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The map label for this gene is mutM

Identifier: 114332459

GI number: 114332459

Start: 2640577

End: 2641392

Strand: Direct

Name: mutM

Synonym: Neut_2512

Alternate gene names: 114332459

Gene position: 2640577-2641392 (Clockwise)

Preceding gene: 114332458

Following gene: 114332462

Centisome position: 99.23

GC content: 48.41

Gene sequence:

>816_bases
ATGCCGGAACTGCCTGAAGTCGAAGTCACCCGGCGTGGAATAGACGCCCACCTGGCCGGCAGATACATTACACAGGTAAA
AATACGAAATTACGCTTTACGCTGGCCGGTATCGCCTGAATTGATCACACTGCTCCCCGGTCAAAGAATTAACACCATTA
CCAGACGAGCAAAATATCTTCTGTTTGCTTGCAGCAAAGGCACACTTATCATACATCTGGGCATGTCGGGCAGTTTGCGC
GTACTACCTGTATCCACGCCGTCATTACTGCATGATCATTTTGAACTGTGGCTGGATAATGAAAAAATGCTGCGTTTTCG
TGATCCTCGGCGGTTTGGCGTAATATTGTGGTGGGATGGGGATGTTCGCCAACATCCATTATTGCAAAAGTTGGGCCCTG
AACCCCTGAGTGATGCTTTTAATGGATTGTTTCTGCATGAAAAAATACAAAGACGCAGTATCAGCATCAAAGAAGCACTC
ATGAATCAGCATATCGTGGTCGGCATAGGTAACATTTATGCTAATGAAGCCTTGTTTCATGCCGGTATTTCTCCCCTGAT
TGCCGCAGGCAGTCTGAGTACGGCGCTTTGTGCGAGATTGGTTGATGCTGTCAAGATGACCTTGCAGCGTGCAATTGAAG
CAGGCGGGAGCAGTTTGCGCGATTTTACTGATTGCGATGGTAGCCCAGGTTGCTTTCAGCAACAATATTGGGTGTACGGG
CGAACAGGGCAGCCATGCCGGAAATGTGGCGCACTTGTGAGTAAAACTCGCCAGGGACAACGATCCAGCTTTTTCTGTGC
GCAGTGCCAAAAATAA

Upstream 100 bases:

>100_bases
ACTGATATTTCTTGTAAGTGGACTCTTCATCAGCTGGTACCGCAAACGCAGATGACGTGTAATCCAGTTTCTGCTGTTTG
CTACAAATTTTTGTCAGATC

Downstream 100 bases:

>100_bases
AAAAGCCAGTCAAAGATTCAGCTCACGAGCTTAATCAAACCTCATGCTGCTGCAACCAGGTATCCAGCAATCGGCGCAGT
GATTCAATCGGACGATAACC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPELPEVEVTRRGIDAHLAGRYITQVKIRNYALRWPVSPELITLLPGQRINTITRRAKYLLFACSKGTLIIHLGMSGSLR
VLPVSTPSLLHDHFELWLDNEKMLRFRDPRRFGVILWWDGDVRQHPLLQKLGPEPLSDAFNGLFLHEKIQRRSISIKEAL
MNQHIVVGIGNIYANEALFHAGISPLIAAGSLSTALCARLVDAVKMTLQRAIEAGGSSLRDFTDCDGSPGCFQQQYWVYG
RTGQPCRKCGALVSKTRQGQRSSFFCAQCQK

Sequences:

>Translated_271_residues
MPELPEVEVTRRGIDAHLAGRYITQVKIRNYALRWPVSPELITLLPGQRINTITRRAKYLLFACSKGTLIIHLGMSGSLR
VLPVSTPSLLHDHFELWLDNEKMLRFRDPRRFGVILWWDGDVRQHPLLQKLGPEPLSDAFNGLFLHEKIQRRSISIKEAL
MNQHIVVGIGNIYANEALFHAGISPLIAAGSLSTALCARLVDAVKMTLQRAIEAGGSSLRDFTDCDGSPGCFQQQYWVYG
RTGQPCRKCGALVSKTRQGQRSSFFCAQCQK
>Mature_270_residues
PELPEVEVTRRGIDAHLAGRYITQVKIRNYALRWPVSPELITLLPGQRINTITRRAKYLLFACSKGTLIIHLGMSGSLRV
LPVSTPSLLHDHFELWLDNEKMLRFRDPRRFGVILWWDGDVRQHPLLQKLGPEPLSDAFNGLFLHEKIQRRSISIKEALM
NQHIVVGIGNIYANEALFHAGISPLIAAGSLSTALCARLVDAVKMTLQRAIEAGGSSLRDFTDCDGSPGCFQQQYWVYGR
TGQPCRKCGALVSKTRQGQRSSFFCAQCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=271, Percent_Identity=52.7675276752767, Blast_Score=286, Evalue=7e-79,
Organism=Escherichia coli, GI1786932, Length=283, Percent_Identity=24.3816254416961, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_NITEC (Q0AD66)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748681.1
- ProteinModelPortal:   Q0AD66
- SMR:   Q0AD66
- STRING:   Q0AD66
- GeneID:   4273366
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2512
- NMPDR:   fig|335283.3.peg.728
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   HMSSGAD
- PhylomeDB:   Q0AD66
- ProtClustDB:   PRK01103
- BioCyc:   NEUT335283:NEUT_2512-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30440; Mature: 30309

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 261-261 BINDING 91-91 BINDING 110-110 BINDING 152-152

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVTRRGIDAHLAGRYITQVKIRNYALRWPVSPELITLLPGQRINTITRRAKYL
CCCCCCCHHHHCCCCHHHHHHHHEEEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHEE
LFACSKGTLIIHLGMSGSLRVLPVSTPSLLHDHFELWLDNEKMLRFRDPRRFGVILWWDG
EEEECCCEEEEEECCCCCEEEEECCCHHHHHHHHHEEECCCHHEEECCCCEEEEEEEECC
DVRQHPLLQKLGPEPLSDAFNGLFLHEKIQRRSISIKEALMNQHIVVGIGNIYANEALFH
CCCCCCHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHH
AGISPLIAAGSLSTALCARLVDAVKMTLQRAIEAGGSSLRDFTDCDGSPGCFQQQYWVYG
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCEEEEC
RTGQPCRKCGALVSKTRQGQRSSFFCAQCQK
CCCCHHHHHHHHHHHHCCCCCCCCHHHCCCC
>Mature Secondary Structure 
PELPEVEVTRRGIDAHLAGRYITQVKIRNYALRWPVSPELITLLPGQRINTITRRAKYL
CCCCCCHHHHCCCCHHHHHHHHEEEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHEE
LFACSKGTLIIHLGMSGSLRVLPVSTPSLLHDHFELWLDNEKMLRFRDPRRFGVILWWDG
EEEECCCEEEEEECCCCCEEEEECCCHHHHHHHHHEEECCCHHEEECCCCEEEEEEEECC
DVRQHPLLQKLGPEPLSDAFNGLFLHEKIQRRSISIKEALMNQHIVVGIGNIYANEALFH
CCCCCCHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHH
AGISPLIAAGSLSTALCARLVDAVKMTLQRAIEAGGSSLRDFTDCDGSPGCFQQQYWVYG
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCEEEEC
RTGQPCRKCGALVSKTRQGQRSSFFCAQCQK
CCCCHHHHHHHHHHHHCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA