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The map label for this gene is hemC [H]

Identifier: 162219161

GI number: 162219161

Start: 1075100

End: 1076026

Strand: Direct

Name: hemC [H]

Synonym: Neut_1037

Alternate gene names: 162219161

Gene position: 1075100-1076026 (Clockwise)

Preceding gene: 114331033

Following gene: 114331037

Centisome position: 40.4

GC content: 52.32

Gene sequence:

>927_bases
ATGTCTAGTCCTGAAAAAATTGTTATTGCGTCACGCGAGAGCCAGCTTGCTTTATGGCAGGCAAATTTCATTCGAAGTCG
TCTGCTTGAATTATACCCGCAAACTGATATCACCATACTTGGCATGACGACTAAGGGAGATCAGATTCTGGATGTTTCCT
TGTCAAAAATTGGTGGCAAGGGGCTTTTTATCAAAGAGCTTGAACTGGCTCTGGAAGACGGCCGTGCGGACATCGCAGTA
CATTCTATGAAAGATGTGCCGATGATTGTTCCGTCTGGATTCAGGCTGGCCGCCATCACAGAACGGGAAGATCCGCGTGA
TGCATTTGTTTCCAATGATTTTACCAGCCTGGAAGAATTGCCCACCGGAAGCGTGGTAGGGACTTCCAGTTTGCGGCGAG
AATCCCAGTTACGGGCGCGCTTCCCGCATCTGCAAGTGCGTCCGTTGCGTGGTAACGTGCAAACGCGACTGCGAAAGCTC
GACGAGGGGGAATACAGTGCAATCATTCTGGCTGCAGCTGGACTGAAACGGCTGGAGCTGGGATATCGCATCAGCATGCT
GATACCACCCGAGCTGAGTCTTCCGGCGGTTGGACAGGGTGCGTTGGGTATCGAGTGTCGCGATAATGATCCTGATATGG
TGGAATGGATGAAGCCGCTACACCATGCCACAACTGCTTATTGTGTGGAGGCAGAGCGTGCTATGAGCCGTGTGTTGGGG
GGCAGCTGCCAAGTACCGCTGGGTGGCTTTGCTGAAATTTTTGAAGGGGTATTGACGCTGCGTGGTTTTGTGGCCACCCC
TGACGGATCAAAAATAATCGCAGATAAATTATGTGGCAAGCCGGAATCAGGAGAACGGGTGGGCGAGCAACTGGCGCAAA
ACCTGAAAACGCACGGTGCGGAAGAGATTCTTGCCGCCCTGGCCTGA

Upstream 100 bases:

>100_bases
GGGCTCGGGTCACCGGGATAAAATGCAGTTATTTGCCATCATCCGGACCGGGGTCGCCCGTGCTAGAATGGCGGCATTGC
TTCAAAATCAGATTCTTATT

Downstream 100 bases:

>100_bases
GATGTGATCGGGGCAGATATTGGCACTTGATCGGTTAGCCGGTAAAAGTATTCTGATTACCCGCCCTTTGCATCAGGCGG
GTAATCTGGCTGCACGAATC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSSPEKIVIASRESQLALWQANFIRSRLLELYPQTDITILGMTTKGDQILDVSLSKIGGKGLFIKELELALEDGRADIAV
HSMKDVPMIVPSGFRLAAITEREDPRDAFVSNDFTSLEELPTGSVVGTSSLRRESQLRARFPHLQVRPLRGNVQTRLRKL
DEGEYSAIILAAAGLKRLELGYRISMLIPPELSLPAVGQGALGIECRDNDPDMVEWMKPLHHATTAYCVEAERAMSRVLG
GSCQVPLGGFAEIFEGVLTLRGFVATPDGSKIIADKLCGKPESGERVGEQLAQNLKTHGAEEILAALA

Sequences:

