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The map label for this gene is hisG

Identifier: 114331203

GI number: 114331203

Start: 1259684

End: 1260334

Strand: Direct

Name: hisG

Synonym: Neut_1205

Alternate gene names: 114331203

Gene position: 1259684-1260334 (Clockwise)

Preceding gene: 114331202

Following gene: 114331204

Centisome position: 47.34

GC content: 49.92

Gene sequence:

>651_bases
ATGCCGGATATCACCATAGCTCTTTCCAAGGGGCGAATCTTTGAGGATACTATTCCGTTTCTGGAAGCTGCCGGCATTAT
CCCGCAGGATGATCCGGATACTTCCCGTAAACTGATCATTGAGACCAACCGTCCCGATGTCAGACTCGTTATGGTGCGGG
CTACAGATGTGCCAACCTATGTACAGTATGGCGCTGCTGATTTGGGCGTGGCCGGGAAAGATGTGCTGCTGGAGCATGAT
GGAGTCGGGTTGTATCAGCCCCTGGATCTAAAAATCGCCCGCTGTCATATGATGGTTGCAGTGCGAGACGGCTATGATTA
TGCTTCGGCAGTTTTTCAGGGCGCGCGCTTGCGTGTGGCTACCAAATATGTAAAAACCGCGCGCAGCCATTTTGCTGCAA
AAGGGATGCATGTCGATCTGATCAAATTATATGGTTCAATGGAGCTTGCCCCGCTTGTTGACTTGGCGGATGCAATTGTT
GATCTGGTTTCGACTGGCGGAACACTCAAAGCAAATCGTTTGCAAGCCGTCGAGGAAATTATGCCAATCTCAGCTCGCCT
GATTGTAAATCAGGCGGCGCTGAAGCTGAAAAATCCCACAATACAACCTTTGTTAGAAGCGTTTAATGCAGCAATCCCCG
CAAATGTGTAG

Upstream 100 bases:

>100_bases
TTTGGATTTCCAGAATCGTCGACCTGATTATGTCAATACAGTAATTGATAAATTGATTAATTGGGAATTTGCTGCGGCGA
ATCTCGCATAACGACTATTG

Downstream 100 bases:

>100_bases
TCCTCTCAACTCTTAATTACTATGATTCAAATCAGGCGGCTGTCGTCCTCAGATATTGATTTCCAAGAAGAACTTAGATC
ACTATTGAGTTTTGAGATAT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MPDITIALSKGRIFEDTIPFLEAAGIIPQDDPDTSRKLIIETNRPDVRLVMVRATDVPTYVQYGAADLGVAGKDVLLEHD
GVGLYQPLDLKIARCHMMVAVRDGYDYASAVFQGARLRVATKYVKTARSHFAAKGMHVDLIKLYGSMELAPLVDLADAIV
DLVSTGGTLKANRLQAVEEIMPISARLIVNQAALKLKNPTIQPLLEAFNAAIPANV

Sequences:

>Translated_216_residues
MPDITIALSKGRIFEDTIPFLEAAGIIPQDDPDTSRKLIIETNRPDVRLVMVRATDVPTYVQYGAADLGVAGKDVLLEHD
GVGLYQPLDLKIARCHMMVAVRDGYDYASAVFQGARLRVATKYVKTARSHFAAKGMHVDLIKLYGSMELAPLVDLADAIV
DLVSTGGTLKANRLQAVEEIMPISARLIVNQAALKLKNPTIQPLLEAFNAAIPANV
>Mature_215_residues
PDITIALSKGRIFEDTIPFLEAAGIIPQDDPDTSRKLIIETNRPDVRLVMVRATDVPTYVQYGAADLGVAGKDVLLEHDG
VGLYQPLDLKIARCHMMVAVRDGYDYASAVFQGARLRVATKYVKTARSHFAAKGMHVDLIKLYGSMELAPLVDLADAIVD
LVSTGGTLKANRLQAVEEIMPISARLIVNQAALKLKNPTIQPLLEAFNAAIPANV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=223, Percent_Identity=32.7354260089686, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320896, Length=198, Percent_Identity=31.3131313131313, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_NITEC (Q0AGS2)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747425.1
- ProteinModelPortal:   Q0AGS2
- SMR:   Q0AGS2
- STRING:   Q0AGS2
- GeneID:   4272165
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1205
- NMPDR:   fig|335283.3.peg.1504
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   NEUT335283:NEUT_1205-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23450; Mature: 23318

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDITIALSKGRIFEDTIPFLEAAGIIPQDDPDTSRKLIIETNRPDVRLVMVRATDVPTY
CCCEEEEEECCCEEHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCHH
VQYGAADLGVAGKDVLLEHDGVGLYQPLDLKIARCHMMVAVRDGYDYASAVFQGARLRVA
HHCCCHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHCCCHHHHH
TKYVKTARSHFAAKGMHVDLIKLYGSMELAPLVDLADAIVDLVSTGGTLKANRLQAVEEI
HHHHHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
MPISARLIVNQAALKLKNPTIQPLLEAFNAAIPANV
HCCHHHHHHHHHHHEECCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PDITIALSKGRIFEDTIPFLEAAGIIPQDDPDTSRKLIIETNRPDVRLVMVRATDVPTY
CCEEEEEECCCEEHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCHH
VQYGAADLGVAGKDVLLEHDGVGLYQPLDLKIARCHMMVAVRDGYDYASAVFQGARLRVA
HHCCCHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHCCCHHHHH
TKYVKTARSHFAAKGMHVDLIKLYGSMELAPLVDLADAIVDLVSTGGTLKANRLQAVEEI
HHHHHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
MPISARLIVNQAALKLKNPTIQPLLEAFNAAIPANV
HCCHHHHHHHHHHHEECCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA