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The map label for this gene is hisB [H]

Identifier: 114331881

GI number: 114331881

Start: 2021133

End: 2021720

Strand: Direct

Name: hisB [H]

Synonym: Neut_1906

Alternate gene names: 114331881

Gene position: 2021133-2021720 (Clockwise)

Preceding gene: 114331880

Following gene: 114331882

Centisome position: 75.95

GC content: 48.81

Gene sequence:

>588_bases
ATGCGCAAAGCCCAAGTTACTCGCAACACTCAGGAAACACAAATTACCGTAGCAATCAACCTGGACGGCCAGGGCAAAGC
GGAATTGGATAGCGGCGTTCCTTTTCTTGATCACATGCTGGATCAGATTGCCCGCCATGGCATGATTGACTTGAATGTTG
CAGCCAAAGGCGACCTTCATATCGATGCCCACCATACTGTGGAAGATATTGGCATTGCACTGGGTCAGGCACTGAATCGT
GCCATTGGTGACAAAAAAGGAATATTTCGCTACGGTCATGCATATGTGCCTCTGGACGAAACCTTGTCAAGAGTAGTCAT
CGATTTGTCCGGAAGGCCTGGCTTGCAGTTCAACACCACATTTACACGTGCGGTTATCGGCTCTTTCGATGTCGATCTGA
TCCAGGAATTCTTTCAGGGCTTTGTCAATCATGCCATGATGACACTGCACATAGATAACCTCGCCGGTAAAAACGCACAT
CACCAGGCTGAATCTATTTTCAAGGCATTCGGCCGTGCACTGCGTATGGCTGTAACAATTGATCCACGCTGCGATGACCT
TATTCCATCCACCAAAGGCGTGCTGTAG

Upstream 100 bases:

>100_bases
GCCCGAAGAAAACGATTATTTCTGCAATACACTGCAAGATTTGATCGCTGAAAATTAACCGGAAGACTAAACAAAACACT
CCGTTCAAATTTAAATACTC

Downstream 100 bases:

>100_bases
GTAAAAAAACGCTCAGAACATCTGATACGAACATGAACTCGATTGCCGTTGTAGATTATGGGATGGGCAACCTGAGATCG
GTATCCAAAGCACTGGAATA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRKAQVTRNTQETQITVAINLDGQGKAELDSGVPFLDHMLDQIARHGMIDLNVAAKGDLHIDAHHTVEDIGIALGQALNR
AIGDKKGIFRYGHAYVPLDETLSRVVIDLSGRPGLQFNTTFTRAVIGSFDVDLIQEFFQGFVNHAMMTLHIDNLAGKNAH
HQAESIFKAFGRALRMAVTIDPRCDDLIPSTKGVL

Sequences:

>Translated_195_residues
MRKAQVTRNTQETQITVAINLDGQGKAELDSGVPFLDHMLDQIARHGMIDLNVAAKGDLHIDAHHTVEDIGIALGQALNR
AIGDKKGIFRYGHAYVPLDETLSRVVIDLSGRPGLQFNTTFTRAVIGSFDVDLIQEFFQGFVNHAMMTLHIDNLAGKNAH
HQAESIFKAFGRALRMAVTIDPRCDDLIPSTKGVL
>Mature_195_residues
MRKAQVTRNTQETQITVAINLDGQGKAELDSGVPFLDHMLDQIARHGMIDLNVAAKGDLHIDAHHTVEDIGIALGQALNR
AIGDKKGIFRYGHAYVPLDETLSRVVIDLSGRPGLQFNTTFTRAVIGSFDVDLIQEFFQGFVNHAMMTLHIDNLAGKNAH
HQAESIFKAFGRALRMAVTIDPRCDDLIPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=49.4845360824742, Blast_Score=194, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=41.743119266055, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21425; Mature: 21425

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAQVTRNTQETQITVAINLDGQGKAELDSGVPFLDHMLDQIARHGMIDLNVAAKGDLH
CCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCEE
IDAHHTVEDIGIALGQALNRAIGDKKGIFRYGHAYVPLDETLSRVVIDLSGRPGLQFNTT
ECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEECCHHHHHHHHEEECCCCCCCEECCH
FTRAVIGSFDVDLIQEFFQGFVNHAMMTLHIDNLAGKNAHHQAESIFKAFGRALRMAVTI
HHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEEE
DPRCDDLIPSTKGVL
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRKAQVTRNTQETQITVAINLDGQGKAELDSGVPFLDHMLDQIARHGMIDLNVAAKGDLH
CCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCEE
IDAHHTVEDIGIALGQALNRAIGDKKGIFRYGHAYVPLDETLSRVVIDLSGRPGLQFNTT
ECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEECCHHHHHHHHEEECCCCCCCEECCH
FTRAVIGSFDVDLIQEFFQGFVNHAMMTLHIDNLAGKNAHHQAESIFKAFGRALRMAVTI
HHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEEE
DPRCDDLIPSTKGVL
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]