>Translated_308_residues
MSSPEKIVIASRESQLALWQANFIRSRLLELYPQTDITILGMTTKGDQILDVSLSKIGGKGLFIKELELALEDGRADIAV
HSMKDVPMIVPSGFRLAAITEREDPRDAFVSNDFTSLEELPTGSVVGTSSLRRESQLRARFPHLQVRPLRGNVQTRLRKL
DEGEYSAIILAAAGLKRLELGYRISMLIPPELSLPAVGQGALGIECRDNDPDMVEWMKPLHHATTAYCVEAERAMSRVLG
GSCQVPLGGFAEIFEGVLTLRGFVATPDGSKIIADKLCGKPESGERVGEQLAQNLKTHGAEEILAALA
>Mature_307_residues
SSPEKIVIASRESQLALWQANFIRSRLLELYPQTDITILGMTTKGDQILDVSLSKIGGKGLFIKELELALEDGRADIAVH
SMKDVPMIVPSGFRLAAITEREDPRDAFVSNDFTSLEELPTGSVVGTSSLRRESQLRARFPHLQVRPLRGNVQTRLRKLD
EGEYSAIILAAAGLKRLELGYRISMLIPPELSLPAVGQGALGIECRDNDPDMVEWMKPLHHATTAYCVEAERAMSRVLGG
SCQVPLGGFAEIFEGVLTLRGFVATPDGSKIIADKLCGKPESGERVGEQLAQNLKTHGAEEILAALA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=275, Percent_Identity=48, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI66933009, Length=275, Percent_Identity=48, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI48994974, Length=297, Percent_Identity=57.5757575757576, Blast_Score=335, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=39.2405063291139, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20130425, Length=323, Percent_Identity=41.4860681114551, Blast_Score=216, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33558; Mature: 33427

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPEKIVIASRESQLALWQANFIRSRLLELYPQTDITILGMTTKGDQILDVSLSKIGGK
CCCCCEEEEECCCCCEEHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEHHHCCCC
GLFIKELELALEDGRADIAVHSMKDVPMIVPSGFRLAAITEREDPRDAFVSNDFTSLEEL
CEEHHHHHHHHHCCCCEEEEECCCCCCEECCCCCEEEEEECCCCCHHHHHCCCCHHHHHC
PTGSVVGTSSLRRESQLRARFPHLQVRPLRGNVQTRLRKLDEGEYSAIILAAAGLKRLEL
CCCCEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCEEEEEEECCCHHEEC
GYRISMLIPPELSLPAVGQGALGIECRDNDPDMVEWMKPLHHATTAYCVEAERAMSRVLG
CEEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSCQVPLGGFAEIFEGVLTLRGFVATPDGSKIIADKLCGKPESGERVGEQLAQNLKTHGA
CCCCCCCCCHHHHHHHHHHHCCEEECCCCCEEHHHHHCCCCCCHHHHHHHHHHHHHHCCH
EEILAALA
HHHHHHCC
>Mature Secondary Structure 
SSPEKIVIASRESQLALWQANFIRSRLLELYPQTDITILGMTTKGDQILDVSLSKIGGK
CCCCEEEEECCCCCEEHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEHHHCCCC
GLFIKELELALEDGRADIAVHSMKDVPMIVPSGFRLAAITEREDPRDAFVSNDFTSLEEL
CEEHHHHHHHHHCCCCEEEEECCCCCCEECCCCCEEEEEECCCCCHHHHHCCCCHHHHHC
PTGSVVGTSSLRRESQLRARFPHLQVRPLRGNVQTRLRKLDEGEYSAIILAAAGLKRLEL
CCCCEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCEEEEEEECCCHHEEC
GYRISMLIPPELSLPAVGQGALGIECRDNDPDMVEWMKPLHHATTAYCVEAERAMSRVLG
CEEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSCQVPLGGFAEIFEGVLTLRGFVATPDGSKIIADKLCGKPESGERVGEQLAQNLKTHGA
CCCCCCCCCHHHHHHHHHHHCCEEECCCCCEEHHHHHCCCCCCHHHHHHHHHHHHHHCCH
EEILAALA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]