Click here to switch to the map view.

The map label for this gene is panC

Identifier: 114332252

GI number: 114332252

Start: 2418346

End: 2419179

Strand: Reverse

Name: panC

Synonym: Neut_2292

Alternate gene names: 114332252

Gene position: 2419179-2418346 (Counterclockwise)

Preceding gene: 114332253

Following gene: 114332249

Centisome position: 90.91

GC content: 47.6

Gene sequence:

>834_bases
GTGGAAATAATCACTGATATCGCATCGTTGCGTGTGCGGCTTCAAGATGAAGCTTCAATAGCCCTGGTGCCAACTATGGG
TAATCTGCATGCGGGCCATTTATCTCTGGTGCGGATCGCTCAGCAGCATGCTGCTTGTACCGTCGTCAGTATCTTCGTCA
ATCGTTTGCAATTTGCTCCGCATGAAGATTATGACCGCTATCCACGTACCCAGGAGAACGATTGTCGCTTGCTGGAAGAA
TATGGTGTGGATATCGTATTTATTCCAGGTGAAAAAACACTTTTTCCTATCCCACAGGAATTTCAGTTACTGCTTCCACC
TGTGGCAGATACGCTGGAAGGTGCTTGTCGCCCTGGATTTTTCCGTGGGGTGACAACGGTTGTATTGAAGCTGTTCAATA
TCGTGCAGCCACAGGTTGCGATATTCGGTGAAAAAGACTACCAGCAACTGCAGATTATCTGCAGGATGGTTGCTCAACTG
AATCTGCCCGTAGAAATTATTGCTGGCCAGACGATACGGGCAGAAGACGGTCTGGCGCTCAGTTCACGTAATAATTACCT
TGATAACATCCAGCGGCAGAAAGCGAGCGAGCTGGCTTGTAATCTGAAGAAAATTGGAGAAAGTATTGCTTCGGGTGAAC
GAAATTTCCCACAGTTAGAATGGTCTGCCATCGAAAGGCTGAATATGCACGGCTGGAAAGTTGACTATATTTCGGTACGA
CAGAATCGCACGCTGTTACCGGCAACAGCGTGCGATTCTGGTTTGGTCATATTGGGCGCGGCGTGGCTGGATCAAATTCG
GCTGATTGACAATTTTCCGTTGGTATTGTCATAA

Upstream 100 bases:

>100_bases
GTATTCAGGTGGCAGTCAGGAATTATGTGAAAGCAGTCAAAACCGGAGAATTTCCTGCGCATGAACATATGTTCTGACAG
GTACGATACGAATTATTCAC

Downstream 100 bases:

>100_bases
CAAGAATAATAATGGACTGGCTATCACAGCCATACCATCTTGCCCATTTCCAGTGGGTGAGTCAGCAGCGGGTGATAGGG
GTAGACACGTAGATAATATT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEIITDIASLRVRLQDEASIALVPTMGNLHAGHLSLVRIAQQHAACTVVSIFVNRLQFAPHEDYDRYPRTQENDCRLLEE
YGVDIVFIPGEKTLFPIPQEFQLLLPPVADTLEGACRPGFFRGVTTVVLKLFNIVQPQVAIFGEKDYQQLQIICRMVAQL
NLPVEIIAGQTIRAEDGLALSSRNNYLDNIQRQKASELACNLKKIGESIASGERNFPQLEWSAIERLNMHGWKVDYISVR
QNRTLLPATACDSGLVILGAAWLDQIRLIDNFPLVLS

Sequences:

>Translated_277_residues
MEIITDIASLRVRLQDEASIALVPTMGNLHAGHLSLVRIAQQHAACTVVSIFVNRLQFAPHEDYDRYPRTQENDCRLLEE
YGVDIVFIPGEKTLFPIPQEFQLLLPPVADTLEGACRPGFFRGVTTVVLKLFNIVQPQVAIFGEKDYQQLQIICRMVAQL
NLPVEIIAGQTIRAEDGLALSSRNNYLDNIQRQKASELACNLKKIGESIASGERNFPQLEWSAIERLNMHGWKVDYISVR
QNRTLLPATACDSGLVILGAAWLDQIRLIDNFPLVLS
>Mature_277_residues
MEIITDIASLRVRLQDEASIALVPTMGNLHAGHLSLVRIAQQHAACTVVSIFVNRLQFAPHEDYDRYPRTQENDCRLLEE
YGVDIVFIPGEKTLFPIPQEFQLLLPPVADTLEGACRPGFFRGVTTVVLKLFNIVQPQVAIFGEKDYQQLQIICRMVAQL
NLPVEIIAGQTIRAEDGLALSSRNNYLDNIQRQKASELACNLKKIGESIASGERNFPQLEWSAIERLNMHGWKVDYISVR
QNRTLLPATACDSGLVILGAAWLDQIRLIDNFPLVLS

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=263, Percent_Identity=47.5285171102662, Blast_Score=232, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322046, Length=284, Percent_Identity=38.7323943661972, Blast_Score=161, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_NITEC (Q0ADS3)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748474.1
- ProteinModelPortal:   Q0ADS3
- SMR:   Q0ADS3
- STRING:   Q0ADS3
- GeneID:   4274315
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2292
- NMPDR:   fig|335283.3.peg.31
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   ASSKENH
- PhylomeDB:   Q0ADS3
- ProtClustDB:   PRK00380
- BioCyc:   NEUT335283:NEUT_2292-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31077; Mature: 31077

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 149-149 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIITDIASLRVRLQDEASIALVPTMGNLHAGHLSLVRIAQQHAACTVVSIFVNRLQFAP
CCHHHHHHHHEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HEDYDRYPRTQENDCRLLEEYGVDIVFIPGEKTLFPIPQEFQLLLPPVADTLEGACRPGF
CCCHHCCCCCCCCHHHHHHHCCCEEEEECCCCEECCCCHHHHEECCCHHHHHHCCCCCCH
FRGVTTVVLKLFNIVQPQVAIFGEKDYQQLQIICRMVAQLNLPVEIIAGQTIRAEDGLAL
HHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCEEE
SSRNNYLDNIQRQKASELACNLKKIGESIASGERNFPQLEWSAIERLNMHGWKVDYISVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEEEC
QNRTLLPATACDSGLVILGAAWLDQIRLIDNFPLVLS
CCCEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCEEC
>Mature Secondary Structure
MEIITDIASLRVRLQDEASIALVPTMGNLHAGHLSLVRIAQQHAACTVVSIFVNRLQFAP
CCHHHHHHHHEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HEDYDRYPRTQENDCRLLEEYGVDIVFIPGEKTLFPIPQEFQLLLPPVADTLEGACRPGF
CCCHHCCCCCCCCHHHHHHHCCCEEEEECCCCEECCCCHHHHEECCCHHHHHHCCCCCCH
FRGVTTVVLKLFNIVQPQVAIFGEKDYQQLQIICRMVAQLNLPVEIIAGQTIRAEDGLAL
HHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCEEE
SSRNNYLDNIQRQKASELACNLKKIGESIASGERNFPQLEWSAIERLNMHGWKVDYISVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEEEC
QNRTLLPATACDSGLVILGAAWLDQIRLIDNFPLVLS
CCCEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA