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The map label for this gene is hisC1 [H]

Identifier: 114331880

GI number: 114331880

Start: 2020011

End: 2021090

Strand: Direct

Name: hisC1 [H]

Synonym: Neut_1905

Alternate gene names: 114331880

Gene position: 2020011-2021090 (Clockwise)

Preceding gene: 114331879

Following gene: 114331881

Centisome position: 75.91

GC content: 45.09

Gene sequence:

>1080_bases
ATGACTTCTTTGTCACCTGACCAGATTATCCGCCAGGAAATTCTTGCACTATCAGCCTACCACGTCCCGCCCGCGAAGGA
CATGATCAAGCTGGACGCAATGGAAAATCCCTATCAGCTCCCCTCCTTTTTGGGTGAAGAGATTACCCGGATTACAGCAG
GCGCGCATATCAACCGCTACCCTGATCCGCATGCCGCGGCACTCAAAGAAACGCTTCGAACATCGCTATCTATTCCAGAT
GGAATGGAAATCATGCTGGGAAATGGTTCAGATGAAATCATTCAAATCATCATGCTGGCAGCTGCAAAACCAGGAGCAAA
GCTACTGACTGTTGAACCCGGATTTGCCATGTTCAAAATGATTGCTACATTTACAAATATGGAATATGTCGGCATTCCGT
TAAGACCAGATTTCTCGCTGGATCTTGACATGATGCTCACGGCAATTTCACACCACCAGCCAGCTATTCTGTTTTTGGCC
TACCCGAACAACCCCAGCGGCAATCTGTTTGACGAGGCCGCCCTGAATAAAATAATTCAAATATCCAAAGGTCTGGTTGT
AATAGACGAAGCTTATCATCCATTTGCAGGGAAAAGTTTTATTGAAAAACTCCCAAATTATCCGAATTTACTGGTTATGC
GAACGCTTTCGAAATTGGGATTGGCCGGGCTTCGCCTCGGGTTCCTGGTCGGCAGGCCGAGCTGGCTGTATCATCTGGAG
AAATTGCGCCTGCCTTACAATGTCAATGTAATTACCCAGCTTATGGCAGAAAAAATCATGCAACATTACGATACGCTACA
ACATCAGGCTGACATAATTAAACAAACCCGAACCAAATTAAGAATCTTTCTTGAAAGCCTGAAAGGTGTTGAAGCCTATC
CCTCTGATGCCAATTTCATTTTATTCCGGCTCAACAACGCCAGCCATGTTTTCAAGCAACTTCAGCAGCGTCGTATTTTG
GTGAAGAACCTTGACAACAGCCACCCCTTATTAAAAAATTGCCTCCGTGTAACAGTTGGCACGCCCGAAGAAAACGATTA
TTTCTGCAATACACTGCAAGATTTGATCGCTGAAAATTAA

Upstream 100 bases:

>100_bases
CATCAGCGCAGTTCTCTTTTATTTTGGTGGAAAAGATAAAGATGATAACAATCCCAAGTAAATGACAGGATTGTACGACA
TCTCTCCTTCTTTTTGATAC

Downstream 100 bases:

>100_bases
CCGGAAGACTAAACAAAACACTCCGTTCAAATTTAAATACTCATGCGCAAAGCCCAAGTTACTCGCAACACTCAGGAAAC
ACAAATTACCGTAGCAATCA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTSLSPDQIIRQEILALSAYHVPPAKDMIKLDAMENPYQLPSFLGEEITRITAGAHINRYPDPHAAALKETLRTSLSIPD
GMEIMLGNGSDEIIQIIMLAAAKPGAKLLTVEPGFAMFKMIATFTNMEYVGIPLRPDFSLDLDMMLTAISHHQPAILFLA
YPNNPSGNLFDEAALNKIIQISKGLVVIDEAYHPFAGKSFIEKLPNYPNLLVMRTLSKLGLAGLRLGFLVGRPSWLYHLE
KLRLPYNVNVITQLMAEKIMQHYDTLQHQADIIKQTRTKLRIFLESLKGVEAYPSDANFILFRLNNASHVFKQLQQRRIL
VKNLDNSHPLLKNCLRVTVGTPEENDYFCNTLQDLIAEN

Sequences:

>Translated_359_residues
MTSLSPDQIIRQEILALSAYHVPPAKDMIKLDAMENPYQLPSFLGEEITRITAGAHINRYPDPHAAALKETLRTSLSIPD
GMEIMLGNGSDEIIQIIMLAAAKPGAKLLTVEPGFAMFKMIATFTNMEYVGIPLRPDFSLDLDMMLTAISHHQPAILFLA
YPNNPSGNLFDEAALNKIIQISKGLVVIDEAYHPFAGKSFIEKLPNYPNLLVMRTLSKLGLAGLRLGFLVGRPSWLYHLE
KLRLPYNVNVITQLMAEKIMQHYDTLQHQADIIKQTRTKLRIFLESLKGVEAYPSDANFILFRLNNASHVFKQLQQRRIL
VKNLDNSHPLLKNCLRVTVGTPEENDYFCNTLQDLIAEN
>Mature_358_residues
TSLSPDQIIRQEILALSAYHVPPAKDMIKLDAMENPYQLPSFLGEEITRITAGAHINRYPDPHAAALKETLRTSLSIPDG
MEIMLGNGSDEIIQIIMLAAAKPGAKLLTVEPGFAMFKMIATFTNMEYVGIPLRPDFSLDLDMMLTAISHHQPAILFLAY
PNNPSGNLFDEAALNKIIQISKGLVVIDEAYHPFAGKSFIEKLPNYPNLLVMRTLSKLGLAGLRLGFLVGRPSWLYHLEK
LRLPYNVNVITQLMAEKIMQHYDTLQHQADIIKQTRTKLRIFLESLKGVEAYPSDANFILFRLNNASHVFKQLQQRRILV
KNLDNSHPLLKNCLRVTVGTPEENDYFCNTLQDLIAEN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=331, Percent_Identity=28.7009063444109, Blast_Score=127, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6322075, Length=388, Percent_Identity=31.701030927835, Blast_Score=145, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40420; Mature: 40289

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLSPDQIIRQEILALSAYHVPPAKDMIKLDAMENPYQLPSFLGEEITRITAGAHINRY
CCCCCHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCC
PDPHAAALKETLRTSLSIPDGMEIMLGNGSDEIIQIIMLAAAKPGAKLLTVEPGFAMFKM
CCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
IATFTNMEYVGIPLRPDFSLDLDMMLTAISHHQPAILFLAYPNNPSGNLFDEAALNKIIQ
HHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
ISKGLVVIDEAYHPFAGKSFIEKLPNYPNLLVMRTLSKLGLAGLRLGFLVGRPSWLYHLE
HHCCEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHH
KLRLPYNVNVITQLMAEKIMQHYDTLQHQADIIKQTRTKLRIFLESLKGVEAYPSDANFI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LFRLNNASHVFKQLQQRRILVKNLDNSHPLLKNCLRVTVGTPEENDYFCNTLQDLIAEN
EEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TSLSPDQIIRQEILALSAYHVPPAKDMIKLDAMENPYQLPSFLGEEITRITAGAHINRY
CCCCHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCC
PDPHAAALKETLRTSLSIPDGMEIMLGNGSDEIIQIIMLAAAKPGAKLLTVEPGFAMFKM
CCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
IATFTNMEYVGIPLRPDFSLDLDMMLTAISHHQPAILFLAYPNNPSGNLFDEAALNKIIQ
HHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
ISKGLVVIDEAYHPFAGKSFIEKLPNYPNLLVMRTLSKLGLAGLRLGFLVGRPSWLYHLE
HHCCEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHH
KLRLPYNVNVITQLMAEKIMQHYDTLQHQADIIKQTRTKLRIFLESLKGVEAYPSDANFI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LFRLNNASHVFKQLQQRRILVKNLDNSHPLLKNCLRVTVGTPEENDYFCNTLQDLIAEN
EEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]