Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 114332137

GI number: 114332137

Start: 2302290

End: 2302715

Strand: Reverse

Name: ndk

Synonym: Neut_2172

Alternate gene names: 114332137

Gene position: 2302715-2302290 (Counterclockwise)

Preceding gene: 114332138

Following gene: 114332136

Centisome position: 86.53

GC content: 44.6

Gene sequence:

>426_bases
ATGGTAGTTGAAAGGACTTTATCCATAATTAAGCCTGATGCAGTGGCAAAAAATGTTATTGGGCAGATCTATGCAAGATT
TGAGGCGGCTGGCTTGAAGGTTGTTGCTGCTCGCATGGCGCATTTATCAAGAGTTGAAGCGGAAAATTTTTACGCGATCC
ATAGGGAAAGACCTTTCTTTAAAGATCTGGTTGAATTCATGATTTCCGGGCCGGTGATGATCCAGGTGCTGGAGGGGGAA
AATGCAATTGCCAAAAATCGTGAGTTGATGGGTGCCACAGATCCGAAAAAAGCAGAAAAAGGTACGATTCGCGCTGATTT
TGCAGAAAATATTGATGCCAATGCTGTGCATGGTTCAGATGCGCCGGAAACTGCCGCTGTGGAAATAGCCTGTTTCTTCC
CATCTTTAGAAGTGTATTCACGCTGA

Upstream 100 bases:

>100_bases
CGCTTCTCTTTCTAGTTCCCTAAGTTACTGTTTGGTAAACCACATAAAGGTTTTTTGTTAGAATACCAGCTTGTGACGAA
CTATTTCTATGAGGTATTTG

Downstream 100 bases:

>100_bases
AAACCTGTAGATTTGCCGATCTAAAAGGCCGGATACAATGATTAACCTGCTTGATTTCAATAAAACAGGGCTTATCCATT
TTTGCGAAGAAATGGGTGAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MVVERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAARMAHLSRVEAENFYAIHRERPFFKDLVEFMISGPVMIQVLEGE
NAIAKNRELMGATDPKKAEKGTIRADFAENIDANAVHGSDAPETAAVEIACFFPSLEVYSR

Sequences:

>Translated_141_residues
MVVERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAARMAHLSRVEAENFYAIHRERPFFKDLVEFMISGPVMIQVLEGE
NAIAKNRELMGATDPKKAEKGTIRADFAENIDANAVHGSDAPETAAVEIACFFPSLEVYSR
>Mature_141_residues
MVVERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAARMAHLSRVEAENFYAIHRERPFFKDLVEFMISGPVMIQVLEGE
NAIAKNRELMGATDPKKAEKGTIRADFAENIDANAVHGSDAPETAAVEIACFFPSLEVYSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=42.962962962963, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI38045913, Length=131, Percent_Identity=39.6946564885496, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI4557797, Length=131, Percent_Identity=39.6946564885496, Blast_Score=110, Evalue=3e-25,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=38.6861313868613, Blast_Score=106, Evalue=7e-24,
Organism=Homo sapiens, GI37574614, Length=140, Percent_Identity=37.1428571428571, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI7019465, Length=140, Percent_Identity=37.1428571428571, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=35.5072463768116, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=34.5323741007194, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI4505413, Length=142, Percent_Identity=34.5070422535211, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI148839372, Length=129, Percent_Identity=34.8837209302326, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=58.1560283687943, Blast_Score=173, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=41.1764705882353, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=38.9705882352941, Blast_Score=113, Evalue=9e-27,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=43.0656934306569, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_NITEC (Q0AE38)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748359.1
- ProteinModelPortal:   Q0AE38
- SMR:   Q0AE38
- STRING:   Q0AE38
- GeneID:   4272821
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2172
- NMPDR:   fig|335283.3.peg.223
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q0AE38
- ProtClustDB:   PRK00668
- BioCyc:   NEUT335283:NEUT_2172-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15524; Mature: 15524

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAARMAHLSRVEAENFYAIHRERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCHH
KDLVEFMISGPVMIQVLEGENAIAKNRELMGATDPKKAEKGTIRADFAENIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCHHCCCCCCCCCCCCCCCCCCEEECHHCCCCCCCCCCCC
APETAAVEIACFFPSLEVYSR
CCCCCEEEEEEECCCHHHHCC
>Mature Secondary Structure
MVVERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAARMAHLSRVEAENFYAIHRERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCHH
KDLVEFMISGPVMIQVLEGENAIAKNRELMGATDPKKAEKGTIRADFAENIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCHHCCCCCCCCCCCCCCCCCCEEECHHCCCCCCCCCCCC
APETAAVEIACFFPSLEVYSR
CCCCCEEEEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA