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The map label for this gene is frmB [H]

Identifier: 114331377

GI number: 114331377

Start: 1457067

End: 1457936

Strand: Direct

Name: frmB [H]

Synonym: Neut_1386

Alternate gene names: 114331377

Gene position: 1457067-1457936 (Clockwise)

Preceding gene: 114331376

Following gene: 114331379

Centisome position: 54.76

GC content: 49.2

Gene sequence:

>870_bases
ATGACAATCAAACTGGAAATTCGCAGCCAGCACCGCTGTTTTGGTGGTCTTCAAAGTTATTATCAGCATCATTCAGAAAT
TATCGGCTTACCGATGCGCTTCTCAGTGTATGTGCCGCCCGAAGCCGGTGAGCAGCGTTTACCCGTACTGTTTTTTCTAG
CCGGGCTGACCTGTACAGAAGAAACTTTCATGATTAAGGCCGGTGCACAACGTTATGCTGCCGAGCTCGGGCTGATGCTG
GTCAGTATGGATACCAGCCCACGCAATACCGGCATTCCTGGTGAAGCGGATGATTGGGAATTTGGATCAGGCGCCGGGTT
CTATCTTGATGCCATAGAATCCCCCTGGTCCAAATACTTTCACATGGAAAGCTATGTGACACAAGAGCTGTACAACATCA
TACTGGGTCAATTTCCAGTTGATCCGAAAAGTGTGGGAATTTCAGGACATTCAATGGGAGGACATGGTGCGTTAACCCTG
GCGTTACGCCACCCTGAGCTGTACCAGTCAGTTTCTGCCTTTGCGCCGATAGCAGCCCCCATTCACTGCCCTTGGGGACA
AAAGGCATTCAGTCGTTACCTGGGGAAATCGCCAGAAAGCTGGCATAAACACGATGCAACCGCTCTGATCGAATCTGGTC
ACCGACTACCAACCCCGTTAATTGATCAGGGACTAGACGATCCTTTTCTTGCTGAGCAATTACATCCCAGCTATTTTGAA
GCCGCCTGTCAGCAAGCTGAACAGCCCATTATTTTGCGTCGCCATGCTGGCTATGATCACAGCTACTTTTTTATCAGCAC
TTTTATTGAAGATCATTTGCGACATCACCACACTTTCCTGACGTTGGATCCGGCTGATTCAGCAGGTTGA

Upstream 100 bases:

>100_bases
TACACACACCCTGAAACTGGAAGACATCAACGAAGGTTTCAAATTGATGGAAGCCGGAAAATCTATTCGTTCTGTTGTAA
TTTACTGATGACTTAAAAAA

Downstream 100 bases:

>100_bases
TTCAATCTGGATTTTCTTGCTATATCTCATCGTCATTGTGCGACAGCGACAACCTCTCCCTCTCGCCTTTTCGAGCATGT
TCGTGCGAAGCAATCCAGAG

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTIKLEIRSQHRCFGGLQSYYQHHSEIIGLPMRFSVYVPPEAGEQRLPVLFFLAGLTCTEETFMIKAGAQRYAAELGLML
VSMDTSPRNTGIPGEADDWEFGSGAGFYLDAIESPWSKYFHMESYVTQELYNIILGQFPVDPKSVGISGHSMGGHGALTL
ALRHPELYQSVSAFAPIAAPIHCPWGQKAFSRYLGKSPESWHKHDATALIESGHRLPTPLIDQGLDDPFLAEQLHPSYFE
AACQQAEQPIILRRHAGYDHSYFFISTFIEDHLRHHHTFLTLDPADSAG

Sequences:

>Translated_289_residues
MTIKLEIRSQHRCFGGLQSYYQHHSEIIGLPMRFSVYVPPEAGEQRLPVLFFLAGLTCTEETFMIKAGAQRYAAELGLML
VSMDTSPRNTGIPGEADDWEFGSGAGFYLDAIESPWSKYFHMESYVTQELYNIILGQFPVDPKSVGISGHSMGGHGALTL
ALRHPELYQSVSAFAPIAAPIHCPWGQKAFSRYLGKSPESWHKHDATALIESGHRLPTPLIDQGLDDPFLAEQLHPSYFE
AACQQAEQPIILRRHAGYDHSYFFISTFIEDHLRHHHTFLTLDPADSAG
>Mature_288_residues
TIKLEIRSQHRCFGGLQSYYQHHSEIIGLPMRFSVYVPPEAGEQRLPVLFFLAGLTCTEETFMIKAGAQRYAAELGLMLV
SMDTSPRNTGIPGEADDWEFGSGAGFYLDAIESPWSKYFHMESYVTQELYNIILGQFPVDPKSVGISGHSMGGHGALTLA
LRHPELYQSVSAFAPIAAPIHCPWGQKAFSRYLGKSPESWHKHDATALIESGHRLPTPLIDQGLDDPFLAEQLHPSYFEA
ACQQAEQPIILRRHAGYDHSYFFISTFIEDHLRHHHTFLTLDPADSAG

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=282, Percent_Identity=51.4184397163121, Blast_Score=304, Evalue=5e-83,
Organism=Escherichia coli, GI1786551, Length=278, Percent_Identity=45.3237410071942, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=48.7455197132617, Blast_Score=265, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17510185, Length=277, Percent_Identity=44.043321299639, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322393, Length=298, Percent_Identity=34.2281879194631, Blast_Score=169, Evalue=4e-43,
Organism=Drosophila melanogaster, GI45551932, Length=284, Percent_Identity=51.056338028169, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=51.2367491166078, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 32333; Mature: 32202

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKLEIRSQHRCFGGLQSYYQHHSEIIGLPMRFSVYVPPEAGEQRLPVLFFLAGLTCTE
CEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHEECCCCCCC
ETFMIKAGAQRYAAELGLMLVSMDTSPRNTGIPGEADDWEFGSGAGFYLDAIESPWSKYF
CEEEEECCHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCHHHHHH
HMESYVTQELYNIILGQFPVDPKSVGISGHSMGGHGALTLALRHPELYQSVSAFAPIAAP
HHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCEEEEEEECHHHHHHHHHHCCCCCC
IHCPWGQKAFSRYLGKSPESWHKHDATALIESGHRLPTPLIDQGLDDPFLAEQLHPSYFE
EECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHCCHHHHH
AACQQAEQPIILRRHAGYDHSYFFISTFIEDHLRHHHTFLTLDPADSAG
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure 
TIKLEIRSQHRCFGGLQSYYQHHSEIIGLPMRFSVYVPPEAGEQRLPVLFFLAGLTCTE
EEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHEECCCCCCC
ETFMIKAGAQRYAAELGLMLVSMDTSPRNTGIPGEADDWEFGSGAGFYLDAIESPWSKYF
CEEEEECCHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCHHHHHH
HMESYVTQELYNIILGQFPVDPKSVGISGHSMGGHGALTLALRHPELYQSVSAFAPIAAP
HHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCEEEEEEECHHHHHHHHHHCCCCCC
IHCPWGQKAFSRYLGKSPESWHKHDATALIESGHRLPTPLIDQGLDDPFLAEQLHPSYFE
EECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHCCHHHHH
AACQQAEQPIILRRHAGYDHSYFFISTFIEDHLRHHHTFLTLDPADSAG
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA