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The map label for this gene is ribE [H]

Identifier: 114332462

GI number: 114332462

Start: 2644024

End: 2644629

Strand: Direct

Name: ribE [H]

Synonym: Neut_2515

Alternate gene names: 114332462

Gene position: 2644024-2644629 (Clockwise)

Preceding gene: 114332459

Following gene: 114332463

Centisome position: 99.36

GC content: 47.85

Gene sequence:

>606_bases
ATGTTTACTGGAATCATCAAAGCAGTTGGCCGTATCAGGCACGTCTATCCCAAAGAAGACGCTGTTCGTATCCATATTGA
TCCCGGCAAGCTGGATCTCACAGATGTCGCCATTGGGGATAGTATTGCCGTCAATGGTGCCTGTCTGACACTCACTGCAT
TTGAGGAAGGGTGCTTCACCGTCGATGTATCCGGTGAAACATTGAGTTGTACACATGGTCTGGATATTCCCGGCAATCCG
GTCAACCTGGAAAAAGCGTTACGATTTTCTGATCGGCTCGATGGTCACCTGGTCAGCGGGCATGTGGAAGGAGTCGGTGA
AGTTGTACAATTCACACAAGCAGGTGATCGCTGCCTGCTGGCAATCCAGCCGCCGCCACAATTGTTTAAATATATTATCC
CCAAGGGGTCAATTACGATCGATGGCGTCAGTCTTACGGTGAATCAGGTGGCATCTGAACGGGTTGAAATCAACCTTATT
CCCCATACATTAGCCAATACAACTTTCAAACAGTTTGAGCCCGGCAAAAAAGTGAATCTCGAAACAGATATGATAGCGAA
ATACGTGGCACGTTTACTCGATCAGGCACAAGGCAAGCAATCATGA

Upstream 100 bases:

>100_bases
ATCCCGGATAAACTGTTGATTATAACAGTGTTCGAACTATCAGACTGACCGGGGTATTATCTATTTACAATGGAATTTGT
TTCAAAACTCGGGAAAAGGC

Downstream 100 bases:

>100_bases
CAATCTCATCGATTGAAGAAGTTCTGGCAGACTTCAAAAATGGAAAGATGGTTATCCTCATTGACGAGGAAAATCGTGAG
AATGAGGGCGATCTGGTACT

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MFTGIIKAVGRIRHVYPKEDAVRIHIDPGKLDLTDVAIGDSIAVNGACLTLTAFEEGCFTVDVSGETLSCTHGLDIPGNP
VNLEKALRFSDRLDGHLVSGHVEGVGEVVQFTQAGDRCLLAIQPPPQLFKYIIPKGSITIDGVSLTVNQVASERVEINLI
PHTLANTTFKQFEPGKKVNLETDMIAKYVARLLDQAQGKQS

Sequences:

>Translated_201_residues
MFTGIIKAVGRIRHVYPKEDAVRIHIDPGKLDLTDVAIGDSIAVNGACLTLTAFEEGCFTVDVSGETLSCTHGLDIPGNP
VNLEKALRFSDRLDGHLVSGHVEGVGEVVQFTQAGDRCLLAIQPPPQLFKYIIPKGSITIDGVSLTVNQVASERVEINLI
PHTLANTTFKQFEPGKKVNLETDMIAKYVARLLDQAQGKQS
>Mature_201_residues
MFTGIIKAVGRIRHVYPKEDAVRIHIDPGKLDLTDVAIGDSIAVNGACLTLTAFEEGCFTVDVSGETLSCTHGLDIPGNP
VNLEKALRFSDRLDGHLVSGHVEGVGEVVQFTQAGDRCLLAIQPPPQLFKYIIPKGSITIDGVSLTVNQVASERVEINLI
PHTLANTTFKQFEPGKKVNLETDMIAKYVARLLDQAQGKQS

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=187, Percent_Identity=38.5026737967914, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319733, Length=203, Percent_Identity=37.4384236453202, Blast_Score=115, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 21747; Mature: 21747

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGIIKAVGRIRHVYPKEDAVRIHIDPGKLDLTDVAIGDSIAVNGACLTLTAFEEGCFT
CCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCEEECCEEEEEEEECCCEEE
VDVSGETLSCTHGLDIPGNPVNLEKALRFSDRLDGHLVSGHVEGVGEVVQFTQAGDRCLL
EEECCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCCEEEE
AIQPPPQLFKYIIPKGSITIDGVSLTVNQVASERVEINLIPHTLANTTFKQFEPGKKVNL
EECCCHHHHHHHCCCCCEEEEEEEEEHHHHCCCEEEEEEECHHHHCCCHHHCCCCCEECC
ETDMIAKYVARLLDQAQGKQS
CHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFTGIIKAVGRIRHVYPKEDAVRIHIDPGKLDLTDVAIGDSIAVNGACLTLTAFEEGCFT
CCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCEEECCEEEEEEEECCCEEE
VDVSGETLSCTHGLDIPGNPVNLEKALRFSDRLDGHLVSGHVEGVGEVVQFTQAGDRCLL
EEECCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCCEEEE
AIQPPPQLFKYIIPKGSITIDGVSLTVNQVASERVEINLIPHTLANTTFKQFEPGKKVNL
EECCCHHHHHHHCCCCCEEEEEEEEEHHHHCCCEEEEEEECHHHHCCCHHHCCCCCEECC
ETDMIAKYVARLLDQAQGKQS
CHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144477 [H]