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The map label for this gene is aas [H]

Identifier: 114797277

GI number: 114797277

Start: 2098134

End: 2099720

Strand: Direct

Name: aas [H]

Synonym: HNE_2022

Alternate gene names: 114797277

Gene position: 2098134-2099720 (Clockwise)

Preceding gene: 114798090

Following gene: 114799904

Centisome position: 56.63

GC content: 62.82

Gene sequence:

>1587_bases
ATGCAGCAATCGATCCAGCCACTGGTGCCCGCACCGCTTGCCTACAAGCCGCAGCGCACCCGCACGGACCTGTTTTCCGC
GCTGCTTCGCGCCTCACGCGAGTTTGGCGGCGGCAAGACGATTGTGGTGGACGGCGACGAGCGGGCGCTGACCTATAAGG
AAATCATCCGGGCGGCTTTCGGGCTGGGCTCGGCGCTGAAAAAAGGCACCAGGAAAGGCGAGGCGGTGGCCATCATGCTG
CCGACCGGCGTGGGCGCGGTGATCGCGTTTTATGCCGTCAGCGCGTTCGGGCGCGTGCCGGCGATGCTGAATTTTACCGC
TGGCTCGAAAAACCTGAAGGCGGCGATGAAGGCCGCCAAGGTGAAGCGGATCATCACGGCGCACAAATTTGTGGAACTGG
GCGGGCTGGAGACGCTGATCGAGGATCTCTCGAAGGTTGCCGAGATCATCTATCTTGAGGATGTGCGGGAGAATCTGTCG
CTCGGCAACAAGCTGACGGCGGTGGCCGGGACGCTGCTGCCGGGGCTGGTGGCGGCGGGGCCGAGCCACAAGAAGCCGGC
CGTGATCCTGTTCACATCCGGCACCGAGGGCGAGCCCAAGGGCGTTGTGCTGAGCCATGAGAATGTGATGGCGAATGTCG
AGCAGGTGCGCGCGCATATCGGGCTTGGTCCTGATACGGATGTACTGTTCAATCCGCTGCCGATGTTTCACTGTTTCGGG
CTGACCGTGGGCGCGATCCTGCCTATTGTGGCGGGCATCAAGGTGTTCTTTCACCCCTCCCCGCTTCAGCCCAAGGAAAT
CGTGCGCCGGATCAGCGAGCACAAGCCCACGATCATGCTGGCGACCGATACGTTCATTTCGCAATATGCGCGGACGGCGG
AAGACGGCGATCTCAGTTCCATTCGCCTCGCTGTTTGCGGCGCAGAGCGGGTGAAGGATGAGACGCGGGCTTATGTTCGC
CGGAAGTTTGATATCGAGATTCTGGAAGGATATGGCGCGACCGAAGCGTCACCCGTGGTGGCGGCCAATCAGTGGGAAGA
TAACCGTCCGGGTACGGTTGGGAAGCTGATGTCGGATATGGAATCGCGGCTGGTGCCGGTGGAGGGCATGCCCGAGGGCG
GGAAGCTGCATATTCGCGGGCCCAACATCATGCTGGGTTATCTGCGCCCGTCCAATCCCGGCGTGATCGAGAAGCTGATC
GATGGCTGGCATGATACCGGCGACATCGTGACCGTGGACGAGGACGGGTTCATCCGCATCATGGGCCGCGTGAAGCGCTT
TGCGAAGATTGGCGGGGAGATGGTGTCGCTCGCCGTGGTGGAGAATTGCGCGGCGGCTGTGTGGCCGGACAATATGCATG
CGGCGGTTACCCTGCCCGACCCGAAGAAGGGCGAGCAGGTGATCCTGCTGACCGACGCGCCGGAAGCGACGCGGGAGCCG
ATCCTGAGCTGGGCAAAGCAGCATGGCGTGCCGGAGATTTCCGTTCCGCGCCGGGTGTTCCGTGTGGCCGAGATCCCCGT
GCTGGGGACGGGCAAGGTGGATTATGGCGCCGTGGGGATTGCGGCCGAGCGGCTGATGAACGACTGA

Upstream 100 bases:

>100_bases
GGAGGTGGGGCGCACTGGCAATATCTGTTGCAGATATGACGCAACATGACAGAATATTACAAAATTCGGCTCAAGCCGGT
ATGATTCAGGGCGGAAACCT

Downstream 100 bases:

