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The map label for this gene is argF

Identifier: 114332032

GI number: 114332032

Start: 2184081

End: 2185004

Strand: Reverse

Name: argF

Synonym: Neut_2066

Alternate gene names: 114332032

Gene position: 2185004-2184081 (Counterclockwise)

Preceding gene: 114332033

Following gene: 114332031

Centisome position: 82.11

GC content: 48.16

Gene sequence:

>924_bases
ATGCAGATCAGGCATTTTTTACAGTTCAAGGATTTTGACCGGTTGGAATTCGAATACCTGTTCGACCGGACGCGCTGGAT
CAAGAATGAATTCAAGCAATATCGCCGCTACTGGCCGCTGACTGACCGTACGTTGGCCATGATTTTTGAAAAACACTCCA
CGCGCACGCGCCTTTCATTTGAAGCAGGCATGCATCAGTTGGGTGGCAGTGCTATCTATCTCTCAACACGTGATACCCAA
TTGGGCCGTGGCGAACCGGTGGAGGATGCAGCCAGAGTTATTTCAAGAATGGTTGATATCATTACCATTCGTACTCACGA
GCATCAGATTATTGAACGTTTTGCCGAGAATTCACGGGTGCCGGTGATCAATGGCCTGACGGACGAATATCATCCTTGCC
AGATTCTGGCAGATATCTTTACCTTCATAGAACATCGCGGAAGTATCACAGGCAAAACCATAACCTGGATTGGAGATTCC
AATAACGTGTGCAATACCTGGCTGCAAGCTGCCGAAATTTTTGACTTCAATGTACATGTTTCTACACCACCGGGTTATGA
AGTGGAGCCCGAGCGGGCGGGTTTGTATGGCACAGATCACTATGAACAGTTTGTCTCGCCGCACGATGCAGTGAAAGATG
CTGATCTGGTCACAACGGATGTGTGGACCAGCATGGGTTTCGAAGATGAGTTGGATACACGTAAAAATGATTTTGCAGAT
TTTTGTGTGGATGCTGAGATGATGGCCTGTGCAAAAAAAGAAGCCTTGTTCATGCATTGTCTGCCAGCACACCGAGGCGA
AGAGGTGGATGCGGAAGTCATTGATGGCCCCCAATCGGTGGTATGGGATGAAGCAGAGAACCGGCTACACACACAAAAAG
CGTTGATGGAGTACTTGCTGCTGGGCAGGATTAGTGTCAGGTAA

Upstream 100 bases:

>100_bases
TTTTTTATTTTTCCGGATTCAAGTGATTTCTGTTTCATCTACCTGATAGAGAGCCAGAAATATAAAAATCTCCGGATGTT
TTTGTTGGTAGAAATCATTT

Downstream 100 bases:

>100_bases
TCTTTTAATTACCTGTAAATTTTTGATTGTAAAGAGACATGGATAAAGTTAAGAAAGCGGTATTGGCATTTTCGGGGGGG
TTGGATACCTCGGTCATACT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MQIRHFLQFKDFDRLEFEYLFDRTRWIKNEFKQYRRYWPLTDRTLAMIFEKHSTRTRLSFEAGMHQLGGSAIYLSTRDTQ
LGRGEPVEDAARVISRMVDIITIRTHEHQIIERFAENSRVPVINGLTDEYHPCQILADIFTFIEHRGSITGKTITWIGDS
NNVCNTWLQAAEIFDFNVHVSTPPGYEVEPERAGLYGTDHYEQFVSPHDAVKDADLVTTDVWTSMGFEDELDTRKNDFAD
FCVDAEMMACAKKEALFMHCLPAHRGEEVDAEVIDGPQSVVWDEAENRLHTQKALMEYLLLGRISVR

Sequences:

>Translated_307_residues
MQIRHFLQFKDFDRLEFEYLFDRTRWIKNEFKQYRRYWPLTDRTLAMIFEKHSTRTRLSFEAGMHQLGGSAIYLSTRDTQ
LGRGEPVEDAARVISRMVDIITIRTHEHQIIERFAENSRVPVINGLTDEYHPCQILADIFTFIEHRGSITGKTITWIGDS
NNVCNTWLQAAEIFDFNVHVSTPPGYEVEPERAGLYGTDHYEQFVSPHDAVKDADLVTTDVWTSMGFEDELDTRKNDFAD
FCVDAEMMACAKKEALFMHCLPAHRGEEVDAEVIDGPQSVVWDEAENRLHTQKALMEYLLLGRISVR
>Mature_307_residues
MQIRHFLQFKDFDRLEFEYLFDRTRWIKNEFKQYRRYWPLTDRTLAMIFEKHSTRTRLSFEAGMHQLGGSAIYLSTRDTQ
LGRGEPVEDAARVISRMVDIITIRTHEHQIIERFAENSRVPVINGLTDEYHPCQILADIFTFIEHRGSITGKTITWIGDS
NNVCNTWLQAAEIFDFNVHVSTPPGYEVEPERAGLYGTDHYEQFVSPHDAVKDADLVTTDVWTSMGFEDELDTRKNDFAD
FCVDAEMMACAKKEALFMHCLPAHRGEEVDAEVIDGPQSVVWDEAENRLHTQKALMEYLLLGRISVR

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=307, Percent_Identity=38.4364820846906, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI18105007, Length=304, Percent_Identity=27.9605263157895, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI1786469, Length=326, Percent_Identity=35.8895705521472, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1790703, Length=325, Percent_Identity=35.3846153846154, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI2367364, Length=309, Percent_Identity=27.5080906148867, Blast_Score=88, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193204318, Length=324, Percent_Identity=25.6172839506173, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322373, Length=320, Percent_Identity=34.6875, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6322331, Length=287, Percent_Identity=28.2229965156794, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24642586, Length=308, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_NITEC (Q0AEE3)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748254.1
- ProteinModelPortal:   Q0AEE3
- SMR:   Q0AEE3
- STRING:   Q0AEE3
- GeneID:   4273210
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2066
- NMPDR:   fig|335283.3.peg.2268
- eggNOG:   COG0078
- HOGENOM:   HBG579429
- OMA:   CVVTDTW
- PhylomeDB:   Q0AEE3
- ProtClustDB:   PRK00779
- BioCyc:   NEUT335283:NEUT_2066-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 35661; Mature: 35661

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 104-104 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIRHFLQFKDFDRLEFEYLFDRTRWIKNEFKQYRRYWPLTDRTLAMIFEKHSTRTRLSF
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHEEEH
EAGMHQLGGSAIYLSTRDTQLGRGEPVEDAARVISRMVDIITIRTHEHQIIERFAENSRV
HHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCC
PVINGLTDEYHPCQILADIFTFIEHRGSITGKTITWIGDSNNVCNTWLQAAEIFDFNVHV
CEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHEEEEEEE
STPPGYEVEPERAGLYGTDHYEQFVSPHDAVKDADLVTTDVWTSMGFEDELDTRKNDFAD
CCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCHHHH
FCVDAEMMACAKKEALFMHCLPAHRGEEVDAEVIDGPQSVVWDEAENRLHTQKALMEYLL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LGRISVR
HHHHCCC
>Mature Secondary Structure
MQIRHFLQFKDFDRLEFEYLFDRTRWIKNEFKQYRRYWPLTDRTLAMIFEKHSTRTRLSF
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHEEEH
EAGMHQLGGSAIYLSTRDTQLGRGEPVEDAARVISRMVDIITIRTHEHQIIERFAENSRV
HHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCC
PVINGLTDEYHPCQILADIFTFIEHRGSITGKTITWIGDSNNVCNTWLQAAEIFDFNVHV
CEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHEEEEEEE
STPPGYEVEPERAGLYGTDHYEQFVSPHDAVKDADLVTTDVWTSMGFEDELDTRKNDFAD
CCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCHHHH
FCVDAEMMACAKKEALFMHCLPAHRGEEVDAEVIDGPQSVVWDEAENRLHTQKALMEYLL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LGRISVR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA