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The map label for this gene is phoQ [H]

Identifier: 114797185

GI number: 114797185

Start: 1339492

End: 1340919

Strand: Direct

Name: phoQ [H]

Synonym: HNE_1307

Alternate gene names: 114797185

Gene position: 1339492-1340919 (Clockwise)

Preceding gene: 114797709

Following gene: 114799426

Centisome position: 36.15

GC content: 64.78

Gene sequence:

>1428_bases
ATGAGTGAGGCCCCACACCCCAAACGTAGTTTGATTGACCGCTGGTCCAGCGTCTCGCTGGCCCGGCGTGTCATGATTGC
GGCGGCGATCTGGGGCTTTGTGGTGTTGATCGGGGGGGCGCTGGCGCTGTCGGCGCTTTACCGGGCGCAGACGCTGTCGC
TGATTGAGGACGATCTGGGGCAGACGCTGGTGACGCTTTCCAGAGAGCTGACGCGGGAAGACGCCTTTCTGGCCGATGGG
CGGGTGACCGATACCGACCGGAATTTCTTCTCCAATGATGCGCGCTTTCAGACGCAGTATTCCGGCCATTACTGGGCGGT
GGTGGGCCTGACGCCGGAGATGGAGGTTGCCGGGGATTTCCGCTCGCGCAGCCTTTGGGATGAAGCGGTGCCGGTGACGC
CGGAGCTGATCGAGCGGGCGGTGGTGTTGCCGGGCGTTACGCAGTACGCCAACTATCCGGGGCCGCTGGATCAGGTATCG
CGCGTGGCGGCGATGGCGGTGATCGTCGAAAACCGGGATACGCCGCTGGTGCTGGTGGCGGCCGCCGACCGCACACCGAA
CGATGAGGCGGCGACAGGCTTTCGCAATATGCTTCTTGGCACCATGATTGCGCTGTTTGGCGGGGTGTTTGCGGCGATGA
TGATTGCTGTGCGCTACTCGCTGAACCCGCTGCACAAGCTGGAAGCCGATGTCGCGAAAGTGCGCGGGGGCGAGACGGTG
AAGCTGGCGGGGGATTATCCGGCAGAGGTTCGTCCGCTGACGGAGGAGCTGAACAAGCTGATCGAGCACAACCGGGAAGT
GGTGGAGCGGGCGCGCACACATGTGGGCAATCTGGCCCATGCGCTGAAGACGCCGCTGGCGGTGCTGCGCAATGAAGCCA
AGGGCGGCTCCCAGCTGGATGATGTCGTGCGCCGGCAGGCCGAGGCGATGCAGACCAATGTGGAGCATTATCTGAAGCGG
GCGCGGATGGCGGCGCGGGCCGAGGCGATTGGCGCGCGCACGGATGTGCGCCCCGTGCTCGACGGGCTGGCGCGGATGCT
GAACCGGCTGTTTGATGCGCGCGGAATTGATGTGACGGTTGCCGGCGCGCAGAGCGCGGTTTTCCGCGGCGAGCAGCAGG
ACTTTGAGGAGATGGCGGGCAACCTGATGGAAAACGCCTGCAAATGGGCGGCCAGCGAGGTGCTGGTATCGGTGAGTGAC
AGTCCGCAGGAGCTGGTCATCACGGTGGAAGATGACGGGCCGGGCCTGACGCCGGAGCAGCGGGCGGGCGCGATGAAGCG
CGGGGTGCGGCTAGATGAAACAACGCCGGGGACTGGGCTGGGGCTGTCGATTGTTACAGAACTGGCGGAGCTGCATAAGG
GCAGCCTTGAACTCGGCGACGCTGCGCTTGGCGGCCTGAAGGCTACTTTGAGATTTCCCCGGCCATGA

Upstream 100 bases:

>100_bases
GACCGTATCCAGACCGAACGCGGCCTTGGCTATCGCCTGATCGTGCCAGAGGACGAAGCGCGCGTTGCGGGCTGATACCG
AACGCGGCTAGATCGCCTCC

Downstream 100 bases:

>100_bases
AACATCTGAACCTCATTATTCTTGGGCTTTGTCTTGTGCTTGGCGCGGGCGGGTATCTGTTGATCGGCAAGCCGGGCATG
GCCGACCAGCCGATGGAGAC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSEAPHPKRSLIDRWSSVSLARRVMIAAAIWGFVVLIGGALALSALYRAQTLSLIEDDLGQTLVTLSRELTREDAFLADG
RVTDTDRNFFSNDARFQTQYSGHYWAVVGLTPEMEVAGDFRSRSLWDEAVPVTPELIERAVVLPGVTQYANYPGPLDQVS
RVAAMAVIVENRDTPLVLVAAADRTPNDEAATGFRNMLLGTMIALFGGVFAAMMIAVRYSLNPLHKLEADVAKVRGGETV
KLAGDYPAEVRPLTEELNKLIEHNREVVERARTHVGNLAHALKTPLAVLRNEAKGGSQLDDVVRRQAEAMQTNVEHYLKR
ARMAARAEAIGARTDVRPVLDGLARMLNRLFDARGIDVTVAGAQSAVFRGEQQDFEEMAGNLMENACKWAASEVLVSVSD
SPQELVITVEDDGPGLTPEQRAGAMKRGVRLDETTPGTGLGLSIVTELAELHKGSLELGDAALGGLKATLRFPRP

Sequences:

>Translated_475_residues
MSEAPHPKRSLIDRWSSVSLARRVMIAAAIWGFVVLIGGALALSALYRAQTLSLIEDDLGQTLVTLSRELTREDAFLADG
RVTDTDRNFFSNDARFQTQYSGHYWAVVGLTPEMEVAGDFRSRSLWDEAVPVTPELIERAVVLPGVTQYANYPGPLDQVS
RVAAMAVIVENRDTPLVLVAAADRTPNDEAATGFRNMLLGTMIALFGGVFAAMMIAVRYSLNPLHKLEADVAKVRGGETV
KLAGDYPAEVRPLTEELNKLIEHNREVVERARTHVGNLAHALKTPLAVLRNEAKGGSQLDDVVRRQAEAMQTNVEHYLKR
ARMAARAEAIGARTDVRPVLDGLARMLNRLFDARGIDVTVAGAQSAVFRGEQQDFEEMAGNLMENACKWAASEVLVSVSD
SPQELVITVEDDGPGLTPEQRAGAMKRGVRLDETTPGTGLGLSIVTELAELHKGSLELGDAALGGLKATLRFPRP
>Mature_474_residues
SEAPHPKRSLIDRWSSVSLARRVMIAAAIWGFVVLIGGALALSALYRAQTLSLIEDDLGQTLVTLSRELTREDAFLADGR
VTDTDRNFFSNDARFQTQYSGHYWAVVGLTPEMEVAGDFRSRSLWDEAVPVTPELIERAVVLPGVTQYANYPGPLDQVSR
VAAMAVIVENRDTPLVLVAAADRTPNDEAATGFRNMLLGTMIALFGGVFAAMMIAVRYSLNPLHKLEADVAKVRGGETVK
LAGDYPAEVRPLTEELNKLIEHNREVVERARTHVGNLAHALKTPLAVLRNEAKGGSQLDDVVRRQAEAMQTNVEHYLKRA
RMAARAEAIGARTDVRPVLDGLARMLNRLFDARGIDVTVAGAQSAVFRGEQQDFEEMAGNLMENACKWAASEVLVSVSDS
PQELVITVEDDGPGLTPEQRAGAMKRGVRLDETTPGTGLGLSIVTELAELHKGSLELGDAALGGLKATLRFPRP

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=273, Percent_Identity=32.2344322344322, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1789403, Length=275, Percent_Identity=29.0909090909091, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789808, Length=326, Percent_Identity=25.7668711656442, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788393, Length=365, Percent_Identity=22.4657534246575, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790346, Length=242, Percent_Identity=24.7933884297521, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=278, Percent_Identity=24.4604316546763, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790551, Length=281, Percent_Identity=26.6903914590747, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51627; Mature: 51495

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAPHPKRSLIDRWSSVSLARRVMIAAAIWGFVVLIGGALALSALYRAQTLSLIEDDLG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLVTLSRELTREDAFLADGRVTDTDRNFFSNDARFQTQYSGHYWAVVGLTPEMEVAGDF
HHHHHHHHHHHHHHHHEECCCCCCCCCCHHCCCCCEEEEECCEEEEEEECCCCHHHCCCH
RSRSLWDEAVPVTPELIERAVVLPGVTQYANYPGPLDQVSRVAAMAVIVENRDTPLVLVA
HHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHEECCCCCEEEEE
AADRTPNDEAATGFRNMLLGTMIALFGGVFAAMMIAVRYSLNPLHKLEADVAKVRGGETV
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
KLAGDYPAEVRPLTEELNKLIEHNREVVERARTHVGNLAHALKTPLAVLRNEAKGGSQLD
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
DVVRRQAEAMQTNVEHYLKRARMAARAEAIGARTDVRPVLDGLARMLNRLFDARGIDVTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
AGAQSAVFRGEQQDFEEMAGNLMENACKWAASEVLVSVSDSPQELVITVEDDGPGLTPEQ
ECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCCCCCCHH
RAGAMKRGVRLDETTPGTGLGLSIVTELAELHKGSLELGDAALGGLKATLRFPRP
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHEECCCCC
>Mature Secondary Structure 
SEAPHPKRSLIDRWSSVSLARRVMIAAAIWGFVVLIGGALALSALYRAQTLSLIEDDLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLVTLSRELTREDAFLADGRVTDTDRNFFSNDARFQTQYSGHYWAVVGLTPEMEVAGDF
HHHHHHHHHHHHHHHHEECCCCCCCCCCHHCCCCCEEEEECCEEEEEEECCCCHHHCCCH
RSRSLWDEAVPVTPELIERAVVLPGVTQYANYPGPLDQVSRVAAMAVIVENRDTPLVLVA
HHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHEECCCCCEEEEE
AADRTPNDEAATGFRNMLLGTMIALFGGVFAAMMIAVRYSLNPLHKLEADVAKVRGGETV
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
KLAGDYPAEVRPLTEELNKLIEHNREVVERARTHVGNLAHALKTPLAVLRNEAKGGSQLD
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
DVVRRQAEAMQTNVEHYLKRARMAARAEAIGARTDVRPVLDGLARMLNRLFDARGIDVTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
AGAQSAVFRGEQQDFEEMAGNLMENACKWAASEVLVSVSDSPQELVITVEDDGPGLTPEQ
ECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCCCCCCHH
RAGAMKRGVRLDETTPGTGLGLSIVTELAELHKGSLELGDAALGGLKATLRFPRP
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA