Click here to switch to the map view.

The map label for this gene is wecA [H]

Identifier: 114332086

GI number: 114332086

Start: 2245860

End: 2247419

Strand: Direct

Name: wecA [H]

Synonym: Neut_2121

Alternate gene names: 114332086

Gene position: 2245860-2247419 (Clockwise)

Preceding gene: 114332085

Following gene: 114332088

Centisome position: 84.4

GC content: 45.06

Gene sequence:

>1560_bases
ATGACAGAATTCGATCTCCCGAAGCAGCTCGCACTATTTATTATCAGCACGATACTGGCTGGCCTTACCATCCGACTGGC
AATTCCTCTGGCACATATCAGCGGCATTCTGGATCGCCCAGGAGAGCATAAACAACACAAACATCTCACACCGTTTGTGG
GGGGCACAGGAATCTTTGTTTCTCTTCTCGCTGCCCTTCCTCTCCTTGGCTACCTCTATCCGGAACAATCCGTGAAATGG
CTAGGACTAGGGATCAGCTCCAGCATCATCTTTATCATGGGCCTGATCGATGACATTATTTATCTTCATTTCAAAACACG
CCTGGTCATACAAGCCCTGTCAGCATTAATTATCGTACTGGTAAGTGAAGTGATATTGATTGATATTGGCAACTTACCAT
TTGGCGAGATACTCGCATTACCTGGCATTGCAGCAACTTTCACCATTTTTGCCATCATTGGAAGTATCAATGCTTTCAAC
ATGATAGATGGAATTGATGGTTTATCTGGATCCGTGTCACTAACAAGCTTGCTGCTGCTGGGCATAGTTGCTCTCGCTAC
CGGCCACCAATCCAGCCTCATTATTATCATTGCACTCATCGGTGGCGTTGTGGGGTTCCTGTTTTTCAACTTACGTCGCC
CTCTACAACCTCGTGCCAAAGTATTTCTGGGCGATAACGGCAGTATGCTGCTGGGACTTCTGATTACCTGGCTTCTGATA
GACCTCTCGCAAGGCAGCAGCCGTGCCATGACGCCGGTAACGGCCCTCTGGCTATTTTCTGTTCCTCTGATGGATACCAT
CAGTATCATGTTGCGCCGGATTTGGCAGCACAAGTCGCCATTCAAACCCGACCGCAACCATTTTCACCATATCCTTCTCG
ATGCTGGGTATCGTGTTAACGACGCAGTATTTACCATTACTTCTGTGCAACTACTGTTTGGCCTGACAGGGTTGGCCGGC
CTGTATCTGGGTATCCACGAACAGGTAATGCTTCTGGCTTTCCTGGCACTTTTTTTCGGGTATTTCTATCTGACACTTTA
CCCATGGCATCTGATTACCGCTTTACGCTATTTGCATACTTTCCGGGGCCTGATTCCGACCGAAAGTCGTGGCTTTTTCC
TGGGTAGCTACACAGCAGAGGAAGCTAAAAATATAGTCCACATGATTTCGCAAGAATTACGGCCCAGCCTGGATTCATTG
ATACATGTAATCAAAAATAAAACCTCTGCCAACGACACAGAAAAATATGCAGTAATTGTCAACATACGATTGCTGGATAC
GGATACCAAAACGATGAAAAATGAAATTGGAAGCTTCATTGCATCGGCACAAAAACATATAAATGAACGCTGCCATATTC
AGTTACGCCCTTTTATAGAGCGAAACCCGCAGAATGATCGAAGAAAATTATCTGAGCGTGATAATTCTTATGGAGGAAGA
CGTTTGGCTGACTCGCGAAAAGATAATCAGAAATTATTAATATTCGAAGCAATATATGACCAGGATTCAATCGCCAAACA
AAATTCCACCGACAATCAGCCTAATAAAGAAAATTCATAA

Upstream 100 bases:

>100_bases
GCGTAAATCTGAAGGGTGTGATATTCAATGGCATTCCCGAAACTTCATCACGCCACAGATATACACAGTATAGCTACCAA
TATGATTATCGCAGCAAGAA

Downstream 100 bases:

>100_bases
TCTGCATACCTCCTTGCAGACATAGCACCAAACCTGATCAGGTTTCCTTCGCAGCAAGCAGCACGAGATTTATGCAGGCT
CCTCTGATCCAGAATCCACC

Product: glycosyl transferase family protein

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MTEFDLPKQLALFIISTILAGLTIRLAIPLAHISGILDRPGEHKQHKHLTPFVGGTGIFVSLLAALPLLGYLYPEQSVKW
LGLGISSSIIFIMGLIDDIIYLHFKTRLVIQALSALIIVLVSEVILIDIGNLPFGEILALPGIAATFTIFAIIGSINAFN
MIDGIDGLSGSVSLTSLLLLGIVALATGHQSSLIIIIALIGGVVGFLFFNLRRPLQPRAKVFLGDNGSMLLGLLITWLLI
DLSQGSSRAMTPVTALWLFSVPLMDTISIMLRRIWQHKSPFKPDRNHFHHILLDAGYRVNDAVFTITSVQLLFGLTGLAG
LYLGIHEQVMLLAFLALFFGYFYLTLYPWHLITALRYLHTFRGLIPTESRGFFLGSYTAEEAKNIVHMISQELRPSLDSL
IHVIKNKTSANDTEKYAVIVNIRLLDTDTKTMKNEIGSFIASAQKHINERCHIQLRPFIERNPQNDRRKLSERDNSYGGR
RLADSRKDNQKLLIFEAIYDQDSIAKQNSTDNQPNKENS

