Click here to switch to the map view.

The map label for this gene is hemD [H]

Identifier: 114331037

GI number: 114331037

Start: 1076046

End: 1076828

Strand: Direct

Name: hemD [H]

Synonym: Neut_1038

Alternate gene names: 114331037

Gene position: 1076046-1076828 (Clockwise)

Preceding gene: 162219161

Following gene: 114331038

Centisome position: 40.44

GC content: 52.11

Gene sequence:

>783_bases
TTGGCACTTGATCGGTTAGCCGGTAAAAGTATTCTGATTACCCGCCCTTTGCATCAGGCGGGTAATCTGGCTGCACGAAT
CAAGGGGTTGGGCGGAGAGCCATGGTTGTTCCCCGTGCTGGAGATTTCTGATAGCGAAAACAAGCAGCCGTTACTGGATA
TGATTGCGCGGCTTGATGATTTTGATCTGGCTGTTTTTGTCAGCCCGAATGCGGTGGAAAGAGTTATGCCGCTGGTTCAT
GCAGAGCGCCGCTGGCCTGAGCATGTACGTGTTGCAACCGTGGGAAAGGGGAGTGCCCGGGCGCTCGAACACCATGGTAT
TCCCGCTGTCATTGTTCCAGAAGATGGTTCTGATAGCGAAGCCTTGTTGCGCGTGCCACAACTGCAGATCATGCAGGGTA
AGCGCATCATAATTTTTCGCGGTAATGGCGGGCGGAAATTGCTTGGGGATACGCTACGTGATCGTGGCGCCAGTGTTGAC
TATGTTGAATGCTATCGTCGCCACCGGCCGGAGGTTGATCCCTTGCCGTTGCTGAAGTACTGGCATGATAACGGGATCCA
GGCAGTAGTCATCAGCAGCAGCGAAGGTCTGGATAATTTATTTGACATGATCGGTAAAACAGGCCAACAATTGCTCAGAG
CTACCGCCGTGTTTACGGCACATGACCGGATTGAGTGCAAGGCAAGAGAGCTGGGTATCAGGAAGATATACCGCACTCCT
CTCGGAGATGAAGGGACTGTGCAAGGTTTGTTGGAGTACTTCGAAAAAATACAGTCACACTGA

Upstream 100 bases:

>100_bases
TCAGGAGAACGGGTGGGCGAGCAACTGGCGCAAAACCTGAAAACGCACGGTGCGGAAGAGATTCTTGCCGCCCTGGCCTG
AGATGTGATCGGGGCAGATA

Downstream 100 bases:

>100_bases
TAGCATCCGATCATATGAATAAATACATGCAGATTTCGACTTCCGGATCAGCTCGCCGCTTGGCTGTTTTCATACTGATG
ATCTTGTTAATTGCAGTGAC

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MALDRLAGKSILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDDFDLAVFVSPNAVERVMPLVH
AERRWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSEALLRVPQLQIMQGKRIIIFRGNGGRKLLGDTLRDRGASVD
YVECYRRHRPEVDPLPLLKYWHDNGIQAVVISSSEGLDNLFDMIGKTGQQLLRATAVFTAHDRIECKARELGIRKIYRTP
LGDEGTVQGLLEYFEKIQSH

Sequences:

>Translated_260_residues
MALDRLAGKSILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDDFDLAVFVSPNAVERVMPLVH
AERRWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSEALLRVPQLQIMQGKRIIIFRGNGGRKLLGDTLRDRGASVD
YVECYRRHRPEVDPLPLLKYWHDNGIQAVVISSSEGLDNLFDMIGKTGQQLLRATAVFTAHDRIECKARELGIRKIYRTP
LGDEGTVQGLLEYFEKIQSH
>Mature_259_residues
ALDRLAGKSILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDDFDLAVFVSPNAVERVMPLVHA
ERRWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSEALLRVPQLQIMQGKRIIIFRGNGGRKLLGDTLRDRGASVDY
VECYRRHRPEVDPLPLLKYWHDNGIQAVVISSSEGLDNLFDMIGKTGQQLLRATAVFTAHDRIECKARELGIRKIYRTPL
GDEGTVQGLLEYFEKIQSH

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=229, Percent_Identity=35.3711790393013, Blast_Score=134, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29015; Mature: 28884

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDRLAGKSILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDD
CCCCHHCCCEEEEECCCHHHCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHCCCC
FDLAVFVSPNAVERVMPLVHAERRWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSE
CCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCEEEEECCCCCCH
ALLRVPQLQIMQGKRIIIFRGNGGRKLLGDTLRDRGASVDYVECYRRHRPEVDPLPLLKY
HHHCCCCHHEECCCEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHH
WHDNGIQAVVISSSEGLDNLFDMIGKTGQQLLRATAVFTAHDRIECKARELGIRKIYRTP
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
LGDEGTVQGLLEYFEKIQSH
CCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALDRLAGKSILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDD
CCCHHCCCEEEEECCCHHHCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHCCCC
FDLAVFVSPNAVERVMPLVHAERRWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSE
CCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCEEEEECCCCCCH
ALLRVPQLQIMQGKRIIIFRGNGGRKLLGDTLRDRGASVDYVECYRRHRPEVDPLPLLKY
HHHCCCCHHEECCCEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHH
WHDNGIQAVVISSSEGLDNLFDMIGKTGQQLLRATAVFTAHDRIECKARELGIRKIYRTP
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
LGDEGTVQGLLEYFEKIQSH
CCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3054815; 3320969; 3277628; 3040684; 1379743; 9278503 [H]