Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 114797176

GI number: 114797176

Start: 1853924

End: 1855504

Strand: Direct

Name: guaA [H]

Synonym: HNE_1808

Alternate gene names: 114797176

Gene position: 1853924-1855504 (Clockwise)

Preceding gene: 114798023

Following gene: 114800128

Centisome position: 50.04

GC content: 59.65

Gene sequence:

>1581_bases
ATGACACAGCAAGCCGATTCCGTCCTTAAAGCTCATGAGCGCGTCCTGATTGTCGACTTTGGCAGTCAGGTGACCCAGTT
GATCGCCCGGCGCCTGCGCGAAAGCGGCGTTTATTGCGAGATACACCCTTTCAACAAGGTCGACGGCGCGTTCTTGGCTG
CCTTCGGGCCGCAGGCCCTCATCCTGTCGGGAGGCCCCGCCAGCGTCACCTGGAAAGACGCGCCCCTCGCGGATCAGGCA
ATTTTCGACAGCGGCCTGCCGATTCTCGGCATCTGCTATGGCCAACAGGTCATGATGCACCAGCTCGGTGGCAAGGTAGA
AAGCGGAACCAGCCGGGAGTTTGGCCGCGCCTTCATCGAGCAGGTGGAGGCCGACCCAATTCTGGAAGGTCTGTTCGAGG
GCGATAATTCAGAGCAGGTCTGGATGAGCCATGGCGATCACGTCGCCGAAATGGCGCCCGGCTTTGGCGTAATCGCCAGA
TCCCCCGGCGCGCCCTATGCGGTCATTGCTGATCCCGAACGGAAATTCTACGGCACGCAGTTTCATCCCGAGGTCGTCCA
CACAACCCACGGCGCGCGCCTGCTCAGAAACTTCACGCACGGCGTGGCAGGCCTCAAGGGCGACTGGACGATGGCAGCTT
ACCGCGCCGAGGCGATCCAGAAAATCCGTAATCAGGTGGGCAAGGGCAGGGTGATCTGCGGTCTCTCCGGCGGCGTGGAT
TCGTCCGTAGCCGCCGTACTCATCCATGAAGCGATCGGGGATCAGCTGACCTGCGTTTATGTTGACCACGGACTGATGCG
TGCTGGCGAAAGCGAGCAGGTCGTCAGCCTCTTCCGTGAGCACTATAACATTCCATTGGTGCACGTTGACGCTTCCGAAT
TGTTCTTGGGTCAGCTCGACGGCGTCACGGACCCTGAAAAAAAGCGCAAGATCATCGGCGGCCTCTTTATCGATGTGTTC
GATGCCGAAGCCAACAAGATCGGCGGCGCGGATTTCCTTGCGCAAGGCACTCTGTATCCGGACGTCATCGAAAGCGTATC
TGCCATCGGCGGCCCGTCCGTGACGATCAAAAGCCACCACAATGTCGGCGGCCTTCCGGCGCGAATGAAAATGAAACTGG
TCGAACCGCTGCGCGAGTTGTTCAAGGATGAGGTGCGCGCGCTCGGCCGCGAACTTGGCCTGCCGGAGGCCTTCGTTGGG
CGCCATCCATTCCCCGGCCCAGGGCTTGCCATCCGCATTCCCGGTGCCATCACTCGGGAAAAAGCAGACACGCTCCGAAA
GGCAGATGCCATCTATATCGACGAGATCCGCAAGGCTGGTCTTTACGATGAAATCTGGCAGGCATTCAGCGTTCTGCTTC
CGGTAAACACCGTGGGTGTCATGGGGGACGAACGCACCTACGAAGCCGTACTCGCCCTTCGCGCCGTTACATCGACTGAT
GGTATGACTGCTGACTATTACCCCTTCGAGCACGCCTTCCTCGGGCGCGTGGCCACTCGGATAATAAACGAAGTCAAGGG
CGTCAACCGCGTCGTCTACGACGTAACGTCAAAACCGCCTGGCACGATCGAGTGGGAATAG

Upstream 100 bases:

>100_bases
GGGTGCGGTCATGCCGCTTAGCTAAAGCCTTCCTGCCCAAATAGGCAAATGCCGCGTTTGACGGCCTTTCGCGACAGGAA
AACCCCCGCTAATAGAGGCC

Downstream 100 bases:

>100_bases
GGCCGCCGACGGCCTGATGGCATAAAACTTGCGCTGGCTGGTGCCGGACACCCCAAGGCGGCTTACCCCTCCATGGGCTG
GCCAGCGAGCGCCGCCGCTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTQQADSVLKAHERVLIVDFGSQVTQLIARRLRESGVYCEIHPFNKVDGAFLAAFGPQALILSGGPASVTWKDAPLADQA
IFDSGLPILGICYGQQVMMHQLGGKVESGTSREFGRAFIEQVEADPILEGLFEGDNSEQVWMSHGDHVAEMAPGFGVIAR
SPGAPYAVIADPERKFYGTQFHPEVVHTTHGARLLRNFTHGVAGLKGDWTMAAYRAEAIQKIRNQVGKGRVICGLSGGVD
SSVAAVLIHEAIGDQLTCVYVDHGLMRAGESEQVVSLFREHYNIPLVHVDASELFLGQLDGVTDPEKKRKIIGGLFIDVF
DAEANKIGGADFLAQGTLYPDVIESVSAIGGPSVTIKSHHNVGGLPARMKMKLVEPLRELFKDEVRALGRELGLPEAFVG
RHPFPGPGLAIRIPGAITREKADTLRKADAIYIDEIRKAGLYDEIWQAFSVLLPVNTVGVMGDERTYEAVLALRAVTSTD
GMTADYYPFEHAFLGRVATRIINEVKGVNRVVYDVTSKPPGTIEWE

Sequences:

>Translated_526_residues
MTQQADSVLKAHERVLIVDFGSQVTQLIARRLRESGVYCEIHPFNKVDGAFLAAFGPQALILSGGPASVTWKDAPLADQA
IFDSGLPILGICYGQQVMMHQLGGKVESGTSREFGRAFIEQVEADPILEGLFEGDNSEQVWMSHGDHVAEMAPGFGVIAR
SPGAPYAVIADPERKFYGTQFHPEVVHTTHGARLLRNFTHGVAGLKGDWTMAAYRAEAIQKIRNQVGKGRVICGLSGGVD
SSVAAVLIHEAIGDQLTCVYVDHGLMRAGESEQVVSLFREHYNIPLVHVDASELFLGQLDGVTDPEKKRKIIGGLFIDVF
DAEANKIGGADFLAQGTLYPDVIESVSAIGGPSVTIKSHHNVGGLPARMKMKLVEPLRELFKDEVRALGRELGLPEAFVG
RHPFPGPGLAIRIPGAITREKADTLRKADAIYIDEIRKAGLYDEIWQAFSVLLPVNTVGVMGDERTYEAVLALRAVTSTD
GMTADYYPFEHAFLGRVATRIINEVKGVNRVVYDVTSKPPGTIEWE
>Mature_525_residues
TQQADSVLKAHERVLIVDFGSQVTQLIARRLRESGVYCEIHPFNKVDGAFLAAFGPQALILSGGPASVTWKDAPLADQAI
FDSGLPILGICYGQQVMMHQLGGKVESGTSREFGRAFIEQVEADPILEGLFEGDNSEQVWMSHGDHVAEMAPGFGVIARS
PGAPYAVIADPERKFYGTQFHPEVVHTTHGARLLRNFTHGVAGLKGDWTMAAYRAEAIQKIRNQVGKGRVICGLSGGVDS
SVAAVLIHEAIGDQLTCVYVDHGLMRAGESEQVVSLFREHYNIPLVHVDASELFLGQLDGVTDPEKKRKIIGGLFIDVFD
AEANKIGGADFLAQGTLYPDVIESVSAIGGPSVTIKSHHNVGGLPARMKMKLVEPLRELFKDEVRALGRELGLPEAFVGR
HPFPGPGLAIRIPGAITREKADTLRKADAIYIDEIRKAGLYDEIWQAFSVLLPVNTVGVMGDERTYEAVLALRAVTSTDG
MTADYYPFEHAFLGRVATRIINEVKGVNRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=37.6363636363636, Blast_Score=301, Evalue=8e-82,
Organism=Escherichia coli, GI1788854, Length=518, Percent_Identity=53.2818532818533, Blast_Score=569, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=37.7622377622378, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=37.7622377622378, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=37.7622377622378, Blast_Score=307, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6323873, Length=527, Percent_Identity=53.1309297912713, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI281365319, Length=551, Percent_Identity=35.02722323049, Blast_Score=272, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57191; Mature: 57060

