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The map label for this gene is recQ [H]

Identifier: 114332470

GI number: 114332470

Start: 2651312

End: 2652931

Strand: Reverse

Name: recQ [H]

Synonym: Neut_2523

Alternate gene names: 114332470

Gene position: 2652931-2651312 (Counterclockwise)

Preceding gene: 114332471

Following gene: 114332469

Centisome position: 99.69

GC content: 52.47

Gene sequence:

>1620_bases
ATGACTTCCCTGGCTGTCCGTGCACAAACTCTGCTCAGAGAAATCTTTGGTTACACCGAATTTCGCGGGCAGCAGGCTGA
AATCATTACCCATATCGCAAACGGAAACAGTTGCCTGGTCTTAATGCCGACTGGTGGCGGTAAATCGTTATGCTACCAGC
TGCCAGCATTATTGCGGGATGGCGTGGCCATTGTCATCTCACCACTGATTGCACTGATGGAAAATCAGGTCTCTGTATTG
CATGAACGCGGTGTGCGGGCAACATATCTTAATTCTACGCAAACTTCCAAAGCTGCAGCAGTAATCGAACAAGACATGCT
GGCGGGCAACTACGATCTGGTCTATGTTGCACCGGAAAGATTACTGACCAACCGCTTTCACGCGCTGCTGCAGCGTATTC
CCATTGCCCTGTTTGCTATTGATGAAGCGCATTGCGTTTCCCAGTGGGGGCACGATTTCCGGCCAGAATACGGCAGGCTT
TCAATGCTGCCGGAGAAATTTCCGGGCGTACCGCGTATCGCCCTGACTGCCAGCGCTGATGCCAGAACCCGCACCGATAT
TCTGCGTTGTCTTGAGTTAGGCCAGGCACGTGCTTTCATCAGTAGTTTTGATCGTCCCAATCTTTGCTACCGCATTACCG
CCCGATCCAACAGCCGGCGACAGCTGTTAAACTTTATCCGCAATCAGCATCCCGGCGAGGCAGGTATCGTTTATTGCCAA
TCCCGCAAAAAAACTGAAGAAACAGCCGCCTGGCTGAATGCTAATCACATTCCGGCGCTTGCCTACCATGCCGGTATGGA
AACACCTGTACGCACACAACACCAGAAAAAATTTCTGCGGGAGAACGGCATTGTCATGATCGCTACCTCGGCATTCGGGC
TGGGGATTGATAAACCGGATATCCGTTTTGTTGCGCACCTGGATTTGCCCAGAAGTATTGAAAGCTATTATCAGGAAACC
GGCCGGGCCGGGCGGGATGGCCTGCCGGCTGATGCATGGATGGTGTATGGGCCAAGCGATATTATCCGGTTGCGTTATCA
GGCTGAATCCAACGCAGGACAAATATCCATTCCAGTCCAGCAAGCCGCTACTGCCCGGCTGGATGCGTTGCTGGCGCTGT
GTGAAACAACCGCCTGTCGCAGAACACGATTGCTTGACTATTTTGGCGAACCATCTGATTCAAGCAGTGAACTGGCATGT
GGCAATTGTGATGCCTGCCTGACCACCACTCCCGTTCAGGATGTCACGCTTGCTGCCCAGAAAGCACTGTCCTGCGTTTA
CCGGACAGGTCAGAATTTTGGCATGGAATATCTGATTGATGTCCTGACCGGAAAACAGACCAACCGGATCAGGCAATGGG
GACATGATCGCGTCAGCACCTTCGGCATTGGTCATGAACTCAGCATCGAAGGCTGGCGCATCGTATTCAGACACCTGCTG
GCACTGGGTTATTTCACTGCTGGCGGGGAACGGTTTACCCTGCAGCTCGCACCGGCGGCCAGAGGTATTTTGCGTGGAGA
AACCCGCATAAAGCTGCGTTTGTCACCTTATCATCATTCTGCTTCACACCAGCAAGCTCCCATTGGTTTATCTGCGCCTG
ATGTATGTGAAATCCGGTAA

Upstream 100 bases:

>100_bases
CAGGAGAGCTCAAATCGCAGCCAACGCCACCGCGTTACGCTGGTAAAGGTCGGCCGACCAAGCGTGTGCGGCGCGACCTG
GAGCGCTTTGTGGACGGGAA

Downstream 100 bases:

