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The map label for this gene is hitA [H]

Identifier: 114331887

GI number: 114331887

Start: 2024969

End: 2025319

Strand: Direct

Name: hitA [H]

Synonym: Neut_1912

Alternate gene names: 114331887

Gene position: 2024969-2025319 (Clockwise)

Preceding gene: 114331886

Following gene: 114331888

Centisome position: 76.1

GC content: 45.58

Gene sequence:

>351_bases
ATGGAAGATTGTATATTCTGCAAAATCGTACGTGGTGAAATTCCAGCCACTAAAATCCATGAAGATGATGAAACAATAGC
GTTTTATGATATTCATCCGGCAGCGCCTGTGCATTTTATGCTGATACCCAAACAACATATCGAATCATTAAATGAAGTTG
ACCTGAGTCATCAGCAGCTACTCGGGAAAATGCTGTGGCTAGCTCCCCGCTTGGCGGCAGACCAGGGATGTACAGATGGG
TTTCGAACCATTATCAACACCGGGCGGGTAGGAGGACAGGAAATTTTCCATCTTCATCTTCATGTTATCGGGGGGAAGGA
TCGCTTGCCCGCTATGATTCATCACGGCTAA

Upstream 100 bases:

>100_bases
GCTATACTGTCGGAACTGGAGCGAAGAGAAGGAGTATCCGGTATCGAAGAGAAATTGTCACGATCTCAAAACCAACCTGA
GCCAACTAAGGCTGAATGAT

Downstream 100 bases:

>100_bases
TCCGCTTAAGGAGCAAATAATGGGAAGTTTTAGTATTTGGCACTGGCTGGTTGTTCTGGCGATCGTTGTGCTGGTATTTG
GGACCAAAAAACTGCGCAAC

Product: histidine triad (HIT) protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MEDCIFCKIVRGEIPATKIHEDDETIAFYDIHPAAPVHFMLIPKQHIESLNEVDLSHQQLLGKMLWLAPRLAADQGCTDG
FRTIINTGRVGGQEIFHLHLHVIGGKDRLPAMIHHG

Sequences:

>Translated_116_residues
MEDCIFCKIVRGEIPATKIHEDDETIAFYDIHPAAPVHFMLIPKQHIESLNEVDLSHQQLLGKMLWLAPRLAADQGCTDG
FRTIINTGRVGGQEIFHLHLHVIGGKDRLPAMIHHG
>Mature_116_residues
MEDCIFCKIVRGEIPATKIHEDDETIAFYDIHPAAPVHFMLIPKQHIESLNEVDLSHQQLLGKMLWLAPRLAADQGCTDG
FRTIINTGRVGGQEIFHLHLHVIGGKDRLPAMIHHG

Specific function: Unknown

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Homo sapiens, GI4885413, Length=104, Percent_Identity=47.1153846153846, Blast_Score=110, Evalue=3e-25,
Organism=Homo sapiens, GI14211923, Length=103, Percent_Identity=41.747572815534, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1787346, Length=116, Percent_Identity=43.9655172413793, Blast_Score=105, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17506713, Length=105, Percent_Identity=46.6666666666667, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320078, Length=110, Percent_Identity=35.4545454545455, Blast_Score=74, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28574010, Length=105, Percent_Identity=44.7619047619048, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581222, Length=105, Percent_Identity=44.7619047619048, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR019808
- InterPro:   IPR001310 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 13037; Mature: 13037

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00892 HIT_1 ; PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDCIFCKIVRGEIPATKIHEDDETIAFYDIHPAAPVHFMLIPKQHIESLNEVDLSHQQL
CCCCEEEEEECCCCCCCEECCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHCCCCHHHH
LGKMLWLAPRLAADQGCTDGFRTIINTGRVGGQEIFHLHLHVIGGKDRLPAMIHHG
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCEEECCC
>Mature Secondary Structure
MEDCIFCKIVRGEIPATKIHEDDETIAFYDIHPAAPVHFMLIPKQHIESLNEVDLSHQQL
CCCCEEEEEECCCCCCCEECCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHCCCCHHHH
LGKMLWLAPRLAADQGCTDGFRTIINTGRVGGQEIFHLHLHVIGGKDRLPAMIHHG
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA