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The map label for this gene is czcC [H]

Identifier: 114331744

GI number: 114331744

Start: 1873383

End: 1874636

Strand: Reverse

Name: czcC [H]

Synonym: Neut_1767

Alternate gene names: 114331744

Gene position: 1874636-1873383 (Counterclockwise)

Preceding gene: 114331745

Following gene: 114331743

Centisome position: 70.45

GC content: 53.51

Gene sequence:

>1254_bases
ATGTGTAATATTATTTTCTCGTGGGTTCTGTGTGGCCTGACTTTATTTATGCTGAATTGCTCGGTTCTGGCAGCAGGTGG
CGGCTATACTGTTGCAGATATTCAGCGCATGGGGTTGCAGGCCAATGGCCTGTTGCAAGCAGCGCGTTCACAGGTTGATA
TTGCACAGGCGGGAGTAACCAGTGCATCGGCATTTCCCAACCCGGAAATAACCTTCATGGCCGGACCTGATAGTCCGCGA
TTGCCGGAAATCGATACCGGACCATCTTCCATGCAGCGGCAGGTAACCGTCAGCCAACCACTGGAAAATCCATGGGTGCG
ACGTGCCCGCATTGGGGCGGCAGAATCCGGCGTTGAAGCCAGTCGCGCAAATCTGGAACAGGCCCGAGCAGATCTAGCGG
CACAACTCCGGGTGCATATCTACGAATTTTTGTTACGGCGTGGCCTGGCAGAAATGGAATCAGATATTTTTAATTTGATG
GGGGAAATTCAACGCCGTATCAAACTGAGTGTTGAATCAGGTGAAATTGCCCGGTTTGAGCTAATTCGGGCCGATACCGA
GGTAATGACAGCGGCGAGTAGAAAAGAGGCAGCATTGCTGAACACGGAGCGGGCGCGAATCGCGCTGCTGCAGCTGACAG
CCGGTACGCTGCCTGCTGAGTTTGATGTGATCGCTTCACTCAGCGACCCAGTGGAACTGCCTTCACTGGAGATGTTACGT
ACGGAATTACCCGCTACAAACCCGGAAATTCAACGGCTGGAAGCAGAACAGGATCGCGCACGTTTACGTATTGATCAGGA
GCGCGCTTCTGTGCTCCCATCCGTGGATATTCTGTACAGCAATTATCAGGATAGGCAATTTACATCGAATACTGCCGGAC
TGAGCGTTCGCATCCCATTATTTTATCAGCGACGTGGTGAAGTTGATGCGGCAGTTTCAGATGCAGCTAGGGTACGCGAA
ACGCTCGATTATCGTCGCTACGAGATCGGCCGGTTGCTGGAGTCTGCCTGGCAGGCCATGGAGATTGCCCGGCGCAGGGT
GGAGATGTTCGAAGGCGGCATCGTTAAGGAGGCGAAAGCTGCGCTGCGCGTGGCGGAAGCTGCTTTCCGGTTGGGAGAAA
GAGATTTTATCGAGGTACTGGATACTCAACGGGTGCTACGTAATGCGCGCTCGGAATTATTGCAGGCCCAGTTCGAATTG
CAGGCAGCAGCAGCAGAGATAGATCGGCTGCGGGCGCATTATCCACAGGAGTAA

Upstream 100 bases:

>100_bases
CAGAAAACTTAATTAAAATATTTAAATTTATGTGCAATCGTATGATTGATAACTTTATGCGGGTACTGCTGTTGGAGTAT
GAATAATTATCATTTTTCGT

Downstream 100 bases:

>100_bases
TTTTCCCCAATGAGTTTCCAGATACAAACTATTGCAGTTATTTTTGCATTCGTAGTGCTTTCTATTTCGGGTTGCAGCAG
CAAAGAAGAGCAGGATTCCC

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MCNIIFSWVLCGLTLFMLNCSVLAAGGGYTVADIQRMGLQANGLLQAARSQVDIAQAGVTSASAFPNPEITFMAGPDSPR
LPEIDTGPSSMQRQVTVSQPLENPWVRRARIGAAESGVEASRANLEQARADLAAQLRVHIYEFLLRRGLAEMESDIFNLM
GEIQRRIKLSVESGEIARFELIRADTEVMTAASRKEAALLNTERARIALLQLTAGTLPAEFDVIASLSDPVELPSLEMLR
TELPATNPEIQRLEAEQDRARLRIDQERASVLPSVDILYSNYQDRQFTSNTAGLSVRIPLFYQRRGEVDAAVSDAARVRE
TLDYRRYEIGRLLESAWQAMEIARRRVEMFEGGIVKEAKAALRVAEAAFRLGERDFIEVLDTQRVLRNARSELLQAQFEL
QAAAAEIDRLRAHYPQE

Sequences:

>Translated_417_residues
MCNIIFSWVLCGLTLFMLNCSVLAAGGGYTVADIQRMGLQANGLLQAARSQVDIAQAGVTSASAFPNPEITFMAGPDSPR
LPEIDTGPSSMQRQVTVSQPLENPWVRRARIGAAESGVEASRANLEQARADLAAQLRVHIYEFLLRRGLAEMESDIFNLM
GEIQRRIKLSVESGEIARFELIRADTEVMTAASRKEAALLNTERARIALLQLTAGTLPAEFDVIASLSDPVELPSLEMLR
TELPATNPEIQRLEAEQDRARLRIDQERASVLPSVDILYSNYQDRQFTSNTAGLSVRIPLFYQRRGEVDAAVSDAARVRE
TLDYRRYEIGRLLESAWQAMEIARRRVEMFEGGIVKEAKAALRVAEAAFRLGERDFIEVLDTQRVLRNARSELLQAQFEL
QAAAAEIDRLRAHYPQE
>Mature_417_residues
MCNIIFSWVLCGLTLFMLNCSVLAAGGGYTVADIQRMGLQANGLLQAARSQVDIAQAGVTSASAFPNPEITFMAGPDSPR
LPEIDTGPSSMQRQVTVSQPLENPWVRRARIGAAESGVEASRANLEQARADLAAQLRVHIYEFLLRRGLAEMESDIFNLM
GEIQRRIKLSVESGEIARFELIRADTEVMTAASRKEAALLNTERARIALLQLTAGTLPAEFDVIASLSDPVELPSLEMLR
TELPATNPEIQRLEAEQDRARLRIDQERASVLPSVDILYSNYQDRQFTSNTAGLSVRIPLFYQRRGEVDAAVSDAARVRE
TLDYRRYEIGRLLESAWQAMEIARRRVEMFEGGIVKEAKAALRVAEAAFRLGERDFIEVLDTQRVLRNARSELLQAQFEL
QAAAAEIDRLRAHYPQE

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46477; Mature: 46477

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNIIFSWVLCGLTLFMLNCSVLAAGGGYTVADIQRMGLQANGLLQAARSQVDIAQAGVT
CCHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
SASAFPNPEITFMAGPDSPRLPEIDTGPSSMQRQVTVSQPLENPWVRRARIGAAESGVEA
CCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHCEEHHCCCCCHHHHHHHCCCCCCCCHH
SRANLEQARADLAAQLRVHIYEFLLRRGLAEMESDIFNLMGEIQRRIKLSVESGEIARFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHH
LIRADTEVMTAASRKEAALLNTERARIALLQLTAGTLPAEFDVIASLSDPVELPSLEMLR
HHHCCHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHHHCCCCCCCCCHHHHHH
TELPATNPEIQRLEAEQDRARLRIDQERASVLPSVDILYSNYQDRQFTSNTAGLSVRIPL
HHCCCCCHHHHHHHHHHHHHHHEECHHHHHHCCCHHHHHCCCCCCCCCCCCCCEEEEEEE
FYQRRGEVDAAVSDAARVRETLDYRRYEIGRLLESAWQAMEIARRRVEMFEGGIVKEAKA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALRVAEAAFRLGERDFIEVLDTQRVLRNARSELLQAQFELQAAAAEIDRLRAHYPQE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MCNIIFSWVLCGLTLFMLNCSVLAAGGGYTVADIQRMGLQANGLLQAARSQVDIAQAGVT
CCHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
SASAFPNPEITFMAGPDSPRLPEIDTGPSSMQRQVTVSQPLENPWVRRARIGAAESGVEA
CCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHCEEHHCCCCCHHHHHHHCCCCCCCCHH
SRANLEQARADLAAQLRVHIYEFLLRRGLAEMESDIFNLMGEIQRRIKLSVESGEIARFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHH
LIRADTEVMTAASRKEAALLNTERARIALLQLTAGTLPAEFDVIASLSDPVELPSLEMLR
HHHCCHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHHHCCCCCCCCCHHHHHH
TELPATNPEIQRLEAEQDRARLRIDQERASVLPSVDILYSNYQDRQFTSNTAGLSVRIPL
HHCCCCCHHHHHHHHHHHHHHHEECHHHHHHCCCHHHHHCCCCCCCCCCCCCCEEEEEEE
FYQRRGEVDAAVSDAARVRETLDYRRYEIGRLLESAWQAMEIARRRVEMFEGGIVKEAKA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALRVAEAAFRLGERDFIEVLDTQRVLRNARSELLQAQFELQAAAAEIDRLRAHYPQE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]