>100_bases
GCGCGGCTCAGGCGGCGTTGCTCAGCGGCGCCGCGTTTTCCTCATCCATGAATTCGCGGATCAGCGCGCCGGTTTCCTCG
GCGCGGGTGACGAGGAAGAG

Product: 2-acylglycerophosphoethanolamine acyltransferase/acyl-[acyl-carrier-protein] synthetase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MQQSIQPLVPAPLAYKPQRTRTDLFSALLRASREFGGGKTIVVDGDERALTYKEIIRAAFGLGSALKKGTRKGEAVAIML
PTGVGAVIAFYAVSAFGRVPAMLNFTAGSKNLKAAMKAAKVKRIITAHKFVELGGLETLIEDLSKVAEIIYLEDVRENLS
LGNKLTAVAGTLLPGLVAAGPSHKKPAVILFTSGTEGEPKGVVLSHENVMANVEQVRAHIGLGPDTDVLFNPLPMFHCFG
LTVGAILPIVAGIKVFFHPSPLQPKEIVRRISEHKPTIMLATDTFISQYARTAEDGDLSSIRLAVCGAERVKDETRAYVR
RKFDIEILEGYGATEASPVVAANQWEDNRPGTVGKLMSDMESRLVPVEGMPEGGKLHIRGPNIMLGYLRPSNPGVIEKLI
DGWHDTGDIVTVDEDGFIRIMGRVKRFAKIGGEMVSLAVVENCAAAVWPDNMHAAVTLPDPKKGEQVILLTDAPEATREP
ILSWAKQHGVPEISVPRRVFRVAEIPVLGTGKVDYGAVGIAAERLMND

Sequences:

>Translated_528_residues
MQQSIQPLVPAPLAYKPQRTRTDLFSALLRASREFGGGKTIVVDGDERALTYKEIIRAAFGLGSALKKGTRKGEAVAIML
PTGVGAVIAFYAVSAFGRVPAMLNFTAGSKNLKAAMKAAKVKRIITAHKFVELGGLETLIEDLSKVAEIIYLEDVRENLS
LGNKLTAVAGTLLPGLVAAGPSHKKPAVILFTSGTEGEPKGVVLSHENVMANVEQVRAHIGLGPDTDVLFNPLPMFHCFG
LTVGAILPIVAGIKVFFHPSPLQPKEIVRRISEHKPTIMLATDTFISQYARTAEDGDLSSIRLAVCGAERVKDETRAYVR
RKFDIEILEGYGATEASPVVAANQWEDNRPGTVGKLMSDMESRLVPVEGMPEGGKLHIRGPNIMLGYLRPSNPGVIEKLI
DGWHDTGDIVTVDEDGFIRIMGRVKRFAKIGGEMVSLAVVENCAAAVWPDNMHAAVTLPDPKKGEQVILLTDAPEATREP
ILSWAKQHGVPEISVPRRVFRVAEIPVLGTGKVDYGAVGIAAERLMND
>Mature_528_residues
MQQSIQPLVPAPLAYKPQRTRTDLFSALLRASREFGGGKTIVVDGDERALTYKEIIRAAFGLGSALKKGTRKGEAVAIML
PTGVGAVIAFYAVSAFGRVPAMLNFTAGSKNLKAAMKAAKVKRIITAHKFVELGGLETLIEDLSKVAEIIYLEDVRENLS
LGNKLTAVAGTLLPGLVAAGPSHKKPAVILFTSGTEGEPKGVVLSHENVMANVEQVRAHIGLGPDTDVLFNPLPMFHCFG
LTVGAILPIVAGIKVFFHPSPLQPKEIVRRISEHKPTIMLATDTFISQYARTAEDGDLSSIRLAVCGAERVKDETRAYVR
RKFDIEILEGYGATEASPVVAANQWEDNRPGTVGKLMSDMESRLVPVEGMPEGGKLHIRGPNIMLGYLRPSNPGVIEKLI
DGWHDTGDIVTVDEDGFIRIMGRVKRFAKIGGEMVSLAVVENCAAAVWPDNMHAAVTLPDPKKGEQVILLTDAPEATREP
ILSWAKQHGVPEISVPRRVFRVAEIPVLGTGKVDYGAVGIAAERLMND

