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The map label for this gene is uvrY [H]

Identifier: 114331815

GI number: 114331815

Start: 1947987

End: 1948619

Strand: Reverse

Name: uvrY [H]

Synonym: Neut_1839

Alternate gene names: 114331815

Gene position: 1948619-1947987 (Counterclockwise)

Preceding gene: 114331816

Following gene: 114331813

Centisome position: 73.23

GC content: 51.03

Gene sequence:

>633_bases
ATGATCAAGGTGATGATCACTGATGATCATGCAATTGTGCGCCAGGGGCTCAAGCAGATTCTGAGCGAGACCGGTGACAT
CAGCGTAACCGGGGAAGCGGAAAGCGGTTTCCAGGCGATGAAGGTTGTGCGTCAACAGGATTTTGATGTGATGTTGCTGG
ATATTTCATTGCCAGATCGGAACGGGCTGGATGTGCTCAAGCAAATTAAGAAGGAACAGTCGAATCTGGCGGTGCTGATG
CTAAGCATGCACAATGAAAGCGAGTTTGCGATCCGTGCCCTCAAGGCGGGGGCGGCTGGTTATCTGAACAAGCAGAGTGC
GCCGGCGCAACTGGTTACCGCGATTCGTCAGGTTGCATCCGGCCAGAAATTCATTACCCCTGCGCTGGCAATGGAGCTGG
CAAACGCGATTACCTCGAATACAGATCGGCCGCTGCACGCTTCATTATCCGACCGGGAATTTCAGACGTTGTGCCTGATT
GCTTCCGGCAAAGGGCTTTCCGAAATTTCAGAAGAAATATGTCTGAGCCCGAAAACTGTCAGTGTTTATCGTGCCAGGTT
ATTGGAAAAACTAAAGCTTACCAACAACAGCGAATTAATCCGCTACGCCATCATGCATCACCTGGTCGATTGA

Upstream 100 bases:

>100_bases
GGTGAATGGGCAGTCTTCATCGTCTTATCAGGATGAGTGGCCGGATTGAGGGATGAAACATGAGACAAGGAATGTCAGCT
GATAGGGTGAGGATGTAATC

Downstream 100 bases:

>100_bases
CCCTTTCCTGCGCTCTTTGAGCCAATTACCTTAAAATCCTCTTTGGTCAAGCCTTCCACGAAGCCGCAGGCATCGGTAGC
GGCCTGCTGCATGTGGCCCA

Product: two component transcriptional regulator, LuxR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIKVMITDDHAIVRQGLKQILSETGDISVTGEAESGFQAMKVVRQQDFDVMLLDISLPDRNGLDVLKQIKKEQSNLAVLM
LSMHNESEFAIRALKAGAAGYLNKQSAPAQLVTAIRQVASGQKFITPALAMELANAITSNTDRPLHASLSDREFQTLCLI
ASGKGLSEISEEICLSPKTVSVYRARLLEKLKLTNNSELIRYAIMHHLVD

Sequences:

>Translated_210_residues
MIKVMITDDHAIVRQGLKQILSETGDISVTGEAESGFQAMKVVRQQDFDVMLLDISLPDRNGLDVLKQIKKEQSNLAVLM
LSMHNESEFAIRALKAGAAGYLNKQSAPAQLVTAIRQVASGQKFITPALAMELANAITSNTDRPLHASLSDREFQTLCLI
ASGKGLSEISEEICLSPKTVSVYRARLLEKLKLTNNSELIRYAIMHHLVD
>Mature_210_residues
MIKVMITDDHAIVRQGLKQILSETGDISVTGEAESGFQAMKVVRQQDFDVMLLDISLPDRNGLDVLKQIKKEQSNLAVLM
LSMHNESEFAIRALKAGAAGYLNKQSAPAQLVTAIRQVASGQKFITPALAMELANAITSNTDRPLHASLSDREFQTLCLI
ASGKGLSEISEEICLSPKTVSVYRARLLEKLKLTNNSELIRYAIMHHLVD

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=212, Percent_Identity=41.0377358490566, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=40.2985074626866, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1786747, Length=209, Percent_Identity=32.5358851674641, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=34.4262295081967, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1788521, Length=192, Percent_Identity=30.7291666666667, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788712, Length=199, Percent_Identity=28.1407035175879, Blast_Score=90, Evalue=9e-20,
Organism=Escherichia coli, GI1788546, Length=206, Percent_Identity=29.6116504854369, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI87082052, Length=125, Percent_Identity=32, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786784, Length=115, Percent_Identity=29.5652173913043, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=30.5084745762712, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23090; Mature: 23090

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVMITDDHAIVRQGLKQILSETGDISVTGEAESGFQAMKVVRQQDFDVMLLDISLPDR
CEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCC
NGLDVLKQIKKEQSNLAVLMLSMHNESEFAIRALKAGAAGYLNKQSAPAQLVTAIRQVAS
CCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
GQKFITPALAMELANAITSNTDRPLHASLSDREFQTLCLIASGKGLSEISEEICLSPKTV
CCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHH
SVYRARLLEKLKLTNNSELIRYAIMHHLVD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKVMITDDHAIVRQGLKQILSETGDISVTGEAESGFQAMKVVRQQDFDVMLLDISLPDR
CEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCC
NGLDVLKQIKKEQSNLAVLMLSMHNESEFAIRALKAGAAGYLNKQSAPAQLVTAIRQVAS
CCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
GQKFITPALAMELANAITSNTDRPLHASLSDREFQTLCLIASGKGLSEISEEICLSPKTV
CCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHH
SVYRARLLEKLKLTNNSELIRYAIMHHLVD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]