>100_bases
ATACTTCTTCTTGGGTCCGTTGGACTGTGACGATCCAGCTTTTCCCCCGATTTATACACAGTAAAAAACAGATTTTTTTA
TGAATAGAGCCAGAGTGTTG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MTSLAVRAQTLLREIFGYTEFRGQQAEIITHIANGNSCLVLMPTGGGKSLCYQLPALLRDGVAIVISPLIALMENQVSVL
HERGVRATYLNSTQTSKAAAVIEQDMLAGNYDLVYVAPERLLTNRFHALLQRIPIALFAIDEAHCVSQWGHDFRPEYGRL
SMLPEKFPGVPRIALTASADARTRTDILRCLELGQARAFISSFDRPNLCYRITARSNSRRQLLNFIRNQHPGEAGIVYCQ
SRKKTEETAAWLNANHIPALAYHAGMETPVRTQHQKKFLRENGIVMIATSAFGLGIDKPDIRFVAHLDLPRSIESYYQET
GRAGRDGLPADAWMVYGPSDIIRLRYQAESNAGQISIPVQQAATARLDALLALCETTACRRTRLLDYFGEPSDSSSELAC
GNCDACLTTTPVQDVTLAAQKALSCVYRTGQNFGMEYLIDVLTGKQTNRIRQWGHDRVSTFGIGHELSIEGWRIVFRHLL
ALGYFTAGGERFTLQLAPAARGILRGETRIKLRLSPYHHSASHQQAPIGLSAPDVCEIR

Sequences:

>Translated_539_residues
MTSLAVRAQTLLREIFGYTEFRGQQAEIITHIANGNSCLVLMPTGGGKSLCYQLPALLRDGVAIVISPLIALMENQVSVL
HERGVRATYLNSTQTSKAAAVIEQDMLAGNYDLVYVAPERLLTNRFHALLQRIPIALFAIDEAHCVSQWGHDFRPEYGRL
SMLPEKFPGVPRIALTASADARTRTDILRCLELGQARAFISSFDRPNLCYRITARSNSRRQLLNFIRNQHPGEAGIVYCQ
SRKKTEETAAWLNANHIPALAYHAGMETPVRTQHQKKFLRENGIVMIATSAFGLGIDKPDIRFVAHLDLPRSIESYYQET
GRAGRDGLPADAWMVYGPSDIIRLRYQAESNAGQISIPVQQAATARLDALLALCETTACRRTRLLDYFGEPSDSSSELAC
GNCDACLTTTPVQDVTLAAQKALSCVYRTGQNFGMEYLIDVLTGKQTNRIRQWGHDRVSTFGIGHELSIEGWRIVFRHLL
ALGYFTAGGERFTLQLAPAARGILRGETRIKLRLSPYHHSASHQQAPIGLSAPDVCEIR
>Mature_538_residues
TSLAVRAQTLLREIFGYTEFRGQQAEIITHIANGNSCLVLMPTGGGKSLCYQLPALLRDGVAIVISPLIALMENQVSVLH
ERGVRATYLNSTQTSKAAAVIEQDMLAGNYDLVYVAPERLLTNRFHALLQRIPIALFAIDEAHCVSQWGHDFRPEYGRLS
MLPEKFPGVPRIALTASADARTRTDILRCLELGQARAFISSFDRPNLCYRITARSNSRRQLLNFIRNQHPGEAGIVYCQS
RKKTEETAAWLNANHIPALAYHAGMETPVRTQHQKKFLRENGIVMIATSAFGLGIDKPDIRFVAHLDLPRSIESYYQETG
RAGRDGLPADAWMVYGPSDIIRLRYQAESNAGQISIPVQQAATARLDALLALCETTACRRTRLLDYFGEPSDSSSELACG
NCDACLTTTPVQDVTLAAQKALSCVYRTGQNFGMEYLIDVLTGKQTNRIRQWGHDRVSTFGIGHELSIEGWRIVFRHLLA
LGYFTAGGERFTLQLAPAARGILRGETRIKLRLSPYHHSASHQQAPIGLSAPDVCEIR