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQADSVLKAHERVLIVDFGSQVTQLIARRLRESGVYCEIHPFNKVDGAFLAAFGPQAL
CCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCEE
ILSGGPASVTWKDAPLADQAIFDSGLPILGICYGQQVMMHQLGGKVESGTSREFGRAFIE
EEECCCCEEEECCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
QVEADPILEGLFEGDNSEQVWMSHGDHVAEMAPGFGVIARSPGAPYAVIADPERKFYGTQ
HHCCCHHHHHHHCCCCCCEEEECCCCCHHHHCCCCCEEECCCCCCEEEEECCCHHHCCCC
FHPEVVHTTHGARLLRNFTHGVAGLKGDWTMAAYRAEAIQKIRNQVGKGRVICGLSGGVD
CCCHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
SSVAAVLIHEAIGDQLTCVYVDHGLMRAGESEQVVSLFREHYNIPLVHVDASELFLGQLD
HHHHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHCC
GVTDPEKKRKIIGGLFIDVFDAEANKIGGADFLAQGTLYPDVIESVSAIGGPSVTIKSHH
CCCCHHHHHHHHHHHEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCC
NVGGLPARMKMKLVEPLRELFKDEVRALGRELGLPEAFVGRHPFPGPGLAIRIPGAITRE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCHHHH
KADTLRKADAIYIDEIRKAGLYDEIWQAFSVLLPVNTVGVMGDERTYEAVLALRAVTSTD
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHCCC
GMTADYYPFEHAFLGRVATRIINEVKGVNRVVYDVTSKPPGTIEWE
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TQQADSVLKAHERVLIVDFGSQVTQLIARRLRESGVYCEIHPFNKVDGAFLAAFGPQAL
CCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCEE
ILSGGPASVTWKDAPLADQAIFDSGLPILGICYGQQVMMHQLGGKVESGTSREFGRAFIE
EEECCCCEEEECCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
QVEADPILEGLFEGDNSEQVWMSHGDHVAEMAPGFGVIARSPGAPYAVIADPERKFYGTQ
HHCCCHHHHHHHCCCCCCEEEECCCCCHHHHCCCCCEEECCCCCCEEEEECCCHHHCCCC
FHPEVVHTTHGARLLRNFTHGVAGLKGDWTMAAYRAEAIQKIRNQVGKGRVICGLSGGVD
CCCHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
SSVAAVLIHEAIGDQLTCVYVDHGLMRAGESEQVVSLFREHYNIPLVHVDASELFLGQLD
HHHHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHCC
GVTDPEKKRKIIGGLFIDVFDAEANKIGGADFLAQGTLYPDVIESVSAIGGPSVTIKSHH
CCCCHHHHHHHHHHHEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCC
NVGGLPARMKMKLVEPLRELFKDEVRALGRELGLPEAFVGRHPFPGPGLAIRIPGAITRE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCHHHH
KADTLRKADAIYIDEIRKAGLYDEIWQAFSVLLPVNTVGVMGDERTYEAVLALRAVTSTD
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHCCC
GMTADYYPFEHAFLGRVATRIINEVKGVNRVVYDVTSKPPGTIEWE
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA