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The map label for this gene is ispH [H]

Identifier: 114331878

GI number: 114331878

Start: 2018426

End: 2019397

Strand: Reverse

Name: ispH [H]

Synonym: Neut_1903

Alternate gene names: 114331878

Gene position: 2019397-2018426 (Counterclockwise)

Preceding gene: 114331896

Following gene: 114331876

Centisome position: 75.89

GC content: 49.38

Gene sequence:

>972_bases
ATGATCAAGGTGTTGCTTGCAAACCCGAGAGGGTTCTGTGCTGGTGTTGACCGAGCTATTGAAATCGTTGAACGTGCATT
GACGATGTATGGCGCCCCCATCTATGTGAGGCATGAGGTTGTCCACAATCGTTTCGTGGTTGAAGATCTGGAGAAAAAAG
GAGCGGTATTTGTAGAAAATTTGGAGGAAGTGCCGGAAGGGAGCATGCTTATCTTCAGTGCTCATGGTGTTTCCCACGAA
GTAAGAAGAGATGCAGCCGCTCGTAAGCTGCAGATATTTGATGCTACCTGTCCGCTTGTTACCAAGGTACACGTGGAAGT
GGCCAAAATGGACCGAGAGGGCAAGGAGATCGTCATGATCGGCCATCAGGGTCACCCTGAGGTTGAGGGAACCATGGGGC
AGATCGAGAAGAAAAAAGGGACGATGTACCTTGTGGAAACAGCGGAAGACGTATCCGGACTACAGGTCAAGGATGAAGAT
AATCTGGCATATGTCACCCAGACAACATTGTCTGTTGATGATGCAGCGCGCGTGATTGAGGCACTGAAACGACGTTTTCC
AAAGATTGTTGGCCCGAAAAAAGATGATATTTGCTACGCTACGCAAAATCGACAGGATGCTGTCAAAAAGTTGGTCAAGC
TCTGTGATCTGGTGATTGTGGTGGGTTCGCCAAACAGTTCGAATTCAAATCGCCTTTGTGAGGTGGCCAGAAACGAGAAT
GTAGAAGCATATATGGTCGATCAGGCGGCACAGTTGCAGGAGAGCTGGCTGGCCAACAAGCAGTGTATTGGAATTACTGC
AGGTGCGTCTGCTCCGGAGATACTGGTTCAGCAGGTACTGGAGCGTCTTGAGCAGATTGCGACAAAACAGTCGAATCAGG
GTGTGGTGGTGGAAGAGCTGGCGGGAGTCCTTGAATCCGTAACATTCCCATTACCAAAGGCTGAGCCAGTCGGTTTCAAC
AAGCATATCTGA

Upstream 100 bases:

>100_bases
AGTATGTGTTAATAGGATAGGCTTCAGAGATGAAAACTGAAAACCCCTTCGGGATTATTTTATAATCAAACCTGTGCATA
AATCATGGAGAAATAGGCTG

Downstream 100 bases:

>100_bases
TTGAAATTACCCAGACAGATTCCATCCTTGCTGATAGGGTGTGGTATCAAAAGGTTGAGCTCGTTGCATGATCTCGTTTG
TTAATATTTCTGCGCTGCCA

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MIKVLLANPRGFCAGVDRAIEIVERALTMYGAPIYVRHEVVHNRFVVEDLEKKGAVFVENLEEVPEGSMLIFSAHGVSHE
VRRDAAARKLQIFDATCPLVTKVHVEVAKMDREGKEIVMIGHQGHPEVEGTMGQIEKKKGTMYLVETAEDVSGLQVKDED
NLAYVTQTTLSVDDAARVIEALKRRFPKIVGPKKDDICYATQNRQDAVKKLVKLCDLVIVVGSPNSSNSNRLCEVARNEN
VEAYMVDQAAQLQESWLANKQCIGITAGASAPEILVQQVLERLEQIATKQSNQGVVVEELAGVLESVTFPLPKAEPVGFN
KHI

Sequences:

>Translated_323_residues
MIKVLLANPRGFCAGVDRAIEIVERALTMYGAPIYVRHEVVHNRFVVEDLEKKGAVFVENLEEVPEGSMLIFSAHGVSHE
VRRDAAARKLQIFDATCPLVTKVHVEVAKMDREGKEIVMIGHQGHPEVEGTMGQIEKKKGTMYLVETAEDVSGLQVKDED
NLAYVTQTTLSVDDAARVIEALKRRFPKIVGPKKDDICYATQNRQDAVKKLVKLCDLVIVVGSPNSSNSNRLCEVARNEN
VEAYMVDQAAQLQESWLANKQCIGITAGASAPEILVQQVLERLEQIATKQSNQGVVVEELAGVLESVTFPLPKAEPVGFN
KHI
>Mature_323_residues
MIKVLLANPRGFCAGVDRAIEIVERALTMYGAPIYVRHEVVHNRFVVEDLEKKGAVFVENLEEVPEGSMLIFSAHGVSHE
VRRDAAARKLQIFDATCPLVTKVHVEVAKMDREGKEIVMIGHQGHPEVEGTMGQIEKKKGTMYLVETAEDVSGLQVKDED
NLAYVTQTTLSVDDAARVIEALKRRFPKIVGPKKDDICYATQNRQDAVKKLVKLCDLVIVVGSPNSSNSNRLCEVARNEN
VEAYMVDQAAQLQESWLANKQCIGITAGASAPEILVQQVLERLEQIATKQSNQGVVVEELAGVLESVTFPLPKAEPVGFN
KHI

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=312, Percent_Identity=59.2948717948718, Blast_Score=398, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 35622; Mature: 35622

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLLANPRGFCAGVDRAIEIVERALTMYGAPIYVRHEVVHNRFVVEDLEKKGAVFVEN
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEEHH
LEEVPEGSMLIFSAHGVSHEVRRDAAARKLQIFDATCPLVTKVHVEVAKMDREGKEIVMI
HHHCCCCCEEEEEECCCCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEE
GHQGHPEVEGTMGQIEKKKGTMYLVETAEDVSGLQVKDEDNLAYVTQTTLSVDDAARVIE
CCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCEEECCCCEEEEEEEEECHHHHHHHHH
ALKRRFPKIVGPKKDDICYATQNRQDAVKKLVKLCDLVIVVGSPNSSNSNRLCEVARNEN
HHHHHCHHHCCCCCCCEEEECCCHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHCCCC
VEAYMVDQAAQLQESWLANKQCIGITAGASAPEILVQQVLERLEQIATKQSNQGVVVEEL
CEEEEHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AGVLESVTFPLPKAEPVGFNKHI
HHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKVLLANPRGFCAGVDRAIEIVERALTMYGAPIYVRHEVVHNRFVVEDLEKKGAVFVEN
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEEHH
LEEVPEGSMLIFSAHGVSHEVRRDAAARKLQIFDATCPLVTKVHVEVAKMDREGKEIVMI
HHHCCCCCEEEEEECCCCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEE
GHQGHPEVEGTMGQIEKKKGTMYLVETAEDVSGLQVKDEDNLAYVTQTTLSVDDAARVIE
CCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCEEECCCCEEEEEEEEECHHHHHHHHH
ALKRRFPKIVGPKKDDICYATQNRQDAVKKLVKLCDLVIVVGSPNSSNSNRLCEVARNEN
HHHHHCHHHCCCCCCCEEEECCCHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHCCCC
VEAYMVDQAAQLQESWLANKQCIGITAGASAPEILVQQVLERLEQIATKQSNQGVVVEEL
CEEEEHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AGVLESVTFPLPKAEPVGFNKHI
HHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]