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=557, Percent_Identity=35.3680430879713, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI14591902, Length=515, Percent_Identity=33.9805825242718, Blast_Score=291, Evalue=2e-78,
Organism=Homo sapiens, GI14591904, Length=515, Percent_Identity=33.9805825242718, Blast_Score=291, Evalue=2e-78,
Organism=Homo sapiens, GI169218196, Length=507, Percent_Identity=33.9250493096647, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI110735439, Length=507, Percent_Identity=33.9250493096647, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI148612816, Length=435, Percent_Identity=35.632183908046, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI51242943, Length=397, Percent_Identity=35.7682619647355, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI51242947, Length=397, Percent_Identity=35.7682619647355, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI284005309, Length=364, Percent_Identity=35.989010989011, Blast_Score=192, Evalue=8e-49,
Organism=Escherichia coli, GI48994977, Length=507, Percent_Identity=47.9289940828402, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI87082221, Length=326, Percent_Identity=24.8466257668712, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25145561, Length=501, Percent_Identity=38.9221556886228, Blast_Score=318, Evalue=7e-87,
Organism=Caenorhabditis elegans, GI32564293, Length=525, Percent_Identity=34.0952380952381, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71987997, Length=413, Percent_Identity=37.2881355932203, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71987993, Length=413, Percent_Identity=37.2881355932203, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17552866, Length=447, Percent_Identity=34.4519015659955, Blast_Score=234, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6323844, Length=527, Percent_Identity=35.2941176470588, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24646066, Length=488, Percent_Identity=39.7540983606557, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24664226, Length=449, Percent_Identity=36.5256124721604, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI62472181, Length=449, Percent_Identity=36.5256124721604, Blast_Score=271, Evalue=9e-73,
Organism=Drosophila melanogaster, GI24664230, Length=449, Percent_Identity=36.5256124721604, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI21358123, Length=349, Percent_Identity=38.9684813753582, Blast_Score=208, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 59808; Mature: 59677

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLAVRAQTLLREIFGYTEFRGQQAEIITHIANGNSCLVLMPTGGGKSLCYQLPALLRD
CCCHHHHHHHHHHHHHCHHHCCCCCEEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHC
GVAIVISPLIALMENQVSVLHERGVRATYLNSTQTSKAAAVIEQDMLAGNYDLVYVAPER
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECHHH
LLTNRFHALLQRIPIALFAIDEAHCVSQWGHDFRPEYGRLSMLPEKFPGVPRIALTASAD
HHHHHHHHHHHHCCEEEEEECHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCC
ARTRTDILRCLELGQARAFISSFDRPNLCYRITARSNSRRQLLNFIRNQHPGEAGIVYCQ
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEC
SRKKTEETAAWLNANHIPALAYHAGMETPVRTQHQKKFLRENGIVMIATSAFGLGIDKPD
CCCCHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCC
IRFVAHLDLPRSIESYYQETGRAGRDGLPADAWMVYGPSDIIRLRYQAESNAGQISIPVQ
CEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCEEEECHH
QAATARLDALLALCETTACRRTRLLDYFGEPSDSSSELACGNCDACLTTTPVQDVTLAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHH
KALSCVYRTGQNFGMEYLIDVLTGKQTNRIRQWGHDRVSTFGIGHELSIEGWRIVFRHLL
HHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHCCCCCEECCCHHHHHHHHHH
ALGYFTAGGERFTLQLAPAARGILRGETRIKLRLSPYHHSASHQQAPIGLSAPDVCEIR
HHHHEECCCCEEEEEECHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSLAVRAQTLLREIFGYTEFRGQQAEIITHIANGNSCLVLMPTGGGKSLCYQLPALLRD
CCHHHHHHHHHHHHHCHHHCCCCCEEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHC
GVAIVISPLIALMENQVSVLHERGVRATYLNSTQTSKAAAVIEQDMLAGNYDLVYVAPER
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECHHH
LLTNRFHALLQRIPIALFAIDEAHCVSQWGHDFRPEYGRLSMLPEKFPGVPRIALTASAD
HHHHHHHHHHHHCCEEEEEECHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCC
ARTRTDILRCLELGQARAFISSFDRPNLCYRITARSNSRRQLLNFIRNQHPGEAGIVYCQ
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEC
SRKKTEETAAWLNANHIPALAYHAGMETPVRTQHQKKFLRENGIVMIATSAFGLGIDKPD
CCCCHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCC
IRFVAHLDLPRSIESYYQETGRAGRDGLPADAWMVYGPSDIIRLRYQAESNAGQISIPVQ
CEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCEEEECHH
QAATARLDALLALCETTACRRTRLLDYFGEPSDSSSELACGNCDACLTTTPVQDVTLAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHH
KALSCVYRTGQNFGMEYLIDVLTGKQTNRIRQWGHDRVSTFGIGHELSIEGWRIVFRHLL
HHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHCCCCCEECCCHHHHHHHHHH
ALGYFTAGGERFTLQLAPAARGILRGETRIKLRLSPYHHSASHQQAPIGLSAPDVCEIR
HHHHEECCCCEEEEEECHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]