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The map label for this gene is galE [H]

Identifier: 114331854

GI number: 114331854

Start: 1993460

End: 1994467

Strand: Reverse

Name: galE [H]

Synonym: Neut_1879

Alternate gene names: 114331854

Gene position: 1994467-1993460 (Counterclockwise)

Preceding gene: 114331855

Following gene: 114331853

Centisome position: 74.95

GC content: 50.89

Gene sequence:

>1008_bases
ATGAAGGTTCTTGTTACTGGAGGAGCTGGTTACATTGGTTCGCACACCTGCGTCGAATTACTGACAGCCGGATATGAGGT
TGTCGTGTTTGATAATTTTTGCAACAGCCATCCGGAGGCATTGCGCCGGGTAGAAAAAATCACCGGTAAGAAACTTGCTG
TAGTCAGGGGGGATGTGCGAGACCAGGCGACCATTGAAAAGGTCCTGAAAGATTACCATTGTGAGGCTGTCATTCACTTT
GCCGGGCTCAAGGCGGTAGGGGAGTCGGTAGAAAAACCACTTGAGTATTATGACAATAACGTTATCAGTACTCTCCGGTT
GCTGGCCGCAATGCAGAATTGTGCTGTATACACACTGGTTTTCAGCTCTTCAGCAACTGTTTATGGCGAACCACAACGTT
TACCTTTGACGGAAGATCATCCGTTATCTGCCACCAATCCCTATGGCCGCAGCAAACTTATGATTGAAGAAATGTTGCGC
GATGTGTATCGGGCCAATCCTCAATTTCGCATTGCCATCCTGCGTTATTTCAATCCTGTGGGTGCACACGACAGCGGGTT
GATTGGCGAGGATCCGCAAGGGATTCCCAATAATCTGATGCCTTTCGTCGCACAAGTTGCGGTGGGGCGGCGTGAACATC
TGAATGTGTGGGGAAGTGATTACCCGACGCATGATGGAACCGGCGTGCGAGATTACATTCATGTGGTGGATTTGGCACTG
GGGCATCTCAGTGCGCTGGGGCACCTTGCCACACCGCAGTGTCTTGCAGTCAATCTTGGCACTGGTACCGGTTACAGCGT
GCTGGATGTGGTCAAGGCTTTTGAGAATGCAAGTGGCCAGCATGTTCCGTATCAGCTATCACCCAGACGGGCAGGGGATG
TGGCGACTTGTTATGCTGATCCTGCACTGGCTGAAAAGATACTGGAGTGGAATGCGCAGCGTGATCTGGCTGCGATGTGC
CGAGATCACTGGCGCTGGCAGAAATGTAATCCGGAAGGATATGTATAA

Upstream 100 bases:

>100_bases
ACTTAGGGAAAACGTATTTAGATGAAAACAAGCTTTGCTTGCGCGGCGGCAGCAGTGATTGCTTAATCTGGTATTTATTC
AGATCTGATAAGGTGTTGAT

Downstream 100 bases:

>100_bases
ACCCGTACCAGATCAGTTTGCTTTTGTACTGTAAACGCCAGAGTGGTTCTGGGTGACATTGAGGTGTGTAATTCAATCTC
TGCAGCAGGTAGCGCAGGAG

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKVLVTGGAGYIGSHTCVELLTAGYEVVVFDNFCNSHPEALRRVEKITGKKLAVVRGDVRDQATIEKVLKDYHCEAVIHF
AGLKAVGESVEKPLEYYDNNVISTLRLLAAMQNCAVYTLVFSSSATVYGEPQRLPLTEDHPLSATNPYGRSKLMIEEMLR
DVYRANPQFRIAILRYFNPVGAHDSGLIGEDPQGIPNNLMPFVAQVAVGRREHLNVWGSDYPTHDGTGVRDYIHVVDLAL
GHLSALGHLATPQCLAVNLGTGTGYSVLDVVKAFENASGQHVPYQLSPRRAGDVATCYADPALAEKILEWNAQRDLAAMC
RDHWRWQKCNPEGYV

Sequences:

