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The map label for this gene is hemF

Identifier: 114331929

GI number: 114331929

Start: 2070845

End: 2071750

Strand: Reverse

Name: hemF

Synonym: Neut_1956

Alternate gene names: 114331929

Gene position: 2071750-2070845 (Counterclockwise)

Preceding gene: 114331935

Following gene: 114331928

Centisome position: 77.85

GC content: 50.55

Gene sequence:

>906_bases
ATGGACTTTGCACAAGTCAAGGATTATCTGGTTAATTTACAGAATAATATTGTGGCCGGATTGGAGCAGGCTGATGGTGG
TTCATTTCGTCGCGATTCATGGGATCGCCCGGAAGGTGGGGGAGGAACCAGTTGTGTGATCGAAGAAGGCAATGTATTGG
AGCGTGGTGGTGTCAATTTTTCCCATGTACATGGGAAAGGTTTGCCTGCCTCGGCTACAGCAGCCCGGCCAGAACTTGCA
GGCAGGGCGTTTGAAGCAGCGGGGGTTTCACTGGTGCTGCATCCGCGCAATCCCTATGCACCGACTGTCCACATGAATGT
CCGTTTTTTTGCCGCCATCAAAGAAGGAGCCGAACCAGTCTGGTGGTTTGGCGGGGGTATGGATCTTACGCCTTACTATG
GTTTCGAAGAGGATGCTATTCATTTTCATCAGATCTGCAAGCATGCACTTCAGCCTTCGGGTAGTGAATATTACCCACGT
TTCAAAAAATGGTGTGATGAATACTTTTACCTGAAACACCGCAAAGAACCGCGTGGAATAGGTGGTGTATTTTTTGACGA
CCTCAACCAGCCGGATTTTGTCACCTGTTTCAACCTGACCAAAAGTGTAGGGGATCAGTTTCTGGCGGCGTATGTCCCCA
TCCTGCAAAAACGCTGCAATCTTCCTTATGGCGAACGTGAACGGGATTTTCAAGCCTATCGCCGCGGTCGTTATGTGGAA
TTTAACCTGGTATGGGATCGCGGAACGCTGTTTGGCCTACAGTCAGGGGGGCGTACCGAATCTATCCTGATGTCACTGCC
GCCTATCGTCAAATGGCGTTACGATTGGTCACCCGCAGCGGGTAGCCCGGAAGCAAAGCTCTATACTGATTTCCTGATTG
GCAAGGACTGGCTGCCGCTTGATTGA

Upstream 100 bases:

>100_bases
AGTGGTGGCGTGGTATCAGCGTGCTAATTTGAATGTGTGAAGGTAGAATTGCCCGAAAAGGCCGATTGACGAATATCAGC
ATCACATATTGGGAGAGGAT

Downstream 100 bases:

>100_bases
TGAGACAACTTCAAAAATAGCAGATCTGAGTACAAGCTGGATTTGTTATTGATGTGCGCTTGGCACGAGCGCACTCTTTG
AATCTCCTCGGACGGTTAGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MDFAQVKDYLVNLQNNIVAGLEQADGGSFRRDSWDRPEGGGGTSCVIEEGNVLERGGVNFSHVHGKGLPASATAARPELA
GRAFEAAGVSLVLHPRNPYAPTVHMNVRFFAAIKEGAEPVWWFGGGMDLTPYYGFEEDAIHFHQICKHALQPSGSEYYPR
FKKWCDEYFYLKHRKEPRGIGGVFFDDLNQPDFVTCFNLTKSVGDQFLAAYVPILQKRCNLPYGERERDFQAYRRGRYVE
FNLVWDRGTLFGLQSGGRTESILMSLPPIVKWRYDWSPAAGSPEAKLYTDFLIGKDWLPLD

Sequences:

