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The map label for this gene is gcvT

Identifier: 114331928

GI number: 114331928

Start: 2069016

End: 2070107

Strand: Reverse

Name: gcvT

Synonym: Neut_1955

Alternate gene names: 114331928

Gene position: 2070107-2069016 (Counterclockwise)

Preceding gene: 114331929

Following gene: 114331927

Centisome position: 77.79

GC content: 49.45

Gene sequence:

>1092_bases
ATGCTGAAGACAACCCCTCTGAATGCGGCACACCGTGGCATGCACGCAAAAATGGTGGATTTTGGTGGTTGGGATATGCC
CTTACACTATGGTTCCCAGTTGGATGAGCATCATGCTGTCAGACGTGATGCCGGCATGTTTGATGTCTCCCATATGCTGA
CAGTCGATCTTCACGGCGAAAATGTTCGTCAATTTCTGCGAGGATTGGTAGCAAATAATATCGATAAGCTTACCGTTCCT
GGTAAGGCGCTCTATACCTGTATGTTGAATCCTGCTGGTGGGATTATCGATGATCTGATCATTTATTTCCTGTCCGAATC
CTGGTTTCGTCTGGTGGTGAATGCCGGTACGGCGGATAAGGATATTGACTGGATTACCTTGCAATCCAGTCAACATGCAC
CTGATTTAACCATCACTCCACGTCGTGACCTTGCCATGATCGCTGTGCAAGGGCCGAATGCTCGTGCAAAAGTATGGGCT
GTTATTCCAGATTCCAAAGCAGCTTCAGAAGACCTGAAGCCATTCCAGTCAGTAGCATTTGGCAACTATTTCATTGCGCG
TACCGGCTATACCGGTGAGGATGGCTTTGAAATTACATTACCCGCCGATGAGGCTGCAGCTTTTTGGCAAAAGCTGCATG
CGGCGGGTGTGGCCCCGGCTGGCCTGGGTTCACGCGACACCCTGCGTCTGGAAGCAGGTATGAATCTTTATGGTCAGGAT
ATGGACGAAACCACCAATCCGCTCGAATCCGGATTGGCGTGGACCGTAGATCTAAAAAGCGAGCGGGATTTTATTGGCAA
ACAGGCCTTGCTTGAAAAGCCGGTTAATCAACAATTGGTAGGACTGGTTCTGCTGGATAAGGGCGTATTACGCAACCATC
AAAAAATTATTACACAGCATGAGGGTATCGCTGGTGAGGGAGAAATCACCAGTGGTGGATTTTCGCCCACTTTAAATCAG
TCGATTGCACTGGCTCGTATTCCGGTGGGAATCGCTGCAGGAGAGCAGGTACATGTTGTCGTGCGGGATAAACAGCTTGC
GGCAAGGGTTGTTAAATACCCGTTTGTACGCAATGGCCAGGCACTGATCTGA

Upstream 100 bases:

>100_bases
GGGTAGTTGATATCTGTTGGCCGCTGCGATCATGAGTAGTATTGCGTGGATGCAGAAATAGCACAGATAAAACTTTCCTT
TTACTTTTGAGAGAGAATAA

Downstream 100 bases:

>100_bases
TTTTTGTAAAAGTATCAGCAGATAAAGCATTTTGAATTTTTAAACCTAAATTTAGGGGAGTGACGGATAAATGAGCGTTC
CAGCAGAGCTGAAATATGCA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MLKTTPLNAAHRGMHAKMVDFGGWDMPLHYGSQLDEHHAVRRDAGMFDVSHMLTVDLHGENVRQFLRGLVANNIDKLTVP
GKALYTCMLNPAGGIIDDLIIYFLSESWFRLVVNAGTADKDIDWITLQSSQHAPDLTITPRRDLAMIAVQGPNARAKVWA
VIPDSKAASEDLKPFQSVAFGNYFIARTGYTGEDGFEITLPADEAAAFWQKLHAAGVAPAGLGSRDTLRLEAGMNLYGQD
MDETTNPLESGLAWTVDLKSERDFIGKQALLEKPVNQQLVGLVLLDKGVLRNHQKIITQHEGIAGEGEITSGGFSPTLNQ
SIALARIPVGIAAGEQVHVVVRDKQLAARVVKYPFVRNGQALI

Sequences:

>Translated_363_residues
MLKTTPLNAAHRGMHAKMVDFGGWDMPLHYGSQLDEHHAVRRDAGMFDVSHMLTVDLHGENVRQFLRGLVANNIDKLTVP
GKALYTCMLNPAGGIIDDLIIYFLSESWFRLVVNAGTADKDIDWITLQSSQHAPDLTITPRRDLAMIAVQGPNARAKVWA
VIPDSKAASEDLKPFQSVAFGNYFIARTGYTGEDGFEITLPADEAAAFWQKLHAAGVAPAGLGSRDTLRLEAGMNLYGQD
MDETTNPLESGLAWTVDLKSERDFIGKQALLEKPVNQQLVGLVLLDKGVLRNHQKIITQHEGIAGEGEITSGGFSPTLNQ
SIALARIPVGIAAGEQVHVVVRDKQLAARVVKYPFVRNGQALI
>Mature_363_residues
MLKTTPLNAAHRGMHAKMVDFGGWDMPLHYGSQLDEHHAVRRDAGMFDVSHMLTVDLHGENVRQFLRGLVANNIDKLTVP
GKALYTCMLNPAGGIIDDLIIYFLSESWFRLVVNAGTADKDIDWITLQSSQHAPDLTITPRRDLAMIAVQGPNARAKVWA
VIPDSKAASEDLKPFQSVAFGNYFIARTGYTGEDGFEITLPADEAAAFWQKLHAAGVAPAGLGSRDTLRLEAGMNLYGQD
MDETTNPLESGLAWTVDLKSERDFIGKQALLEKPVNQQLVGLVLLDKGVLRNHQKIITQHEGIAGEGEITSGGFSPTLNQ
SIALARIPVGIAAGEQVHVVVRDKQLAARVVKYPFVRNGQALI