>Translated_335_residues
MKVLVTGGAGYIGSHTCVELLTAGYEVVVFDNFCNSHPEALRRVEKITGKKLAVVRGDVRDQATIEKVLKDYHCEAVIHF
AGLKAVGESVEKPLEYYDNNVISTLRLLAAMQNCAVYTLVFSSSATVYGEPQRLPLTEDHPLSATNPYGRSKLMIEEMLR
DVYRANPQFRIAILRYFNPVGAHDSGLIGEDPQGIPNNLMPFVAQVAVGRREHLNVWGSDYPTHDGTGVRDYIHVVDLAL
GHLSALGHLATPQCLAVNLGTGTGYSVLDVVKAFENASGQHVPYQLSPRRAGDVATCYADPALAEKILEWNAQRDLAAMC
RDHWRWQKCNPEGYV
>Mature_335_residues
MKVLVTGGAGYIGSHTCVELLTAGYEVVVFDNFCNSHPEALRRVEKITGKKLAVVRGDVRDQATIEKVLKDYHCEAVIHF
AGLKAVGESVEKPLEYYDNNVISTLRLLAAMQNCAVYTLVFSSSATVYGEPQRLPLTEDHPLSATNPYGRSKLMIEEMLR
DVYRANPQFRIAILRYFNPVGAHDSGLIGEDPQGIPNNLMPFVAQVAVGRREHLNVWGSDYPTHDGTGVRDYIHVVDLAL
GHLSALGHLATPQCLAVNLGTGTGYSVLDVVKAFENASGQHVPYQLSPRRAGDVATCYADPALAEKILEWNAQRDLAAMC
RDHWRWQKCNPEGYV

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=341, Percent_Identity=60.7038123167155, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI56118217, Length=341, Percent_Identity=60.7038123167155, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI189083684, Length=341, Percent_Identity=60.7038123167155, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI42516563, Length=316, Percent_Identity=25.9493670886076, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7657641, Length=277, Percent_Identity=26.7148014440433, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=56.25, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI48994969, Length=284, Percent_Identity=23.5915492957746, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=50.4347826086956, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=50.7204610951009, Blast_Score=354, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17568069, Length=279, Percent_Identity=26.1648745519713, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=342, Percent_Identity=51.7543859649123, Blast_Score=350, Evalue=1e-97,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=58.4795321637427, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI21356223, Length=318, Percent_Identity=23.2704402515723, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36950; Mature: 36950

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVTGGAGYIGSHTCVELLTAGYEVVVFDNFCNSHPEALRRVEKITGKKLAVVRGDVR
CEEEEECCCCCCCHHHHHHHHHCCCEEEEECCHHCCCHHHHHHHHHHCCCEEEEEECCCC
DQATIEKVLKDYHCEAVIHFAGLKAVGESVEKPLEYYDNNVISTLRLLAAMQNCAVYTLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEE
FSSSATVYGEPQRLPLTEDHPLSATNPYGRSKLMIEEMLRDVYRANPQFRIAILRYFNPV
EECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHEECCCCC
GAHDSGLIGEDPQGIPNNLMPFVAQVAVGRREHLNVWGSDYPTHDGTGVRDYIHVVDLAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
GHLSALGHLATPQCLAVNLGTGTGYSVLDVVKAFENASGQHVPYQLSPRRAGDVATCYAD
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEECCC
PALAEKILEWNAQRDLAAMCRDHWRWQKCNPEGYV
HHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCC
>Mature Secondary Structure
MKVLVTGGAGYIGSHTCVELLTAGYEVVVFDNFCNSHPEALRRVEKITGKKLAVVRGDVR
CEEEEECCCCCCCHHHHHHHHHCCCEEEEECCHHCCCHHHHHHHHHHCCCEEEEEECCCC
DQATIEKVLKDYHCEAVIHFAGLKAVGESVEKPLEYYDNNVISTLRLLAAMQNCAVYTLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEE
FSSSATVYGEPQRLPLTEDHPLSATNPYGRSKLMIEEMLRDVYRANPQFRIAILRYFNPV
EECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHEECCCCC
GAHDSGLIGEDPQGIPNNLMPFVAQVAVGRREHLNVWGSDYPTHDGTGVRDYIHVVDLAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
GHLSALGHLATPQCLAVNLGTGTGYSVLDVVKAFENASGQHVPYQLSPRRAGDVATCYAD
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEECCC
PALAEKILEWNAQRDLAAMCRDHWRWQKCNPEGYV
HHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]