>Translated_301_residues
MDFAQVKDYLVNLQNNIVAGLEQADGGSFRRDSWDRPEGGGGTSCVIEEGNVLERGGVNFSHVHGKGLPASATAARPELA
GRAFEAAGVSLVLHPRNPYAPTVHMNVRFFAAIKEGAEPVWWFGGGMDLTPYYGFEEDAIHFHQICKHALQPSGSEYYPR
FKKWCDEYFYLKHRKEPRGIGGVFFDDLNQPDFVTCFNLTKSVGDQFLAAYVPILQKRCNLPYGERERDFQAYRRGRYVE
FNLVWDRGTLFGLQSGGRTESILMSLPPIVKWRYDWSPAAGSPEAKLYTDFLIGKDWLPLD
>Mature_301_residues
MDFAQVKDYLVNLQNNIVAGLEQADGGSFRRDSWDRPEGGGGTSCVIEEGNVLERGGVNFSHVHGKGLPASATAARPELA
GRAFEAAGVSLVLHPRNPYAPTVHMNVRFFAAIKEGAEPVWWFGGGMDLTPYYGFEEDAIHFHQICKHALQPSGSEYYPR
FKKWCDEYFYLKHRKEPRGIGGVFFDDLNQPDFVTCFNLTKSVGDQFLAAYVPILQKRCNLPYGERERDFQAYRRGRYVE
FNLVWDRGTLFGLQSGGRTESILMSLPPIVKWRYDWSPAAGSPEAKLYTDFLIGKDWLPLD

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Homo sapiens, GI41393599, Length=304, Percent_Identity=43.75, Blast_Score=270, Evalue=8e-73,
Organism=Escherichia coli, GI1788777, Length=297, Percent_Identity=64.983164983165, Blast_Score=410, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6320249, Length=313, Percent_Identity=46.6453674121406, Blast_Score=282, Evalue=6e-77,
Organism=Drosophila melanogaster, GI17864388, Length=298, Percent_Identity=48.6577181208054, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM6_NITEC (Q0AEP6)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748151.1
- ProteinModelPortal:   Q0AEP6
- SMR:   Q0AEP6
- STRING:   Q0AEP6
- GeneID:   4273308
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1956
- NMPDR:   fig|335283.3.peg.1081
- eggNOG:   COG0408
- HOGENOM:   HBG631180
- OMA:   HMNTRFV
- PhylomeDB:   Q0AEP6
- ProtClustDB:   PRK05330
- BioCyc:   NEUT335283:NEUT_1956-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00333
- InterPro:   IPR001260
- InterPro:   IPR018375
- Gene3D:   G3DSA:3.40.1500.10
- PANTHER:   PTHR10755
- PIRSF:   PIRSF000166
- PRINTS:   PR00073

Pfam domain/function: PF01218 Coprogen_oxidas; SSF102886 Coprogen_oxidas

EC number: =1.3.3.3

Molecular weight: Translated: 34004; Mature: 34004

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: ACT_SITE 104-104 BINDING 90-90

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFAQVKDYLVNLQNNIVAGLEQADGGSFRRDSWDRPEGGGGTSCVIEEGNVLERGGVNF
CCHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCE
SHVHGKGLPASATAARPELAGRAFEAAGVSLVLHPRNPYAPTVHMNVRFFAAIKEGAEPV
EEECCCCCCCCCCCCCHHHHCCEECCCCEEEEEECCCCCCCEEEECEEEEEEHHCCCCEE
WWFGGGMDLTPYYGFEEDAIHFHQICKHALQPSGSEYYPRFKKWCDEYFYLKHRKEPRGI
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GGVFFDDLNQPDFVTCFNLTKSVGDQFLAAYVPILQKRCNLPYGERERDFQAYRRGRYVE
CCEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEE
FNLVWDRGTLFGLQSGGRTESILMSLPPIVKWRYDWSPAAGSPEAKLYTDFLIGKDWLPL
EEEEECCCEEEEECCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCEEEEHHHCCCCCCCC
D
C
>Mature Secondary Structure
MDFAQVKDYLVNLQNNIVAGLEQADGGSFRRDSWDRPEGGGGTSCVIEEGNVLERGGVNF
CCHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCE
SHVHGKGLPASATAARPELAGRAFEAAGVSLVLHPRNPYAPTVHMNVRFFAAIKEGAEPV
EEECCCCCCCCCCCCCHHHHCCEECCCCEEEEEECCCCCCCEEEECEEEEEEHHCCCCEE
WWFGGGMDLTPYYGFEEDAIHFHQICKHALQPSGSEYYPRFKKWCDEYFYLKHRKEPRGI
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GGVFFDDLNQPDFVTCFNLTKSVGDQFLAAYVPILQKRCNLPYGERERDFQAYRRGRYVE
CCEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEE
FNLVWDRGTLFGLQSGGRTESILMSLPPIVKWRYDWSPAAGSPEAKLYTDFLIGKDWLPL
EEEEECCCEEEEECCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCEEEEHHHCCCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA