRELIAKGLVHAVH
DISDGGLAVAAAEMALAGNVGIMLDAQADRLGSLSPLAYLFSETQGRYLVAAKNEDEVFDLLGDIPALFAGTVENTGAIT
LIHDLRKSEKTVLPLQDLRAAHEGWLPGYMNAV
>Mature_752_residues
TDTAAILSHLTAEQDAASGVGHGIKADEWERLVSRLGRNPNLVELGIYSVMWSEHCSYKSSRRHLSKFPTKGPRVIQGPG
ENAGVIDIGDGQAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVALVNALRFGDPSHPKTRQLVAGVVAGIG
GYGNCVGVPTVAGETQFDEGYNGNILVNAMAVGLADQDKIFYARGALPGLQILYVGSKTGRDGIHGATMASAEFTEGEED
NRPTVQVGDPFTEKLLIEACLELMATDAIQSIQDMGAAGLTSSSVEMADKGGVGIEMDLDKVPQRETGMTAYEIMLSESQ
ERMLMILKPGKEAVAKKIFDKWDLDAEVIGVTTDSGRLVLKQFGEVVCDIPVAPLGEDAPNYDRPWTEPPKRPDFDISKH
PAPANYAEVLTKLMSTPDMASKRWVWEQYDRHVMNDTIDSSQSGGDAAIVRVHGTNKALAICSDCNPHYVAADPYEGGKQ
AVAEAYRNLSAVGATPIAITDNLNFGNPEKPATMGYIVKAIEGMAEACRVLNFPVVSGNVSLYNETDGKAIPPTPVVGGV
GLIDDLSKIATLKGAQPGDALIIIGENAADFGASLYARKWLGLKGDDLGPPPPVDLEDEIQTSAIVRELIAKGLVHAVHD
ISDGGLAVAAAEMALAGNVGIMLDAQADRLGSLSPLAYLFSETQGRYLVAAKNEDEVFDLLGDIPALFAGTVENTGAITL
IHDLRKSEKTVLPLQDLRAAHEGWLPGYMNAV

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=669, Percent_Identity=27.0553064275037, Blast_Score=109, Evalue=1e-23,
Organism=Escherichia coli, GI48994899, Length=779, Percent_Identity=26.0590500641849, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321498, Length=793, Percent_Identity=23.9596469104666, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24582111, Length=750, Percent_Identity=26.1333333333333, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24582109, Length=750, Percent_Identity=26.1333333333333, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17137292, Length=750, Percent_Identity=26.1333333333333, Blast_Score=116, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80141; Mature: 80009

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTAAILSHLTAEQDAASGVGHGIKADEWERLVSRLGRNPNLVELGIYSVMWSEHCSYK
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCHH
SSRRHLSKFPTKGPRVIQGPGENAGVIDIGDGQAAIFKMESHNHPSYIEPYQGAATGVGG
HHHHHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHH
ILRDVFTMGARPVALVNALRFGDPSHPKTRQLVAGVVAGIGGYGNCVGVPTVAGETQFDE
HHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GYNGNILVNAMAVGLADQDKIFYARGALPGLQILYVGSKTGRDGIHGATMASAEFTEGEE
CCCCCEEEEEEEECCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCC
DNRPTVQVGDPFTEKLLIEACLELMATDAIQSIQDMGAAGLTSSSVEMADKGGVGIEMDL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEECH
DKVPQRETGMTAYEIMLSESQERMLMILKPGKEAVAKKIFDKWDLDAEVIGVTTDSGRLV
HHCCCCCCCCEEEEHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCHH
LKQFGEVVCDIPVAPLGEDAPNYDRPWTEPPKRPDFDISKHPAPANYAEVLTKLMSTPDM
HHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
ASKRWVWEQYDRHVMNDTIDSSQSGGDAAIVRVHGTNKALAICSDCNPHYVAADPYEGGK
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCEEECCCCCCHH
QAVAEAYRNLSAVGATPIAITDNLNFGNPEKPATMGYIVKAIEGMAEACRVLNFPVVSGN
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
VSLYNETDGKAIPPTPVVGGVGLIDDLSKIATLKGAQPGDALIIIGENAADFGASLYARK
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHH
WLGLKGDDLGPPPPVDLEDEIQTSAIVRELIAKGLVHAVHDISDGGLAVAAAEMALAGNV
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCC
GIMLDAQADRLGSLSPLAYLFSETQGRYLVAAKNEDEVFDLLGDIPALFAGTVENTGAIT
EEEEECCHHHCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHCHHHHHHCCCCCCCCEE
LIHDLRKSEKTVLPLQDLRAAHEGWLPGYMNAV
EEEHHHHCCCCCCCHHHHHHHHCCCCCCHHCCC
>Mature Secondary Structure 
TDTAAILSHLTAEQDAASGVGHGIKADEWERLVSRLGRNPNLVELGIYSVMWSEHCSYK
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCHH
SSRRHLSKFPTKGPRVIQGPGENAGVIDIGDGQAAIFKMESHNHPSYIEPYQGAATGVGG
HHHHHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHH
ILRDVFTMGARPVALVNALRFGDPSHPKTRQLVAGVVAGIGGYGNCVGVPTVAGETQFDE
HHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GYNGNILVNAMAVGLADQDKIFYARGALPGLQILYVGSKTGRDGIHGATMASAEFTEGEE
CCCCCEEEEEEEECCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCC
DNRPTVQVGDPFTEKLLIEACLELMATDAIQSIQDMGAAGLTSSSVEMADKGGVGIEMDL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEECH
DKVPQRETGMTAYEIMLSESQERMLMILKPGKEAVAKKIFDKWDLDAEVIGVTTDSGRLV
HHCCCCCCCCEEEEHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCHH
LKQFGEVVCDIPVAPLGEDAPNYDRPWTEPPKRPDFDISKHPAPANYAEVLTKLMSTPDM
HHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
ASKRWVWEQYDRHVMNDTIDSSQSGGDAAIVRVHGTNKALAICSDCNPHYVAADPYEGGK
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCEEECCCCCCHH
QAVAEAYRNLSAVGATPIAITDNLNFGNPEKPATMGYIVKAIEGMAEACRVLNFPVVSGN
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
VSLYNETDGKAIPPTPVVGGVGLIDDLSKIATLKGAQPGDALIIIGENAADFGASLYARK
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHH
WLGLKGDDLGPPPPVDLEDEIQTSAIVRELIAKGLVHAVHDISDGGLAVAAAEMALAGNV
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCC
GIMLDAQADRLGSLSPLAYLFSETQGRYLVAAKNEDEVFDLLGDIPALFAGTVENTGAIT
EEEEECCHHHCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHCHHHHHHCCCCCCCCEE
LIHDLRKSEKTVLPLQDLRAAHEGWLPGYMNAV
EEEHHHHCCCCCCCHHHHHHHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]