Sequences:

>Translated_519_residues
MTEFDLPKQLALFIISTILAGLTIRLAIPLAHISGILDRPGEHKQHKHLTPFVGGTGIFVSLLAALPLLGYLYPEQSVKW
LGLGISSSIIFIMGLIDDIIYLHFKTRLVIQALSALIIVLVSEVILIDIGNLPFGEILALPGIAATFTIFAIIGSINAFN
MIDGIDGLSGSVSLTSLLLLGIVALATGHQSSLIIIIALIGGVVGFLFFNLRRPLQPRAKVFLGDNGSMLLGLLITWLLI
DLSQGSSRAMTPVTALWLFSVPLMDTISIMLRRIWQHKSPFKPDRNHFHHILLDAGYRVNDAVFTITSVQLLFGLTGLAG
LYLGIHEQVMLLAFLALFFGYFYLTLYPWHLITALRYLHTFRGLIPTESRGFFLGSYTAEEAKNIVHMISQELRPSLDSL
IHVIKNKTSANDTEKYAVIVNIRLLDTDTKTMKNEIGSFIASAQKHINERCHIQLRPFIERNPQNDRRKLSERDNSYGGR
RLADSRKDNQKLLIFEAIYDQDSIAKQNSTDNQPNKENS
>Mature_518_residues
TEFDLPKQLALFIISTILAGLTIRLAIPLAHISGILDRPGEHKQHKHLTPFVGGTGIFVSLLAALPLLGYLYPEQSVKWL
GLGISSSIIFIMGLIDDIIYLHFKTRLVIQALSALIIVLVSEVILIDIGNLPFGEILALPGIAATFTIFAIIGSINAFNM
IDGIDGLSGSVSLTSLLLLGIVALATGHQSSLIIIIALIGGVVGFLFFNLRRPLQPRAKVFLGDNGSMLLGLLITWLLID
LSQGSSRAMTPVTALWLFSVPLMDTISIMLRRIWQHKSPFKPDRNHFHHILLDAGYRVNDAVFTITSVQLLFGLTGLAGL
YLGIHEQVMLLAFLALFFGYFYLTLYPWHLITALRYLHTFRGLIPTESRGFFLGSYTAEEAKNIVHMISQELRPSLDSLI
HVIKNKTSANDTEKYAVIVNIRLLDTDTKTMKNEIGSFIASAQKHINERCHIQLRPFIERNPQNDRRKLSERDNSYGGRR
LADSRKDNQKLLIFEAIYDQDSIAKQNSTDNQPNKENS

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) [H]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=274, Percent_Identity=36.4963503649635, Blast_Score=181, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 57791; Mature: 57659

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFDLPKQLALFIISTILAGLTIRLAIPLAHISGILDRPGEHKQHKHLTPFVGGTGIFV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
SLLAALPLLGYLYPEQSVKWLGLGISSSIIFIMGLIDDIIYLHFKTRLVIQALSALIIVL
HHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSEVILIDIGNLPFGEILALPGIAATFTIFAIIGSINAFNMIDGIDGLSGSVSLTSLLLL
HHHHHHEECCCCCHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHH
GIVALATGHQSSLIIIIALIGGVVGFLFFNLRRPLQPRAKVFLGDNGSMLLGLLITWLLI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHH
DLSQGSSRAMTPVTALWLFSVPLMDTISIMLRRIWQHKSPFKPDRNHFHHILLDAGYRVN
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCEEC
DAVFTITSVQLLFGLTGLAGLYLGIHEQVMLLAFLALFFGYFYLTLYPWHLITALRYLHT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRGLIPTESRGFFLGSYTAEEAKNIVHMISQELRPSLDSLIHVIKNKTSANDTEKYAVIV
HHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
NIRLLDTDTKTMKNEIGSFIASAQKHINERCHIQLRPFIERNPQNDRRKLSERDNSYGGR
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHCCCCCHHHHHHHHCCCCCCCC
RLADSRKDNQKLLIFEAIYDQDSIAKQNSTDNQPNKENS
CCCCCCCCCCEEEEEEEHHCCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEFDLPKQLALFIISTILAGLTIRLAIPLAHISGILDRPGEHKQHKHLTPFVGGTGIFV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
SLLAALPLLGYLYPEQSVKWLGLGISSSIIFIMGLIDDIIYLHFKTRLVIQALSALIIVL
HHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSEVILIDIGNLPFGEILALPGIAATFTIFAIIGSINAFNMIDGIDGLSGSVSLTSLLLL
HHHHHHEECCCCCHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHH
GIVALATGHQSSLIIIIALIGGVVGFLFFNLRRPLQPRAKVFLGDNGSMLLGLLITWLLI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHH
DLSQGSSRAMTPVTALWLFSVPLMDTISIMLRRIWQHKSPFKPDRNHFHHILLDAGYRVN
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCEEC
DAVFTITSVQLLFGLTGLAGLYLGIHEQVMLLAFLALFFGYFYLTLYPWHLITALRYLHT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRGLIPTESRGFFLGSYTAEEAKNIVHMISQELRPSLDSLIHVIKNKTSANDTEKYAVIV
HHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
NIRLLDTDTKTMKNEIGSFIASAQKHINERCHIQLRPFIERNPQNDRRKLSERDNSYGGR
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHCCCCCHHHHHHHHCCCCCCCC
RLADSRKDNQKLLIFEAIYDQDSIAKQNSTDNQPNKENS
CCCCCCCCCCEEEEEEEHHCCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]