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=538, Percent_Identity=25.4646840148699, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI187761345, Length=547, Percent_Identity=23.217550274223, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI187761343, Length=547, Percent_Identity=23.217550274223, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38505220, Length=505, Percent_Identity=25.3465346534653, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI42544132, Length=499, Percent_Identity=23.4468937875752, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI227499619, Length=333, Percent_Identity=24.024024024024, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789201, Length=520, Percent_Identity=41.7307692307692, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1788107, Length=509, Percent_Identity=24.950884086444, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI145693145, Length=496, Percent_Identity=25.2016129032258, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1786810, Length=506, Percent_Identity=23.9130434782609, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI221142682, Length=465, Percent_Identity=22.7956989247312, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560308, Length=512, Percent_Identity=25.390625, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=521, Percent_Identity=26.1036468330134, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71994703, Length=510, Percent_Identity=25.0980392156863, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71994694, Length=510, Percent_Identity=25.0980392156863, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71994690, Length=511, Percent_Identity=25.2446183953033, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=329, Percent_Identity=27.0516717325228, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=481, Percent_Identity=23.4927234927235, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17538037, Length=312, Percent_Identity=28.525641025641, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17507435, Length=470, Percent_Identity=24.2553191489362, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17557194, Length=311, Percent_Identity=24.7588424437299, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=272, Percent_Identity=25, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531443, Length=273, Percent_Identity=25.2747252747253, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=493, Percent_Identity=24.3407707910751, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320852, Length=421, Percent_Identity=26.8408551068884, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18859661, Length=503, Percent_Identity=27.037773359841, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355181, Length=551, Percent_Identity=24.3194192377495, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24581924, Length=549, Percent_Identity=24.0437158469945, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI62471679, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62471683, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62471685, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24586636, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62471689, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62471681, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI62471687, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24586634, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI22026970, Length=472, Percent_Identity=23.5169491525424, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356441, Length=286, Percent_Identity=26.5734265734266, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281365686, Length=288, Percent_Identity=23.9583333333333, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 56921; Mature: 56921

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQSIQPLVPAPLAYKPQRTRTDLFSALLRASREFGGGKTIVVDGDERALTYKEIIRAAF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
GLGSALKKGTRKGEAVAIMLPTGVGAVIAFYAVSAFGRVPAMLNFTAGSKNLKAAMKAAK
CCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
VKRIITAHKFVELGGLETLIEDLSKVAEIIYLEDVRENLSLGNKLTAVAGTLLPGLVAAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
PSHKKPAVILFTSGTEGEPKGVVLSHENVMANVEQVRAHIGLGPDTDVLFNPLPMFHCFG
CCCCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHH
LTVGAILPIVAGIKVFFHPSPLQPKEIVRRISEHKPTIMLATDTFISQYARTAEDGDLSS
HHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHCCCCCCCCE
IRLAVCGAERVKDETRAYVRRKFDIEILEGYGATEASPVVAANQWEDNRPGTVGKLMSDM
EEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCHHHHHHHHH
ESRLVPVEGMPEGGKLHIRGPNIMLGYLRPSNPGVIEKLIDGWHDTGDIVTVDEDGFIRI
HHCEECCCCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHCCCCCCCCEEEECCCCHHHH
MGRVKRFAKIGGEMVSLAVVENCAAAVWPDNMHAAVTLPDPKKGEQVILLTDAPEATREP
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHH
ILSWAKQHGVPEISVPRRVFRVAEIPVLGTGKVDYGAVGIAAERLMND
HHHHHHHCCCCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQQSIQPLVPAPLAYKPQRTRTDLFSALLRASREFGGGKTIVVDGDERALTYKEIIRAAF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
GLGSALKKGTRKGEAVAIMLPTGVGAVIAFYAVSAFGRVPAMLNFTAGSKNLKAAMKAAK
CCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
VKRIITAHKFVELGGLETLIEDLSKVAEIIYLEDVRENLSLGNKLTAVAGTLLPGLVAAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
PSHKKPAVILFTSGTEGEPKGVVLSHENVMANVEQVRAHIGLGPDTDVLFNPLPMFHCFG
CCCCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHH
LTVGAILPIVAGIKVFFHPSPLQPKEIVRRISEHKPTIMLATDTFISQYARTAEDGDLSS
HHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHCCCCCCCCE
IRLAVCGAERVKDETRAYVRRKFDIEILEGYGATEASPVVAANQWEDNRPGTVGKLMSDM
EEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCHHHHHHHHH
ESRLVPVEGMPEGGKLHIRGPNIMLGYLRPSNPGVIEKLIDGWHDTGDIVTVDEDGFIRI
HHCEECCCCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHCCCCCCCCEEEECCCCHHHH
MGRVKRFAKIGGEMVSLAVVENCAAAVWPDNMHAAVTLPDPKKGEQVILLTDAPEATREP
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHH
ILSWAKQHGVPEISVPRRVFRVAEIPVLGTGKVDYGAVGIAAERLMND
HHHHHHHCCCCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA