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The map label for this gene is yhfN [H]

Identifier: 114332249

GI number: 114332249

Start: 2413761

End: 2415029

Strand: Reverse

Name: yhfN [H]

Synonym: Neut_2289

Alternate gene names: 114332249

Gene position: 2415029-2413761 (Counterclockwise)

Preceding gene: 114332252

Following gene: 114332248

Centisome position: 90.75

GC content: 46.26

Gene sequence:

>1269_bases
ATGCATATTTTCACCATTGTTTTTATTCTTGCGCTGACATTGACTACGCTGGTGCAGTTGTGGCTGGCTACCCGGCACAT
ACGCCATATAACAGCAAACCGCGACCAGGTTCCAGCTGCTTTCGCTTCACAAATTGAATTATCTGCTCACCAGAAAGCAG
CTGATTATACCTGTGCAAAAGTACGCCTGAGTTATCCAGGCATACTGCTCAACACAGGTTTGTTGCTAGTGTTGACACTG
GGTGGTGGATTGGAATTGCTGTCGGACTTCTGGTATTCCTGGTTCAGTGATCCGCTATGGCATGGGATGGTACTCATTTT
TAGTGTATTAGCTCTGCTGAGTATAGTTGCAATCCCTTTTAATTATTACCGTACATTCGTCATTGAACAGCAATACGGAT
TCAACAAGATGACGCGAGCCATGTTTTTTACTGATCTCGTCAAGCAGACCGTAGTGGTGGCATTGTTGGGTGCGCCATTG
TTGTTGAGTGTCCTGTGGTTGATGGAAAAAACAGGAGATAACTGGTGGTTATATACTTGGTTGACCTGGATAGGTTTTAA
CCTGTTTCTACTGGCGGTTTATCCTAACTGGATTGCCCCGCTGTTCAACAAGTTTTCACCGTTGGAAAATGATTTACTCA
AGGCTCGTATTGAAAATCTGTTGCGGAAGTGTGGTTTTGAATCCAGTGGGTTGTTCGTTATGGATGGCTCTCGTCGCAGC
AGTCATGGCAATGCCTATTTTACCGGGTTTGGTAAAACGAAGCGGATTGTGTTCTTTGATACGTTGCTGAACCGTTTGGA
AGCTGCGGAAATCGAAGCGGTGCTGGCACATGAGCTGGGCCATTTCAAACGGCATCATGTCATCAAGCGGATTGCGCTGT
CGTTTGTAGTCAGTCTGTTGTTTCTATGGGTGTTGGGTTATCTAATGCAGCAACCGTGGTTCTATAATGGACTGGGTGTT
CAGGTGGCTGATGTGCCATCAACCGCCATGGCACTATTGCTGTTCTTTCTGGTGATGCCGGTATTTACCTTTTTGCTGCA
ACCATTATCCAGTATCTATTCACGCAAACATGAATTTGAGGCAGATGAATATGCAGCTCAGCAATCATCGGCGGCAGATA
TGATCCAGGCGCTGGTCAAGATGTATCAGGATAACGCTGCGACGCTGACACCTGATCCGCTACATTCTGCTTTTTATGAT
TCGCACCCGCCAGCAGCAATTCGGGTTGCGCATCTCAAGAAAATAATCACAACAGGAGCTGCAGCATGA

Upstream 100 bases:

>100_bases
TACTCGTCGTGATCGGTCTGCTCCTCTGTTTTCCGGGGGGGGACATAAAGAATAAAATCCTAGCATGTCCTGTTCAGATA
CTTAATTTCCAGGTGGTTTT

Downstream 100 bases:

>100_bases
CTAATATCTGTGACTTGGCTGACCGGAAATGTAAGCCGTGCGAGGGAGGAGTTCCTCCATTGAGGAAAGAAGAAGCTGAA
AATTTGTTGAAGCAGTTGGA

Product: Ste24 endopeptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MHIFTIVFILALTLTTLVQLWLATRHIRHITANRDQVPAAFASQIELSAHQKAADYTCAKVRLSYPGILLNTGLLLVLTL
GGGLELLSDFWYSWFSDPLWHGMVLIFSVLALLSIVAIPFNYYRTFVIEQQYGFNKMTRAMFFTDLVKQTVVVALLGAPL
LLSVLWLMEKTGDNWWLYTWLTWIGFNLFLLAVYPNWIAPLFNKFSPLENDLLKARIENLLRKCGFESSGLFVMDGSRRS
SHGNAYFTGFGKTKRIVFFDTLLNRLEAAEIEAVLAHELGHFKRHHVIKRIALSFVVSLLFLWVLGYLMQQPWFYNGLGV
QVADVPSTAMALLLFFLVMPVFTFLLQPLSSIYSRKHEFEADEYAAQQSSAADMIQALVKMYQDNAATLTPDPLHSAFYD
SHPPAAIRVAHLKKIITTGAAA

Sequences:

>Translated_422_residues
MHIFTIVFILALTLTTLVQLWLATRHIRHITANRDQVPAAFASQIELSAHQKAADYTCAKVRLSYPGILLNTGLLLVLTL
GGGLELLSDFWYSWFSDPLWHGMVLIFSVLALLSIVAIPFNYYRTFVIEQQYGFNKMTRAMFFTDLVKQTVVVALLGAPL
LLSVLWLMEKTGDNWWLYTWLTWIGFNLFLLAVYPNWIAPLFNKFSPLENDLLKARIENLLRKCGFESSGLFVMDGSRRS
SHGNAYFTGFGKTKRIVFFDTLLNRLEAAEIEAVLAHELGHFKRHHVIKRIALSFVVSLLFLWVLGYLMQQPWFYNGLGV
QVADVPSTAMALLLFFLVMPVFTFLLQPLSSIYSRKHEFEADEYAAQQSSAADMIQALVKMYQDNAATLTPDPLHSAFYD
SHPPAAIRVAHLKKIITTGAAA
>Mature_422_residues
MHIFTIVFILALTLTTLVQLWLATRHIRHITANRDQVPAAFASQIELSAHQKAADYTCAKVRLSYPGILLNTGLLLVLTL
GGGLELLSDFWYSWFSDPLWHGMVLIFSVLALLSIVAIPFNYYRTFVIEQQYGFNKMTRAMFFTDLVKQTVVVALLGAPL
LLSVLWLMEKTGDNWWLYTWLTWIGFNLFLLAVYPNWIAPLFNKFSPLENDLLKARIENLLRKCGFESSGLFVMDGSRRS
SHGNAYFTGFGKTKRIVFFDTLLNRLEAAEIEAVLAHELGHFKRHHVIKRIALSFVVSLLFLWVLGYLMQQPWFYNGLGV
QVADVPSTAMALLLFFLVMPVFTFLLQPLSSIYSRKHEFEADEYAAQQSSAADMIQALVKMYQDNAATLTPDPLHSAFYD
SHPPAAIRVAHLKKIITTGAAA

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=462, Percent_Identity=30.0865800865801, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17505484, Length=423, Percent_Identity=31.6784869976359, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322577, Length=430, Percent_Identity=31.1627906976744, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI19922414, Length=426, Percent_Identity=31.2206572769953, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24654305, Length=439, Percent_Identity=25.7403189066059, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI78707252, Length=422, Percent_Identity=23.4597156398104, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI78707254, Length=422, Percent_Identity=23.4597156398104, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 47824; Mature: 47824

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIFTIVFILALTLTTLVQLWLATRHIRHITANRDQVPAAFASQIELSAHQKAADYTCAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHE
VRLSYPGILLNTGLLLVLTLGGGLELLSDFWYSWFSDPLWHGMVLIFSVLALLSIVAIPF
EEECCCCHHHHCCHHEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
NYYRTFVIEQQYGFNKMTRAMFFTDLVKQTVVVALLGAPLLLSVLWLMEKTGDNWWLYTW
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHH
LTWIGFNLFLLAVYPNWIAPLFNKFSPLENDLLKARIENLLRKCGFESSGLFVMDGSRRS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
SHGNAYFTGFGKTKRIVFFDTLLNRLEAAEIEAVLAHELGHFKRHHVIKRIALSFVVSLL
CCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLWVLGYLMQQPWFYNGLGVQVADVPSTAMALLLFFLVMPVFTFLLQPLSSIYSRKHEFE
HHHHHHHHHCCCCEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ADEYAAQQSSAADMIQALVKMYQDNAATLTPDPLHSAFYDSHPPAAIRVAHLKKIITTGA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCC
AA
CC
>Mature Secondary Structure
MHIFTIVFILALTLTTLVQLWLATRHIRHITANRDQVPAAFASQIELSAHQKAADYTCAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHE
VRLSYPGILLNTGLLLVLTLGGGLELLSDFWYSWFSDPLWHGMVLIFSVLALLSIVAIPF
EEECCCCHHHHCCHHEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
NYYRTFVIEQQYGFNKMTRAMFFTDLVKQTVVVALLGAPLLLSVLWLMEKTGDNWWLYTW
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHH
LTWIGFNLFLLAVYPNWIAPLFNKFSPLENDLLKARIENLLRKCGFESSGLFVMDGSRRS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
SHGNAYFTGFGKTKRIVFFDTLLNRLEAAEIEAVLAHELGHFKRHHVIKRIALSFVVSLL
CCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLWVLGYLMQQPWFYNGLGVQVADVPSTAMALLLFFLVMPVFTFLLQPLSSIYSRKHEFE
HHHHHHHHHCCCCEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ADEYAAQQSSAADMIQALVKMYQDNAATLTPDPLHSAFYDSHPPAAIRVAHLKKIITTGA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]