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=377, Percent_Identity=36.0742705570292, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI257796258, Length=349, Percent_Identity=35.5300859598854, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI257796254, Length=372, Percent_Identity=32.5268817204301, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI257796256, Length=318, Percent_Identity=35.2201257861635, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI197927446, Length=336, Percent_Identity=27.9761904761905, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI21361378, Length=336, Percent_Identity=27.9761904761905, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789272, Length=369, Percent_Identity=56.3685636856369, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17560118, Length=377, Percent_Identity=33.6870026525199, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71994052, Length=346, Percent_Identity=24.8554913294798, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994045, Length=345, Percent_Identity=24.6376811594203, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32563613, Length=267, Percent_Identity=28.0898876404494, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=386, Percent_Identity=34.7150259067358, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI20129441, Length=376, Percent_Identity=35.3723404255319, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI28571104, Length=277, Percent_Identity=28.8808664259928, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI20130091, Length=311, Percent_Identity=27.0096463022508, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_NITEC (Q0AEP7)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748150.1
- ProteinModelPortal:   Q0AEP7
- SMR:   Q0AEP7
- STRING:   Q0AEP7
- GeneID:   4273307
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1955
- NMPDR:   fig|335283.3.peg.1078
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- PhylomeDB:   Q0AEP7
- ProtClustDB:   PRK00389
- BioCyc:   NEUT335283:NEUT_1955-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39622; Mature: 39622

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTTPLNAAHRGMHAKMVDFGGWDMPLHYGSQLDEHHAVRRDAGMFDVSHMLTVDLHGE
CCCCCCCCHHHCCCEEEEEECCCCCCCHHCCCCCHHHHHHHHCCCCEEEEEEEEEEECCH
NVRQFLRGLVANNIDKLTVPGKALYTCMLNPAGGIIDDLIIYFLSESWFRLVVNAGTADK
HHHHHHHHHHHCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCCC
DIDWITLQSSQHAPDLTITPRRDLAMIAVQGPNARAKVWAVIPDSKAASEDLKPFQSVAF
CCEEEEEECCCCCCCEEECCCCCEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHC
GNYFIARTGYTGEDGFEITLPADEAAAFWQKLHAAGVAPAGLGSRDTLRLEAGMNLYGQD
CCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCC
MDETTNPLESGLAWTVDLKSERDFIGKQALLEKPVNQQLVGLVLLDKGVLRNHQKIITQH
CCHHCCHHHCCCEEEEECCCCHHHHHHHHHHHCCCCHHHEEEEEECCHHHHHHHHHHHHC
EGIAGEGEITSGGFSPTLNQSIALARIPVGIAAGEQVHVVVRDKQLAARVVKYPFVRNGQ
CCCCCCCCCCCCCCCCCCCCCEEEEEECEEEECCCEEEEEEECHHHHHHHHHCCCCCCCC
ALI
CCC
>Mature Secondary Structure
MLKTTPLNAAHRGMHAKMVDFGGWDMPLHYGSQLDEHHAVRRDAGMFDVSHMLTVDLHGE
CCCCCCCCHHHCCCEEEEEECCCCCCCHHCCCCCHHHHHHHHCCCCEEEEEEEEEEECCH
NVRQFLRGLVANNIDKLTVPGKALYTCMLNPAGGIIDDLIIYFLSESWFRLVVNAGTADK
HHHHHHHHHHHCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCCC
DIDWITLQSSQHAPDLTITPRRDLAMIAVQGPNARAKVWAVIPDSKAASEDLKPFQSVAF
CCEEEEEECCCCCCCEEECCCCCEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHC
GNYFIARTGYTGEDGFEITLPADEAAAFWQKLHAAGVAPAGLGSRDTLRLEAGMNLYGQD
CCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCC
MDETTNPLESGLAWTVDLKSERDFIGKQALLEKPVNQQLVGLVLLDKGVLRNHQKIITQH
CCHHCCHHHCCCEEEEECCCCHHHHHHHHHHHCCCCHHHEEEEEECCHHHHHHHHHHHHC
EGIAGEGEITSGGFSPTLNQSIALARIPVGIAAGEQVHVVVRDKQLAARVVKYPFVRNGQ
CCCCCCCCCCCCCCCCCCCCCEEEEEECEEEECCCEEEEEEECHHHHHHHHHCCCCCCCC
ALI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA