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The map label for this gene is hisE

Identifier: 114331886

GI number: 114331886

Start: 2024614

End: 2024967

Strand: Direct

Name: hisE

Synonym: Neut_1911

Alternate gene names: 114331886

Gene position: 2024614-2024967 (Clockwise)

Preceding gene: 114331885

Following gene: 114331887

Centisome position: 76.08

GC content: 45.76

Gene sequence:

>354_bases
ATGACCTCCTCTTCAACGATATTACAGCGACTGACTCAGACGATTGAAGCACGCAAAAGCGCCGACCCTGCTCATTCCTA
CATCGCAAAACTGCTAAGCAGCAACGAAGATAAAGTGCTAAAAAAAATTGCTGAAGAAGCCGCTGAAACTATCATGGCTT
GCAAGGACAATGACAGAGAACAGATTATTTATGAAACAGCGGACTTGTGGTTTCATTGCTTGATCATGCTTGCCAGGCAC
GACATCTCGCCGGAAGCTATACTGTCGGAACTGGAGCGAAGAGAAGGAGTATCCGGTATCGAAGAGAAATTGTCACGATC
TCAAAACCAACCTGAGCCAACTAAGGCTGAATGA

Upstream 100 bases:

>100_bases
GCCATACAGGTAGGCAAAGCTGCTTTTTCCGCCAATTGAAAAATGGGGAATGGGTAATCACAGAGCCCGTTATCAAAGAC
CCATCACAAATTTATACCCA

Downstream 100 bases:

>100_bases
TATGGAAGATTGTATATTCTGCAAAATCGTACGTGGTGAAATTCCAGCCACTAAAATCCATGAAGATGATGAAACAATAG
CGTTTTATGATATTCATCCG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MTSSSTILQRLTQTIEARKSADPAHSYIAKLLSSNEDKVLKKIAEEAAETIMACKDNDREQIIYETADLWFHCLIMLARH
DISPEAILSELERREGVSGIEEKLSRSQNQPEPTKAE

Sequences:

>Translated_117_residues
MTSSSTILQRLTQTIEARKSADPAHSYIAKLLSSNEDKVLKKIAEEAAETIMACKDNDREQIIYETADLWFHCLIMLARH
DISPEAILSELERREGVSGIEEKLSRSQNQPEPTKAE
>Mature_116_residues
TSSSTILQRLTQTIEARKSADPAHSYIAKLLSSNEDKVLKKIAEEAAETIMACKDNDREQIIYETADLWFHCLIMLARHD
ISPEAILSELERREGVSGIEEKLSRSQNQPEPTKAE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=35.2272727272727, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_NITEC (Q0AET9)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748108.1
- ProteinModelPortal:   Q0AET9
- SMR:   Q0AET9
- STRING:   Q0AET9
- GeneID:   4273695
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1911
- NMPDR:   fig|335283.3.peg.1035
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   NEUT335283:NEUT_1911-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 13214; Mature: 13083

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSSTILQRLTQTIEARKSADPAHSYIAKLLSSNEDKVLKKIAEEAAETIMACKDNDRE
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHH
QIIYETADLWFHCLIMLARHDISPEAILSELERREGVSGIEEKLSRSQNQPEPTKAE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TSSSTILQRLTQTIEARKSADPAHSYIAKLLSSNEDKVLKKIAEEAAETIMACKDNDRE
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHH
QIIYETADLWFHCLIMLARHDISPEAILSELERREGVSGIEEKLSRSQNQPEPTKAE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA